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NSTTSVDTSRGIVSVDTLEAIAERVLWLSTSMVHHANRVRSDSSGLKVGGHQASSASMVTIMTSLWFQQL QAGDRVSVKPHASPVLHSINYLLGALDEEHMTTLREFGGLQSYPSRSKDPDPVDYSTGSVGIGATAPIWG AVARRYVNAQLDAGGNGRQYSLVGDAELDEGAVWEAILDPGIAELGEVVWIVDLNRQSLDRVVPNIAAHR LEAMFDAAGWQVITVNFGRLLRSLFSRPGGEALRRRIVAMENAEYQRLLRCDAEQIRQRLPGDGPLSGEI AALIADIDDATLTAAIRNLGGHDLAALIETYQQIDDTRPTVIIAYTIKGFGLPTEGHPQNHSALLSHDEY AALAARLGMNPNSPWQRFAPEGPMGRLCAETAERLRRDPIPAAESPTVPSDIGRTPKGTATTQAALGRVL LDLIREAPDAAKRVVTVSPDVSSTTNLAGWVNKVGVWSASERHNWFADDAQTLMHWNERPSGQHMELGIA ETNLVGLIGELGATWSRWGQTLFPIGVLYDPFVERALEPWSFGIYAGGQSILIGTPSGVSLAAEGGAHQS IKTPSIGLEQPGCISYEPAFAIDVEWTLLASLARLGRPDGTSAYLRLSTRPVDQALAAVPDDPAARERRR RQVVAGGYPLRRPDGAKVTIAAMGAVITEALAAADRLNRAGVPADVLCITSPGLLFQAWQARQGRRSADT WILDQLFPADRATPMVTVLDGHPHALAFLTNIQQVRLTALGVSGFGQAGTLEDVYRYHGIDTDSIVRAAL DVAT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4046 | aceE_1 | - | 100% (775) | pyruvate dehydrogenase E1 component AceE_1 |
| M. marinum M | MMAR_3334 | aceE | 2e-41 | 24.69% (802) | pyruvate dehydrogenase E1 component AceE |
| M. marinum M | MMAR_0276 | dxs2 | 1e-06 | 33.04% (112) | 1-deoxy-D-xylulose 5-phosphate synthase Dxs2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2265 | aceE | 8e-41 | 24.59% (801) | pyruvate dehydrogenase subunit E1 |
| M. gilvum PYR-GCK | Mflv_2781 | aceE | 3e-44 | 25.28% (803) | pyruvate dehydrogenase subunit E1 |
| M. tuberculosis H37Rv | Rv2241 | aceE | 1e-40 | 24.59% (801) | pyruvate dehydrogenase subunit E1 |
| M. leprae Br4923 | MLBr_01651 | aceE | 5e-45 | 25.19% (806) | pyruvate dehydrogenase subunit E1 |
| M. abscessus ATCC 19977 | MAB_1884c | aceE | 2e-43 | 25.49% (816) | pyruvate dehydrogenase subunit E1 |
| M. avium 104 | MAV_2196 | aceE | 4e-43 | 25.56% (802) | pyruvate dehydrogenase subunit E1 |
| M. smegmatis MC2 155 | MSMEG_2471 | - | 0.0 | 82.45% (775) | pyruvate dehydrogenase alpha subunit |
| M. thermoresistible (build 8) | TH_2532 | - | 0.0 | 72.82% (758) | PUTATIVE pyruvate dehydrogenase alpha subunit |
| M. ulcerans Agy99 | MUL_3912 | aceE_1 | 0.0 | 99.61% (775) | pyruvate dehydrogenase E1 component AceE_1 |
| M. vanbaalenii PYR-1 | Mvan_3752 | aceE | 5e-44 | 24.81% (802) | pyruvate dehydrogenase subunit E1 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2265|M.bovis_AF2122/97 -----------------------------MASYLPDIDPEETSEWLESFD
Rv2241|M.tuberculosis_H37Rv -----------------------------MASYLPDIDPEETSEWLESFD
MLBr_01651|M.leprae_Br4923 MTIEFARPDLAKNPSSTNESNSVRVIREGVASYLPDIDPEETAEWLESFD
MAV_2196|M.avium_104 MTTEFVRHDLATNPTGPAEPDRVRVIREGVASYLPDIDPEETSEWLESFD
