For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
LTIEFARPDLAKNPSSTNESNSVRVIREGVASYLPDIDPEETAEWLESFDELLKHSGPSRARYLILRLLE RAGEQRVTIPALTWTDYVNTIPTELEPWFPGDEDIERRYRTWIRWNAAIMVHRAQRPGVGVGGHISTYAS SAALYEVGFNHFFRGKSHPSGGDQVFIQGHASPGIYARAFLEGRLSADQLDGFRQEHSHPGGGLPSYPHP RLMPDFWEFPTVSMGLGPLNAIYQARFNRYLHDRGIKDTSDQHVWCFLGDGEMDEPESRGLAHVASLEDL DNLIFVINCNLQRLDGPVRGNGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVDLMNATPDG DYQTYKANDGRFVRDHFFGRDPRTKALVEHMSDQEIWNLKRGGHDYRKVYASYRAAVDHKGQPTVILAKT IKGYALGKHFESRNATHQMKKLTLEDLKEFRDTQRIPISDTELEENPYLPPYYHPGPDSPEIRYLLDRRR ALGGFLPERRTKSGALTLPGRDTYAALKTGSGQQEVATTMAIVRTFKEVLRHKEVGPRIVPIIPDEARTF GMDSWFPSLKIYNHNGQLYTAVDAQLMLAYKESEVGQILHEGIDEAGSVGSFIAAGTSYSTHNEPMIPIY IFYSMFGFQRTGDGLWAAADQMARGFLLGATAGRTTLTGEGLQHADGHSLLLAATNPAVVTYDPAFAYEI AYIVESGLTRMFGEDPENVFFYITVYNEPYPQPPEPENFDPDGVLRGMYRYYTAKEQRSNKAHILASGVS MPAALTAAEMLSTQWDVAADVWSVTSWGELNRDGMSIETARLRYPDQPTSVPYVTQVLSEARSDNAGPVI AVSDWMRAVPEQIRPWVPGTYVTLGTDGFGFSDTRTATRRYFNTDAESQVVAVLEALARDGEIDPSVPVA ATRQYQIDDVQAAPEQTSDPGPGVQN
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. leprae Br4923 | MLBr_01651 | aceE | - | 100% (936) | pyruvate dehydrogenase subunit E1 |
M. leprae Br4923 | MLBr_00583 | tkt | 1e-06 | 24.60% (252) | transketolase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2265 | aceE | 0.0 | 89.49% (904) | pyruvate dehydrogenase subunit E1 |
M. gilvum PYR-GCK | Mflv_2781 | aceE | 0.0 | 84.32% (931) | pyruvate dehydrogenase subunit E1 |
M. tuberculosis H37Rv | Rv2241 | aceE | 0.0 | 89.60% (904) | pyruvate dehydrogenase subunit E1 |
M. abscessus ATCC 19977 | MAB_1884c | aceE | 0.0 | 80.60% (907) | pyruvate dehydrogenase subunit E1 |
M. marinum M | MMAR_3334 | aceE | 0.0 | 85.71% (931) | pyruvate dehydrogenase E1 component AceE |
M. avium 104 | MAV_2196 | aceE | 0.0 | 88.18% (931) | pyruvate dehydrogenase subunit E1 |
M. smegmatis MC2 155 | MSMEG_4323 | aceE | 0.0 | 83.03% (931) | pyruvate dehydrogenase subunit E1 |
M. thermoresistible (build 8) | TH_1339 | aceE | 0.0 | 82.28% (931) | Probable pyruvate dehydrogenase E1 component aceE (PYRUVATE |
M. ulcerans Agy99 | MUL_1308 | aceE | 0.0 | 85.50% (931) | pyruvate dehydrogenase subunit E1 |
M. vanbaalenii PYR-1 | Mvan_3752 | aceE | 0.0 | 84.00% (925) | pyruvate dehydrogenase subunit E1 |
