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MTTLLIDNIGSLVTNDPTLDAGPLGVLRDAAVVVEDGRIAWYGATSAAPAADTRLDAAGRAVIPGFVDSH AHLVFAGDRSEEFAARMSGTPYQAGGIRTTVTATRDATDATLKSTVTRLAAEALRSGTTTLECKSGYGLT VEQELRSLQVAAEITDEVTFMGAHVVPPEYAETPDDYVELVCTAMLDACAPAAKWVDVFCERGAFDLDQS RAILQAGIARGLQPRVHANQLGPGPGVQLAVECNAASADHVTHVSDADIAALAGSNTVATLLPAAEFSTR AAYPDGRRLIDAGVTVALSPDCNPGSSFTTNMPFCIAVAVREMHLTPDEAVWAATAGGARALRRDDVGHL AVGARADLALLDAPSHIHLAYRPGVPLVAAVLRNGEIVWQTKEVTS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1182 | hutI | - | 100% (396) | imidazolonepropionase |
| M. smegmatis MC2 155 | MSMEG_6887 | - | 2e-12 | 26.67% (405) | amidohydrolase family protein |
| M. smegmatis MC2 155 | MSMEG_1298 | - | 2e-12 | 24.35% (386) | guanine deaminase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0076 | - | 3e-13 | 26.52% (396) | hypothetical protein Mb0076 |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv0074 | - | 3e-13 | 26.52% (396) | hypothetical protein Rv0074 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2927c | - | 6e-08 | 25.12% (406) | hydroxydechloroatrazine ethylaminohydrolase |
| M. marinum M | MMAR_2844 | - | 7e-09 | 25.69% (432) | metal-dependent hydrolase |
| M. avium 104 | MAV_4703 | - | 1e-05 | 42.86% (70) | amidohydrolase family protein |
| M. thermoresistible (build 8) | TH_3200 | - | 2e-14 | 27.23% (393) | PUTATIVE amidohydrolase |
| M. ulcerans Agy99 | MUL_2914 | - | 4e-08 | 25.52% (431) | hydroxydechloroatrazine ethylaminohydrolase |
| M. vanbaalenii PYR-1 | Mvan_3150 | - | 1e-13 | 25.06% (415) | amidohydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0076|M.bovis_AF2122/97 ---MGDLSISQVSARPGRIGIRARQMFDGYRFQ-RGPVLVVVEDGRISAV
Rv0074|M.tuberculosis_H37Rv ---MGDLSISQVSARPGRIGIRARQMFDGYRFQ-RGPVLVVVEDGRISAV
MMAR_2844|M.marinum_M MSTILLTLMLECRVPKLVIDRVSIATVDPKAAE-FSEGHIIVEDDLIVAV
MUL_2914|M.ulcerans_Agy99 --------MLECRVPKLVIDRISIATVDPKAAE-FSEGHIIVEDDLIVAV
MAB_2927c|M.abscessus_ATCC_199 ------------MNPITLIENVFAATVDKSRRE-IADARVVIEGGRIAAV
Mvan_3150|M.vanbaalenii_PYR-1 --------------MTERQVLHGGTVLTGPQWR-PRPADLLIAGGRIEAV
TH_3200|M.thermoresistible__bu --------------VVSKLLLHNALLIDGTGVPPVRDAAVLIDDGRIGWA
MSMEG_1182|M.smegmatis_MC2_155 --------MTTLLIDNIGSLVTNDPTLDAGPLGVLRDAAVVVEDGRIAWY
MAV_4703|M.avium_104 --------------MTYDLIIRNGSIVDGLGGE-PYVGDVAVRDGVIAAV
. : : .. *
Mb0076|M.bovis_AF2122/97 D-----FAGSACPDMNLVDLGESTLLPGLVDAHAHLC-WDPDGR------
Rv0074|M.tuberculosis_H37Rv D-----FAGSACPDMNLVDLGESTLLPGLVDAHAHLC-WDPDGR------
MMAR_2844|M.marinum_M G----DGPAPEVPGATVIDGRGCLATPGLVNTHEHLYQWITRGY------
MUL_2914|M.ulcerans_Agy99 G----DGPAPEVPGATVIDGRGCLATPGLVNTHEHLYQWITRGH------
MAB_2927c|M.abscessus_ATCC_199 LTAGENNPWQELPGVERVDGSGCLLTPGLVNTHHHLYQWITRGL------
Mvan_3150|M.vanbaalenii_PYR-1 AAP----GSLAGVDAATHDVTGRLVIPGLINAHTHSHTAPARGA------
TH_3200|M.thermoresistible__bu GPG--DDIPPSADGATRIDVGGNAVCPGFFDCHVHFSLPGTRGS------
MSMEG_1182|M.smegmatis_MC2_155 G-----ATSAAPAADTRLDAAGRAVIPGFVDSHAHLVFAGDRSE------
MAV_4703|M.avium_104 G------AVNGATANREIDATGRLVTPGFVDLHTHYDGQAVWSERLTPSS
* **:.: * * .