Mflv_2781|M.gilvum_PYR-GCK MTTEFVRQDLAQNSSSTGEPDRVRVIREGVASYLPDIDPEETGEWLESFD
Mvan_3752|M.vanbaalenii_PYR-1 -----MRQDLAQNSGSTAEPDRVRVIREGVASYLPDIDPEETGEWLESFD
MAB_1884c|M.abscessus_ATCC_199 ------------------------MIREGVASYLPDIDPDETGEWLESFD
MMAR_4046|M.marinum_M ------------------------------MNSTTSVDTSRGIVSVDTLE
MUL_3912|M.ulcerans_Agy99 ------------------------------MNSTTSVDTSRGIVSVDTLE
MSMEG_2471|M.smegmatis_MC2_155 ------------------MSFLLTVAQAGPMSLTAAHTLDVDTARLDTLQ
TH_2532|M.thermoresistible__bu ------------------------------MN-RPVMTSPLTADELDVLR
. . :: :
Mb2265|M.bovis_AF2122/97 TLLQRCGPSRARYLMLRLLERAGEQRVAIPALTSTDYVNTIPTELEPWFP
Rv2241|M.tuberculosis_H37Rv TLLQRCGPSRARYLMLRLLERAGEQRVAIPALTSTDYVNTIPTELEPWFP
MLBr_01651|M.leprae_Br4923 ELLKHSGPSRARYLILRLLERAGEQRVTIPALTWTDYVNTIPTELEPWFP
MAV_2196|M.avium_104 ELLERSGPSRARYLMLRLLERAGEQRVAIPSLTSTDYVNTIPTELEPWFP
Mflv_2781|M.gilvum_PYR-GCK DLLERSGPARARYLMLRLLERAGEQRVAIPALTSTDYVNTIPTELEPWFP
Mvan_3752|M.vanbaalenii_PYR-1 DLLERSGPARARYLMLRLLERSREKRVAIPALTSTDYVNTIPTELEPWFP
MAB_1884c|M.abscessus_ATCC_199 GLLARSGPARARYLMLRLLERANAGRVAIPALTSTDYVNTIPTENEPWFP
MMAR_4046|M.marinum_M AIAER-----VLWLSTSMVHHANR--------------------------
MUL_3912|M.ulcerans_Agy99 AIAER-----VLWLSTSMVHHANR--------------------------
MSMEG_2471|M.smegmatis_MC2_155 QIEQR-----VLWLSTAMIHHANR--------------------------
TH_2532|M.thermoresistible__bu EVEKR-----VLWLSTAIIDHANR--------------------------
: : . :* ::.::
Mb2265|M.bovis_AF2122/97 GDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFN
Rv2241|M.tuberculosis_H37Rv GDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFN
MLBr_01651|M.leprae_Br4923 GDEDIERRYRTWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFN
MAV_2196|M.avium_104 GDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFN
Mflv_2781|M.gilvum_PYR-GCK GDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFN
Mvan_3752|M.vanbaalenii_PYR-1 GDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFN
MAB_1884c|M.abscessus_ATCC_199 GDEDTERRFRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFN
MMAR_4046|M.marinum_M ---------------------VRSDSSGLKVGGHQASSASMVTIMTSLWF
MUL_3912|M.ulcerans_Agy99 ---------------------VRSDSSGLKVGGHQASSASMVTIMTSLWF
MSMEG_2471|M.smegmatis_MC2_155 ---------------------VRPNTSGLKVGGHQASSASMVTIMTALWF
TH_2532|M.thermoresistible__bu ---------------------VRPNSSGLKVGGHQASSASMVTLMTSLWF
*.: .*: **** :: ** .:: :
Mb2265|M.bovis_AF2122/97 HFFRGKSHPGGGDQVFIQGHASPGIYARAFLEGRLTAEQLDGFRQEHSHV
Rv2241|M.tuberculosis_H37Rv HFFRGKSHPGGGDQVFIQGHASPGIYARAFLEGRLTAEQLDGFRQEHSHV
