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TDQPPPGGSYPPPPPPPGSSGGSEPPAGGYQAPPPPSAPSGGGYPPPPPPPSPSTSGYPPPPPPPSAPGG SAYPPPPPPPPLEGGYPPPPPPSAGGYAPPPPGPAIRALPAESYTPWITRVLAALIDFAPYVVVTGIGWL IMMVTTTSSCVTDISQYDIGQYCVSQPSMIGQLAQWLLSLVGLAYLVWDYGYRQGTTGSSIGKSIMKFKV VSETTGEPLGFGMSVVRQLAHIVDAIICYIGFLFPLWDAKRQTLADKIMTTVCLPL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4389 | pra | - | 100% (267) | proline-rich antigen, Pra |
| M. marinum M | MMAR_2166 | - | 2e-23 | 54.95% (111) | proline and glycine rich transmembrane protein |
| M. marinum M | MMAR_4208 | - | 9e-20 | 49.15% (118) | proline and glycine rich transmembrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1107 | pra | 1e-117 | 73.78% (267) | proline-rich antigen |
| M. gilvum PYR-GCK | Mflv_2045 | - | 2e-33 | 43.21% (162) | RDD domain-containing protein |
| M. tuberculosis H37Rv | Rv1078 | pra | 1e-116 | 73.41% (267) | proline-rich antigen |
| M. leprae Br4923 | MLBr_02395 | Ag36 | 1e-100 | 65.19% (270) | proline rich antigenic protein |
| M. abscessus ATCC 19977 | MAB_1196 | - | 1e-45 | 50.27% (185) | proline-rich antigen |
| M. avium 104 | MAV_1202 | - | 1e-97 | 63.30% (267) | Pra protein |
| M. smegmatis MC2 155 | MSMEG_5266 | - | 4e-53 | 52.43% (206) | RDD family protein |
| M. thermoresistible (build 8) | TH_3105 | - | 6e-12 | 41.07% (112) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_0202 | pra | 1e-145 | 90.64% (267) | proline-rich antigen Pra-like protein |
| M. vanbaalenii PYR-1 | Mvan_4672 | - | 4e-39 | 46.51% (172) | RDD domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4389|M.marinum_M MTDQPPPGGSYP-PPPPPPGSSGGSEPPAGGYQA----PPPPSAPSGGGY
MUL_0202|M.ulcerans_Agy99 MTDQPPPGGSYP-PPPPPPGSSGGSEPPAGGYQA----PPPPSAPSGGGY
Mb1107|M.bovis_AF2122/97 MTEQPPPGGSYP-PPPPPPGPSGGHE------------PPPAAPPGGSGY
Rv1078|M.tuberculosis_H37Rv MTEQPPPGGSYP-PPPPPPGPSGGHE------------PPPAAPPGGSGY
MAV_1202|M.avium_104 MTDQPPPGGAYP-PPPSSPGSPGGQP------------TPPP-----GGQ
MLBr_02395|M.leprae_Br4923 MTDQPPPSGSNPTPAPPPPGSSGGYEPSFAPSELGSAYPPPTAPPVGGSY
Mflv_2045|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4672|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5266|M.smegmatis_MC2_155 -MTQLPPQGPGPAPYGPHPGGHPGPQ------------------------
MAB_1196|M.abscessus_ATCC_1997 MTEVPPP-------------------------------------------
TH_3105|M.thermoresistible__bu MTNPGNADGTPPAEGQPGPSETGADDLAR--------EPTGGADPTASEH
MMAR_4389|M.marinum_M PPPPPPPSPSTSGYPPPPPPPSAPGGSAYPPPPPPPPLEGGYPPPPPPSA