Mb0076|M.bovis_AF2122/97 PED-----LAGDPHAVLVGRARRHAAAALRSG------------------
Rv0074|M.tuberculosis_H37Rv PED-----LAGDPHAVLVGRARRHAAAALRSG------------------
MMAR_2844|M.marinum_M TQKGTLFQWLTEMYPVWGRLDAELEFAAASAG------------------
MUL_2914|M.ulcerans_Agy99 TQKGTLFQWLTEMYPVWGRLDAELEFAAASAG------------------
MAB_2927c|M.abscessus_ATCC_199 AADHTLFQWLTALYPVWQGIDADSLHVAAQGA------------------
Mvan_3150|M.vanbaalenii_PYR-1 ARAWTLEDSLLNGGWMAAPRSEELTELAALLT------------------
TH_3200|M.thermoresistible__bu VYERALVTESYHTFQLLDRLKVTLENGVTTAR------------------
MSMEG_1182|M.smegmatis_MC2_155 EFAARMSGTPYQAGGIRTTVTATRDATDATLK------------------
MAV_4703|M.avium_104 AHGVTTVVMGNCGVGFAPCRQSDHDVLVDVMAGVEDIPGVVMTDGLPWTW
.
Mb0076|M.bovis_AF2122/97 -----ITTIRDLG--------------DRDYAALALREEYRQKTTVGPEL
Rv0074|M.tuberculosis_H37Rv -----ITTIRDLG--------------DRDYAALALREEYRQKTTVGPEL
MMAR_2844|M.marinum_M -----LAGLALTGCT---------TTMDHHYVFPHAGGDMLGAEIAAAKR
MUL_2914|M.ulcerans_Agy99 -----LAGLALTGCT---------TTMDHHYVFPHAGGDMLGAEIVAAKR
MAB_2927c|M.abscessus_ATCC_199 -----LSWLALSGCT---------TTTDHHYVFPSDAGDLLEAEIEAARQ
Mvan_3150|M.vanbaalenii_PYR-1 -----ATELIASGCTGAFDLIAQAGGPDPAGCHAAARGYARAGLRTVLAP
TH_3200|M.thermoresistible__bu -----DLMGIDTGVR------------QAVADGLIPGPRLQVAVNMLSQT
MSMEG_1182|M.smegmatis_MC2_155 -----STVTRLAA--------------EALRSGTTTLECKSGYGLTVEQE
MAV_4703|M.avium_104 ETFPEYLDTLEAGKRDIDVAAYLPHSPLRVYVMGQRGADREPATAEDLAK
.
Mb0076|M.bovis_AF2122/97 VVSGPPLTRSGGHCWFLGG--VADSVEE--LVDAVQERAARGADWIKVMA
Rv0074|M.tuberculosis_H37Rv VVSGPPLTRSGGHCWFLGG--VADSVEE--LVDAVQERAARGADWIKVMA
MMAR_2844|M.marinum_M IGVRFHPTRGSMDLGVASGGLPPEHTVE--DIDTILTTCQDAVREHHDPT
MUL_2914|M.ulcerans_Agy99 IGVRFHPTRGSMDLGVASGGLPPEHTVE--DIDTILTTCQDAVREHHDPT
MAB_2927c|M.abscessus_ATCC_199 VGLRFDPTRGSMDLGRSAGGLPPDGLVE--SIDTALEASDAAIARWHDPA
Mvan_3150|M.vanbaalenii_PYR-1 MVADRTLHEAVPAIGACCGAPSTGKPGP--STADVLAACTAYVRNFPALQ
TH_3200|M.thermoresistible__bu AGHADFRLPSGIDATAMMGGARVDSVDD--VRRRVRDLIAQGADLIKVAS
MSMEG_1182|M.smegmatis_MC2_155 LRSLQVAAEITDEVTFMGAHVVPPEYAE--TPDDYVELVCTAMLDACAPA
MAV_4703|M.avium_104 MRALAKEAVEVGALGFASSRLTIHKTESGSPIPSYDAAREEIEQIARGVV
.
