For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
AAMTRRLRALPALLIFVVTACTSPPAPVEQPTAAGQLTPMLVEVLSTPRWFTGTDGRTHLAYELLLTNVA PAEVNVAALEVRDADSGATLMSLSDDALREAMSLAASPSPPTTAVPSSAMTVVWLDVPSSGPPAAALTHR LTIDPPQGVTLDAVAWTFTTDPVYVDRRPPVVLGPPLAGPRWIALGSCCDGPHRRATYPIDGRWYIAQRY AIDFNLLDAQNRPGIGDPVLPNSFPTFGQPVYAVADGVIAMADDGRPDLRVGQARDEPTPQDAGGNRVAI DIGDGHYAIYAHLREGSIKVRANDRVRRGDHIADVGSSGTTGGPHLHFQVNDRPSVVYADGLPYVFDSFD VTGRTPPLEEVLPYYDTLEPIPVSTADTGRRDDQLPLGRDVLTFPAADG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1192 | - | - | 100% (400) | M23 peptidase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0247 | - | 7e-63 | 40.06% (352) | secreted peptidase |
| M. smegmatis MC2 155 | MSMEG_5526 | - | 1e-07 | 32.63% (95) | peptidoglycan-binding LysM |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0975c | - | 5e-08 | 35.48% (93) | hypothetical protein Mb0975c |
| M. gilvum PYR-GCK | Mflv_1864 | - | 2e-08 | 32.98% (94) | peptidase M23B |
| M. tuberculosis H37Rv | Rv0950c | - | 5e-08 | 35.48% (93) | hypothetical protein Rv0950c |
| M. leprae Br4923 | MLBr_00154 | - | 3e-06 | 33.33% (93) | hypothetical protein MLBr_00154 |
| M. abscessus ATCC 19977 | MAB_1055c | - | 2e-07 | 32.63% (95) | hypothetical protein MAB_1055c |
| M. marinum M | MMAR_3448 | - | 5e-44 | 31.92% (354) | hypothetical protein MMAR_3448 |
| M. avium 104 | MAV_1073 | - | 6e-09 | 33.68% (95) | M23 peptidase domain-containing protein |
| M. thermoresistible (build 8) | TH_1774 | - | 3e-09 | 37.63% (93) | peptidoglycan-binding LysM |
| M. ulcerans Agy99 | MUL_2722 | - | 5e-41 | 32.01% (328) | hypothetical protein MUL_2722 |
| M. vanbaalenii PYR-1 | Mvan_4871 | - | 4e-09 | 34.04% (94) | peptidase M23B |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0975c|M.bovis_AF2122/97 --MAAIRTPR----DRWPHHHRN--------EVTEIIPLDGF--LDGLAL
Rv0950c|M.tuberculosis_H37Rv --MAAIRTPR----DRWPHHHRN--------EVTEIIPLDGF--LDGLAL
MAV_1073|M.avium_104 --MRVGRAPG----ARSAEPHRT--------EVTEILPLDGFD-FDDLDF
MLBr_00154|M.leprae_Br4923 MAAEAVRSFR----NRWLNHQRN--------DVTEIIPVDGF---DDFDD
Mflv_1864|M.gilvum_PYR-GCK --MPQHRLPR----SRAALTTPG------LSEVTDIIPFDEFGALGDIDD
Mvan_4871|M.vanbaalenii_PYR-1 --MPQHRLPR----SIEVLAAPG------PTEVTDIIPFNEFG---DLSD
TH_1774|M.thermoresistible__bu --LAKHRAVSPAGDSTDAHRHPRQGFDPHPAEITEIIPLSGFGRLSDLGA
MAB_1055c|M.abscessus_ATCC_199 --MPIDEFGL-----SDALERPE----LEDYDVYEDAPEEGA----EIED
MMAR_3448|M.marinum_M --MAYEQPRH-----RARSPFWKS-LAVFWLALSVAACSSSTTSAEGAST
MUL_2722|M.ulcerans_Agy99 --MLIEYHWR-----RRRFDQRQ-------RHRQRARGSNGSRRVHTADH
MSMEG_1192|M.smegmatis_MC2_155 --MAAMTRRLRALPALLIFVVTACTSPPAPVEQPTAAGQLTPMLVEVLST
Mb0975c|M.bovis_AF2122/97 YDELDF---------------------------AELDDLDLG-DDCVFDY
Rv0950c|M.tuberculosis_H37Rv YDELDF---------------------------AELDDLDLG-DDCVFDY
MAV_1073|M.avium_104 CDDAG-----------------------------DHGDLDFS-TDSPFDN
MLBr_00154|M.leprae_Br4923 LYDLDF---------------------------AEIDELQFSDDDYNFCN
Mflv_1864|M.gilvum_PYR-GCK LEFLQ---------------------------------------DAAFGR
Mvan_4871|M.vanbaalenii_PYR-1 LEFLP---------------------------------------HAAFDR
TH_1774|M.thermoresistible__bu DTDFYG---------------------------DAWDD----EWDVAFDR
MAB_1055c|M.abscessus_ATCC_199 QTALD---------------------------------------QLEQDW
MMAR_3448|M.marinum_M NANGTNNALEGVTVPDAFTPLTIAPISRPTFPFPGTDGKYHLAYDVQITN
MUL_2722|M.ulcerans_Agy99 RAN---------------QPADVS--------VPGTDDKYHLAYDVQITN
MSMEG_1192|M.smegmatis_MC2_155 PRWFTG-----------------------------TDGRTHLAYELLLTN
.