MUL_0202|M.ulcerans_Agy99 PPPPPPPPPSTSGYPPPPPPP---------------PLEGGYPPPPPPSA
Mb1107|M.bovis_AF2122/97 APPPPP--SSGSGYPPPPPPP-----------------GGGAYPPPPPSA
Rv1078|M.tuberculosis_H37Rv APPPPP--SSGSGYPPPPPPP-----------------GGGAYPPPPPSA
MAV_1202|M.avium_104 QPPPPP----GGSYPPP-PPP------------------GGSYPPPPPPS
MLBr_02395|M.leprae_Br4923 PPPPPP----GGSYPPPPPP-------------------GGSYPPPPPST
Mflv_2045|M.gilvum_PYR-GCK ------------------------------------------------MR
Mvan_4672|M.vanbaalenii_PYR-1 ------------------------------------------------MT
MSMEG_5266|M.smegmatis_MC2_155 -----------GGYPPPWQPN----------------------PYQTPVP
MAB_1196|M.abscessus_ATCC_1997 ---------------------------------------------PPQGP
TH_3105|M.thermoresistible__bu TPDQPTAADQAADQAGDRPDE-------------------QAFDGSWAAA
MMAR_4389|M.marinum_M GGYAPPPPGPAIRALPAESYTPWITRVLAALIDFAPYVVVTGIG-WLIMM
MUL_0202|M.ulcerans_Agy99 GGYAPPPPGPAIRALPAESYTPWITRVLAALIDFAPYVVVTGIG-WLIMM
Mb1107|M.bovis_AF2122/97 GGYAPPPPGPAIRTMPTESYTPWITRVLAAFIDWAPYVVLVGIG-WVIML
Rv1078|M.tuberculosis_H37Rv GGYAPPPPGPAIRTMPTESYTPWITRVLAAFIDWAPYVVLVGIG-WVIML
MAV_1202|M.avium_104 GGYAPPPPGPAIRTLPTQDYAPWLTRALAFVIDILPYVVVHGIG-TAILV
MLBr_02395|M.leprae_Br4923 GAYAPPPPGPAIRSLPKEAYTFWVTRVLAYVIDNIPATVLLGIG-MLIQT
Mflv_2045|M.gilvum_PYR-GCK -------------TAARNPHTSWTRRVAAGILDAVPVMLGWGIW-ESVAI
Mvan_4672|M.vanbaalenii_PYR-1 GNLSGQPP-----AMPRRVYTSWSARVAAFFVDMVPLGLAWGIW-EVVAL
MSMEG_5266|M.smegmatis_MC2_155 GPYGPPT------VPNPQAYTPWFDRVIAFVIDQLPIAVVTVIG-YLVVF
MAB_1196|M.abscessus_ATCC_1997 GGYPPPPPAAGAPALPGGNFEIWIRRVGAYIIDVIPVALLSGIG-GGIAG
TH_3105|M.thermoresistible__bu GETAPAYGESPPAGFAPLDYPGAGAGTEPYQPSGYPAPPPGAQYPPPYPP
. . . . *
MMAR_4389|M.marinum_M VTTTSS-CVTD-----ISQYDIGQYCVSQPSMIGQLAQWLLSLVG-----
MUL_0202|M.ulcerans_Agy99 VTTTPS-CVTD-----ISQYDIGQYCVSQPSMIGQLAQWLLSLVG-----
Mb1107|M.bovis_AF2122/97 VTQTSS-CVTS-----ISEYDVGQFCVSQPSMIGQLVQWLLSVGG-----
Rv1078|M.tuberculosis_H37Rv VTQTSS-CVTS-----ISEYDVGQFCVSQPSMIGQLVQWLLSVGG-----
MAV_1202|M.avium_104 ATQQTA-CITD-----VTQYAVNQYCATQNSTLGLVAQWLASIVG-----
MLBr_02395|M.leprae_Br4923 LTKQEA-CVTD-----ITQYNVNQYCATQPTGIGMLAFWFAWLMA-----
Mflv_2045|M.gilvum_PYR-GCK GAASTE-CVT--------YDNGGVACTAIGSPAGDVVGVLMVFLS-----
Mvan_4672|M.vanbaalenii_PYR-1 RSATLD-CVT--------FDNGGVSCSSGISSVGYLAFALTVAVS-----
MSMEG_5266|M.smegmatis_MC2_155 GILAGA-SQG----------SSDGEITTGVGIVAAVLIFVLSLAP-----
MAB_1196|M.abscessus_ATCC_1997 GTATTADCVGDSFGDPMTGGMSYVSCQPEYTGVGWAAYILFSLAA-----
TH_3105|M.thermoresistible__bu GPQQPGYGYPAPPPYDAPRYPTPPYDPAQPPQFGAGQFGAAGYPDPNQPG
. .