MLBr_01651|M.leprae_Br4923 HFFRGKSHPSGGDQVFIQGHASPGIYARAFLEGRLSADQLDGFRQEHSHP
MAV_2196|M.avium_104 HFFRGKSHPGGGDQIFIQGHASPGIYARAFLEGRLTADQLDGFRQEHSHA
Mflv_2781|M.gilvum_PYR-GCK HFFRGKSHPGGGDQVFIQGHASPGIYARAFLEGRLTTDQLDGFRQEHSHA
Mvan_3752|M.vanbaalenii_PYR-1 HFFRGKSHPGGGDQIFIQGHASPGIYARAYLEGRLSADQLDGFRQEHSHP
MAB_1884c|M.abscessus_ATCC_199 HFFRGNAHPGGGDQIFIQGHASPGIYARAFLEGRLTTDQLDGFRQEKSHP
MMAR_4046|M.marinum_M QQLQ------AGDRVSVKPHASPVLHSINYLLGALDEEHMTTLR-----E
MUL_3912|M.ulcerans_Agy99 QQLQ------AGDRVSVKPHASPVLHSINYLLGALDEEHMTTLR-----E
MSMEG_2471|M.smegmatis_MC2_155 EQLR------SGDRVSVKPHASPVLHSLNYLLGRLDEKYLTTLR-----Q
TH_2532|M.thermoresistible__bu RHLR------AEDRVSVKPHASPVLHAINYLLGRLDRSHLTRLR-----E
. :: . *:: :: **** ::: :* * * . : :*
Mb2265|M.bovis_AF2122/97 GGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNHYLHDRGIKDTS
Rv2241|M.tuberculosis_H37Rv GGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNHYLHDRGIKDTS
MLBr_01651|M.leprae_Br4923 GGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNRYLHDRGIKDTS
MAV_2196|M.avium_104 GGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNHYLHDRGIKDTS
Mflv_2781|M.gilvum_PYR-GCK GGGLPSYPHPRLMPDFWEFPTVSMGLGPMNAIYQARFNHYLHDRDIKDTS
Mvan_3752|M.vanbaalenii_PYR-1 GGGLPSYPHPRLMPDFWEFPTVSMGLGPMNAIYQARFNHYLHDRGIKDTS
MAB_1884c|M.abscessus_ATCC_199 GGGLPSYPHPRLMPDFWQFPTVSMGLGPMNAIMQARFNHYLRDRGIKDTS
MMAR_4046|M.marinum_M FGGLQSYPSRSKDPDPVDYSTGSVGIGATAPIWGAVARRYVN-AQLDAGG
MUL_3912|M.ulcerans_Agy99 FGGLQSYPSRSKDPDPVDYSTGSVGIGATAPIWGAVARRYVN-AQLDAGG
MSMEG_2471|M.smegmatis_MC2_155 FGGLQSYPSRSKDPDPVDYSTGSVGIGATAPIWGAVARRFVD-AHYGPTG
TH_2532|M.thermoresistible__bu FGGLQSYPSRTKDPDPVDYSTGSVGIGATAPIWGAIARRYVD-TAFGKAG
*** *** ** ::.* *:*:*. .* * .::: .
Mb2265|M.bovis_AF2122/97 DQHVWCFLGDGEMDEPESRGLAHVGALEGLDNLTFVINCNLQRLDGPVRG
Rv2241|M.tuberculosis_H37Rv DQHVWCFLGDGEMDEPESRGLAHVGALEGLDNLTFVINCNLQRLDGPVRG
MLBr_01651|M.leprae_Br4923 DQHVWCFLGDGEMDEPESRGLAHVASLEDLDNLIFVINCNLQRLDGPVRG
MAV_2196|M.avium_104 DQHVWCFLGDGEMDEPESRGLIQVAANEALDNLTFVINCNLQRLDGPVRG
Mflv_2781|M.gilvum_PYR-GCK KQHVWAFLGDGEMDEPESRGLIQVAANEGLDNLTFVVNCNLQRLDGPVRG
Mvan_3752|M.vanbaalenii_PYR-1 KQHVWAFLGDGEMDEPESRGLIQVAANEALDNLTFVVNCNLQRLDGPVRG
MAB_1884c|M.abscessus_ATCC_199 DQRVWAFLGDGEMDEPESRGLAHIAATEGLDNLTFVVNCNLQRLDGPVRG
MMAR_4046|M.marinum_M NGRQYSLVGDAELDEGAVWEAILDPGIAELGEVVWIVDLNRQSLDRVVPN
MUL_3912|M.ulcerans_Agy99 NGRQYSLVGDAELDEGAVWEAILDPGIAELGEVVWIVDLNRQSLDRVVPN
MSMEG_2471|M.smegmatis_MC2_155 AGRQYSLVGDAELDEGAVWEAILDPGIAELGEVVWIVDLNRQSLDRVVPN
TH_2532|M.thermoresistible__bu AGRQYSLVGDAELDEGAVWEAVLDPAVAELGEIVWIVDLNRQSLDRVVPN
: :.::**.*:** . *.:: :::: * * ** * .