Mb0975c|M.bovis_AF2122/97 EAQLLAAPELDDLDDADDLAPEWLVAPTVVLTP-----------------
Rv0950c|M.tuberculosis_H37Rv EAQLLAAPELDDLDDADDLAPEWLVAPTVVLTP-----------------
MAV_1073|M.avium_104 EAQVLLAPELDDLNETDDLRPLWLAAPVTEVLPR--------TTVAARTE
MLBr_00154|M.leprae_Br4923 ETQVLLASEIDDLQDIDSLASEPLAASANVAPN-----------------
Mflv_1864|M.gilvum_PYR-GCK DAEVIDAPELDDCHDTDDLTPLRLAVPAEFRAEPAAARRASTRAYRDSHT
Mvan_4871|M.vanbaalenii_PYR-1 DTQVIHAPELDDLHDTDDLTPLQLAVPSEFRAAPRADRRPSGRAYRDSHT
TH_1774|M.thermoresistible__bu ESEVVSAPELDDL-DPDAEAPLRLVVPSEFRPDPRDER-PSGHAYRDSHT
MAB_1055c|M.abscessus_ATCC_199 EED---TDEADRIRASIEATADWFAASAARTRDP----------------
MMAR_3448|M.marinum_M ATGAPAALTSVDVVDAQDPSKVLTSFSGTQLVDP----------------
MUL_2722|M.ulcerans_Agy99 ATGAPAALTSVDVVDSQDPSKVLTSFSGTQLVDP----------------
MSMEG_1192|M.smegmatis_MC2_155 VAPAEVNVAALEVRDADSGATLMSLSDDALREA-----------------
Mb0975c|M.bovis_AF2122/97 ---------EVTPVSRRVGQHRK-QPIGAARGRLLISAMAAGAAAAAAHT
Rv0950c|M.tuberculosis_H37Rv ---------EVTPVSRRVGQHRK-QPIGAARGRLLISAMAAGAAAAAAHT
MAV_1073|M.avium_104 RRPERPRGADVVGVARRGGQHRK-QPTSAARGRLLISAMAAGAAAAAAHT
MLBr_00154|M.leprae_Br4923 ----------FTSAPRRPCQHRK-QPTSATRGRLLISAMAAGAMATAAHT
Mflv_1864|M.gilvum_PYR-GCK DVSDGSAKTDVIDMRAHKGQHRKTEVP--VKGRLVVAAMAVGATAAGAYT
Mvan_4871|M.vanbaalenii_PYR-1 DVSDGTAKTDIIDMRGRTGLHRKAEVP--VKGRLVVAAMAVGATAAGAYT
TH_1774|M.thermoresistible__bu DVSDGTAATDVIAI-GRRGQHRKPEPTSAGKGRLMIAAMAAGATAAGAYS
MAB_1055c|M.abscessus_ATCC_199 ----RDTPTDKLPRISSGGVHRRREIGQVGKTRLALAAMAAGAAAAAGYN
MMAR_3448|M.marinum_M ----KCSYGNCNRLRQLTGRPSTDFTIPPQGSRALLLDFTFDKLAQFPKA
MUL_2722|M.ulcerans_Agy99 ----KCSYGNCNRLRQLTGRPSTDFTIPPQGSRALLLDFTFDKLAQFPKA
MSMEG_1192|M.smegmatis_MC2_155 -----------MSLAASPSPPTTAVPSSAMTVVWLDVPSSGPPAAALTHR
: *