MMAR_4389|M.marinum_M -LAYLVWDYGYRQGTTGSSIGKSIMKFKVVSETTGEPLGFG--MSVVRQL
MUL_0202|M.ulcerans_Agy99 -LAYLVWDYGYRQGTTGSSIGKSIMKFKVVSETTGEPLGFG--MSVVRQL
Mb1107|M.bovis_AF2122/97 -LAYLVWNYGYRQGTTGSSIGKSVLKFKVVSETTGQPIGFG--MSVVRQL
Rv1078|M.tuberculosis_H37Rv -LAYLVWNYGYRQGTIGSSIGKSVLKFKVVSETTGQPIGFG--MSVVRQL
MAV_1202|M.avium_104 -LFYLIWNYGYRQGTTGSSVGKSVMKFKVVSEVTGQPVGFG--MSVVRAL
MLBr_02395|M.leprae_Br4923 -TAYLVWNYGYRQGATGSSIGKTVMKFKVISEATGQPIGFG--MSVVRQL
Mflv_2045|M.gilvum_PYR-GCK -VAYLCWNFGLRQGRRGASIGKSVMGFRMVDEKTWQAVGFG--RSMLRLL
Mvan_4672|M.vanbaalenii_PYR-1 -VAYLVWNYGHRQGVSGSSVGKSVLRFQVLDEKTWRPVGFG--ASVLRQA
MSMEG_5266|M.smegmatis_MC2_155 -IAYGVWNMGYRQGTTGQSIGKSVMKFKVVSEQTGQPIGFL--MSLVRQV
MAB_1196|M.abscessus_ATCC_1997 -LAFAVWNWGLKQGTTGSSIGKGLLGIRVLGEATGQPIGFG--MSVVRQI
TH_3105|M.thermoresistible__bu YPGYYGYPQGYSQGYTQPPSTNTLSIWSLVISLISIPLLCSGLLSFLAPP
: : * ** . : : :: . .: *.:
MMAR_4389|M.marinum_M AHIVDAIICYIGF--LFPLWDAKRQTLADKIMTTVCLPL-----------
MUL_0202|M.ulcerans_Agy99 AHIVDAVICYIGF--LFPLWDAKRQTLADKIMTTVCLPL-----------
Mb1107|M.bovis_AF2122/97 AHFIDAIICFVGF--LFPLWDAKRQTLADKIMTTVCVPI-----------
Rv1078|M.tuberculosis_H37Rv AHFIDAIICFVGF--LFPLWDAKRQTLADKIMTTVCVPI-----------
MAV_1202|M.avium_104 AHFVDAIICFIGF--LFPLWDSKRQTLADKIMTTVCLPLDGSESPPS---
MLBr_02395|M.leprae_Br4923 AHFVDAVICCIGF--LFPLWDSKRQTLADKIMTTVCLPI-----------
Mflv_2045|M.gilvum_PYR-GCK VHVVDAVPLGIGF--LFPLWDRRRQTLADKLMGTVCVPVQGTVLGTRR--
Mvan_4672|M.vanbaalenii_PYR-1 VHLLDAAVCFIGF--LCPLWDRRRQTLADKLTGTVCVPKRY---------
MSMEG_5266|M.smegmatis_MC2_155 AHIVDGLICYVGY--LFPLWDAKRQTLADKIMTTVCVPVDRQPPQLSYPP
MAB_1196|M.abscessus_ATCC_1997 AHFLDAVICYIGF--LLPLFTAKRQTIADMLVKTVVVPK-----------
TH_3105|M.thermoresistible__bu AAIAGIVLGSLGLNQIKNTGENGRALAIGGIVAGAAVLVMVVVIILMIML
. . . :* : * . : . :
MMAR_4389|M.marinum_M -------------------------------
MUL_0202|M.ulcerans_Agy99 -------------------------------
Mb1107|M.bovis_AF2122/97 -------------------------------
Rv1078|M.tuberculosis_H37Rv -------------------------------
MAV_1202|M.avium_104 -------------------------------
MLBr_02395|M.leprae_Br4923 -------------------------------
Mflv_2045|M.gilvum_PYR-GCK -------------------------------
Mvan_4672|M.vanbaalenii_PYR-1 -------------------------------
MSMEG_5266|M.smegmatis_MC2_155 QQQFQQAYAPQYQQPYPPYPPQNPPGFNEMR
MAB_1196|M.abscessus_ATCC_1997 -------------------------------
TH_3105|M.thermoresistible__bu AAAAGA-------------------------