Mb2265|M.bovis_AF2122/97 NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDRALVNLMNTTPDG
Rv2241|M.tuberculosis_H37Rv NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTPDG
MLBr_01651|M.leprae_Br4923 NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVDLMNATPDG
MAV_2196|M.avium_104 NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTPDG
Mflv_2781|M.gilvum_PYR-GCK NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTPDG
Mvan_3752|M.vanbaalenii_PYR-1 NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTPDG
MAB_1884c|M.abscessus_ATCC_199 NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTADG
MMAR_4046|M.marinum_M --IAAHRLEAMFDAAGWQVITVNFGRLLRSLFSRPGGEALRRRIVAMENA
MUL_3912|M.ulcerans_Agy99 --IAAHRLETMFDAAGWQVITVNFGRLLRSLFSRPGGEALRRRIVAMENA
MSMEG_2471|M.smegmatis_MC2_155 --IAARRLEKMFDAAGWQVITVKFGRLLESLFARPGGDALRSRILDMPNP
TH_2532|M.thermoresistible__bu --IAAGKLQGMFSAAGWQVLTLKYGQLLEELFAREGGAALRARIDAMTNP
.*: :* .***:*:.: :*: *: . ** : :
Mb2265|M.bovis_AF2122/97 DYQTYKANDGGYVRDHFFGRDPR---TKALVENMSDQDIWNLKR--GGHD
Rv2241|M.tuberculosis_H37Rv DYQTYKANDGGYVRDHFFGRDPR---TKALVENMSDQDIWNLKR--GGHD
MLBr_01651|M.leprae_Br4923 DYQTYKANDGRFVRDHFFGRDPR---TKALVEHMSDQEIWNLKR--GGHD
MAV_2196|M.avium_104 DYQTYKANDGAYVRDHFFGRDPR---TKALVENMTDAEIWNLKR--GGHD
Mflv_2781|M.gilvum_PYR-GCK DYQTYKANDGSYVRDHFFGRDPR---TKALVEPMTDAEIWNLKR--GGHD
Mvan_3752|M.vanbaalenii_PYR-1 DYQTYKANDGAYVRDHFFGRDPR---TKALVENMTDREIWNLKR--GGHD
MAB_1884c|M.abscessus_ATCC_199 DYQTYKANDGAYVREHFFGRDPR---TKELVKDLTDAQVWNLKR--GGHD
MMAR_4046|M.marinum_M EYQRLLRCDAEQIRQRLPGDGPLSGEIAALIADIDDATLTAAIRNLGGHD
MUL_3912|M.ulcerans_Agy99 EYQRLLRCDAEQIRQRLPGDGPLSGEIAALIADIDDATLTAAIRNLGGHD
MSMEG_2471|M.smegmatis_MC2_155 EYQRLLRCTAGDIRTRLPGDGPRSGEIASLIADLDDQTLTAAIRNLGGHD
TH_2532|M.thermoresistible__bu EYQRLLRCDADELRHRLPGDGPSADAIRSLLERLDDDTLLNAIANLAGHD
:** . :* :: * .* *: : * : .***
Mb2265|M.bovis_AF2122/97 YRKVYAAYRAAVDHKGQPTVILAKTIKGYALGKHFEGRNATHQMKKLTLE
Rv2241|M.tuberculosis_H37Rv YRKVYAAYRAAVDHKGQPTVILAKTIKGYALGKHFEGRNATHQMKKLTLE
MLBr_01651|M.leprae_Br4923 YRKVYASYRAAVDHKGQPTVILAKTIKGYALGKHFESRNATHQMKKLTLE
MAV_2196|M.avium_104 YRKVYAAYRAAVDHKGQPTVILAKTIKGYSLGAHFQGRNATHQMKKLALE
Mflv_2781|M.gilvum_PYR-GCK YRKVYAAYHAAMEHKGQPTVILAKTIKGYTLGKHFEGRNATHQMKKLALQ
Mvan_3752|M.vanbaalenii_PYR-1 YRKVYAAYHAALEHKGQPTVILAKTIKGYTLGKHFEGRNATHQMKKLALQ
MAB_1884c|M.abscessus_ATCC_199 YRKVYAAYRAATEHKGQPTVILAKTIKGYTLGKHFEGRNATHQMKKLTLD
MMAR_4046|M.marinum_M LAALIETYQQIDDTR--PTVIIAYTIKGFGLPTEGHPQNHSALLSHDEYA
MUL_3912|M.ulcerans_Agy99 LAALIEAYQQIDDTR--PTVIIAYTIKGFGLPTEGHPQNHSALLNHDEYA
MSMEG_2471|M.smegmatis_MC2_155 LAALTQAYREIDDTR--PTVIIAYTVKGHGLPTEGHPQNHSALLSHDEFD
TH_2532|M.thermoresistible__bu LSSLDEAFAAIDDTR--PTVIFAYTVKGYGLATRGHPQNHSALLKEPQMR
: :: : : ****:* *:**. * . . :* : :..
