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TAHSHVRDVDVRDVSDPDDPCLDDFRDLNSIDRRPDLPSGKGLVIAEGVLVVQRMLASRFSPRALLGTDR RLLELKDDLAGVGVPYYRVSPDVMAQVVGFHLNRGVLAAASRVVEPSVGQVVDGARTIAVLEGVNDHENL GSIFRNAAGLGVDAVIFGSGCADPLYRRAVRVSMGHALLVPYARATDWPAELVALKERGFRLLALTPKGD ARALPEAMDAVGDQPVALLVGAEGPGLTAAALRISDLRVRIPMSRGTDSLNVATAAALAFYERARLGQ*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4651 | - | - | 100% (279) | rRNA methyltransferase |
| M. marinum M | MMAR_2451 | tsnR | 9e-21 | 31.90% (232) | 23S rRNA methyltransferase TsnR |
| M. marinum M | MMAR_5079 | - | 6e-17 | 28.96% (221) | tRNA/rRNA methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0905 | - | 1e-126 | 83.15% (273) | rRNA methyltransferase |
| M. gilvum PYR-GCK | Mflv_1715 | - | 1e-108 | 72.83% (265) | tRNA/rRNA methyltransferase (SpoU) |
| M. tuberculosis H37Rv | Rv0881 | - | 1e-126 | 83.15% (273) | rRNA methyltransferase |
| M. leprae Br4923 | MLBr_01397 | tsnR | 1e-17 | 35.81% (148) | putative rRNA methyltransferase |
| M. abscessus ATCC 19977 | MAB_0881 | - | 1e-109 | 75.19% (266) | putative tRNA/rRNA methyltransferase |
| M. avium 104 | MAV_1009 | - | 1e-124 | 83.52% (267) | SpoU rRNA methylase family protein |
| M. smegmatis MC2 155 | MSMEG_5687 | - | 1e-106 | 72.00% (275) | 23s ribosomal RNA methyltransferase |
| M. thermoresistible (build 8) | TH_1372 | - | 1e-112 | 75.56% (266) | POSSIBLE RRNA METHYLTRANSFERASE (RRNA METHYLASE) |
| M. ulcerans Agy99 | MUL_0269 | - | 1e-147 | 98.51% (268) | rRNA methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_5036 | - | 1e-114 | 75.65% (271) | tRNA/rRNA methyltransferase (SpoU) |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4651|M.marinum_M --------------------------------------------------
MUL_0269|M.ulcerans_Agy99 --------------------------------------------------
Mb0905|M.bovis_AF2122/97 --------------------------------------------------
Rv0881|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1009|M.avium_104 MPDSDARLASDLSLAVMRLARQLRFRNPSSPVSLSQLSALAMLANEGPMT
MAB_0881|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1715|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5036|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5687|M.smegmatis_MC2_155 --------------------------------------------------
TH_1372|M.thermoresistible__bu --------------------------------------------------
MLBr_01397|M.leprae_Br4923 --------------------------------------------------
MMAR_4651|M.marinum_M --------------------------------------------------
MUL_0269|M.ulcerans_Agy99 --------------------------------------------------
Mb0905|M.bovis_AF2122/97 --------------------------------------------------
Rv0881|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1009|M.avium_104 PGALAVRERVRPPSMTRVIASLAEMGLVDRTPHPVDGRQVLVSVSEAGAE
MAB_0881|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1715|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5036|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5687|M.smegmatis_MC2_155 --------------------------------------------------
