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VMPFTTRPTLTGWHGMAASTHWLASGTAQAVLERGGNAFDAAAAAGFVLHVAEPHLNGPGGDMVALVSTA TTSEPVVLVGQGPAPEGATIAAFRERGLTHVPGAGALAAAVPAAVETWFHLLERYGTWRLSDVLGYAAEY AERGIECSEQLSAVLATMARHFTAHWPTSRDVWLPDGTPPAPGDLVRNPAYAAVLRRLSEAGATGTRVAG IDRARRMWRNEIASAIVEFTSRPHRHSGGGDHAGVLTTSDFQNLRIGSEASLRLRFRGVDVVKAGFWSSG PVLLQALGILDQAAASRSIDPDTAAGAHTIVETVKLAMADREAYYGDARPDQGVLGQLLSVEYCAERAGA ITDHAATVVDPGVLPGIRPYRSRTTVTPHDELGTGEPTVSRTGETRGDTCHLDVVDRFGNMISATPSGGW LQSSPAVPGLGFCLGTRLQMTWLDEDSPSALKPGTRPRTTLSPTMVLEAGVPVTSLGTPGGDQQDQWQLL YLLRTIVTGMTPQQAIDAPMYHTTAFPGSFVPRTASERGVVVEDRAGTEVIDGLRGRGHDVTVTDGWSLG RLSMVGRDRVTGRLCAAANPRGGTGYAVGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_0184 | - | - | 100% (590) | transferase |
| M. smegmatis MC2 155 | MSMEG_3076 | ggt | 5e-31 | 27.77% (569) | gamma-glutamyltransferase |
| M. smegmatis MC2 155 | MSMEG_1463 | - | 1e-28 | 27.16% (589) | gamma-glutamyltranspeptidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0796c | ggtA | 5e-37 | 28.16% (561) | bifunctional cephalosporin |
| M. gilvum PYR-GCK | Mflv_3716 | - | 4e-31 | 28.12% (569) | gamma-glutamyltransferase |
| M. tuberculosis H37Rv | Rv0773c | ggtA | 5e-37 | 28.16% (561) | bifunctional cephalosporin |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2788 | - | 1e-26 | 27.83% (575) | gamma-glutamyltranspeptidase (GgtB) |
| M. marinum M | MMAR_3713 | ggtB | 2e-37 | 28.10% (573) | gamma-glutamyltranspeptidase precursor GgtB |
| M. avium 104 | MAV_0717 | ggt | 3e-36 | 27.63% (561) | gamma-glutamyltransferase |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0486 | ggtA | 7e-23 | 27.56% (439) | bifunctional acylase, GgtA |
| M. vanbaalenii PYR-1 | Mvan_1330 | - | 8e-25 | 24.96% (597) | gamma-glutamyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3716|M.gilvum_PYR-GCK MAVMWATRRTTTSALRVLLGLSLILTGCTARQDT-PAAPPGPCDIVANGT
MMAR_3713|M.marinum_M ---MTFVKRCG----AVLAVAALALAGCGTTHVG-APNSAGPCEIVPNGT
MAB_2788|M.abscessus_ATCC_1997 ---MRALTRAL----AIASIALLASAGCAGDMTSRPGGAAEPCGITANGV
Mb0796c|M.bovis_AF2122/97 --------------------------------------------------
Rv0773c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_0717|M.avium_104 --------------------------------------------------
MUL_0486|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1330|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_0184|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_3716|M.gilvum_PYR-GCK PVSSD-------GGRSDDTAPETATGYRSDMTAVHTRSYAVATANPLATR