Mb2265|M.bovis_AF2122/97 DLKEFRDTQRIPVSDAQLEENPYLPPYYHPGLNAPEIRYMLDRRRALGGF
Rv2241|M.tuberculosis_H37Rv DLKEFRDTQRIPVSDAQLEENPYLPPYYHPGLNAPEIRYMLDRRRALGGF
MLBr_01651|M.leprae_Br4923 DLKEFRDTQRIPISDTELEENPYLPPYYHPGPDSPEIRYLLDRRRALGGF
MAV_2196|M.avium_104 DLKHFRDAMRIPISDAQLDENPYLPPYYHPGSDAPEIRYMLDRRRTLGGF
Mflv_2781|M.gilvum_PYR-GCK DLKDFRDVQRIPVSDSQLEENPYLPPYYHPGPEAPEIRYMLDRRRALGGF
Mvan_3752|M.vanbaalenii_PYR-1 DLKDFRDAQRIPVSDEQLEADPYLPPYYHPGPEAPEIRYMLDRRRALGGF
MAB_1884c|M.abscessus_ATCC_199 DLKDFRDKQRIPISDAQLEENPYLPPYYHPGPEAPEIRYMLDRRRALGGF
MMAR_4046|M.marinum_M ALAARLGMN----------------------PNSPWQRFAPEGPMGRLCA
MUL_3912|M.ulcerans_Agy99 ALAARLGMN----------------------PNSPWQRFAPEGPMGRLCA
MSMEG_2471|M.smegmatis_MC2_155 ALATRLGMD----------------------PNAPWQRFAQDSDAGRLCV
TH_2532|M.thermoresistible__bu ELAEILGTD----------------------LDDPWRPFPTDSPAAHLCT
* . : * : :
Mb2265|M.bovis_AF2122/97 VPERRTKSKALTLPGRDIYAPLKKGSGHQEVATTMATVRTFKEVLRDK-Q
Rv2241|M.tuberculosis_H37Rv VPERRTKSKALTLPGRDIYAPLKKGSGHQEVATTMATVRTFKEVLRDK-Q
MLBr_01651|M.leprae_Br4923 LPERRTKSGALTLPGRDTYAALKTGSGQQEVATTMAIVRTFKEVLRHK-E
MAV_2196|M.avium_104 LPERRTKAKALRLPGRDIYAALKKGSGTQEVATTMATVRTFKEVLRDK-E
Mflv_2781|M.gilvum_PYR-GCK LPERRTKTKALTLPGRDTYKALKKGSGKQEVATTMATVRTFKELLRDK-N
Mvan_3752|M.vanbaalenii_PYR-1 LPERRTKSRALTLPGRDVYKALKKGSGKQEVATTMATVRTFKELLRDK-N
MAB_1884c|M.abscessus_ATCC_199 VPSRRTTSRPLTLPGSETYASIKKGSGKQEVATTMALVRTFKELLRDK-N
MMAR_4046|M.marinum_M ETAERLRRDPIPAAESPTVPSDIGRTPKGTATTQAALGRVLLDLIREAPD
MUL_3912|M.ulcerans_Agy99 ETAERLRRDPIPAAESPTVPSDIGRTPKGTATTQAALGRVLLDLIREAPD
MSMEG_2471|M.smegmatis_MC2_155 AAAQRLSRDDITAIDPPAVPGDIGRTPKGTATTQAALGRVLLDLSREAPD
TH_2532|M.thermoresistible__bu QTAERLRRSDPVITEPAPVPTDFGRTPSGRATTQAYLGRVLLDLTRQAPD
. .* : .:* *.: :: *. :
Mb2265|M.bovis_AF2122/97 IGPRIVPIIPDEARTFGMDSWFPSLKIYNRNGQ-LYTAVDADLMLAYKES
Rv2241|M.tuberculosis_H37Rv IGPRIVPIIPDEARTFGMDSWFPSLKIYNRNGQ-LYTAVDADLMLAYKES
MLBr_01651|M.leprae_Br4923 VGPRIVPIIPDEARTFGMDSWFPSLKIYNHNGQ-LYTAVDAQLMLAYKES
MAV_2196|M.avium_104 IGPRIVPIIPDEARTFGMDSWFPSLKIYNRNGQ-LYTAVDAELMLAYKES
Mflv_2781|M.gilvum_PYR-GCK IGWRIVPIIPDEARTFGMDSWFPSLKIYNRNGQ-LYTAVDAELMLAYKES
Mvan_3752|M.vanbaalenii_PYR-1 IGSRIVPIIPDEARTFGMDSWFPSLKIYNRNGQ-LYTAVDAELMLAYKES
