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THSQRRDKLKAQIAASGLDAMLISDLINVRYLSGFSGSNGALLVFADERDAVLATDGRYRTQAASQAPDL EVAIERAVGRYLAGRAGEAGVGKLGFESHVVTVDGLDALAGALEGKNTELVRASGTVESLREVKDAGELA LLRLACEAADAALTDLVARGGLRPGRTERQVSRELEALMLDHGADAVSFETIVAAGANSAIPHHRPTDAV LQVGDFVKIDFGALVAGYHSDMTRTFVLGKAADWQLEIYQLVAEAQQAGRQALLPGAELRGVDAAARQLI ADAGYGEHFGHGLGHGVGLQIHEAPGIGVTSAGTLLAGSVVTVEPGVYLPGRGGVRIEDTLVVAGGTPKM PETAGQTPELLTRFPKELAIL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2535c | pepQ | - | 100% (372) | PROBABLE CYTOPLASMIC PEPTIDASE PEPQ |
| M. tuberculosis H37Rv | Rv2089c | pepE | 1e-37 | 39.29% (224) | dipeptidase PepE |
| M. tuberculosis H37Rv | Rv0734 | mapA | 1e-16 | 31.47% (232) | methionine aminopeptidase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2564c | pepQ | 0.0 | 100.00% (372) | putative cytoplasmic peptidase PEPQ |
| M. gilvum PYR-GCK | Mflv_3753 | - | 1e-148 | 74.19% (372) | peptidase M24 |
| M. leprae Br4923 | MLBr_00521 | pepQ | 1e-171 | 82.71% (376) | putative cytoplasmic peptidase |
| M. abscessus ATCC 19977 | MAB_2838c | - | 1e-126 | 65.84% (363) | putative cytoplasmic peptidase PepQ |
| M. marinum M | MMAR_2180 | pepQ | 1e-177 | 83.87% (372) | cytoplasmic peptidase PepQ |
| M. avium 104 | MAV_3412 | - | 1e-168 | 80.75% (374) | peptidase, M24 family protein |
| M. smegmatis MC2 155 | MSMEG_3034 | - | 1e-152 | 72.30% (379) | metallopeptidase, M24 family protein |
| M. thermoresistible (build 8) | TH_0106 | pepQ | 1e-142 | 75.78% (351) | PROBABLE CYTOPLASMIC PEPTIDASE PEPQ |
| M. ulcerans Agy99 | MUL_1764 | pepQ | 1e-177 | 83.87% (372) | cytoplasmic peptidase PepQ |
| M. vanbaalenii PYR-1 | Mvan_2650 | - | 1e-147 | 72.58% (372) | peptidase M24 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3753|M.gilvum_PYR-GCK MTISARRDRLRRLLADAGLDAMLVSDLVNVRYLSGFTGSNAALLVLAQD-
Mvan_2650|M.vanbaalenii_PYR-1 MTISQRRDRLRQRLADAELDAMLVSDLVNVRYLSGFTGSNAALLILAED-
MSMEG_3034|M.smegmatis_MC2_155 MTISQRRERLRQRLAAADLDAMLVTDLVNVRYLSGFTGSNAALLVRVDD-
TH_0106|M.thermoresistible__bu ---------------------MLVTDLTNVRYLSGFTGSNAALLVKADG-
Rv2535c|M.tuberculosis_H37Rv MTHSQRRDKLKAQIAASGLDAMLISDLINVRYLSGFSGSNGALLVFADE-
Mb2564c|M.bovis_AF2122/97 MTHSQRRDKLKAQIAASGLDAMLISDLINVRYLSGFSGSNGALLVFADE-
MLBr_00521|M.leprae_Br4923 MTHSQRRDNLKSQIATTGLDAMLVTCLINVRYLSGFTGSNGALLVFADE-
MMAR_2180|M.marinum_M MTHSQRRHNLKSKISAAGLDAMLVTDLINVRYLSGFSGSNGALLVFADE-
MUL_1764|M.ulcerans_Agy99 MTHSQRRHNLKSKISAAGLDAMLVTDLINVRYLSGFSGSNGALLVFADE-
MAV_3412|M.avium_104 MTHSQRRDRLRARLEADGLDALLVTDLINVRYLSGFTGSNGALLVFADD-
MAB_2838c|M.abscessus_ATCC_199 ------------MLRAEDLDALLVTDLINIRYLTGFTGSAAALWVAAGDG
:*:: * *:***:**:** .** : .