MMAR_3713|M.marinum_M PAPKTSVAAAAPSSRNVATNPEIATGYRTDMTPVHTAHYSVSAANPLATQ
MAB_2788|M.abscessus_ATCC_1997 PITKT-AATQAATERNISTNPEVATGYRTGMTAVRTASYAAATANPLATQ
Mb0796c|M.bovis_AF2122/97 --------------------------------MPILATNVVCTSQPLAAQ
Rv0773c|M.tuberculosis_H37Rv --------------------------------MPILATNVVCTSQPLAAQ
MAV_0717|M.avium_104 -----------------MNQPFGWDFPYAWPRKPVLADNVVCTSQPLAAQ
MUL_0486|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1330|M.vanbaalenii_PYR-1 -------------------------MATAQRPPALSANAMVSSSHPAASL
MSMEG_0184|M.smegmatis_MC2_155 ------------------------MMPFTTRPTLTGWHGMAASTHWLASG
Mflv_3716|M.gilvum_PYR-GCK AACEVLRDGGTAADALVTAQAVLGLVEPQSSGLGGGGFLLYYDAAAQSVQ
MMAR_3713|M.marinum_M AACRVLRDGGTAADAVVAAQAVLGLVEPQSSGIGGGGVLLYYDARTRSVQ
MAB_2788|M.abscessus_ATCC_1997 AACKVLRDGGSAADALVAAQAVLGLVEPQSSGIGGGGFLVYYDAASGAVQ
Mb0796c|M.bovis_AF2122/97 AGLRMLADGGNAVDAAVATAITLTVVEPVSNGIGSDAFSIVWDGQKLHGL
Rv0773c|M.tuberculosis_H37Rv AGLRMLADGGNAVDAAVATAITLTVVEPVSNGIGSDAFSIVWDGQKLHGL
MAV_0717|M.avium_104 AGLRMLAEGGSAVDAAIATAITLTIVEPVSNGMGSDAFAIVWDGEKVHGL
MUL_0486|M.ulcerans_Agy99 ----MQRSGG-----DLICRIRLALRLDLSVRMAAHAHPGRQ--RRVH-L
Mvan_1330|M.vanbaalenii_PYR-1 AGARVLADGGNAIDATLAMAALTWLTLPGQCGIGGDAFAVVREPDGRVWT
MSMEG_0184|M.smegmatis_MC2_155 TAQAVLERGGNAFDAAAAAGFVLHVAEPHLNGPGGDMVALVSTATTSEPV
: ** : ..
Mflv_3716|M.gilvum_PYR-GCK AFDGRETAPAAATENSLRWISDTDRTEPKPDARASGRSIGVPGIVAMLAQ
MMAR_3713|M.marinum_M AYDGREVAPAAATENYMRWISDADHSAPRPDPRASGRSIGVPGILRMLEM
MAB_2788|M.abscessus_ATCC_1997 TYDGREVAPAAATENYLRWVDDADRTAPRPDVRSSGRSIGVPGILRMLYD
Mb0796c|M.bovis_AF2122/97 NASGRSPSAWTPEY-----------FGGNAVPVLGWNSVTVPGAVSAWVE
Rv0773c|M.tuberculosis_H37Rv NASGRSPSAWTPEY-----------FGGNAVPVLGWNSVTVPGAVSAWVE
MAV_0717|M.avium_104 NASGRSPAAWTPEY-----------FGGNAVPVLGWNSVTVPGAVSAWTE
MUL_0486|M.ulcerans_Agy99 TAAGR-PSGSS-----------------DACRRRERRRRRYR------HR
Mvan_1330|M.vanbaalenii_PYR-1 VNGSGYGPDGGTPEFY-------AAQGLSSIPLDGPLAVAVPGAVAALRA
MSMEG_0184|M.smegmatis_MC2_155 VLVGQGPAPEGATIAAFR------ERGLTHVPGAGALAAAVPAAVETWFH
. .
Mflv_3716|M.gilvum_PYR-GCK VHAEHGRTPWRDLFSPAVTLADDGFDVSARLAAAIAAAAPKLALDDDAAA
MMAR_3713|M.marinum_M VHNEHGTTPWRDLFSPAVALADNGFDISPRMAAAISDSAPQLGADPQARG
MAB_2788|M.abscessus_ATCC_1997 VHAEHGAAPWRELFTPAVQLADDGFEISPRLAAAITDSAASLALDPEADL
Mb0796c|M.bovis_AF2122/97 LHARFGRLPFETLFEPAISYGRNGFLVSPTVAAQWAAQVPLFASQPGFAD
Rv0773c|M.tuberculosis_H37Rv LHARFGRLPFETLFEPAISYGRNGFLVSPTVAAQWAAQVPLFASQPGFAD