TH_1372|M.thermoresistible__bu --------------------------------------------------
MLBr_01397|M.leprae_Br4923 --------------------------------------------------
MMAR_4651|M.marinum_M ------------------------------------MTA---HSHVRDVD
MUL_0269|M.ulcerans_Agy99 --------------------------------------------------
Mb0905|M.bovis_AF2122/97 ------------------------------------MTEGRCAQHPDGLD
Rv0881|M.tuberculosis_H37Rv ------------------------------------MTEGRCAQHPDGLD
MAV_1009|M.avium_104 LVKANRRARQEWLAKRLVHAGRRRARNPAPRGRSDAGPGRRRPVNTDALD
MAB_0881|M.abscessus_ATCC_1997 ------------------------------------------------ML
Mflv_1715|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5036|M.vanbaalenii_PYR-1 -------------------------------------------MIANNVE
MSMEG_5687|M.smegmatis_MC2_155 ---------------------------------------------MSPLQ
TH_1372|M.thermoresistible__bu ----------------------------VHTLSGPNPDDPDGPDVTDGPD
MLBr_01397|M.leprae_Br4923 --------------------------------------------------
MMAR_4651|M.marinum_M VRDVSDPDDPCLDDFRDLNSIDRRPDLPSGKGLVIAEGVLVVQRMLASRF
MUL_0269|M.ulcerans_Agy99 MRDVSDPDDPCLDDFRDLNSIDRRPDLPSGKGLVIAEGVLVVQRMLASRF
Mb0905|M.bovis_AF2122/97 VQDVCDPDDPRLDDFRDLNSIDRRPDLPTGKALVIAEGVLVVQRMLASRF
Rv0881|M.tuberculosis_H37Rv VQDVCDPDDPRLDDFRDLNSIDRRPDLPTGKALVIAEGVLVVQRMLASRF
MAV_1009|M.avium_104 VRDVDDPDDPRLDDFRDLNSVDRRPDLPSGKGLVIAEGVLVVQRMLASRF
MAB_0881|M.abscessus_ATCC_1997 VIDVHDPADSRLDSFRDLNSVDRRPDLPSGKGLVIAEGVLVVQRMLASRF
Mflv_1715|M.gilvum_PYR-GCK MVDITDPADPRLDPFRDLNSVDRRPDLPSGKGLVIAEGVLVVQRMLASRF
Mvan_5036|M.vanbaalenii_PYR-1 VVDVTDPADPRLDDFRDLNSVDRRPDLPSGKGLVIAEGVLVVQRMLASRF
MSMEG_5687|M.smegmatis_MC2_155 VIDIDDPADPRIDDFRDLNSVDRRPDLPTGKALVIAEGVLVVQRMLASRF
TH_1372|M.thermoresistible__bu VTDITDPADPRVDDFRDLNSVDRRPDLPGGKGLVIAEGVLVVQRMLASRF
MLBr_01397|M.leprae_Br4923 --MLTERSARVVAAVKLHRQVARRR-----VRRFLAEGPNLVEAAIVSGL
: : : .: ..: ** .:*** :*: :.* :
MMAR_4651|M.marinum_M SPRALLGTDRRLLELKDDLAG----VGVPYYRVSPDVMAQVVGFHLNRGV
MUL_0269|M.ulcerans_Agy99 SPRALLGTDRRLLELKEDLAG----VGAPYYRVSPDVMAQVVGFHLNRGV
Mb0905|M.bovis_AF2122/97 TPLALFGTDRRLAELKDDLAG----VGAPYYRASADVMARVIGFHLNRGV
Rv0881|M.tuberculosis_H37Rv TPLALFGTDRRLAELKDDLAG----VGAPYYRASADVMARVIGFHLNRGV
MAV_1009|M.avium_104 RPHALLGTERRLAELRDDLAG----VPVPYYRTSADVMARVVGFHLNRGV
MAB_0881|M.abscessus_ATCC_1997 RPLALLGTDRRLSELAADLEP----VDVPYYRASAEVMAEVVGFHLNRGV
Mflv_1715|M.gilvum_PYR-GCK VPRALLGTDRRLTELGTDLDG----LAAPFYRATAEVMAEAIGFHLNRGV
Mvan_5036|M.vanbaalenii_PYR-1 VPRALLGTDRRLTELGTDLAG----LDAPFYRASAEVMADVVGFHLNRGV
MSMEG_5687|M.smegmatis_MC2_155 IPRALLGTDRRLGELAADLDRYPQYADVPFYRASAEVMAEAIGFHLNRGV
TH_1372|M.thermoresistible__bu TPRAFLGTDRRLTELRADLAA----VDAPFYRADAEVMAEVVGFHLNRGV
MLBr_01397|M.leprae_Br4923 VR-DVFVTEVAAQRHATVLAT----LKCPVHPVSERAAKALSDTVTPTGL
.: *: . * * : . . . *:
MMAR_4651|M.marinum_M LAAASRVVEPSVGQVVDGARTIAVLEGVNDHENLGSIFRNAAGLGVDAVI
MUL_0269|M.ulcerans_Agy99 LAAASRVVEPSVGQVVDGARTIAVLEGVNDHENLSSIFRNAAGLGVHAVI
Mb0905|M.bovis_AF2122/97 LAAARRVPEPSVAQVVAGARTVAVLEGVNDHENLGSIFRNAAGLSVDAVV
Rv0881|M.tuberculosis_H37Rv LAAAGRVPEPSVAQVVAGARTVAVLEGVNDHENLGSIFRNAAGLSVDAVV