Mflv_3753|M.gilvum_PYR-GCK ---ETPVLATDGRYRTQAAHQAPDAEVVIERACGPHLAARAAADGVRRLG
Mvan_2650|M.vanbaalenii_PYR-1 ---ETPVLATDGRYRTQAAHQAPDAEVVIERACGPRLAARAAAAGIRRLG
MSMEG_3034|M.smegmatis_MC2_155 ---ATPVLATDGRYRTQAAQQAPDAEVVIERACGPHLAARAAADGVRRLG
TH_0106|M.thermoresistible__bu ---ATAVLATDGRYRTQAARQAPDVELVIERACGPHLAGRAAADGIRRLG
Rv2535c|M.tuberculosis_H37Rv ---RDAVLATDGRYRTQAASQAPDLEVAIERAVGRYLAGRAGEAGVGKLG
Mb2564c|M.bovis_AF2122/97 ---RDAVLATDGRYRTQAASQAPDLEVAIERAVGRYLAGRAGEAGVGKLG
MLBr_00521|M.leprae_Br4923 ---RGAVLATDGRYRTQAAQQVPELEVAIEQSCGRYLAGRAADDGVCILG
MMAR_2180|M.marinum_M ---REAVLATDGRYRTQAAHQAPDLEVAIERAIGRHLSCRAADDGVGRLG
MUL_1764|M.ulcerans_Agy99 ---REAVLATDGRYRTQAAHQAPDLEVAIERAIGRHLSCRAADDGVGRLG
MAV_3412|M.avium_104 ---RPPVLATDGRYRTQAAEQAPDLDVAIERALGRYLAGRAAEAGARTLG
MAB_2838c|M.abscessus_ATCC_199 PEEKATVLCTDGRYRTQAAAQVPDLRALIDRRYGAALVAHAPAG---RAG
.**.********** *.*: *:: * * :* *
Mflv_3753|M.gilvum_PYR-GCK FESHVVTVDAFTALS---EAAGNGCEFVRAAGTVEGLREVKDAGEVALLR
Mvan_2650|M.vanbaalenii_PYR-1 FESHVVTVDAFTALT---KAVGEACEFVRAAGTVEGLREVKDAGEIALLR
MSMEG_3034|M.smegmatis_MC2_155 FESHVVTVEAHSALS---EAAGDKVELVRAAGTVEALREVKDAGEIAMLR
TH_0106|M.thermoresistible__bu FESHVVTVDAHTALQ---QAA-EGVELVRAPRIVERLREVKDAGEIAILR