Mb0076|M.bovis_AF2122/97 TGGFVTTASDPWQPQYGSGQ-LAAVVAAAEQVGLPVTAHAHATAG-----
Rv0074|M.tuberculosis_H37Rv TGGFVTTASDPWQPQYGSGQ-LAAVVAAAEQVGLPVTAHAHATAG-----
MMAR_2844|M.marinum_M KGSMVQISLAPCSPFSVTGELMKQSALLARDLGVRLHTHLSETVEED---
MUL_2914|M.ulcerans_Agy99 KGSMVQISLAPCSPFSVTGELMKQSALLARDLGVRLHTHLSETVEED---
MAB_2927c|M.abscessus_ATCC_199 PGAMVRIGLAPCSPFSVSADLLRQSALLARERGVRLHTHLAETKDES---
Mvan_3150|M.vanbaalenii_PYR-1 G---VMPALAPTIPGHCTPELTVGLGRLAAEHGLRVHTHLAESKPQA---
TH_3200|M.thermoresistible__bu SGGVSSPTDQPDWLGMRTEMVAAVVEECQAYGGRPVAAHAIGYAG-----
MSMEG_1182|M.smegmatis_MC2_155 AKWVDVFCER----GAFDLDQSRAILQAGIARGLQPRVHANQLGP-----
MAV_4703|M.avium_104 DGGGGLLQFVPDIPAGGYQPVLQTVFDVAEDVGLPLTFTLVVANSGDPTW
*
Mb0076|M.bovis_AF2122/97 -----------------------------------IAAAVAAGVDGIEHC
Rv0074|M.tuberculosis_H37Rv -----------------------------------IAAAVAAGVDGIEHC
MMAR_2844|M.marinum_M --------------------------------EFCLAQFGSRPVDYVESL
MUL_2914|M.ulcerans_Agy99 --------------------------------EFCLAQFGSRPVDYVESL
MAB_2927c|M.abscessus_ATCC_199 --------------------------------VYCAERFGCSPLDYMEEL
Mvan_3150|M.vanbaalenii_PYR-1 --------------------------------LAGASRFGHSITRELARL
TH_3200|M.thermoresistible__bu -----------------------------------VKAAVEGGVTSIEHG
MSMEG_1182|M.smegmatis_MC2_155 --------------------------------------------GPGVQL
MAV_4703|M.avium_104 PDAITMIEKANAAGGDITAQLLPRPIGLIIGLQLSANPFVLYPSYREIAH
Mb0076|M.bovis_AF2122/97 TFLS-EGSAAASPDVVEAIVAQGVWCGMTIPRVYPEMPENLVAVVQDGWR
Rv0074|M.tuberculosis_H37Rv TFLS-EGSAAASPDVVEAIVAQGVWCGMTIPRVYPEMPENLVAVVQDGWR
MMAR_2844|M.marinum_M GWLGSDVWMAHCVHLSKGDIAKLAATGTGVAHCPTSNGR-----FGAGIA
MUL_2914|M.ulcerans_Agy99 GWLGSDVWMAHCVHLSKGYIAKLAATGTGVAHCPTSNGR-----FGAGIA
MAB_2927c|M.abscessus_ATCC_199 GWLGPDVWFAHGVHFDDASIARLARTGTGIAHCPTSNGR-----LGAGIA
Mvan_3150|M.vanbaalenii_PYR-1 GVLGDRLTVAHAIWVDDEDIRMLAASGAVAVTVPGSNLR-----LGSGIA
TH_3200|M.thermoresistible__bu -YALDDELRRRMVDQGTYLVPTLLETMHDVEVSPAAKAKS-AHWHEIAHR
MSMEG_1182|M.smegmatis_MC2_155 AVECNAASADHVTHVSDADIAALAGSNTVATLLPAAEFS-----TRAAYP
MAV_4703|M.avium_104 LPLAERVAQMRKPEVRARILADKPGEGHPILYVAQMWDWIYPLGDNPDYE
:
Mb0076|M.bovis_AF2122/97 NIRRLIDAGARVALSTDAGVAPGRR------HDVLPDDLVYLS--RHGFT
Rv0074|M.tuberculosis_H37Rv NIRRLIDAGARVALSTDAGVAPGRR------HDVLPDDLVYLS--RHGFT
MMAR_2844|M.marinum_M PIPELLAADVAVGLGVDGAGAEHRG-LANEMRQAALAARFRLG--PQALD
MUL_2914|M.ulcerans_Agy99 PIPELLAADVAVGLGVDGAGAEHRG-LANEMRQAALAARFRLG--PQALD
MAB_2927c|M.abscessus_ATCC_199 RVRELLAAGVPVGLGVDGAASNESGRLLEEAHQALLLARAVGG--PTALS
Mvan_3150|M.vanbaalenii_PYR-1 DTRAMLAAGLRLAVGTDGANSADAFDALDAVRLTALLSRVSERPARQWLT
TH_3200|M.thermoresistible__bu AVGESAAAGVKIALGTDAGLSPDHG-----TNLAELGLLVRFG----GLT
MSMEG_1182|M.smegmatis_MC2_155 DGRRLIDAGVTVALSPDCNPGSSFT------TNMPFCIAVAVR--EMHLT
MAV_4703|M.avium_104 PDPSTSIAARARARGVDPMEEAYDRLLDDDGRAMLLVATSNLQ--GNSLD
* . . * :
Mb0076|M.bovis_AF2122/97 STEVLTGATAAAAASCGLGHRKGRIAPGYDADLLAVAAGVDHDPAGLCDV
Rv0074|M.tuberculosis_H37Rv STEVLTGATAAAAASCGLGHRKGRIAPGYDADLLAVAAGVDHDPAGLCDV
MMAR_2844|M.marinum_M AREALWMATVGGARCLGRDQDLGSLEVGKLADIALWQLDG-LGHSDVEDP
MUL_2914|M.ulcerans_Agy99 AREALWMATVGGARCLGRDQDLGSLEVGKLADIALWQLDG-LGHSDVEDP
MAB_2927c|M.abscessus_ATCC_199 TRTALELATLGGARLLGRSDEIGSIEVGKCADLVLWDLST-LGHSGIEDP
Mvan_3150|M.vanbaalenii_PYR-1 VEETLDAATAGGAAACG-WTDTGRLAPGRRADFALLDLGARAFRPPTDLA
TH_3200|M.thermoresistible__bu PMEAIVAGTRTSAQLCGLDRELGTLEPGKLADVVVVRGNPLDDIASVGNP
MSMEG_1182|M.smegmatis_MC2_155 PDEAVWAATAGGARALR-RDDVGHLAVGARADLALLDAPSHIHLAYRPGV
MAV_4703|M.avium_104 TVGELLHRDDVVLGLGDGGAHYGMICDASYSTYFLTHWARDRKSGRFSVA
: * : . :
Mb0076|M.bovis_AF2122/97 KAVWRSGTQVPLQASA--VGYNTPS-------------------------
Rv0074|M.tuberculosis_H37Rv KAVWRSGTQVPLQASA--VGYNTPS-------------------------
MMAR_2844|M.marinum_M VWALIYGPPAPLRLLL--VGGNTVVEDGELRTADTETLATDAKNAAVTLR
MUL_2914|M.ulcerans_Agy99 VWALIYGPPAPLRLLL--VGGNTVVEDGELRTADTETLATDAKNAAVTLR
MAB_2927c|M.abscessus_ATCC_199 VAAVILGEVPPIRRSW--VGGRPIVADGQMLTVDTERIAVAVRAAHHGLM
Mvan_3150|M.vanbaalenii_PYR-1 NQLLTAARAADVTDVV--VGGRFVYRDRGFPHLDVAAALNRFDTLVEEFR
TH_3200|M.thermoresistible__bu DNILLVLKEGRPAKDR--GGFFDQRH------------------------
MSMEG_1182|M.smegmatis_MC2_155 PLVAAVLRNGEIVWQT--KEVTS---------------------------
MAV_4703|M.avium_104 DAVRRLTSVPARVAGLGDRGRIAVGYKADLNVIDHAALRLHKPVISHDLP
Mb0076|M.bovis_AF2122/97 -------------------------------------------------
Rv0074|M.tuberculosis_H37Rv -------------------------------------------------
MMAR_2844|M.marinum_M ERG----------------------------------------------
MUL_2914|M.ulcerans_Agy99 ERG----------------------------------------------
MAB_2927c|M.abscessus_ATCC_199 NRER---------------------------------------------
Mvan_3150|M.vanbaalenii_PYR-1 ARVAPVRADADRQTALAAT----ALAGLRRAPSPVRRLIGWR-------
TH_3200|M.thermoresistible__bu -------------------------------------------------
MSMEG_1182|M.smegmatis_MC2_155 -------------------------------------------------
MAV_4703|M.avium_104 AGGRRLDQTADGYVATIVSGEIIAENGVPTAARPGKLVRGRRPGPAPLR