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MSRDLPLTVAAALTVPPLDLGSVVAGQRGLTREVLWVDIMHAPAESFVRPGDLVLTTGADVRQPGVLDFL TYVVTSAAAGVVISPPPEAAVDELLVTLVPYAEQHEFPVVVLPWEVAFSAVQRSLLPLLTPLAPDELVQM VIGRRERDDAGWNDFAEVFAKNLQELALAAGVTVRSSVTDDLVMSHFSPAPSSSTVSALVEAAKRLNAIQ QTAVSWVLLPPQEAVNAAATTAPRTPAPEGPVGPVQFADVLRQHPQCMAIVLQTLQPLIDYDRTRRGQLV RTLEVLLNEATNISAAARTLYLNRHSLLYRIKLIEELTGLSLKNPADRFQLEVSVRVHQINEARTTAGRA ARLTT
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0500 | - | - | 100% (355) | regulator of polyketide synthase expression, putative |
| M. smegmatis MC2 155 | MSMEG_1456 | - | 2e-07 | 31.51% (73) | hypothetical protein MSMEG_1456 |
| M. smegmatis MC2 155 | MSMEG_4370 | - | 5e-07 | 30.43% (92) | regulatory protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2266 | - | 4e-06 | 32.14% (84) | hypothetical protein Mb2266 |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv2242 | - | 4e-06 | 32.14% (84) | hypothetical protein Rv2242 |
| M. leprae Br4923 | MLBr_01652 | - | 9e-06 | 28.80% (125) | hypothetical protein MLBr_01652 |
| M. abscessus ATCC 19977 | MAB_1880c | - | 7e-05 | 28.09% (89) | hypothetical protein MAB_1880c |
| M. marinum M | MMAR_3335 | - | 1e-06 | 30.61% (98) | hypothetical protein MMAR_3335 |
| M. avium 104 | MAV_2195 | - | 3e-06 | 32.14% (84) | hypothetical protein MAV_2195 |
| M. thermoresistible (build 8) | TH_1338 | - | 2e-06 | 26.67% (150) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_1307 | - | 9e-07 | 30.61% (98) | hypothetical protein MUL_1307 |
| M. vanbaalenii PYR-1 | Mvan_5765 | - | 4e-12 | 43.42% (76) | transcriptional regulator, CdaR |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3335|M.marinum_M ---------MNDNQFS-AIARLGSARSPLELLETVPDSLLRRLKQYSG--
MUL_1307|M.ulcerans_Agy99 ---------MNNNQFS-AIARLGSARSPLELLETVPDSLLRRLKQYSG--
Mb2266|M.bovis_AF2122/97 ---------MNDNQLA-PVARP---RSPLELLDTVPDSLLRRLKQYSG--
Rv2242|M.tuberculosis_H37Rv ---------MNDNQLA-PVARP---RSPLELLDTVPDSLLRRLKQYSG--
MLBr_01652|M.leprae_Br4923 ---------MNHNHFV-PAPPR---RLPLELLDTVPDSLLRRLKQYSG--
MAV_2195|M.avium_104 ---------MNDNPFAGPFAKHP--RSPLETLDTVPESVLRRLKQYSG--
TH_1338|M.thermoresistible__bu ---------VPDNRFV----PP---QSTLEVLESVPESVLRRLKQYSG--
MAB_1880c|M.abscessus_ATCC_199 ---------MPDNPATAPRGFR-AARKPRERAE-VPEALLHRIKQYSG--
Mvan_5765|M.vanbaalenii_PYR-1 MSSRTLSTALPFEHWLSALAEIGEAVGGDEPVAEVLDRVARTACTLLGYD
MSMEG_0500|M.smegmatis_MC2_155 --------------------------------------MSR---------
: :
MMAR_3335|M.marinum_M --------------------RLATEAVSAMQERLPFFADLEASQRASVAL
MUL_1307|M.ulcerans_Agy99 --------------------RLATEAVSAMQERLPFFADLEASQRASVAL
Mb2266|M.bovis_AF2122/97 --------------------RLATEAVSAMQERLPFFADLEASQRASVAL
Rv2242|M.tuberculosis_H37Rv --------------------RLATEAVSAMQERLPFFADLEASQRASVAL
MLBr_01652|M.leprae_Br4923 --------------------RLATEAVTAMQERLPFFADLEASQRASVTL
MAV_2195|M.avium_104 --------------------RLATEAVSVMQDRLPFFADLEASQRASVSL
TH_1338|M.thermoresistible__bu --------------------RLATEAVHTMEERLPFFADLEASQRASVHL
MAB_1880c|M.abscessus_ATCC_199 --------------------RLSTEAVHVMEDRLPFFTDLEASQRASVAL
Mvan_5765|M.vanbaalenii_PYR-1 FCAVFLPDEQGRALTIEGSYGLSADYIAQVNANRPILLDVRGDHEAPTSL
MSMEG_0500|M.smegmatis_MC2_155 --------------------DLPLTVAAALTVPPLDLGSVVAGQRG----
*. : : .: ..:..
MMAR_3335|M.marinum_M VVQTAVVNFAEWMQNP----RSDVSYTAQAFELVPQDLTRRIALRHTVDM
MUL_1307|M.ulcerans_Agy99 VVQTAVVNFAEWMQNP----RSDVSYTAQAFELVPQDLTRRIALRHTVDM
Mb2266|M.bovis_AF2122/97 VVQTAVVNFVEWMHDP----HSDVGYTAQAFELVPQDLTRRIALRQTVDM
Rv2242|M.tuberculosis_H37Rv VVQTAVVNFVEWMHDP----HSDVGYTAQAFELVPQDLTRRIALRQTVDM
MLBr_01652|M.leprae_Br4923 VVQTAVVNFVQWMQNP----HSDVSYTAQAFELVPQDLARRIALRHTVDM
MAV_2195|M.avium_104 VVQTAVVNFAEWMQDP----KSNVRHTAQAFELVPQDLARRIALRHSVEM
TH_1338|M.thermoresistible__bu VVQTAVVNFVEWMRDP----RSNVTYTMQAFEVVPQDLTRRIALRQTVEM
MAB_1880c|M.abscessus_ATCC_199 VVQTAINNFVEWIRDP----EGTVGFTMQAFEVVPQDLAKRIALRHSVDM
Mvan_5765|M.vanbaalenii_PYR-1 AYRTGDVVTLEDIELVPDFTWGGVAQEQGYRALISAPLRRPGTVVGALNG
MSMEG_0500|M.smegmatis_MC2_155 --LTREVLWVDIMHAP----AESFVRPGDLVLTTGADVRQPGVLDFLTYV
* : :. . : : .:
MMAR_3335|M.marinum_M VRVTMEFFEEVVPLLARSEEQLTALTVGILKYSRDLAFTA--------AS
MUL_1307|M.ulcerans_Agy99 VRVTMEFFEEVVPLLARSEEQLTALTVGILKYSRDLAFTA--------AS
Mb2266|M.bovis_AF2122/97 VRVTMEFFEEVVPLLARSEEQLTALTVGILKYSRDLAFTA--------AT
Rv2242|M.tuberculosis_H37Rv VRVTMEFFEEVVPLLARSEEQLTALTVGILKYSRDLAFTA--------AT
MLBr_01652|M.leprae_Br4923 VRVTMEFFEEVVPLLARSEEQLTALTVGILKYSRDLAFTA--------AT
MAV_2195|M.avium_104 VRVTMEFFEEVVPLLARSEEQLTALTVGVLKYSRDLAFTA--------AT
TH_1338|M.thermoresistible__bu VRTTMEFFEQVVPLLARSEEQVTALTAGILRYSRDLAFAA--------AT
MAB_1880c|M.abscessus_ATCC_199 VRTAMEFFEEVLPLLARNDEQLVTLTEGILRYSRDLAFGA--------AS
Mvan_5765|M.vanbaalenii_PYR-1 YRTAPHRFDRAEVSLVTTLATQVAIALGTAQLRAKEQATIRELRRAEEVH
MSMEG_0500|M.smegmatis_MC2_155 VTSAAAGVVISPPPEAAVDELLVTLVPYAEQHEFPVVVLP----------
: . . .::. :
MMAR_3335|M.marinum_M AYADAAEARGTWDSRMEASVVDAVVRGDTGPELLSR-AAALNWDTTAP--
MUL_1307|M.ulcerans_Agy99 AYADAAEARGTWDSRMEASVVDAVVRGDTGPELLSR-AAALNWDTTAP--
Mb2266|M.bovis_AF2122/97 AYADAAEARGTWDSRMEASVVDAVVRGDTGPELLSR-AAALNWDTTAP--
Rv2242|M.tuberculosis_H37Rv AYADAAEARGTWDSRMEASVVDAVVRGDTGPELLSR-AAALNWDTTAP--
MLBr_01652|M.leprae_Br4923 AYADAAEARGTWDSRMEASVVDAVVRGDTGPELLSR-AAALNWDTTAP--
MAV_2195|M.avium_104 AYADAAEARGTWDSRMEASVVDAVVRGDTGPELLSR-AAALNWDTTAP--
TH_1338|M.thermoresistible__bu AYADAAEARGAWDTRMEANVVDAVVRGAVGPELQSQ-AAALNWDATAP--
MAB_1880c|M.abscessus_ATCC_199 AYAEAAETRGAWDSRLEATVVDAVVRGDTGPDMLSR-AAALNWDTNAP--
Mvan_5765|M.vanbaalenii_PYR-1 TLLTATALRGEGVSGVAAALSELLGRGVLIEDVYDEPLTDANWTAPDPRA
MSMEG_0500|M.smegmatis_MC2_155 WEVAFSAVQRSLLPLLTPLAPDELVQMVIGRRERDD----AGWNDFAE--
: : . : . : : : . .*
MMAR_3335|M.marinum_M ------ATVVVGTPASARDGS------------DG-SERAIQDVRDAAAQ
MUL_1307|M.ulcerans_Agy99 ------ATVVVGTPASARDGS------------DG-SERAIQDVRDAAAQ
Mb2266|M.bovis_AF2122/97 ------ATVLVGTPAPGPNGSNS----------DGDSERASQDVRDTAAR
Rv2242|M.tuberculosis_H37Rv ------ATVLVGTPAPGPNGSNS----------DGDSERASQDVRDTAAR
MLBr_01652|M.leprae_Br4923 ------ATVVVGTPTPNHDGPNG----------QVSSERASQEVREIAAR
MAV_2195|M.avium_104 ------ATVVVGTPAPGRDGSTG----------PGDSERASQHVRDIAAQ
TH_1338|M.thermoresistible__bu ------ATVVVGLPRPD------------------RLEVVSQDVHHVANR
MAB_1880c|M.abscessus_ATCC_199 ------ATVIVGTPRPD------------------IIATATTLVHEVAQR
Mvan_5765|M.vanbaalenii_PYR-1 QDHVVATVTLDGSPVARIHVAASDSELSRLDVRAVEHATVVTALELLRAR
MSMEG_0500|M.smegmatis_MC2_155 --------------------------------------VFAKNLQELALA
:.
MMAR_3335|M.marinum_M HGRAALTDVHGTWLVAIVSG------------------------------
MUL_1307|M.ulcerans_Agy99 HGRAALTDVHGTWLVAIVSG------------------------------
Mb2266|M.bovis_AF2122/97 HGRAALTDVHGTWLVAIVSG------------------------------
Rv2242|M.tuberculosis_H37Rv HGRAALTDVHGTWLVAIVSG------------------------------
MLBr_01652|M.leprae_Br4923 HGRAALTDVHGTWLVAIISG------------------------------
MAV_2195|M.avium_104 HGRAALTDVHGTWLVAIVSG------------------------------
TH_1338|M.thermoresistible__bu HGRTALSDVHGTWLVTIVSG------------------------------
MAB_1880c|M.abscessus_ATCC_199 HGRGALAVIQGTRLLTIVSG------------------------------
Mvan_5765|M.vanbaalenii_PYR-1 TAAEVEQRIRGSLVADLLSSDDAGIPALLDRARRLGWDLSGVQSLIALRP
MSMEG_0500|M.smegmatis_MC2_155 AGVTVRSSVTDDLVMSHFSP------------------------------
. . : . : .*
MMAR_3335|M.marinum_M ----HLSPTDKVFK-------------DLLEAFSDGP-------------
MUL_1307|M.ulcerans_Agy99 ----HLSPTDKVFK-------------DLLEAFSDGP-------------
Mb2266|M.bovis_AF2122/97 ----QLSPTEKFLK-------------DLLAAFADAP-------------
Rv2242|M.tuberculosis_H37Rv ----QLSPTEKFLK-------------DLLAAFADAP-------------
MLBr_01652|M.leprae_Br4923 ----QLAPTDKFFS-------------DLLHAFSDGP-------------
MAV_2195|M.avium_104 ----QLSPTDKFLG-------------DLLEAFSDGP-------------
TH_1338|M.thermoresistible__bu ----ALSPTDRFLT-------------DLLDVFADGP-------------
MAB_1880c|M.abscessus_ATCC_199 ----PITAHDKFLA-------------DLMKVFSDGP-------------
Mvan_5765|M.vanbaalenii_PYR-1 ADERTLAAADRFTAGVTPHPLVALHRGDLVFVWPADTGPAVPVAHRLLEF
MSMEG_0500|M.smegmatis_MC2_155 ------APSSSTVS-------------ALVEAAKRLN-------------
:. . *: .
MMAR_3335|M.marinum_M --VVIGPTAPMLTAAYHSASEAISGMN-------AVAGWRGAPRPVLARE
MUL_1307|M.ulcerans_Agy99 --VVIGPTAPMLTAAYHSASEAISGMN-------AVAGWRGASRPVLARE
Mb2266|M.bovis_AF2122/97 --VVIGPTAPMLTAAHRSASEAISGMN-------AVAGWRGAPRPVLARE
Rv2242|M.tuberculosis_H37Rv --VVIGPTAPMLTAAHRSASEAISGMN-------AVAGWRGAPRPVLARE
MLBr_01652|M.leprae_Br4923 --VVIGPTAPMLTAAYHSASEAVSGMN-------AVAGWSGAPRPVQARE
MAV_2195|M.avium_104 --VVVGPTAPMLTAAYHSASEAISGMN-------AVGGWRGAPRPVLARE
TH_1338|M.thermoresistible__bu --VVLGPTAPTLSAAYRSATEAIAGMN-------AVAGWSGAPRPVPARE
MAB_1880c|M.abscessus_ATCC_199 --VVVGPTAGSLSASHTSAVEALSGMD-------AVSGWRGAPRPVSSRE
Mvan_5765|M.vanbaalenii_PYR-1 LNAATIPEAPTAAVSRQAAARELPGIFRTVRGALDLAGDRDTATVIDLDE
MSMEG_0500|M.smegmatis_MC2_155 --AIQQTAVSWVLLPPQEAVNAAATTAP------RTPAPEGPVGPVQFAD
. . . . * . . . .. : :
MMAR_3335|M.marinum_M LLPERALMG--DASAIVALHTDVMRPLADAG----PTLIETLDAYLDCGG
MUL_1307|M.ulcerans_Agy99 LLPERALMG--DASAIVALHTDVMRPLADAG----PTLIETLDAYLDCGG
Mb2266|M.bovis_AF2122/97 LLPERALMG--DASAIVALHTDVMRPLADAG----PTLIETLDAYLDCGG
Rv2242|M.tuberculosis_H37Rv LLPERALMG--DASAIVALHTDVMRPLADAG----PTLIETLDAYLDCGG
MLBr_01652|M.leprae_Br4923 LLPERALMG--DASAIVALHTDVMLPLADAG----PTLIETLDAYLDCGG
MAV_2195|M.avium_104 LLPERALMG--DASAIVALHTDVMGPLADAG----PTLIETLDAFLDSGG
TH_1338|M.thermoresistible__bu LLPERALLG--DQTAIAALESEVMRPLADAG----PTLTETLDAFLESGG
MAB_1880c|M.abscessus_ATCC_199 LLPERALLG--DKAAIAALNTEVMRPLADAG----PALTETLDAYLDSGG
Mvan_5765|M.vanbaalenii_PYR-1 PTIDHLLLQLDDPARLRDFASAVLGPAVDYDRTRSTELLHTVRVLLEHGL
MSMEG_0500|M.smegmatis_MC2_155 VLRQHPQCM--------AIVLQTLQPLIDYDRTRRGQLVRTLEVLLNEAT
:: : .: * * . * .*: . *: .
MMAR_3335|M.marinum_M AIEACARKLFVHPNTIRYRLKRITDFTGRDPTQPRDAYVLRVAATVGQLN
MUL_1307|M.ulcerans_Agy99 AIEACARKLFVHPNTIRYRLKRITDFTGRDPTQPRDAYVLRVAATVGQLN
Mb2266|M.bovis_AF2122/97 AIEACARKLFVHPNTVRYRLKRITDFTGRDPTQPRDAYVLRVAATVGQLN
Rv2242|M.tuberculosis_H37Rv AIEACARKLFVHPNTVRYRLKRITDFTGRDPTQPRDAYVLRVAATVGQLN
MLBr_01652|M.leprae_Br4923 AIEACARKLFVHPNTVRYRLKRITDFTGHDPTLPRDAYVLRVAATVGKLN
MAV_2195|M.avium_104 AIEACARKLFVHPNTVRYRLKRITDFTGRDPMQPRDAYVLRVAATVGQLN
TH_1338|M.thermoresistible__bu AIEACARRLFVHPNTVRYRLRRIAEITGRDPAVPRDAYVLRVAVSVSRLT
MAB_1880c|M.abscessus_ATCC_199 AIEACARALFVHPNTVRYRLKRITDFTGRDPTSPRDAYVLRVAATVGRLA
Mvan_5765|M.vanbaalenii_PYR-1 DRRAAAQALHLHPNTVAQRVRRLEELTGLSLARPADLLRLTAALTVSRIA
MSMEG_0500|M.smegmatis_MC2_155 NISAAARTLYLNRHSLLYRIKLIEELTGLSLKNPADRFQLEVSVRVHQIN
*.*: *.:: ::: *:: : ::** . * * * .: * ::
MMAR_3335|M.marinum_M YPTPPSGAANNTITPVPLPVRRGTEGP---
MUL_1307|M.ulcerans_Agy99 YPTPPSGAANNTITPVPLPVRRGTEGP---
Mb2266|M.bovis_AF2122/97 YPTPH-------------------------
Rv2242|M.tuberculosis_H37Rv YPTPH-------------------------
MLBr_01652|M.leprae_Br4923 YPTHH-------------------------
MAV_2195|M.avium_104 YPTHPPSAAGAAMPAVPLPVNGAARGQSGG
TH_1338|M.thermoresistible__bu RQSYQSSTVNPDLGSTAGWRGQAAGGHRAM
MAB_1880c|M.abscessus_ATCC_199 QDHADAFTPEPGVTPVTINVIKT-------
Mvan_5765|M.vanbaalenii_PYR-1 SLS---------------------------
MSMEG_0500|M.smegmatis_MC2_155 EARTTAGRAARLTT----------------