CLUSTAL 2.0.9 multiple sequence alignment MAB_1884c|M.abscessus_ATCC_199 ------------------------MIREGVASYLPDIDPDETGEWLESFD TH_1339|M.thermoresistible__bu LTTEFVRQDLAQNSKSTTGHGRVRVIRDGVAAYLPDIDPEETAEWLESFD MSMEG_4323|M.smegmatis_MC2_155 MTTEFVRQDLAQNSSTAAEPDRVRVIREGVASYLPDIDTEETAEWLESFD Mflv_2781|M.gilvum_PYR-GCK MTTEFVRQDLAQNSSSTGEPDRVRVIREGVASYLPDIDPEETGEWLESFD Mvan_3752|M.vanbaalenii_PYR-1 -----MRQDLAQNSGSTAEPDRVRVIREGVASYLPDIDPEETGEWLESFD Mb2265|M.bovis_AF2122/97 -----------------------------MASYLPDIDPEETSEWLESFD Rv2241|M.tuberculosis_H37Rv -----------------------------MASYLPDIDPEETSEWLESFD MLBr_01651|M.leprae_Br4923 MTIEFARPDLAKNPSSTNESNSVRVIREGVASYLPDIDPEETAEWLESFD MAV_2196|M.avium_104 MTTEFVRHDLATNPTGPAEPDRVRVIREGVASYLPDIDPEETSEWLESFD MMAR_3334|M.marinum_M MTTEFVRHDLAKTSSSASEPDRVRVIREGVASYLPDIDPEETSEWLESFD MUL_1308|M.ulcerans_Agy99 MTTEFVRHDLAKTSSSASEPDRVRVIREGVASYLPDIDPEETSEWLESFD :*:******.:**.******* MAB_1884c|M.abscessus_ATCC_199 GLLARSGPARARYLMLRLLERANAGRVAIPALTSTDYVNTIPTENEPWFP TH_1339|M.thermoresistible__bu QLVERSGPARARYLMLRMLERAREQRVAIPALTSTDYVNTIPTENEPWFP MSMEG_4323|M.smegmatis_MC2_155 ELLERSGPARARYLMLRLLERAGEQRVAIPALTSTDYVNTIPTELEPWFP Mflv_2781|M.gilvum_PYR-GCK DLLERSGPARARYLMLRLLERAGEQRVAIPALTSTDYVNTIPTELEPWFP Mvan_3752|M.vanbaalenii_PYR-1 DLLERSGPARARYLMLRLLERSREKRVAIPALTSTDYVNTIPTELEPWFP Mb2265|M.bovis_AF2122/97 TLLQRCGPSRARYLMLRLLERAGEQRVAIPALTSTDYVNTIPTELEPWFP Rv2241|M.tuberculosis_H37Rv TLLQRCGPSRARYLMLRLLERAGEQRVAIPALTSTDYVNTIPTELEPWFP MLBr_01651|M.leprae_Br4923 ELLKHSGPSRARYLILRLLERAGEQRVTIPALTWTDYVNTIPTELEPWFP MAV_2196|M.avium_104 ELLERSGPSRARYLMLRLLERAGEQRVAIPSLTSTDYVNTIPTELEPWFP MMAR_3334|M.marinum_M ALLEHSGPARARYLMLRLLERAGEQRVAIPSLTSTDYVNTIPTELEPWFP MUL_1308|M.ulcerans_Agy99 ALLEHSGPARARYLMLRLLERAGEQRVAIPSLTSTDYVNTIPTELEPWFP *: :.**:*****:**:***: **:**:** ********** ***** MAB_1884c|M.abscessus_ATCC_199 GDEDTERRFRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFN TH_1339|M.thermoresistible__bu GDEDTERRFRLWIRWNAAIMVHRAQRPGVGVGGHISTYASSATLYEVGFN MSMEG_4323|M.smegmatis_MC2_155 GDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSATLYEVGFN Mflv_2781|M.gilvum_PYR-GCK GDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFN Mvan_3752|M.vanbaalenii_PYR-1 GDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFN Mb2265|M.bovis_AF2122/97 GDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFN Rv2241|M.tuberculosis_H37Rv GDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFN MLBr_01651|M.leprae_Br4923 GDEDIERRYRTWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFN MAV_2196|M.avium_104 GDEDVERRYRAWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFN MMAR_3334|M.marinum_M GDEDVERRYRTWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFN MUL_1308|M.ulcerans_Agy99 GDEDVERRYRTWIRWNAAIMVHRAQRPGVGVGGHISTYASSAALYEVGFN **** ***:* *******************************:******* MAB_1884c|M.abscessus_ATCC_199 HFFRGNAHPGGGDQIFIQGHASPGIYARAFLEGRLTTDQLDGFRQEKSHP TH_1339|M.thermoresistible__bu HFFRGKAHPGGGDQVFIQGHASPGIYARAFLEGRLTADQLDGFRQEHSHP MSMEG_4323|M.smegmatis_MC2_155 HFFRGKSHPGGGDHVFIQGHASPGIYARAFLEGRLTTDQLDGFRQEHSHS Mflv_2781|M.gilvum_PYR-GCK HFFRGKSHPGGGDQVFIQGHASPGIYARAFLEGRLTTDQLDGFRQEHSHA Mvan_3752|M.vanbaalenii_PYR-1 HFFRGKSHPGGGDQIFIQGHASPGIYARAYLEGRLSADQLDGFRQEHSHP Mb2265|M.bovis_AF2122/97 HFFRGKSHPGGGDQVFIQGHASPGIYARAFLEGRLTAEQLDGFRQEHSHV Rv2241|M.tuberculosis_H37Rv HFFRGKSHPGGGDQVFIQGHASPGIYARAFLEGRLTAEQLDGFRQEHSHV MLBr_01651|M.leprae_Br4923 HFFRGKSHPSGGDQVFIQGHASPGIYARAFLEGRLSADQLDGFRQEHSHP MAV_2196|M.avium_104 HFFRGKSHPGGGDQIFIQGHASPGIYARAFLEGRLTADQLDGFRQEHSHA MMAR_3334|M.marinum_M HFFRGKSHPGGGDQVFIQGHASPGIYARAFLEGRLSADQLDGFRQEHSHP MUL_1308|M.ulcerans_Agy99 HFFRGKSHPGGGDQVFIQGHASPGIYARAFLEGRLSADQLDGFRQEHSHP *****::**.***::**************:*****:::********:** MAB_1884c|M.abscessus_ATCC_199 GGGLPSYPHPRLMPDFWQFPTVSMGLGPMNAIMQARFNHYLRDRGIKDTS TH_1339|M.thermoresistible__bu GGGLPSYPHPRLMPDFWEFPTVSMGLGPINAIFQARFNRYLHNRGIKDTS MSMEG_4323|M.smegmatis_MC2_155 GGGLPSYPHPRLMPDFWEFPTVSMGLGPMNAIYQARFNHYLHDRGIKDTS Mflv_2781|M.gilvum_PYR-GCK GGGLPSYPHPRLMPDFWEFPTVSMGLGPMNAIYQARFNHYLHDRDIKDTS Mvan_3752|M.vanbaalenii_PYR-1 GGGLPSYPHPRLMPDFWEFPTVSMGLGPMNAIYQARFNHYLHDRGIKDTS Mb2265|M.bovis_AF2122/97 GGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNHYLHDRGIKDTS Rv2241|M.tuberculosis_H37Rv GGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNHYLHDRGIKDTS MLBr_01651|M.leprae_Br4923 GGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNRYLHDRGIKDTS MAV_2196|M.avium_104 GGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNHYLHDRGIKDTS MMAR_3334|M.marinum_M GGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNHYLHDRGIKDTS MUL_1308|M.ulcerans_Agy99 GGGLPSYPHPRLMPDFWEFPTVSMGLGPLNAIYQARFNHYLHDRGIKDTS *****************:**********:*** *****:**::*.***** MAB_1884c|M.abscessus_ATCC_199 DQRVWAFLGDGEMDEPESRGLAHIAATEGLDNLTFVVNCNLQRLDGPVRG TH_1339|M.thermoresistible__bu GQHVWCFLGDGEMDEPESRGAAHVAALEGLDNLTFVVNCNLQRLDGPVRG MSMEG_4323|M.smegmatis_MC2_155 DQHVWAFLGDGEMDEPESRGLIQVAANEALDNLTFVINCNLQRLDGPVRG Mflv_2781|M.gilvum_PYR-GCK KQHVWAFLGDGEMDEPESRGLIQVAANEGLDNLTFVVNCNLQRLDGPVRG Mvan_3752|M.vanbaalenii_PYR-1 KQHVWAFLGDGEMDEPESRGLIQVAANEALDNLTFVVNCNLQRLDGPVRG Mb2265|M.bovis_AF2122/97 DQHVWCFLGDGEMDEPESRGLAHVGALEGLDNLTFVINCNLQRLDGPVRG Rv2241|M.tuberculosis_H37Rv DQHVWCFLGDGEMDEPESRGLAHVGALEGLDNLTFVINCNLQRLDGPVRG MLBr_01651|M.leprae_Br4923 DQHVWCFLGDGEMDEPESRGLAHVASLEDLDNLIFVINCNLQRLDGPVRG MAV_2196|M.avium_104 DQHVWCFLGDGEMDEPESRGLIQVAANEALDNLTFVINCNLQRLDGPVRG MMAR_3334|M.marinum_M DQHVWCFLGDGEMDEPESRGLAHMGALEGLDNLTFVINCNLQRLDGPVRG MUL_1308|M.ulcerans_Agy99 DQHVWCFLGDGEMDEPESRGLAHMGALEGLDNLTFVINCNLQRLDGPVRG *:**.