MAV_0717|M.avium_104 LHARFGKLPFERLFAPAISYGRNGFPVSPVVAEQWVAQVPLFAGQPGFAE
MUL_0486|M.ulcerans_Agy99 HHPHPGGTGFQRLFGPAITYGRNGFLVSPKVSAQWQAQVALFADQPGFAE
Mvan_1330|M.vanbaalenii_PYR-1 LHLGGATRELEQLWEPAARIAGDGLPCSARTAGDVVTALGDSAP------
MSMEG_0184|M.smegmatis_MC2_155 LLERYGTWRLSDVLGYAAEYAERGIECSEQLSAVLATMARHFTAHWPTSR
. : * . *: * :
Mflv_3716|M.gilvum_PYR-GCK YFLNADRTPKSAGTTLTNPAYAKTLGAVA-ADPEA-----------FYTG
MMAR_3713|M.marinum_M YFLTPDGTPKAVGTRLTNPAYAKALSEIASAGASV-----------FYTG
MAB_2788|M.abscessus_ATCC_1997 YLLNTDGSAKPAGTKITNPAYAKTLGAVAADGPDA-----------FYRG
Mb0796c|M.bovis_AF2122/97 AFMPGGRAPK-PGELFTFPDHAATLEKIAATNGEE-----------FYRG
Rv0773c|M.tuberculosis_H37Rv AFMPGGRAPK-PGELFTFPDHAATLEKIAATNGEE-----------FYRG
MAV_0717|M.avium_104 AFAPEGRAPR-PGERFRLPAHADTLEAIAASRGEA-----------FYRG
MUL_0486|M.ulcerans_Agy99 AFLPGGRAPK-PGELFTFPDHADTLEKIAASTGAA-----------FYRG
Mvan_1330|M.vanbaalenii_PYR-1 ----------AVGSRVPQPELAATIRRLARDPEG------------FYTG
MSMEG_0184|M.smegmatis_MC2_155 DVWLPDGTPPAPGDLVRNPAYAAVLRRLSEAGATGTRVAGIDRARRMWRN
* . * * .: :: :: .
Mflv_3716|M.gilvum_PYR-GCK DIARAIVASVTD----PSGGRTPGLMTVEDLADYTVKQRDPLCTPYRGKE
MMAR_3713|M.marinum_M DIAHDIVAAAGD----TSGGRTPSLITLEDLSAYPAKKREPLCTTYRGRQ
MAB_2788|M.abscessus_ATCC_1997 AIAEAIVAAAAD----TSSGRTPSLMTTADLSGYTAKRRAALCTTYRDHE
Mb0796c|M.bovis_AF2122/97 ELAAKLEAHSAA----NGG-----VMRADDLAAHRVDWVDTITGTYRGYT
Rv0773c|M.tuberculosis_H37Rv ELAAKLEAHSAA----NGG-----VMRADDLAAHRVDWVDTITGTYRGYT
MAV_0717|M.avium_104 ALAARVAEHAAA----NGG-----AMTADDLAAHRADWVETITGDYRGYT
MUL_0486|M.ulcerans_Agy99 ELADKLEAHARA----NDA-----ALRASDLAAHRTDWVGTISTNYRDYT
Mvan_1330|M.vanbaalenii_PYR-1 EFAQRAVAALQA----GGAP----FSGDEWTAGAEVNPEPAITGRYAGAV
MSMEG_0184|M.smegmatis_MC2_155 EIASAIVEFTSRPHRHSGGGDHAGVLTTSDFQNLRIGSEASLRLRFRGVD
:* .. .: : .
Mflv_3716|M.gilvum_PYR-GCK ICGMPPPSSGGIAVAATLGMLERFPMADHAPTDVDLNGGRPSVMGVHLIS
MMAR_3713|M.marinum_M ICGMPTPSSGGVAVAATLGILEHFPMSEYRPDNLDPNGGRPSVMGVHLVA
MAB_2788|M.abscessus_ATCC_1997 ICGMPAPSSGGIAVAATLGILQNFPMASFRPTDIDLDGGKPTVDGVHYIA
Mb0796c|M.bovis_AF2122/97 IHQIP-PNGQGIVALIALGILEHFDMSSWSVDSAES---------VHVQI
Rv0773c|M.tuberculosis_H37Rv IHQIP-PNGQGIVALIALGILEHFDMSSWSVDSAES---------VHVQI
MAV_0717|M.avium_104 VHEIP-PNGHGIVALIALGILERFDMASLPVDSADS---------VHLQI
MUL_0486|M.ulcerans_Agy99 IHEIP-PNGQGIVALIALGILDQFDMSCYPVDSADS---------VHLQI
Mvan_1330|M.vanbaalenii_PYR-1 VHQTPLPTPGWMVLQQAALCDGVVGFSGWLSAEAIDR-----------LA
MSMEG_0184|M.smegmatis_MC2_155 VVKAG-FWSSGPVLLQALGILDQAAASRSIDPDTAAG--------AHTIV
: . : : .
