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DPRSRPPCKIIGLAALMVLVFFGAMLYWQFRGTFIPKTRLTMIAPRAGLVTDPGAKVTFNGVQIGRVSSI TEVTHDGAPAARFALDVTPKYIGSIPANVSATIKATTVFGNKYVSLTSPTDPAPQHITPASVIYATSVTT EFNTLFENVTAISEKVDPDKLNLTLNAAAQALSGLGDRLGTALVNGNAILDDVNPLMPQVHRDIRGLAAL GDIYADASADLWDAVNSTVTVARTVNQRRSDLDAALLASVGLANNGSEVFERGGPYLTRGAADLVPTGQL LDEYSPEIFRTIRNYDEVAPRIRNALGFNGYSLGAAPSGAISGAPNPYIYPENLPRVNARGGPGGRPGCW QTITRDLWPAPYLVMNVGANMAPYNHLEIGQPLLNEYVWGRQFGENTINP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_0415 | mce2A | - | 100% (401) | MCE-family protein Mce2A |
| M. ulcerans Agy99 | MUL_1062 | mce1A | e-145 | 59.67% (424) | MCE-family protein Mce1A |
| M. ulcerans Agy99 | MUL_3918 | mce3A_1 | 6e-60 | 37.54% (357) | MCE-family protein Mce3A_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0175 | mce1A | 1e-142 | 57.34% (443) | MCE-family protein MCE1A |
| M. gilvum PYR-GCK | Mflv_0711 | - | 1e-141 | 58.60% (401) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv0589 | mce2A | 1e-142 | 61.70% (389) | MCE-family protein MCE2A |
| M. leprae Br4923 | MLBr_02589 | mce1A | 1e-141 | 55.81% (430) | putative cell invasion protein |
| M. abscessus ATCC 19977 | MAB_4153c | - | 8e-56 | 33.17% (401) | MCE-family protein |
| M. marinum M | MMAR_4883 | mce2A | 0.0 | 98.00% (401) | MCE-family protein Mce2A |
| M. avium 104 | MAV_4126 | - | 1e-147 | 60.05% (423) | virulence factor Mce family protein |
| M. smegmatis MC2 155 | MSMEG_0134 | - | 1e-141 | 61.01% (395) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_0154 | - | 1e-134 | 57.89% (399) | virulence factor Mce family protein |
| M. vanbaalenii PYR-1 | Mvan_0134 | - | 1e-145 | 60.35% (401) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_0415|M.ulcerans_Agy99 -------------MDPRSRPPCKIIGLAALMVLVFFGAMLYWQFRGTFIP
MMAR_4883|M.marinum_M -------------MDPRSRPPYKIIGLAALMVLVFFGAMLYWQFRGTFIP
Mflv_0711|M.gilvum_PYR-GCK ------MTAP---MNTKRQPPYKIAGVVLALVTILILVLVYLQFRGDFLP
Mvan_0134|M.vanbaalenii_PYR-1 ------MTVPQAALNTRRQPPYKLAGLVLAILTVIAVTLVYLQFRGDFMA
MSMEG_0134|M.smegmatis_MC2_155 MTEPPAPTAP---LNKPKTPPYKLAGLILGLVGVLVLALTWMQFRGQFED
TH_0154|M.thermoresistible__bu ------MTAP---LNAPRTPPYKIVGVVLLLVVALVVTLVWMQFRGAFTP
Rv0589|M.tuberculosis_H37Rv --------MPTLVTRKNRRAWLYVEGVVLLLVGALVLVLVYKQFRGEFTP
MLBr_02589|M.leprae_Br4923 ------MTSS-TKINASRKPPYKLAGVGLLVVAVVIFGLVYGQFRGNFTP
MAV_4126|M.avium_104 -----------MQINSQRIPPYKLLAVAVLLVLALILALIYGQFRGAFTE
Mb0175|M.bovis_AF2122/97 ------MTTP-GKLNKARVPPYKTAGLGLVLVFALVVALVYLQFRGEFTP
MAB_4153c|M.abscessus_ATCC_199 ------------MSDTSTRRAVRLAGTVLASVLVLLTVLTYLAYNDAFAD
. : . : : :.. *
MUL_0415|M.ulcerans_Agy99 KTRLTMIAPRAGLVTDPGAKVTFNGVQIGRVSSITEVTHDGAPAARFALD
MMAR_4883|M.marinum_M KTRLTMIAPRAGLVTDPGAKVTFNGVQIGRVSSITEVTHDGAPAARFALD
Mflv_0711|M.gilvum_PYR-GCK RTQLTMISARSGLSLDSGSKVTFNGVEIGKVSEVEETTVGGEPRAKILLE
Mvan_0134|M.vanbaalenii_PYR-1 RTQLTMISARSGLSMDPGAKVTYNGVEIGRVGNVEETSVDGEPRAKIILD
MSMEG_0134|M.smegmatis_MC2_155 KVQLTVLSGRAGLSMDPGSKVTFNGVPIGRLASIDVVEVDDNPEARLTLD
TH_0154|M.thermoresistible__bu RTQLTLLADRAGLVMDPGSKVTFNGVEIGRVAQIHADTSDDRTRANIVLD
Rv0589|M.tuberculosis_H37Rv KTELTMVAFRAGLVMEAGSKVTYNGVEIGRVGSISEIERDGRPAAKLVLD
MLBr_02589|M.leprae_Br4923 KSKLTMLADRAGLVMDRGSKITYNGVKIGRVADISETVRNGRPVAEFTLD
MAV_4126|M.avium_104 KTQLTMIASRAGLVMDPGSKVTYNGVEIGRVGTISETVRDGKPAAKFTLE
Mb0175|M.bovis_AF2122/97 KTQLTMLSARAGLVMDPGSKVTYNGVEIGRVDTISEVTRDGESAAKFILD
MAB_4153c|M.abscessus_ATCC_199 TKPITVVSPRAGLVMEEGGKVKFHGLQIGKVTSISYAN----DQAKLELA
:*::: *:** : *.*:.::*: **:: : *.: *
MUL_0415|M.ulcerans_Agy99 VTPKYIGSIPANVSATIKATTVFGNKYVSLTSPTDPAPQHITPASVIYAT
MMAR_4883|M.marinum_M VTPKYIGSIPANVSATIKATTVFGNKYVSLTSPTDPAPQHITPASVIYAT
Mflv_0711|M.gilvum_PYR-GCK VNPKYLKLIPRNVNADISATTVFGNKYVSFTSPENPQSERISASDVIDVT
Mvan_0134|M.vanbaalenii_PYR-1 VNPKYLDLIPSNVNADISATTVFGNKYVSFTTPEDPRPERISASDVIDVT
MSMEG_0134|M.smegmatis_MC2_155 VDPKYLDLIPENANVELRATTVFGNKYISFLSPKNPSAERLSASTPIRAQ
TH_0154|M.thermoresistible__bu VDPKYVDLIPSNADVEIKASTVFGNKYVAFASPPDPSLTPITSAATIDVT
Rv0589|M.tuberculosis_H37Rv VNPRYISLIPVNVVADIEAATLFGNKYVALSAPKIPQQQRISSHDVIDVG
MLBr_02589|M.leprae_Br4923 VYPRYLSLIPANVNADIKATTVFGGKYVSLTTPEHPSQKRLTPQTVIDAR
MAV_4126|M.avium_104 VYPRYLKLIPSNVNADIKATTVFGGKYVSLTTPAHPSPQKITPHTIIDAR
Mb0175|M.bovis_AF2122/97 VDPRYIHLIPANVNADIKATTVFGGKYVSLTTPKNPTKRRITPKDVIDVR
MAB_4153c|M.abscessus_ATCC_199 VNAKDLRLIPSNATVRIAGTTVFGAKSVEFLAPQKPSDSSLRPGATVTAE
* .: : ** *. . : .:*:** * : : :* * : . : .
MUL_0415|M.ulcerans_Agy99 SVTTEFNTLFENVTAISEKVDPDKLNLTLNAAAQALSGLGDRLGTALVNG
MMAR_4883|M.marinum_M SVTTEFNTLFENVTAISEKVDPVKLNLTLSAAAQALSGLGDRLGTALVNG
Mflv_0711|M.gilvum_PYR-GCK SVTTEFNTLFETVVEIAEQVDPIKLNQTLTATAQALDGLGDRFGESIING
Mvan_0134|M.vanbaalenii_PYR-1 SVTTEFNTLFETVVSLADQVDPIKLNQTLTATAQALDGLGDRFGESIING
MSMEG_0134|M.smegmatis_MC2_155 GVTTEFNTLFETITAISEQVDPIKLNETLTAAAQALDGLGDKFGRSIVDG
TH_0154|M.thermoresistible__bu KVTTEFNTLFQTVVDIARQVDPIKLNQTLTATAQALDGLGDRFGESIIDG
Rv0589|M.tuberculosis_H37Rv SVTTEFNTLFETITSIAEKVDPIELNATLSAVAQALDGLGGKFGESIVNG
MLBr_02589|M.leprae_Br4923 SVTTEINTLFQTITLIAEKVDPIKLNLTLSAAAQSLAGLGERFGQSIVNG
MAV_4126|M.avium_104 SVTTEINTLFQTITSIAEKVDPVKLNLTLSAAAQSLSGLGEKFGQSVVNA
Mb0175|M.bovis_AF2122/97 SVTTEINTLFQTLTSIAEKVDPVKLNLTLSAAAEALTGLGDKFGESIVNA
MAB_4153c|M.abscessus_ATCC_199 AVALEVNTVFENLTRLLGKIDPVNLNATLTAVGEGLRGNGDNFGQGLVEL
*: *.**:*:.:. : ::** :** **.*..:.* * * .:* .:::
MUL_0415|M.ulcerans_Agy99 NAILDDVNPLMPQVHRDIRGLAALGDIYADASADLWDAVNSTVTVARTVN
MMAR_4883|M.marinum_M NAILDDVNPLMPQVHRDITGLAALGDIYADASTDLWDAVNSTVTVARTVN
Mflv_0711|M.gilvum_PYR-GCK NQILAEINPQMPQIRRDNQLLADFGEVYSNAAPDLFDGLQNAVTTARTLN
Mvan_0134|M.vanbaalenii_PYR-1 NQILSEINPQMPQIRRDNQLLADLGDVYADAAPDLFDGLQNAVTTARTLN
MSMEG_0134|M.smegmatis_MC2_155 NAILADVNPRMPQIRRDITGLANLGEVYADASPDLFDGLDNAVTTARTLN
TH_0154|M.thermoresistible__bu NAILDDLNPQMPQIRYDVQRLADLNAVYAAAAPDLFDGLENAVTTAQTLY
Rv0589|M.tuberculosis_H37Rv NQILAQLNPRLPQLGYDVRRLADLGEVYVDASPDLWSFLQNALTTARTLT
MLBr_02589|M.leprae_Br4923 NSVLDDVNSQLPQARHDIQQLASLGDTYANSASDFFDFLNNSIVTSRTIN
MAV_4126|M.avium_104 NALLDDVNPRMPQARKDIQGLAALGDTYADASPDLFDFLNNAVITSRTIN
Mb0175|M.bovis_AF2122/97 NTVLDDLNSRMPQSRHDIQQLAALGDVYADAAPDLFDFLDSSVTTARTIN
MAB_4153c|M.abscessus_ATCC_199 DQYLDQLNPKLPALQQDFRQAGQVGQIYGDAAPDIVRILDNLPALSRTVV
: * ::*. :* * . .. * ::.*: ::. ::*:
MUL_0415|M.ulcerans_Agy99 QRRSDLDAALLASVGLANNGSEVFERGGPYLTRGAADLVPTGQLLDEYSP
MMAR_4883|M.marinum_M QRRSDLDAALLASVGLANNGSEVFERGGPYLTRGAADLVPTGQLLDEYSP
Mflv_0711|M.gilvum_PYR-GCK EQQGDVDQALMAAVGFGNTGGDIFERGGPYLVRGARDLVPTSALLDKYSP
Mvan_0134|M.vanbaalenii_PYR-1 EQQGDVDQALMAAVGFGNTGGDVFERGGPYLARGAEDLVPTTALLDKYSP
MSMEG_0134|M.smegmatis_MC2_155 EQRGNLDQALVAAVGFGNTGGDIFERGGPYLVRGAQDLLPTSALLDEYSP
TH_0154|M.thermoresistible__bu QERGNLDQTLLASIGFGNTAGEVFERGGPYLVRGSEDLVTVTEILDYHSP
Rv0589|M.tuberculosis_H37Rv SQQRDLDAALLAATGAGNTGEDVFARGGPYLARAAADLVPTATLLDTYSP
MLBr_02589|M.leprae_Br4923 QQQKDLDQVLLAAVGFGNTGADIFSRSGPYLARGAADLVPTAQLLDTYSP
MAV_4126|M.avium_104 AQQKDLDQALLSAAGFGNTGADLFTKGGPYLARGAHDLVPTAQLLDTYSP
Mb0175|M.bovis_AF2122/97 AQQAELDSALLAAAGFGNTTADVFDRGGPYLQRGVADLVPTATLLDTYSP
MAB_4153c|M.abscessus_ATCC_199 DQQQDLKATLLAAIGLGNNGYETLAPAEKDLTAALQRLRAPATLLGRYSP
.: ::. .*::: * .*. : : . * . * . :*. :**
MUL_0415|M.ulcerans_Agy99 EIFRTIRNYDEVAPRIRNALGF-NGYSLGAAPSGAISG------------
MMAR_4883|M.marinum_M EIFCTIRNYDEVAPRIRNALGF-NGYSLGAASSGAISG------------
Mflv_0711|M.gilvum_PYR-GCK SFFCMMRNYHDVEPKIADALGG-NGYSLKTH-SQVLGLG-----------
Mvan_0134|M.vanbaalenii_PYR-1 SFFCMIRNYHDVEPKIADALGG-NGYSLKTH-SEVLGLG-----------
MSMEG_0134|M.smegmatis_MC2_155 ALFCTIRNYHDAAPKLAGALGG-NGYSLLTN-SLVVGV------------
TH_0154|M.thermoresistible__bu ALFCMIRNYHDVAPKVAASLGG-NGYSLRQH-AFLVGP------------
Rv0589|M.tuberculosis_H37Rv ELFCMIRNFHDAAPKVADAVGG-NGYSLAAA-GTILGAP-----------
MLBr_02589|M.leprae_Br4923 AIFCTLRNYHDIEPKVTSFLGG-NGYSINDH-VELLSGLGFLLNPTSAIS
MAV_4126|M.avium_104 ELYCTLHNYHDIVPITGASEGGFNGYSLNMN-TEVTSGLGLLLNPVATIP
Mb0175|M.bovis_AF2122/97 ELFCTIRNFYDADPLAKAAAGGGNGYSLRTN-SEILSGIGISLLSPLALA
MAB_4153c|M.abscessus_ATCC_199 EIPCTLQAISKALVTFTPLIGGVRPGLFLTN-SFPLGAP-----------
: :: . * . : .