************** ::.: * **** **:************* MAB_1884c|M.abscessus_ATCC_199 NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTADG TH_1339|M.thermoresistible__bu NGKIIQELEAFFRGAGWNVIKVVWGREWDALLHADKDGALVNLMNTTPDG MSMEG_4323|M.smegmatis_MC2_155 NGKIIQELESFFRGAGWNVIKVVWGREWDVLLHADRDGALVNLMNSTPDG Mflv_2781|M.gilvum_PYR-GCK NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTPDG Mvan_3752|M.vanbaalenii_PYR-1 NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTPDG Mb2265|M.bovis_AF2122/97 NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDRALVNLMNTTPDG Rv2241|M.tuberculosis_H37Rv NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTPDG MLBr_01651|M.leprae_Br4923 NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVDLMNATPDG MAV_2196|M.avium_104 NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNTTPDG MMAR_3334|M.marinum_M NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNSTPDG MUL_1308|M.ulcerans_Agy99 NGKIIQELESFFRGAGWNVIKVVWGREWDALLHADRDGALVNLMNSTPDG *********:*******************.*****:* ***:***:*.** MAB_1884c|M.abscessus_ATCC_199 DYQTYKANDGAYVREHFFGRDPRTKELVKDLTDAQVWNLKRGGHDYRKVY TH_1339|M.thermoresistible__bu DYQTYKANDGAYVREHFFGRDPRTKALVQNMTDQEIWNLKRGGHDYRKVY MSMEG_4323|M.smegmatis_MC2_155 DYQTYKANDGAYVRDHFFGRDPRTKALVADMSDQEIWNLKRGGHDYRKVY Mflv_2781|M.gilvum_PYR-GCK DYQTYKANDGSYVRDHFFGRDPRTKALVEPMTDAEIWNLKRGGHDYRKVY Mvan_3752|M.vanbaalenii_PYR-1 DYQTYKANDGAYVRDHFFGRDPRTKALVENMTDREIWNLKRGGHDYRKVY Mb2265|M.bovis_AF2122/97 DYQTYKANDGGYVRDHFFGRDPRTKALVENMSDQDIWNLKRGGHDYRKVY Rv2241|M.tuberculosis_H37Rv DYQTYKANDGGYVRDHFFGRDPRTKALVENMSDQDIWNLKRGGHDYRKVY MLBr_01651|M.leprae_Br4923 DYQTYKANDGRFVRDHFFGRDPRTKALVEHMSDQEIWNLKRGGHDYRKVY MAV_2196|M.avium_104 DYQTYKANDGAYVRDHFFGRDPRTKALVENMTDAEIWNLKRGGHDYRKVY MMAR_3334|M.marinum_M DYQTYKANDGAYVRDHFFGRDPRTKALVANMSDQEIWNLKRGGHDYRKVY MUL_1308|M.ulcerans_Agy99 DYQTYKANDGAYVRDHFFGRDPRTKALVANMSDQEIWNLKRGGHDYRKVY ********** :**:********** ** ::* ::************** MAB_1884c|M.abscessus_ATCC_199 AAYRAATEHKGQPTVILAKTIKGYTLGKHFEGRNATHQMKKLTLDDLKDF TH_1339|M.thermoresistible__bu AAYRAAVEHKGQPTVILAKTIKGYSLGANFQGRNATHQMKKLALDDLKHF MSMEG_4323|M.smegmatis_MC2_155 AAYRAAMEHKGQPTVILAKTIKGYTLGQHFEGRNATHQMKKLALEDLKNF Mflv_2781|M.gilvum_PYR-GCK AAYHAAMEHKGQPTVILAKTIKGYTLGKHFEGRNATHQMKKLALQDLKDF Mvan_3752|M.vanbaalenii_PYR-1 