MAB_1884c|M.abscessus_ATCC_199 IGNRIVPIIPDEARTFGMDSWFPSLKIYNRNGQ-LYTSVDAELMLAYKES
MMAR_4046|M.marinum_M AAKRVVTVSPDVSSTTNLAGWVNKVGVWSASERHNWFADDAQTLMHWNER
MUL_3912|M.ulcerans_Agy99 AAKRVVTVSPDVSSTTNLAGWVNKVGVWSASERHNWFADDAQTLMHWNER
MSMEG_2471|M.smegmatis_MC2_155 AAARVVTVSPDVSSTTNLGGWVNKVGVWSATERRNWFADDAETIMHWDER
TH_2532|M.thermoresistible__bu VARRLVTVSPDVSSSTNLGGWVNKVGVWSAAERHNWFADDSETILHWRER
. *:*.: ** : : .: .*. .: ::. : : : *:: :: : *
Mb2265|M.bovis_AF2122/97 EVGQILHEGINEAGSVGSFIAAGTSYATHNEPMIPIYIFYSMFGFQRTGD
Rv2241|M.tuberculosis_H37Rv EVGQILHEGINEAGSVGSFIAAGTSYATHNEPMIPIYIFYSMFGFQRTGD
MLBr_01651|M.leprae_Br4923 EVGQILHEGIDEAGSVGSFIAAGTSYSTHNEPMIPIYIFYSMFGFQRTGD
MAV_2196|M.avium_104 EVGQILHEGINEAGSVGSFIAAGTSYATHNEPMIPIYIFYSMFGFQRTGD
Mflv_2781|M.gilvum_PYR-GCK EVGQILHEGINEAGSTASFTAVGTSYATHNEPMIPIYIFYSMFGFQRTGD
Mvan_3752|M.vanbaalenii_PYR-1 EIGQILHEGINEAGSTASFTAVGTSYATHNEPMIPIYIFYSMFGFQRTGD
MAB_1884c|M.abscessus_ATCC_199 AQGQILHEGINEAGSTASFTAVGTAYSTHDEPMIPLYIFYSMFGFQRTGD
MMAR_4046|M.marinum_M PSGQHMELGIAETNLVGLIGELGATWSRWGQTLFPIGVLYDPFVERALEP
MUL_3912|M.ulcerans_Agy99 PSGQHMELGIAETNLVGLIGELGATWSRWGQTLFPIGVLYDPFVERALEP
MSMEG_2471|M.smegmatis_MC2_155 PSGRHVELGIAETNLVGLLGELGATWSRWGQPLFPIGVLYDPFVERALEP
TH_2532|M.thermoresistible__bu PTGQHIQLGIAEVNLVSLIGELGATWSRWGEPLLPIGVLYDPFVERALEP
*: :. ** *.. .. : *:::: .:.::*: ::*. * :
Mb2265|M.bovis_AF2122/97 SFWAAADQMARGFVLGATAGRTTLTGEGLQHADGHSLLLAATNPAVVAYD
Rv2241|M.tuberculosis_H37Rv SFWAAADQMARGFVLGATAGRTTLTGEGLQHADGHSLLLAATNPAVVAYD
MLBr_01651|M.leprae_Br4923 GLWAAADQMARGFLLGATAGRTTLTGEGLQHADGHSLLLAATNPAVVTYD
MAV_2196|M.avium_104 GLWAAADQMTRGFLLGATAGRTTLTGEGLQHADGHSLLLAATNPAVVAYD
Mflv_2781|M.gilvum_PYR-GCK GLWAAADQMARGFVLGATAGRTTLVGEGLQHADGHSLLLAATNPAVVSYD
Mvan_3752|M.vanbaalenii_PYR-1 GLWAAADQMARGFVLGATAGRTTLVGEGLQHADGHSLLLASTNPAVVAYD
MAB_1884c|M.abscessus_ATCC_199 GLWAAADQMARGFVLGATAGRTTLTGEGLQHADGHSLLLASTNPAVVAYD
MMAR_4046|M.marinum_M --WSFGIYAGGQSILIGTPSGVSLAAEGGAHQSIKTPSIGLEQPGCISYE
MUL_3912|M.ulcerans_Agy99 --WSFGIYAGGQSILIGTPSGVSLAAEGGAHQSIKTPSIGLEQPGCISYE
MSMEG_2471|M.smegmatis_MC2_155 --WSFGIYAGGQSILVGTPSGVTLAAEGGAHQSIKTPSIGIEQPGCISYE
TH_2532|M.thermoresistible__bu --WSFGIYAGGQSILVGTPSGVTLAPEGGAHQSIKTPSIGLEQPGCVSYE
