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AAVELQTLQHNIACVTLNRPTRLNAIDGSLLDAMDDALNALSGGEFRAAILTGAGRGFCAGADLSGTGQP WTKATPTTPPFKATYDAQVRLADQLTRLYELPIPVIAAVNGVAVGGGLAFALHCDIRIAAEDARFGSVFI KAGFSSMDMGTSYLLPRIVGAGVARELMLTGRIIDAVEAYRIRLVHEVVAADELLTAAQKLAGSIAENNA YGVWQTKIGLNAALDAPSLRHAKEIENRTQIISGFTNNPAEAARAHQEKRPPAWDSL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4569 | echA12_2 | - | 100% (268) | enoyl-CoA hydratase, EchA12_2 |
| M. marinum M | MMAR_2278 | echA12 | 8e-37 | 39.25% (265) | enoyl-CoA hydratase, EchA12 |
| M. marinum M | MMAR_4396 | echA8 | 8e-29 | 35.71% (252) | enoyl-CoA hydratase EchA8 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1507 | echA12 | 1e-37 | 38.66% (269) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_4817 | - | 3e-44 | 44.86% (243) | enoyl-CoA hydratase/isomerase |
| M. tuberculosis H37Rv | Rv1472 | echA12 | 3e-37 | 38.66% (269) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_01241 | - | 2e-38 | 40.08% (252) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_0834 | - | 8e-54 | 44.03% (268) | putative enoyl-CoA hydratase/isomerase |
| M. avium 104 | MAV_1060 | - | 1e-118 | 79.62% (265) | enoyl-CoA hydratase/isomerase family protein |
| M. smegmatis MC2 155 | MSMEG_1739 | - | 8e-45 | 43.25% (252) | enoyl-CoA hydratase/isomerase family protein |
| M. thermoresistible (build 8) | TH_2798 | - | 5e-39 | 42.52% (254) | PUTATIVE Enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_4429 | echA12_2 | 1e-146 | 98.48% (263) | enoyl-CoA hydratase, EchA12_2 |
| M. vanbaalenii PYR-1 | Mvan_1625 | - | 9e-47 | 44.53% (256) | enoyl-CoA hydratase/isomerase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4569|M.marinum_M ------------------MAAVELQTLQHNIACVTLNRPTRLNAIDGSLL
MUL_4429|M.ulcerans_Agy99 -----------------------MQTLQHNIACVTLNRPTRLNAIDGSLL
MAV_1060|M.avium_104 ---------------------MEFATLDDDIACITLNRPERLNAIDGSLI
MAB_0834|M.abscessus_ATCC_1997 --------------------MIRVEPREHGILVVTIDRPERRNALDPQTV
Mflv_4817|M.gilvum_PYR-GCK -----------------MSSVLEVARPTPEIAVLTLNRPDKLNALSYELV
Mvan_1625|M.vanbaalenii_PYR-1 -----------------MSSVVEVTRPLPEITVVTLNRPDKLNALSYELV
MSMEG_1739|M.smegmatis_MC2_155 ---------------MSLAQPLDVTRPRPDIAVLTLNRPDKLNALSYELV
Mb1507|M.bovis_AF2122/97 MPHRCAAQVVAG--YRSTVSLVLVEHPRPEIAQITLNRPERMNSMAFDVM
Rv1472|M.tuberculosis_H37Rv MPHRCAAQVVAG--YRSTVSLVLVEHPRPEIAQITLNRPERMNSMAFDVM
TH_2798|M.thermoresistible__bu ---------------------VLVDHPRPHIALVTLNRPERMNSMAFDVM
MLBr_01241|M.leprae_Br4923 MSQTDASCTIAELPYRSVTDLVVLDFPRPEVALITLNRPGRMNSMALDLM
. : :*::** : *:: . :
MMAR_4569|M.marinum_M DAMDDALNALSGG-EFRAAILTGAGRGFCAGADLSGTGQPWTKA--TPTT
MUL_4429|M.ulcerans_Agy99 DAMDDALDALSGG-EFRAAILTGAGRGFCAGADLSGTGQPWTKA--TPTT
MAV_1060|M.avium_104 DGVHEALDVLDTG-DHRVAVLTGAGRGFCAGADLSGTGRPWTRN--KPTT
MAB_0834|M.abscessus_ATCC_1997 AELHAVIESIDGDPKVRVVVLTAVGASFCAGADLKSLPSDFTSAGVTSTA
Mflv_4817|M.gilvum_PYR-GCK EALHAELDALARDNACRAVVLTGAGRGFCSGLDLSAPNPEETGG----GT
Mvan_1625|M.vanbaalenii_PYR-1 ETLHDALDAVAADNTCRVVVLTGAGRGFCSGLDLSAPNPEETGG----GT
MSMEG_1739|M.smegmatis_MC2_155 EALHAALDDIAADNDCRVVVLTGAGRGFCSGLDLSAPNPPEAAG----GT
Mb1507|M.bovis_AF2122/97 VPLKEALAQVSYDNSVRVVVLTGAGRGFSSGADHKSAGVVPHVE----NL
Rv1472|M.tuberculosis_H37Rv VPLKEALAQVSYDNSVRVVVLTGAGRGFSPGADHKSAGVVPHVE----NL
TH_2798|M.thermoresistible__bu VPLKAALDEITYDNDVRVVVLTGAGRGFSSGADHKSAGTVPHVD----GL
MLBr_01241|M.leprae_Br4923 KSLKQVLKRITYDHSVRVVVLTGAGRGFCSGADQKFTAPVPQVE----GL
:. : : . *..:**..* .*..* * .