Rv2535c|M.tuberculosis_H37Rv FESHVVTVDGLDALAGALEGK--NTELVRASGTVESLREVKDAGELALLR
Mb2564c|M.bovis_AF2122/97 FESHVVTVDGLDALAGALEGK--NTELVRASGTVESLREVKDAGELALLR
MLBr_00521|M.leprae_Br4923 FESHVVTVDGLDALTGELEGR--HTELVRAPGTVEVLREVKDAGELALLR
MMAR_2180|M.marinum_M FESHVVTVDGFDALTGALADT--NTELVRASGTVEALREIKDAGELALLR
MUL_1764|M.ulcerans_Agy99 FESHVVTVDGFDALTGALADT--NTELVRASRTVEALREIKDAGELALLR
MAV_3412|M.avium_104 FESNVVTVDGFDALTGELDGRKAATELVKAAGTVEALREVKDAGEVALLR
MAB_2838c|M.abscessus_ATCC_199 FESHVVTVDGFDKLA----EAATDVELVRAPNRIEKLREVKDDSEVLLLE
***:****:. * *:*:*. :* ***:** .*: :*.
Mflv_3753|M.gilvum_PYR-GCK LACEAADAALKDLLERGGLRAGRTERDVRNELESLMLAHGADGASFETIV
Mvan_2650|M.vanbaalenii_PYR-1 LACEAADAALRDLVDQGGLRAGRTEKEVCNELESLMLAHGADGASFETIV
MSMEG_3034|M.smegmatis_MC2_155 LACEAADAALTDLVERGGLRPGRTEKEVRRDLESLMLDHGADGPSFETIV
TH_0106|M.thermoresistible__bu LACEAADAALTDLVAGGGLRPGRTEKQVRRDLESLMLDHGADGPSFETIV
Rv2535c|M.tuberculosis_H37Rv LACEAADAALTDLVARGGLRPGRTERQVSRELEALMLDHGADAVSFETIV
Mb2564c|M.bovis_AF2122/97 LACEAADAALTDLVARGGLRPGRTERQVSRELEALMLDHGADAVSFETIV
MLBr_00521|M.leprae_Br4923 LAAEAADAALTELVARGGVRPGLTEREVGRELEGLMLDHGADALSFETIV
MMAR_2180|M.marinum_M LACEAADAALSDLIKRGGLRPGRTEREVARDLEGLMLDHGADAVSFETIV
MUL_1764|M.ulcerans_Agy99 LACEAADAALSDLIKRGGLRPGRTEREVARDLEGLMLDHGADAVSFETIV
MAV_3412|M.avium_104 LACEAADAALTALVDGGGLRPGRTEREVSRELEALMLDHGADGISFETIV
MAB_2838c|M.abscessus_ATCC_199 RACAAADTALAALIETGGIRPGRTEREVARDLENLMAEHGADGPSFETIV
*. ***:** *: **:*.* **::* .:** ** ****. ******
Mflv_3753|M.gilvum_PYR-GCK AAGANSAIPHHRPTDAVLAAGDFVKIDFGALVAGYHSDMTRTFVLAPVAD
Mvan_2650|M.vanbaalenii_PYR-1 ATGANSAIPHHRPTDAVLAAGDFVKIDFGALVAGYHSDMTRTFVLAPIAD
MSMEG_3034|M.smegmatis_MC2_155 ATGANSAIPHHRPTDAVLATGDFVKIDFGALVSGYHSDMTRTFILGRAEQ
TH_0106|M.thermoresistible__bu AAGANSAIPHHRPTDAELKAGDFVKIDFGALVAGYHSDMTRTFVLGPAAQ
Rv2535c|M.tuberculosis_H37Rv AAGANSAIPHHRPTDAVLQVGDFVKIDFGALVAGYHSDMTRTFVLGKAAD
Mb2564c|M.bovis_AF2122/97 AAGANSAIPHHRPTDAVLQVGDFVKIDFGALVAGYHSDMTRTFVLGKAAD
MLBr_00521|M.leprae_Br4923 AAGPNSAIPHHRPTDTVLAAGDFVKIDFGALVAGYHSDMTRTFVLGPAAD
MMAR_2180|M.marinum_M AAGPNSAIPHHRPTDAVLAKGDFVKIDFGALVAGYHSDMTRTFVLDKAAD
MUL_1764|M.ulcerans_Agy99 AAGPNSAIPHHRPTDAVLAKGDFVKIDFGALVAGYHSDMTRTFVLDKAAD
MAV_3412|M.avium_104 ATGANSAIPHHRPTDAVLADGDFVKIDFGALVGGYHSDMTRTFVLTKAAD
MAB_2838c|M.abscessus_ATCC_199 AAGPNSAIPHHRPTGAMLAAGDFVKIDFGALVAGYHSDMTRTLVLGSAAP
*:*.**********.: * ************.*********::*
Mflv_3753|M.gilvum_PYR-GCK WQREIYSLVAASQQAGRDALAPGVALSTVDAAARQVIADAGYAENFGHGL