*: . :* .*.. .:*. ** * . :: :. :*. ::*:
Mb2265|M.bovis_AF2122/97 PAFAYEIAYIVESGLARMCGENPENIFFYITVYNEPYVQPPEPENFDPEG
Rv2241|M.tuberculosis_H37Rv PAFAYEIAYIVESGLARMCGENPENIFFYITVYNEPYVQPPEPENFDPEG
MLBr_01651|M.leprae_Br4923 PAFAYEIAYIVESGLTRMFGEDPENVFFYITVYNEPYPQPPEPENFDPDG
MAV_2196|M.avium_104 PAFAYEIAYIVESGLARMFGENPEDVYFYITVYNEPYVQPPEPENFDPEG
Mflv_2781|M.gilvum_PYR-GCK PAFAFEIAYIIESGLQRMYGDNPENVYFYMTIYNEPYVQPAEPEGIDVEG
Mvan_3752|M.vanbaalenii_PYR-1 PAFAYEIAYIIESGLHRMYGENPENVYFYMTIYNEPYVQPAEPDGLDVEG
MAB_1884c|M.abscessus_ATCC_199 PAFAYEIAHIVEHGLQRMYGENSENVYFYITLYNEPYVQPAEPENVDTEG
MMAR_4046|M.marinum_M PAFAIDVEWTLLASLARLGRPDGTSAYLRLSTRPVDQALAAVPDDPAARE
MUL_3912|M.ulcerans_Agy99 PAFAIDVEWTLLASLARLGRPDGTSAYLRLSTRPVDQALAAVPDDPAARE
MSMEG_2471|M.smegmatis_MC2_155 PAFAIDVEWTLLASMGRLGRPGGTSAYLRLSTRPVDQSLAAVPTDPAARE
TH_2532|M.thermoresistible__bu PAFAIDTEWVLLASLGRLGKPDGTSAYLRLSTRPVDQRLAAVPDDPAARE
**** : : .: *: . . :: :: .. * .
Mb2265|M.bovis_AF2122/97 VLRGIYRYHAATEQRTN--KAQILASGVAMPAALRAAQMLAAEWDVAADV
Rv2241|M.tuberculosis_H37Rv VLRGIYRYHAATEQRTN--KAQILASGVAMPAALRAAQMLAAEWDVAADV
MLBr_01651|M.leprae_Br4923 VLRGMYRYYTAKEQRSN--KAHILASGVSMPAALTAAEMLSTQWDVAADV
MAV_2196|M.avium_104 LLRGLYRYHVATEQRAN--KAQILASGVAMPSALSAAKMLADEWDVAADV
Mflv_2781|M.gilvum_PYR-GCK LLRGMYRYQAAPQKKSN--SAQILVSGVSMPSALKAAEMLAEEWDVSADV
Mvan_3752|M.vanbaalenii_PYR-1 LLRGMYRYQAAPEKRTN--AAQILVSGVGMPSALKAAELLAQEWDVAADV
MAB_1884c|M.abscessus_ATCC_199 ILRGIYKFRAAPEARTH--RANILASGVSVPDALRAADLLAEQWDVAADV
MMAR_4046|M.marinum_M RRRRQVVAGGYPLRRPDGAKVTIAAMGAVITEALAAADRLNRAG-VPADV
MUL_3912|M.ulcerans_Agy99 RRRRQVVAGGYPLRRPDGAKVTIAAMGAVITEALAAADRLNRAG-VPADV
MSMEG_2471|M.smegmatis_MC2_155 RRRRQVVAGGYPLRRAPGARVTIAAMGAVLPEALAAADRLTEQG-VPADV
TH_2532|M.thermoresistible__bu RRRRHVVAGGYTLRRSERPKVTIAAMGAVVPEALSAADRLQQVG-IPADL
* :. . * . *. :. ** **. * :.**:
Mb2265|M.bovis_AF2122/97 WSVTSWGELNRDGVAIETEKLRHPDRPAGVPYVTRALENAR----GPVIA
Rv2241|M.tuberculosis_H37Rv WSVTSWGELNRDGVAIETEKLRHPDRPAGVPYVTRALENAR----GPVIA
MLBr_01651|M.leprae_Br4923 WSVTSWGELNRDGMSIETARLRYPDQPTSVPYVTQVLSEARSDNAGPVIA
MAV_2196|M.avium_104 WSVTSWGELNRDGVAIDRARLRHPDRPAGVPYVTQALSDAS----GPVVA
Mflv_2781|M.gilvum_PYR-GCK WSVTSWGELNREGVAIEKERLRHPDREVATPYVTEALAGAE----GPVVA