Mb0975c|M.bovis_AF2122/97 AIQQ--SETPRTETVLTAHASALNEGSG-SNPPRGVQVIAAQPAASAAVH
Rv0950c|M.tuberculosis_H37Rv AIQQ--SETPRTETVLTAHASALNEGSG-SNPPRGVQVIAAQPAASAAVH
MAV_1073|M.avium_104 ATSH--ADTPKTDAVLTANASSLTGGAGGSNTVRGPQVIAAEPAATAALH
MLBr_00154|M.leprae_Br4923 VISH--DDIPKTETVLTANASALS-GATVSDATQGVQVITVHPAASTAVH
Mflv_1864|M.gilvum_PYR-GCK MTKN--VPAAPAETVLASDSTTLGDGTVITGSVDGMQIVSVAPASNSTVH
Mvan_4871|M.vanbaalenii_PYR-1 MTNG--TAKAPAETVLASDHTTLGDSTVIAGSTDGMQIVTVAPAANSTVH
TH_1774|M.thermoresistible__bu VVNGDDEKSSTDATVLAADQAAMPD--AIDGATGGMQIVTVAQPAKAIVH
MAB_1055c|M.abscessus_ATCC_199 ALSE-----HDAATAADHHGLALGN-SAAVMATHGPQLVSAPLATDASVT
MMAR_3448|M.marinum_M VMLRLHGTGVTAPGSSAESGPLDTLGAPFDISAGTPRVISPPLRGNNWVA
MUL_2722|M.ulcerans_Agy99 VMLRLHGTGVTAPGSSAESGPLDTLGAPFDISAGTPRVIGPPLRGNNWVA
MSMEG_1192|M.smegmatis_MC2_155 LTID------PPQGVTLDAVAWTFTTDPVYVDRRPPVVLGPPLAGPRWIA
:: :
Mb0975c|M.bovis_AF2122/97 NAEFARGVAFAEERAEREARLQRPLYVMPTKGIFTSSFGYRWGVLHAGID
Rv0950c|M.tuberculosis_H37Rv NAEFARGVAFAEERAEREARLQRPLYVMPTKGIFTSSFGYRWGVLHAGID
MAV_1073|M.avium_104 NQELAKGVAFANDRAQREARLQQPLYVMPTKGIFTSNFGYRWGVLHAGID
MLBr_00154|M.leprae_Br4923 NEEHAKGTAFAHERAQREARLSQPLYVMPTKGIFTSNFGYRWGVLHAGID
Mflv_1864|M.gilvum_PYR-GCK AEEITKAAAFAQERAEREARLTKPQFVMPTTGVWTSGFGYRWGVLHAGID
Mvan_4871|M.vanbaalenii_PYR-1 AEEITKAAAFAQERAEREARLTKPQFAMPTTGVWTSGFGYRWGVLHAGID
TH_1774|M.thermoresistible__bu AEEITKAAAFAQERAEREARLARPQFVMPTTGVWTSGFGYRWGVLHGGID
MAB_1055c|M.abscessus_ATCC_199 DEQLAKATAFATERADREKRLLAPRFVMPTNGTFTSGFGYRWGALHGGID
MMAR_3448|M.marinum_M FNGCCEPGWAHRDSILPLNMKLNNSQRFAIDWMRTNDQGNFFAGDKTNND
MUL_2722|M.ulcerans_Agy99 FNGCCEPGWAHRDSILPLNMKLNNSQRFAIDWMRTNDQGNFFAGDKTNND
MSMEG_1192|M.smegmatis_MC2_155 LGSCCDGPHRRATYPIDGRWYIAQRYAIDFNLLDAQNRPGIGDPVLPN--
: :.. .