Mflv_3716|M.gilvum_PYR-GCK EAERLAYADRDRYVADT-----------------DFVALPGGSPDTLLGN
MMAR_3713|M.marinum_M EAERLAYADRDKYVADA-----------------DFVPPPGGSLSTLVDP
MAB_2788|M.abscessus_ATCC_1997 EAERLAYADRDKYVADT-----------------DFVALPGNSPDTLLNP
Mb0796c|M.bovis_AF2122/97 EALKLAFADAQACVADI-----------------DYMPVH---PKRLLDK
Rv0773c|M.tuberculosis_H37Rv EALKLAFADAQACVADI-----------------DYMPVH---PKRLLDK
MAV_0717|M.avium_104 EAVKLAFADAQAYLADI-----------------EHMPLR---PEHLLDT
MUL_0486|M.ulcerans_Agy99 EALKLAFSDAQHQLADI-----------------DHMTVG---PDQLLDK
Mvan_1330|M.vanbaalenii_PYR-1 RAARLTFADRLALCASD-----------------NDGSRY-----VLTPD
MSMEG_0184|M.smegmatis_MC2_155 ETVKLAMADREAYYGDARPDQGVLGQLLSVEYCAERAGAITDHAATVVDP
.: :*: :* .. : :
Mflv_3716|M.gilvum_PYR-GCK DYLAGRAALISPDRSMGTAEPGNFGPPTAPVPPTPEHGTSHVSVVDRDGN
MMAR_3713|M.marinum_M AYLAGRAALISPQHSMGTAKPGDFGLPTTIAAPVPEHGTSHVSVVDSYGN
MAB_2788|M.abscessus_ATCC_1997 TYLAGRARLISGDTTMGVAKPGEFNIPASAAVSTPEHGTSQVTVVDARGN
Mb0796c|M.bovis_AF2122/97 EYLRQRATLIDPKRAMPAATG------------IPRGGTVYLAAADAAGM
Rv0773c|M.tuberculosis_H37Rv EYLRQRATLIDPKRAMPAATG------------IPRGGTVYLAAADAAGM
MAV_0717|M.avium_104 EYLERRAALIDPARAKPVSAG------------APAGGTVYLTAADAAGM
MUL_0486|M.ulcerans_Agy99 EYLRGRAALIDLKQAKPASAG------------TPKGGTIYLTAADADGL
Mvan_1330|M.vanbaalenii_PYR-1 RIEAQRRDLDCGTEARGPVEVR-------------AGDTTSTVVVDAEGR
MSMEG_0184|M.smegmatis_MC2_155 GVLPGIRPYRSRTTVTPHDELG-TGEPTVSRTGETRGDTCHLDVVDRFGN
.* ..* *
Mflv_3716|M.gilvum_PYR-GCK AASLTTTVESAFGSFHMVDG--FLLNNQLT-DFSAEPAGPDGAPVANRLE
MMAR_3713|M.marinum_M AAALTTTVESAFGSFHMVDG--FLLNNQLS-DFNAQPYDSDGAPVANRIQ
MAB_2788|M.abscessus_ATCC_1997 AASLTTTVESAFGSFHMVDG--FFLNNQLT-DFSAEPVGKDGLPVANRLQ
Mb0796c|M.bovis_AF2122/97 MVSMIQSNYLGFGSGVVVPGTGISLHNRGS-DFTVVPRHP------NRVG
Rv0773c|M.tuberculosis_H37Rv MVSMIQSNYLGFGSGVVVPGTGISLHNRGS-DFTVVPRHP------NRVG
MAV_0717|M.avium_104 MVSMIQSNYMGFGSGVVVPGTGISLQNRGA-NFTAGLGHP------NSVG
MUL_0486|M.ulcerans_Agy99 MVSMIQSNYMGFGSGVVVPGTGISLQNRGS-GFVATPGHP------NQVG
Mvan_1330|M.vanbaalenii_PYR-1 AVSFIHSLAFTFGAKFTVPGTGVILNNRLARGAYLIPGHP------NEVA
MSMEG_0184|M.smegmatis_MC2_155 MISATPSGGWLQ-SSPAVPGLGFCLGTRLQMTWLDEDSPS-------ALK
: : : * * . * .: :