Mvan_2650|M.vanbaalenii_PYR-1 WQRDIYDLVATAQRAGTDALEPGVALKDVDAASRQVIVEAGYGENFGHGL
MSMEG_3034|M.smegmatis_MC2_155 WQLDLYELVAASQAAGREALAAGVELRAVDAASRQVIIDAGYGDHFNHGL
TH_0106|M.thermoresistible__bu WQHELYELVATAQRAGTEALRAGAPLREVDAAARQVIADAGYADNFGHGL
Rv2535c|M.tuberculosis_H37Rv WQLEIYQLVAEAQQAGRQALLPGAELRGVDAAARQLIADAGYGEHFGHGL
Mb2564c|M.bovis_AF2122/97 WQLEIYQLVAEAQQAGRQALLPGAELRGVDAAARQLIADAGYGEHFGHGL
MLBr_00521|M.leprae_Br4923 WQLEIYQLVADAQRAGRKALRPGANLRDVDAAARQLIVDAGYGQQFSHGL
MMAR_2180|M.marinum_M WQLEIYELVAAAQKAGREALSAGAELRDVDGAARQMIVAAGHGDNFGHGL
MUL_1764|M.ulcerans_Agy99 WQLEIYELVAAAQKAGREALSAGAELRDVDGAARQMIVDAGHGDNFGHGL
MAV_3412|M.avium_104 WQLEIYRLVADAQRAGREALRAGADLREVDAAARRVIADAGYGEQFSHSL
MAB_2838c|M.abscessus_ATCC_199 WQQEIHELVLTAQAAGRAALAPGASLKNVDAAARDVITAAGYGENFGHGL
** ::: ** :* ** ** .*. * **.*:* :* **:.::*.*.*
Mflv_3753|M.gilvum_PYR-GCK GHGVGLQIHEAPGINSAAAGTLLAGSAVTVEPGVYLPDRGGVRIEDTLVV
Mvan_2650|M.vanbaalenii_PYR-1 GHGVGLQIHEAPGINAAAAGTLLAGSVVTVEPGVYLPDRGGVRIEDTLVV
MSMEG_3034|M.smegmatis_MC2_155 GHGVGLQIHEAPGLNSAAAGTLLAGSAVTVEPGVYLPGRGGVRIEDTLVV
TH_0106|M.thermoresistible__bu GHGVGLHIHEAPGINAAAVGTLLAGSVVTVEPGVYLPDRGGVRIEDTLVV
Rv2535c|M.tuberculosis_H37Rv GHGVGLQIHEAPGIGVTSAGTLLAGSVVTVEPGVYLPGRGGVRIEDTLVV
Mb2564c|M.bovis_AF2122/97 GHGVGLQIHEAPGIGVTSAGTLLAGSVVTVEPGVYLPGRGGVRIEDTLVV
MLBr_00521|M.leprae_Br4923 GHGVGLEIHEAPGIGTTSAGTLLAGSVVTVEPGVYLSGRGGVRIEDTLVV
MMAR_2180|M.marinum_M GHGVGLQIHEAPGIGATSVGTLLAGSVVTVEPGVYLPGRGGVRIEDTLVV
MUL_1764|M.ulcerans_Agy99 GHGVGLQIHEAPGIGATSVGTLLAGSVVTVEPGVYLPGRGGVRIEDTLVV
MAV_3412|M.avium_104 GHGVGLEIHEAPGIGATSTGTLRAESVVTVEPGVYLPGRGGVRIEDTLVV
MAB_2838c|M.abscessus_ATCC_199 GHGVGLQIHEAPGIGSTATGTLLAGSAVTVEPGVYLPDRGGVRIEDTLVV
******.******:. ::.*** * *.*********..************
Mflv_3753|M.gilvum_PYR-GCK ------------------DKHPELLTRFPKELVII-
Mvan_2650|M.vanbaalenii_PYR-1 ------------------NKRPELLTRFPKELVII-
MSMEG_3034|M.smegmatis_MC2_155 PGGESAEGVVDRFAHNISDAAPELLTRFPKELAIV-
TH_0106|M.thermoresistible__bu G-----------------ETTPDLLTRFPKDLAVLD
Rv2535c|M.tuberculosis_H37Rv AG-GTPKMPETAGQT------PELLTRFPKELAIL-
Mb2564c|M.bovis_AF2122/97 AG-GTPKMPETAGQT------PELLTRFPKELAIL-
MLBr_00521|M.leprae_Br4923 AAKGTSETPITSRPTG---FIPELLTRFPKELAIL-
MMAR_2180|M.marinum_M PN-GGPKTPRSAAQT------PELLTRFPKELTIL-
MUL_1764|M.ulcerans_Agy99 PN-GGPKTPRSAAQT------PELLTRFPKELTIL-
MAV_3412|M.avium_104 PP-------ETAGKP------PELLTRFPKELAVLA
MAB_2838c|M.abscessus_ATCC_199 RP-----------------DGPELLTRFPKELIVID
*:*******:* ::