MUL_0415|M.ulcerans_Agy99 -----------------------------------APNPYIYPENLPRVN
MMAR_4883|M.marinum_M -----------------------------------APNPYIYPENLPRVN
Mflv_0711|M.gilvum_PYR-GCK -----------------------------------AGNAYVYPDNLPRVN
Mvan_0134|M.vanbaalenii_PYR-1 -----------------------------------AGNAYVYPDNLPRVN
MSMEG_0134|M.smegmatis_MC2_155 ------------------------------------GNPYVYPDNLPRVN
TH_0154|M.thermoresistible__bu ------------------------------------GNPYVYPDNLPRVN
Rv0589|M.tuberculosis_H37Rv -------------------------------------NPYVYPDNLPRVN
MLBr_02589|M.leprae_Br4923 IIGAGV---LSQGLLAP---------LGLAGVVNGAANPYIYPENLPRVN
MAV_4126|M.avium_104 VLAS---------LVG-----------GIAGLVGGAPNPYIYPENLPRVN
Mb0175|M.bovis_AF2122/97 TNGAAIGIGLVAGLIASPLAVAANLAGALPGIVGGAPNPYTYPENLPRVN
MAB_4153c|M.abscessus_ATCC_199 --------------------------------------VYTYPDSLPIVN
* **:.** **
MUL_0415|M.ulcerans_Agy99 ARGGP--GGRPGCWQTITRDLWP-APYLVMNVG-ANMAPYNHLEIGQPLL
MMAR_4883|M.marinum_M ARGGP--GGRPGCWQTITRDLWP-APYLVMDVG-ANMAPYNHLEIGQPLL
Mflv_0711|M.gilvum_PYR-GCK AKGGP--GGRPGCWQPITRDLWP-APFLVLDTG-ASVAPYNHMELGQPLF
Mvan_0134|M.vanbaalenii_PYR-1 AKGGP--GGRPGCWQPITRDLWP-APFLVLDTG-ASIAPYNHMELGQPLL
MSMEG_0134|M.smegmatis_MC2_155 AKGGP--EGRPGCWQPITRDLWP-FPYLVMDTG-ASIAPYNHFELGQPMF
TH_0154|M.thermoresistible__bu ATGGP--GGRPGCWQPITRDLWP-APYLVMDTG-ASLAPYNHIELGKPFA
Rv0589|M.tuberculosis_H37Rv AHGGP--GGRPGCWQTITRELWP-APYLVMDTG-ASLAPYNHVELGQPMF
MLBr_02589|M.leprae_Br4923 ARGGP--GGAPGCWQHITRDLWP-TPELVMDTG-NSIAPYNHLDSGSPYA
MAV_4126|M.avium_104 ARGGP--GGAPGCWQPITHDLWP-APELVMDTG-NSLAPYNHLETGSPYA
Mb0175|M.bovis_AF2122/97 ARGGP--GGAPGCWQPITRDLWP-APYLVMDTG-ASLAPYNHMEVGSPYA
MAB_4153c|M.abscessus_ATCC_199 ASGGPNCRGLPNIPTKMQNGSWFRSPFLVTDNAYIPYKPLEELQVNAPDT
* *** * *. : . * * ** : . * :..: . *
MUL_0415|M.ulcerans_Agy99 NEYVWGRQFGENTINP
MMAR_4883|M.marinum_M NEYVWGRQFGENTINP
Mflv_0711|M.gilvum_PYR-GCK TEYVWGRQVGEHTINP
Mvan_0134|M.vanbaalenii_PYR-1 TEYVWGRQVGEHTINP
MSMEG_0134|M.smegmatis_MC2_155 AEYVWGRQVGENTINP
TH_0154|M.thermoresistible__bu IEYVWGRQIGEYTINP
Rv0589|M.tuberculosis_H37Rv TEYVWGRQYGENTINP
MLBr_02589|M.leprae_Br4923 IEYVWGRQVGDNTINP
MAV_4126|M.avium_104 NEYVWGRQVGDNTINP
Mb0175|M.bovis_AF2122/97 VEYVWGRQVGDNTINP
MAB_4153c|M.abscessus_ATCC_199 LQYLYNGAFAKRSEF-
:*::. .. :