Mflv_3716|M.gilvum_PYR-GCK PGKRPRSTMAPTLIFDTSGP-DRR-LYAVAGSPGGSTIIQFVVKTVVGML
MMAR_3713|M.marinum_M PGKRPRSSMAPTFVFDGAPA-EHSSLYAVVGSPGGSTIVQFVVKTLVAML
MAB_2788|M.abscessus_ATCC_1997 PGKRPRSSMAPTLVFERAESGKRGALLLALGSPGGSVIIQFVVKTLVGIL
Mb0796c|M.bovis_AF2122/97 PRKRPYHTIIPGFVTRDGAP------VMSFGVMGGMMQPQGHVQVLVRIA
Rv0773c|M.tuberculosis_H37Rv PRKRPYHTIIPGFVTRDGAP------VMSFGVMGGMMQPQGHVQVLVRIA
MAV_0717|M.avium_104 PNKRPYHTIIPGFVTKGGAP------VMSFGVMGGMMQPQGHVQVMVRIA
MUL_0486|M.ulcerans_Agy99 PRKRPYHTIIPGFVTKDGAP------VLSFGVMGAQMQPQGHVQMMVRIA
Mvan_1330|M.vanbaalenii_PYR-1 PRRKPLHTLNAWVVTDDAGA-----LLHVGNTPGGDGQVQWNMQLLSHVL
MSMEG_0184|M.smegmatis_MC2_155 PGTRPRTTLSPTMVLEAGVP------VTSLGTPGGDQQDQWQLLYLLRTI
* :* :: . .: . . . *. * : :
Mflv_3716|M.gilvum_PYR-GCK DWGLDPQQAVSMVDFGADNSPETNVGGEHPVI-DTADDGADDPLVRGLRE
MMAR_3713|M.marinum_M DWGLDPQQAVSAVDFGAANTPRTNVGGEHPDI-NTADNGAHDPLVEGLRA
MAB_2788|M.abscessus_ATCC_1997 DWGLDPQQAVSMVDFGANNSPKTNVGGEHPSI-DARDNGADDPLIQRLRA
Mb0796c|M.bovis_AF2122/97 DYGQNPQAACDGPRFRWVNGMRVSF-----------ENGFPDSTLDELRQ
Rv0773c|M.tuberculosis_H37Rv DYGQNPQAACDGPRFRWVNGMRVSF-----------ENGFPDSTLDELRQ
MAV_0717|M.avium_104 DHGQNPQAACDGPRFRWVQGTQVSC-----------ENGFPAATLDELRR
MUL_0486|M.ulcerans_Agy99 DYGQNPQAACDGPRFRWVQELKVSC-----------EKGFPPSTLDELRR
Mvan_1330|M.vanbaalenii_PYR-1 DHGLDPAEAVSAPRFTVFPGSDADVVGS-PDE-LRVEQSLPAGVRRQLAA
MSMEG_0184|M.smegmatis_MC2_155 VTGMTPQQAIDAPMYHTTAFPGSFVPRTASERGVVVEDRAGTEVIDGLRG
* * * . : :. *
Mflv_3716|M.gilvum_PYR-GCK LGHKVDLADQSSGLS---AIVRAGDGWVG-GADPRR-EGAVMGDGDAPVS
MMAR_3713|M.marinum_M LGHQVNLADQSSGLS---AITRSKSGWTG-GADPRR-EGVVMGDTS----
MAB_2788|M.abscessus_ATCC_1997 RGHIVDVADQSSGLS---ALVRRGPGWIG-GADPRR-EGLVMGDTG----
Mb0796c|M.bovis_AF2122/97 RGHDLVAVADYSQFGSCQAIWRLDDGYLA-ASDPRR-DGQAAAC------
Rv0773c|M.tuberculosis_H37Rv RGHDLVAVADYSQFGSCQAIWRLDDGYLA-ASDPRR-DGQAAAC------
MAV_0717|M.avium_104 RGHDLVAVDDYNQFGSCQAIWRMDTGYVA-ASDPRR-DGQAAAF------
MUL_0486|M.ulcerans_Agy99 RGHDLVTVEDYNEFGSCQAIWRLEHGYLA-GSDPRR-DGQAAAF------
Mvan_1330|M.vanbaalenii_PYR-1 AGHRVVDQPALGGGGSAQLISVDERGVLAGAADPRQ-EGVALGVD-----
MSMEG_0184|M.smegmatis_MC2_155 RGHDVTVTDGWSLGRLSMVGRDRVTGRLCAAANPRGGTGYAVGR------
** : . * .::** * . .