Mb0975c|M.bovis_AF2122/97 LANAIGTPIYAVSDGVVIDAGPTAGY-----------------------G
Rv0950c|M.tuberculosis_H37Rv LANAIGTPIYAVSDGVVIDAGPTAGY-----------------------G
MAV_1073|M.avium_104 LANSIGTPIYAVSDGVVIEAGPAGGY-----------------------G
MLBr_00154|M.leprae_Br4923 LANAIGTPILAVSDGVVIDVGPTAGY-----------------------G
Mflv_1864|M.gilvum_PYR-GCK IANAIGTPVLAAADGIVIASGAEGGY-----------------------G
Mvan_4871|M.vanbaalenii_PYR-1 IANAIGTPILAAADGVVIAAGPEGGY-----------------------G
TH_1774|M.thermoresistible__bu IANSVGTPILAAADGVVIETGPQGGY-----------------------G
MAB_1055c|M.abscessus_ATCC_199 IANSIGTPIVAAADGVVIATGPTAGY-----------------------G
MMAR_3448|M.marinum_M SYISYGSSVYAVADGTVTSTLDDMEANVPGILPASDPALAAKITVDNVDG
MUL_2722|M.ulcerans_Agy99 SYISYGSSVYAVADGTVTSTLDDMEANVPGILPASDPALAAKITVDNVDG
MSMEG_1192|M.smegmatis_MC2_155 SFPTFGQPVYAVADGVIAMADDGRPDLRVG-------QARDEPTPQDAGG
: * .: *.:** : *
Mb0975c|M.bovis_AF2122/97 MWVKLLHADGTVTLYGHVN--TTLVSVGERVMAGDQIATMGSRGFSTGPH
Rv0950c|M.tuberculosis_H37Rv MWVKLLHADGTVTLYGHVN--TTLVSVGERVMAGDQIATMGSRGFSTGPH
MAV_1073|M.avium_104 MLVKLRHADGTVTLYGHIN--TALVSVGERVMAGDQIATMGNRGNSTGPH
MLBr_00154|M.leprae_Br4923 MWVKLRHADGTVTLYGHVN--TTLVNVGQYVVAGDQIATMGTRGNSTGPH
Mflv_1864|M.gilvum_PYR-GCK NAVKLRHADGTVTLYGHNS--SLLVSVGERVMAGDQIAKMGNTGNSTGPH
Mvan_4871|M.vanbaalenii_PYR-1 NLVKLRHADGTVTLYGHNS--SVLVNVGERVMAGDQIAKMGNTGNSTGPH
TH_1774|M.thermoresistible__bu IWVKLRHYDGTVTVYAHLS--SVLVNVGQRVMAGDQIARMGNTGNSTGPH
MAB_1055c|M.abscessus_ATCC_199 AWVKIRHSDGTVTLYGHIN--TWEVSVGQRVMAGDRIATIGNRGNSTGPH
MMAR_3448|M.marinum_M NHIVLDIGGGAYAMYAHLIKGSLLVKPGDKVKKGQEIAKLGNTGNSNAPH
MUL_2722|M.ulcerans_Agy99 NHIVLDIGGGAYAMYAHLIKGSLLVKPGDKVKKGQEIAKLGNTGNSNAPH
MSMEG_1192|M.smegmatis_MC2_155 NRVAIDIGDGHYAIYAHLREGSIKVRANDRVRRGDHIADVGSSGTTGGPH
: : .* ::*.* : * .: * *:.** :*. * : .**
Mb0975c|M.bovis_AF2122/97 LHFEVLLGG-----------------TERVDPVPWLAKRGLSV-GNYTG-
Rv0950c|M.tuberculosis_H37Rv LHFEVLLGG-----------------TERVDPVPWLAKRGLSV-GNYTG-
MAV_1073|M.avium_104 LHFEVLQGG-----------------TERIDPVPWLAKRGLMV-GNYAG-
MLBr_00154|M.leprae_Br4923 LHFEVLLSG-----------------SERIDPVPWLAKRGIYV-GNYTG-
Mflv_1864|M.gilvum_PYR-GCK LHFEVHLNG-----------------TDRVDPTGWLAKRGLSP-GGYVG-
Mvan_4871|M.vanbaalenii_PYR-1 CHFEVHLNG-----------------TDRVDPVGWLAKRGLTP-GGYVG-
TH_1774|M.thermoresistible__bu LHFEVLLDG-----------------VNRVDPAAWLAKRGVGPNSGYMR-
MAB_1055c|M.abscessus_ATCC_199 LHFEVLLGG-----------------SQRIDPQGWLANKGLTF-TRFGD-
MMAR_3448|M.marinum_M LHFQLMDGPSLLEADALPYVLDTFSYQGQVSPATVWDADNYLS-GSFFGP
MUL_2722|M.ulcerans_Agy99 LHFQLMDGPSLLEADALPYVLDTFSYQGQISPATVWDADNYLS-GSFFGP
MSMEG_1192|M.smegmatis_MC2_155 LHFQVNDRPSVVYADGLPYVFDSFDVTGRTPPLEEVLPYYDTLEPIPVST
**:: : *
Mb0975c|M.bovis_AF2122/97 ------------------------
Rv0950c|M.tuberculosis_H37Rv ------------------------
MAV_1073|M.avium_104 ------------------------
MLBr_00154|M.leprae_Br4923 ------------------------
Mflv_1864|M.gilvum_PYR-GCK ------------------------
Mvan_4871|M.vanbaalenii_PYR-1 ------------------------
TH_1774|M.thermoresistible__bu ------------------------
MAB_1055c|M.abscessus_ATCC_199 ------------------------
MMAR_3448|M.marinum_M DRLAAPEPRTKQLPVLLAIVNFG-
MUL_2722|M.ulcerans_Agy99 DRLAAPEPRTKQLPVLLAIVNFG-
MSMEG_1192|M.smegmatis_MC2_155 ADTGRRDDQLPLGRDVLTFPAADG