MAV_1009|M.avium_104 LAAARRVPEPGVAELLAGSRTVAVLEGVNDHENLGAIFRNAAGLGVDAVI
MAB_0881|M.abscessus_ATCC_1997 LAASRRPEELPAADLLQTARTVAVLEGVNDHENLGSIFRNAAGMGVDAVL
Mflv_1715|M.gilvum_PYR-GCK LASASRAPELTVAEVLDGARTVAVLEGVNDHENLGSVFRNAAGLGVDAVI
Mvan_5036|M.vanbaalenii_PYR-1 LASASRAPELTVPHVLDGARTVAVLEGVNDHENLGSVFRNAAGLGVDGVI
MSMEG_5687|M.smegmatis_MC2_155 LASAPRAAELTVDDVIADARTIAVLEGVNDHENLGSIFRNAAGLAVDAVI
TH_1372|M.thermoresistible__bu LASAARPTELTVPQVLDGARTVAVLEGVNDHENLGSIFRNAAGLGVDAVI
MLBr_01397|M.leprae_Br4923 IAVCEMPTTRLATVLAGSPQLVVAAVEISEPGNAGTVIRIADAMGAAAVI
:* . . : .: :.. :.: * .:::* * .:.. .*:
MMAR_4651|M.marinum_M FGSGCADPLYRRAVRVSMGHALLVPYARATDWPAELVALKERGFRLLALT
MUL_0269|M.ulcerans_Agy99 FGSGCADPLYRRAVRVSMGHALLVPYARATDWPAELVALKERGFRLLALT
Mb0905|M.bovis_AF2122/97 FGTGCADPLYRRAVRVSMGHALLVPYARAADWPTELMTLKESGFRLLAMT
Rv0881|M.tuberculosis_H37Rv FGTGCADPLYRRAVRVSMGHALLVPYARAADWPTELMTLKESGFRLLAMT
MAV_1009|M.avium_104 FGSGCADPLYRRAVRVSMGHALLVPYARATDWPAELKTLKEKGFRLLAMT
MAB_0881|M.abscessus_ATCC_1997 FGSGCADPLYRRAVRVSMGHALLVPFARLPEWPKSLYRLRDSGFRLLAMT
Mflv_1715|M.gilvum_PYR-GCK FGSGCADPLYRRAVRVSMGHALLVPFARAANWPADLNILRDNDFRLLAMT
Mvan_5036|M.vanbaalenii_PYR-1 FGSGCADPLYRRAVRVSMGHALLVPFAKAANWPGDLELLRDQGFRLLAMT
MSMEG_5687|M.smegmatis_MC2_155 FGAGCADPLYRRAVRVSMGHALLVPFARASSWPTDLELLRDKGFRLLAMT
TH_1372|M.thermoresistible__bu FGSGCADPLYRRAVRVSMGHALLVPYARARHWPADLRLLRDNGFQLLAMT
MLBr_01397|M.leprae_Br4923 FGGYTVDPYNGKCLRSSAGSIFSITVVVASDAYAAVTELRAAGLQVLATM
** .** :.:* * * : :. . : *: .:::**
MMAR_4651|M.marinum_M PKGDARALPEAMDAVGDQPVALLVGAEGPGLTAAALRISDLRVRIPMSRG
MUL_0269|M.ulcerans_Agy99 PKGDARALPEAMDAVGDQPVALLVGAEGPGLTAAALRISDLRVRIPMSRG
Mb0905|M.bovis_AF2122/97 PHGNACKLPEAIAAVSHERIALLVGAEGPGLTAAALRISDVRVRIPMSRG
Rv0881|M.tuberculosis_H37Rv PHGNACKLPEAIAAVSHERIALLVGAEGPGLTAAALRISDVRVRIPMSRG
MAV_1009|M.avium_104 PQGSACGLAEAMTAARGDRVAVLVGAEGPGLTPAALRLSDVRVRIPMSRG
MAB_0881|M.abscessus_ATCC_1997 PAGDSKALADAIPPLRAEKVALMVGAEGPGLTDVALRASDLRVRIPMANG
Mflv_1715|M.gilvum_PYR-GCK PDPTVPTLADAVSGLTEERIAILVGAEGPGLKEHTMRSADVRVRIPMARG
Mvan_5036|M.vanbaalenii_PYR-1 PDPTVQTLAQAMSGLAEQRVAILVGAEGPGLKEHTMRASDVRVRIPMSRG
MSMEG_5687|M.smegmatis_MC2_155 PDPSAATLSDAMVQLEGDRVAILVGAEGPGLTERTMRASDVRVRIPMSRG
TH_1372|M.thermoresistible__bu PNPKAETLAAVMPRLAAQKVAVLVGAEGPGLAESTMRAADVRVRIPMSRG
MLBr_01397|M.leprae_Br4923 VDG-ETSLDEAKPLLG-KPTAWLFGSEPHGLSTEIAEAADYRVRIPMVGG
* . . * :.*:* ** . :* ****** *
MMAR_4651|M.marinum_M TDSLNVATAAALAFYERAR--LGQ------------
MUL_0269|M.ulcerans_Agy99 TDSLNVATAAALAFYERAR--LGQ------------
Mb0905|M.bovis_AF2122/97 TDSLNVATAAALAFYERTR--SGHHIGPGT------
Rv0881|M.tuberculosis_H37Rv TDSLNVATAAALAFYERTR--SGHHIGPGT------
MAV_1009|M.avium_104 TDSLNVATAAALAFYERSRPVGGHRAAAGGGDGQSG
MAB_0881|M.abscessus_ATCC_1997 TDSLNVATAAALAFYERAR--LAP------------
Mflv_1715|M.gilvum_PYR-GCK TDSLNVATAAALAFYERDR--SHR------------
Mvan_5036|M.vanbaalenii_PYR-1 TDSLNVATAAALAFYERDR--LGR------------
MSMEG_5687|M.smegmatis_MC2_155 TDSLNVATAAALAFYERAR--LSH------------
TH_1372|M.thermoresistible__bu TDSLNVATAAALAFYERSR--PSG------------
MLBr_01397|M.leprae_Br4923 VESLNVAATAAICLYQSSR--ALRL-----------
.:*****::**:.:*: *