MMAR_4569|M.marinum_M PPFKATYDAQVR-------LADQLTRLYELPIPVIAAVNGVAVGGGLAFA
MUL_4429|M.ulcerans_Agy99 PPFKATYDAQVR-------LADQLTRLYELPIPVIAAVNGVAVGGGLAFA
MAV_1060|M.avium_104 PAFKVNYDAQVR-------LASLYTRIYELDIPVIAAVNGVAVGGGLAFA
MAB_0834|M.abscessus_ATCC_1997 ALLAATDSELVRTLAAQELMASLFERIHRMRQPVIAAVNGHAIGGGFALA
Mflv_4817|M.gilvum_PYR-GCK EFPRSGMRWQER-------IADLTAKIHRLRQPVIAAVQGVAYGGGLGIA
Mvan_1625|M.vanbaalenii_PYR-1 EFPRSGMRWQER-------IADLTAKLHRLRQPAIAAVNGVAYGGGLGIA
MSMEG_1739|M.smegmatis_MC2_155 EFPRSGMRWQER-------IANLTAKLHRLRQPVIAAVNGPAYGGGFALA
Mb1507|M.bovis_AF2122/97 TRPTYALRSMEL-------LDDVILMLRRLHQPVIAAVNGPAIGGGLCLA
Rv1472|M.tuberculosis_H37Rv TRPTYALRSMEL-------LDDVILMLRRLHQPVIAAVNGPAIGGGLCLA
TH_2798|M.thermoresistible__bu TRPSYGLRSMEV-------LDDVILTLRKLHQPVIAAVNGAAIGGGLCLA
MLBr_01241|M.leprae_Br4923 TQPVRALRAMEL-------LEEVILALRRLHQPVIAAINGPAIGGGLCLA
: . : .: *.***::* * ***: :*
MMAR_4569|M.marinum_M LHCDIRIAAEDARFGSVFIKAGFSSMDMGTSYLLPRIVGAGVARELMLTG
MUL_4429|M.ulcerans_Agy99 LHCDIRIAAEDARFGSVFIKAGFSSMDMGTSYLLPRIVGAGVARELMLTG
MAV_1060|M.avium_104 LVSDIRVASEQARFGSVFIKAGFSSMDMGTSYLLPKIVGAGVARELMLTG
MAB_0834|M.abscessus_ATCC_1997 LACDIRFASPAASFGAVFIRHGVSNCDMGTSYHLPRLVGAARAAELMLTG
Mflv_4817|M.gilvum_PYR-GCK AACDIRVAAPTARFCTQFIKLGLGGCDIGVSYTLPRIVGAGVAFDMILTA
Mvan_1625|M.vanbaalenii_PYR-1 AACDIRVASPSARFCTQFIKLGLGGCDIGVSYTLPRILGAGPAFDMILTA
MSMEG_1739|M.smegmatis_MC2_155 AASDIRLAAESARFCTQFIKLGIGGCDIGVSYTLPRIIGAGPAFDLILTA
Mb1507|M.bovis_AF2122/97 LAADIRVASSSAYFRAAGINNGLTASELGLSYLLPRAIGSSRAFEIMLTG
Rv1472|M.tuberculosis_H37Rv LAADIRVASSSAYFRAAGINNGLTASELGLSYLLPRAIGSSRAFEIMLTG
TH_2798|M.thermoresistible__bu LAADIRIASTEAYFRAAGINNGLTASELGLSYLLPRAIGSSRAFEIMLTG
MLBr_01241|M.leprae_Br4923 LAADVRVASTRAYFRAAGINNGLSASELGLSYLLPRAVGSSRAFEIMLSG
.*:*.*: * * : *. *. ::* ** **: :*:. * :::*:.
MMAR_4569|M.marinum_M RIIDAVEAYRIRLVHEVVAADELLTAAQKLAGSIAENNAYGVWQTKIGLN
MUL_4429|M.ulcerans_Agy99 RIIDAVEAYRIRLVHEVVVADELLTAAQKLAGSIAENNAYGVWQTKIGLN
MAV_1060|M.avium_104 RIIDAAEAYRIRLVHEVVAPDQLMPAALRLARSIAENNAYGVWQTKIGLN
MAB_0834|M.abscessus_ATCC_1997 RVFDAQEAYRMGLVFDVVPAEELLDAALSKAREIAVHSPLAVWMTKETMW
Mflv_4817|M.gilvum_PYR-GCK RTVAADEALRLGLVSRVS--DTPVDEALAIAETLCNYGKFGVESTKQVLW
Mvan_1625|M.vanbaalenii_PYR-1 RAVDADEALRLGLVSRVA--DSALDEALAVAETLCGFGKFGVESTKQVLW
MSMEG_1739|M.smegmatis_MC2_155 RAVDATEALRLGLVSRVC--ADVTAEAMDIAETLCGYGKFGVESTKQVLW
Mb1507|M.bovis_AF2122/97 RDVSAEEAERIGLVSRQVPDEQLLDACYAIAARMAGFSRPGIELTKRTLW
Rv1472|M.tuberculosis_H37Rv RDVSAEEAERIGLVSRQVPDEQLLDACYAIAARMAGFSRPGIELTKRTLW
TH_2798|M.thermoresistible__bu RDVDAEEAERIGLVSRRVPPAELLDTCYELADRIAGFSRPGTELTKRTLW
MLBr_01241|M.leprae_Br4923 RDVGAEEAEQIGLVSYRVSDDRLLDTCYSIAARMATFSRSGTELTKRALW
* . * ** :: ** . * :. . . ** :
MMAR_4569|M.marinum_M AALDAPSLRHAKEIENRTQIISG-FTNNPAEAARAHQEKRPPAWDSL---
MUL_4429|M.ulcerans_Agy99 AAPDAPSLRHAKEIENRTEIISG-FTNNPAEAARAHQEKRPPAWDSL---
MAV_1060|M.avium_104 AALDAPSLRHAIELENRTQILSG-FTNNPAEAALAHREKRAPRWDPL---
MAB_0834|M.abscessus_ATCC_1997 QTVDAPSLRHALDLENRTQVMCT-ATGELRRSFDAFREGRG---------
Mflv_4817|M.gilvum_PYR-GCK ANLVASSLEAALHLENRSQILAS-TSGEMRELAAKILRKG----------
Mvan_1625|M.vanbaalenii_PYR-1 ANLEASSLEAALHLENRSQILAS-TSGEMREAAAKILRKP----------
MSMEG_1739|M.smegmatis_MC2_155 ANLDAGCLEAALHVENRSQILAS-TEGGVRAFSEEFRRRPR---------
Mb1507|M.bovis_AF2122/97 SGLDAASLEAHMQAEGLGQLFVRLLTANFEEAVAARAEQRAPVFTDDT--
Rv1472|M.tuberculosis_H37Rv SGLDAASLEAHMQAEGLGQLFVRLLTANFEEAVAARAEQRAPVFTDDT--
TH_2798|M.thermoresistible__bu SGLDAGSLESHMHAEGLGQLYIRLLTHNFEEAVAARKEKRAPRFPDDKI-
MLBr_01241|M.leprae_Br4923 GGLDAASLDKHMQSESLAQLFIALHTSNFEEAAAPCTEKRPTVLVDARGC
* .* . *. :: .
MMAR_4569|M.marinum_M -----
MUL_4429|M.ulcerans_Agy99 -----
MAV_1060|M.avium_104 -----
MAB_0834|M.abscessus_ATCC_1997 -----
Mflv_4817|M.gilvum_PYR-GCK -----
Mvan_1625|M.vanbaalenii_PYR-1 -----
MSMEG_1739|M.smegmatis_MC2_155 -----
Mb1507|M.bovis_AF2122/97 -----
Rv1472|M.tuberculosis_H37Rv -----
TH_2798|M.thermoresistible__bu -----
MLBr_01241|M.leprae_Br4923 ATSPG