Mvan_3752|M.vanbaalenii_PYR-1 WSVTSWGELNRDGVAIEREKLRHPELPAATPYVTKMLAEAA----GPVVA
MAB_1884c|M.abscessus_ATCC_199 WSVTSWGELNRDGLAIDHQALRHPDRPKGVPYVTKALEGAQ----GPKVA
MMAR_4046|M.marinum_M LCITSPGLLFQAWQARQGR----RSADTWILDQLFPADRAT-----PMVT
MUL_3912|M.ulcerans_Agy99 LCITSPGLLFQAWQARQGR----RSADTWILDQLFPADRAT-----PMVT
MSMEG_2471|M.smegmatis_MC2_155 VCVTSPGLLFDAWQARQGHDAANTGADTWILDQLFPADRAL-----PLVT
TH_2532|M.thermoresistible__bu ICVTSPDLLYRAVRAREGR----DDAPSWILEQIFPVERAT-----PLVT
.:** . * : : * * ::
Mb2265|M.bovis_AF2122/97 VSDWMRAVPEQIRPWVPGTYLTLGTDGFGFSDTRPAARRYFNTDAESQVV
Rv2241|M.tuberculosis_H37Rv VSDWMRAVPEQIRPWVPGTYLTLGTDGFGFSDTRPAARRYFNTDAESQVV
MLBr_01651|M.leprae_Br4923 VSDWMRAVPEQIRPWVPGTYVTLGTDGFGFSDTRTATRRYFNTDAESQVV
MAV_2196|M.avium_104 VSDWMRAVPEQIRPWVPGTYVTLGTDGFGFSDTRPAARRYFNTDAESQVV
Mflv_2781|M.gilvum_PYR-GCK VSDWMRAVPEQIRPWVPGTYVTLGTDGFGFSDTRPAARRYYNTDAESIVV
Mvan_3752|M.vanbaalenii_PYR-1 VSDWMRAVPEQIRPWVPGTYITLGTDGFGFSDTRPAARRYYNTDAESVVV
MAB_1884c|M.abscessus_ATCC_199 VSDWMHAVPEQIRPWVPGMYRTLGADGFGISDTRPAARRFFNTDAESVVV
MMAR_4046|M.marinum_M VLDGHPHALAFLTNIQQVRLTALGVSGFGQAGTLEDVYRYHGIDTDSIVR
MUL_3912|M.ulcerans_Agy99 VLDGHPHALAFLTNIQQVRLTALGVSGFGQAGTLEDVYRYHGIDTDSIVR
MSMEG_2471|M.smegmatis_MC2_155 VLDGHPHTLAFLANIQRVRATNLGVSRFGQVGSLDEVHRYHGLDTDSIVR
TH_2532|M.thermoresistible__bu VLDGHPHTLSFLATINRVPSATLGVTEFGQSGSLEDVYRHHGLDTDSIVS
* * . : **. ** .: . *... *::* *
Mb2265|M.bovis_AF2122/97 AVLEALAGDGEIDPSVPVAAARQYRIDDVAAAPEQTTDPGPGA--
Rv2241|M.tuberculosis_H37Rv AVLEALAGDGEIDPSVPVAAARQYRIDDVAAAPEQTTDPGPGA--
MLBr_01651|M.leprae_Br4923 AVLEALARDGEIDPSVPVAATRQYQIDDVQAAPEQTSDPGPGVQN
MAV_2196|M.avium_104 AVLEALARDGEIDPSVPVAAARQYRIDDVLAAPEQTSDPGVA---
Mflv_2781|M.gilvum_PYR-GCK AVLEGLARDGNIDISAAVDAARRYEIDDVMAAPEQTSDPGVA---
Mvan_3752|M.vanbaalenii_PYR-1 AVLEGLARDGNIDISVAVEAAKKYEIDDVMAAPEQTSDPGVA---
MAB_1884c|M.abscessus_ATCC_199 AVLEALADEGSVDRQVAVTAAAQYKIDDVSAADVSYKDTGSA---
MMAR_4046|M.marinum_M AALDVAT--------------------------------------
MUL_3912|M.ulcerans_Agy99 AALDVAT--------------------------------------
MSMEG_2471|M.smegmatis_MC2_155 AALDVSEGTGVAGFTGVSGITGAGS--------------------
TH_2532|M.thermoresistible__bu AALDLIE--------------------------------------
*.*: