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VIELPGGIRIGLIDDPDDAEDATFTLSEAATDDRRVVTVASIADTLELLRQRCERRPQTAAVCDDVLRSA DPDASTFSGVITESLAYSTLQSGAEFARWLDERGPATVPQLPDPVRAHRDGNTLHVRFNRPQRHNAFSTD ARAALLEALEVARLDPSVDEVVLAGNGQSFCSGGDLAEFGSFADPAAAHLARTRYSPALVLDELTARLGR RCRAHVHGQVLGSGLEMACFCGWVSCDPDAKLGLPELELGLVPGAGGTVSITRRIGRWRTAYLVLSGRTI DPTTALSWGLVDEIVSVAAPA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0259 | - | - | 100% (301) | enoyl-CoA hydratase/isomerase |
| M. smegmatis MC2 155 | MSMEG_5198 | - | 4e-20 | 34.83% (178) | carnitinyl-CoA dehydratase |
| M. smegmatis MC2 155 | MSMEG_5277 | - | 7e-19 | 33.14% (172) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1099c | echA8 | 4e-20 | 31.35% (185) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_0448 | - | 1e-120 | 73.47% (294) | enoyl-CoA hydratase/isomerase |
| M. tuberculosis H37Rv | Rv1070c | echA8 | 4e-20 | 31.35% (185) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 4e-20 | 33.14% (172) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_0836c | - | 7e-19 | 32.77% (177) | putative enoyl-CoA hydratase/isomerase |
| M. marinum M | MMAR_0453 | echA8_4 | 1e-118 | 74.73% (273) | enoyl-CoA hydratase, EchA8_4 |
| M. avium 104 | MAV_4960 | - | 1e-115 | 72.66% (278) | enoyl-CoA hydratase/isomerase family protein |
| M. thermoresistible (build 8) | TH_4433 | - | 1e-125 | 77.36% (296) | PUTATIVE enoyl-CoA hydratase/isomerase |
| M. ulcerans Agy99 | MUL_1103 | echA8_4 | 1e-114 | 73.26% (273) | enoyl-CoA hydratase, EchA8_4 |
| M. vanbaalenii PYR-1 | Mvan_0219 | - | 1e-126 | 76.45% (293) | enoyl-CoA hydratase/isomerase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_0259|M.smegmatis_MC2_155 ---MIELP--------------GGIRIGLIDDPDDAED------ATFTLS
TH_4433|M.thermoresistible__bu -VSILQLA--------------DGVVIGLG---EPVDD------ATFTLT
Mflv_0448|M.gilvum_PYR-GCK MNTLVELA--------------GGIVVGVG---TPSDA------ATFTLT
Mvan_0219|M.vanbaalenii_PYR-1 MNSPVELG--------------GGVRVAVG---TPSDD------ATFTVT
MMAR_0453|M.marinum_M MFGVVDLSRAPDATRAAGEISAPGVTVAHGWASELAEAEPWLSAATFTLA
MUL_1103|M.ulcerans_Agy99 MFGVVDLSRAPDATRAAGEISAPGVTVAHGWASELAEAEPWLSAATFTLA
MAV_4960|M.avium_104 MLRVVDLSSAPQD----GPASPPGVIVAVGSADQIARSEFWLDAATFTLT
Mb1099c|M.bovis_AF2122/97 --------------------------MTYETILVERDQ-------RVGII
Rv1070c|M.tuberculosis_H37Rv --------------------------MTYETILVERDQ-------RVGII
MLBr_02402|M.leprae_Br4923 --------------------------MKYDTILVDGYQ-------RVGII
MAB_0836c|M.abscessus_ATCC_199 -------------------------MSAARELLVERDG-------PVVIL
. :
MSMEG_0259|M.smegmatis_MC2_155 EAATDDRRVVTVASIADTLELLRQRCERRPQTAAVCDDVLRSADPDASTF
TH_4433|M.thermoresistible__bu EKPTDDRRAVTVESVQDTLDLLRERCGKWPQTAAVCDDVLRSIDPDGPTR
Mflv_0448|M.gilvum_PYR-GCK DEDTDDRRAVRVASVDEALAELTERCLRWPQAAAVCDDVLRAFDPQGCTF
Mvan_0219|M.vanbaalenii_PYR-1 EDDVDDRRAVTVTSVPDTLAELEERCRRWPQAAAVCDDVLRAFDPGGSTF
MMAR_0453|M.marinum_M EGPCADRRVITVESVSQTLAELRQRCQRWPQASAVCDDVLRTIDPDGPTL
MUL_1103|M.ulcerans_Agy99 EGPCADRRVITVESVSQTLAELRQRVPRWPQARAVCDDVLRTIDPDGSTL
MAV_4960|M.avium_104 EDACTDRRAVTVDSVSTSLDELTARCGRWPHASAICDDVLRAVDPAGPAA
Mb1099c|M.bovis_AF2122/97 TLNRPQALNALNSQVMNEVTSAATELDDDPDIGAIIITGSAKAFAAGADI
Rv1070c|M.tuberculosis_H37Rv TLNRPQALNALNSQVMNEVTSAATELDDDPDIGAIIITGSAKAFAAGADI
MLBr_02402|M.leprae_Br4923 TLNRPQALNALNSQMMNEITNAAKELDIDPDVGAILITGSPKVFAAGADI
MAB_0836c|M.abscessus_ATCC_199 TMNRPHRRNALSTNMVSQFAAAWDEIDHDDGIRAAILTGAGSAYCVGGDL
. .: . . * .
MSMEG_0259|M.smegmatis_MC2_155 SGVITESLAYSTLQSGAEFARWLDERGPATVPQLPDPVRAHRDGNTLHVR
TH_4433|M.thermoresistible__bu SGVITESLAYSTLQSGSEFARWLAERGPKTVPQLPDPVLATRDGDTLRVV
Mflv_0448|M.gilvum_PYR-GCK TGVITESLAYSTLQAGAEFARWLDARGPARVPEIADPVVAERVDDVLTIR
Mvan_0219|M.vanbaalenii_PYR-1 AGVITESLAYSTLQSGSEFARWLAERGPARVPDISDPVVAERHDGRLTIR
MMAR_0453|M.marinum_M AGVLTESLAYSTLQAGPEFARWLDERGPADLPDIADPVQTERDDDTLRIR
MUL_1103|M.ulcerans_Agy99 AGVLTESLAYSTLQAGPEFARWLDERGPADLPDIADPVQTERDDDTLRIR
MAV_4960|M.avium_104 RGLLTESLAYSTLQAGPEFARWLDERGPARMPEIADPVLARRDGDVLRIA
Mb1099c|M.bovis_AF2122/97 KE--MADLTFADAFTADFFATWGKLAAVRT------PTIAAVAGYALGGG
Rv1070c|M.tuberculosis_H37Rv KE--MADLTFADAFTADFFATWGKLAAVRT------PTIAAVAGYALGGG
MLBr_02402|M.leprae_Br4923 KE--MASLTFTDAFDADFFSAWGKLAAVRT------PMIAAVAGYALGGG
MAB_0836c|M.abscessus_ATCC_199 SDGWMVRDGSAPPLDPATIGKGLLLSHTLTK-----PLIAAVNGACLGGG
: :. * : . *
MSMEG_0259|M.smegmatis_MC2_155 FNRPQRHNAFSTDARAALLEALEVARLDPSVDEVVLAGNGQSFCSGGDLA
TH_4433|M.thermoresistible__bu FNRPQRHNAFSTDARAALLEALEVARLDPSVTEVVLTGNGPSFGSGGDLA
Mflv_0448|M.gilvum_PYR-GCK FNRPQRHNAFSTDARAALLDALEVARLDPSVTGMVLTGNGPSFCSGGDLA
Mvan_0219|M.vanbaalenii_PYR-1 FNRPQRHNAFSTDARAALLEALEVARLDPSVDEVVLAGNGPSFCSGGDLA
MMAR_0453|M.marinum_M FNRPQRHNAFSGDARAALLEALTVAQLDPSVSGIVLSGNGPSFCSGGDLA
MUL_1103|M.ulcerans_Agy99 FNRPQRHIAFSGDARAALLEALTVAQLDPSVSGIVLSGNGPSFCSGGDLA
MAV_4960|M.avium_104 FNRPQRHNAFSTDARAALLEALAVAQLDPSVTGIVLSGNGPSFCSGGDLA
Mb1099c|M.bovis_AF2122/97 CELAMMCDVLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLI
Rv1070c|M.tuberculosis_H37Rv CELAMMCDVLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLI
MLBr_02402|M.leprae_Br4923 CELAMMCDLLIAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLI
MAB_0836c|M.abscessus_ATCC_199 CEMLQQTDIRVSDEHATFGLPEVQRGLVPGAGSMVRLKRQIPYTKAMEMI
: * : . : *. . .. ::
MSMEG_0259|M.smegmatis_MC2_155 EFGSFADPAAAHLARTRYSPALVLDELTARLGRRCRAHVHGQVLGSGLEM
TH_4433|M.thermoresistible__bu EFGSFDDPAGAHLARTRHSPALVLAELTERLGPRCRAEVHGLVLGSGLEM
Mflv_0448|M.gilvum_PYR-GCK EFGTFTDPASAHLARTRYSPALVLAEITARLGDKCRAEIHGQVQGSGLEM
Mvan_0219|M.vanbaalenii_PYR-1 EFGTFTDPAGAHLARTRHSPALVLDEITARLGRGCRAELHGQVQGSGLEM
MMAR_0453|M.marinum_M EFGTFADPASAHLARTRHSPALALAALTARLGRACRAEVHGRVLGSGLEM
MUL_1103|M.ulcerans_Agy99 ELGTFADPASAHLARTRHSPALALAALTARLGRACRAEVHGRVLGSGLEM
MAV_4960|M.avium_104 EFGTFADPASAHLARTRHSPALVLDALTARFGRACRAEVHGRVLGSGLEM
Mb1099c|M.bovis_AF2122/97 LTGRTMDAAEAERSGLVSRVVPADDLLTEARATATTISQMSASAARMAKE
Rv1070c|M.tuberculosis_H37Rv LTGRTMDAAEAERSGLVSRVVPADDLLTEARATATTISQMSASAARMAKE
MLBr_02402|M.leprae_Br4923 LTGRTIDAAEAERSGLVSRVVLADDLLPEAKAVATTISQMSRSATRMAKE
MAB_0836c|M.abscessus_ATCC_199 LTGEPLTAFEAYHFGLVGHVVPAGTALDKARSLADRIVRNGPLAVRNAKE
* . * . . : . . :
MSMEG_0259|M.smegmatis_MC2_155 ACFCGWVSCDPDAKLGLPELELGLVPGAGGTVSITRRIGRWRTAYLVLSG
TH_4433|M.thermoresistible__bu ASFCGHVTAHPDAVFGLPELELGLIPGAGGCVSITRRIGRWRTAYLVLTG
Mflv_0448|M.gilvum_PYR-GCK AAFCGTVSCDAGAVLGLPELALGLIPGAGGTVSITRRIGRWRTAYLVLSG
Mvan_0219|M.vanbaalenii_PYR-1 AAFCGWVSCDADAVLGLPELTLGLIPGAGGTVSVTRRIGRWRTAYLVLSG
MMAR_0453|M.marinum_M AAFCGWVQAHPDSVFGLPELSLGLIPGAGGTVSVTRRIGRWRTAYLVLSG
MUL_1103|M.ulcerans_Agy99 AAFCGWVQAQPDSVFGLPELSLGLIPGAGGAVSVTRRIGRWRTAYLALSG
MAV_4960|M.avium_104 AAFCGWVSARDDAVFGLPELALGLIPGAGGTVSITRRIGRWRTAYLVLSG
Mb1099c|M.bovis_AF2122/97 AVNRAFESSLSEGLLYERRLFHSAFATEDQSEGMAAFIEKRAPQFTHR--
Rv1070c|M.tuberculosis_H37Rv AVNRAFESSLSEGLLYERRLFHSAFATEDQSEGMAAFIEKRAPQFTHR--
MLBr_02402|M.leprae_Br4923 AVNRSFESTLAEGLLHERRLFHSTFVTDDQSEGMAAFIEKRAPQFTHR--
MAB_0836c|M.abscessus_ATCC_199 AIVRSGWLAEEDARAIEARLTRPVITSADAREGLAAFKEKREARFTGR--
* . . .* . . .:: : . :
MSMEG_0259|M.smegmatis_MC2_155 RTIDPTTALSWGLVDEIVSVAAPA
TH_4433|M.thermoresistible__bu RRIDAVTALRWGLVDAVSS-----
Mflv_0448|M.gilvum_PYR-GCK RSIDAATALRWGLVDAVG------
Mvan_0219|M.vanbaalenii_PYR-1 RPIDAGTALRWGLVDAVG------
MMAR_0453|M.marinum_M RTIDAGTARDWGLVDSIAVTGD--
MUL_1103|M.ulcerans_Agy99 RTIDAGTARDWGLVDSIAVTGD--
MAV_4960|M.avium_104 RTVGAATALSWGLVDEVEAATASS
Mb1099c|M.bovis_AF2122/97 ------------------------
Rv1070c|M.tuberculosis_H37Rv ------------------------
MLBr_02402|M.leprae_Br4923 ------------------------
MAB_0836c|M.abscessus_ATCC_199 ------------------------