AAYHAALEHKGQPTVILAKTIKGYTLGKHFEGRNATHQMKKLALQDLKDF Mb2265|M.bovis_AF2122/97 AAYRAAVDHKGQPTVILAKTIKGYALGKHFEGRNATHQMKKLTLEDLKEF Rv2241|M.tuberculosis_H37Rv AAYRAAVDHKGQPTVILAKTIKGYALGKHFEGRNATHQMKKLTLEDLKEF MLBr_01651|M.leprae_Br4923 ASYRAAVDHKGQPTVILAKTIKGYALGKHFESRNATHQMKKLTLEDLKEF MAV_2196|M.avium_104 AAYRAAVDHKGQPTVILAKTIKGYSLGAHFQGRNATHQMKKLALEDLKHF MMAR_3334|M.marinum_M AAYRAAVDHKGQPTVILAKTIKGYSLGAHFQGRNATHQMKKLALADLKRF MUL_1308|M.ulcerans_Agy99 AAYRAAVDHKGQPTVILAKTIKGYSLGAHFQGRNATHQMKKLALADLKRF *:*:** :****************:** :*:.**********:* *** * MAB_1884c|M.abscessus_ATCC_199 RDKQRIPISDAQLEENPYLPPYYHPGPEAPEIRYMLDRRRALGGFVPSRR TH_1339|M.thermoresistible__bu RDAMRIPISDEQLEENPYLPPYYHPGPEAPEIRYMLERRRALGGFVPERR MSMEG_4323|M.smegmatis_MC2_155 RDVTRVPVSDAQLEEDPYLPPYYHPGPEAPEIRYLLERRRALGGFVPSRR Mflv_2781|M.gilvum_PYR-GCK RDVQRIPVSDSQLEENPYLPPYYHPGPEAPEIRYMLDRRRALGGFLPERR Mvan_3752|M.vanbaalenii_PYR-1 RDAQRIPVSDEQLEADPYLPPYYHPGPEAPEIRYMLDRRRALGGFLPERR Mb2265|M.bovis_AF2122/97 RDTQRIPVSDAQLEENPYLPPYYHPGLNAPEIRYMLDRRRALGGFVPERR Rv2241|M.tuberculosis_H37Rv RDTQRIPVSDAQLEENPYLPPYYHPGLNAPEIRYMLDRRRALGGFVPERR MLBr_01651|M.leprae_Br4923 RDTQRIPISDTELEENPYLPPYYHPGPDSPEIRYLLDRRRALGGFLPERR MAV_2196|M.avium_104 RDAMRIPISDAQLDENPYLPPYYHPGSDAPEIRYMLDRRRTLGGFLPERR MMAR_3334|M.marinum_M RDSMRIPVSDAQLDEDPYLPPYYHPGSDAPEIRYMLDRRRTLGGFLPERP MUL_1308|M.ulcerans_Agy99 RDSMRIPVSDAQLDEDPYLPPYYHPGSDAPEIRYMLDRRRTLGGFLPERP ** *:*:** :*: :********** ::*****:*:***:****:*.* MAB_1884c|M.abscessus_ATCC_199 TTSRPLTLPGSETYASIKKGSGKQEVATTMALVRTFKELLRDKNIGNRIV TH_1339|M.thermoresistible__bu TTSKALRIPGSDIFRSVRKGSGNQEVATTMATVRTFREVLRDKELGWRIV MSMEG_4323|M.smegmatis_MC2_155 TKSKPLALPGSDTYKALKKGSGSQAVATTMATVRTFKELLRDKNIGPRIV Mflv_2781|M.gilvum_PYR-GCK TKTKALTLPGRDTYKALKKGSGKQEVATTMATVRTFKELLRDKNIGWRIV Mvan_3752|M.vanbaalenii_PYR-1 TKSRALTLPGRDVYKALKKGSGKQEVATTMATVRTFKELLRDKNIGSRIV Mb2265|M.bovis_AF2122/97 TKSKALTLPGRDIYAPLKKGSGHQEVATTMATVRTFKEVLRDKQIGPRIV Rv2241|M.tuberculosis_H37Rv TKSKALTLPGRDIYAPLKKGSGHQEVATTMATVRTFKEVLRDKQIGPRIV MLBr_01651|M.leprae_Br4923 TKSGALTLPGRDTYAALKTGSGQQEVATTMAIVRTFKEVLRHKEVGPRIV MAV_2196|M.avium_104 TKAKALRLPGRDIYAALKKGSGTQEVATTMATVRTFKEVLRDKEIGPRIV MMAR_3334|M.marinum_M TKAKTLTLPGPDAYKVLKKGSGQQEVATTMALVRTFKELLRDKNIGNRIV MUL_1308|M.ulcerans_Agy99 TKAKTLTLPGPDAYKVLKKGSGQQEVATTMALVRTFKELLRDKNIGNRIV *.: .* :** : : ::.*** * ****** ****:*:**.*::* *** MAB_1884c|M.abscessus_ATCC_199 PIIPDEARTFGMDSWFPSLKIYNRNGQLYTSVDAELMLAYKESAQGQILH TH_1339|M.thermoresistible__bu PIIPDEARTFGMDSWFPSLKIYNPNGQLYTSVDADLMLAYKESEAGQILH MSMEG_4323|M.smegmatis_MC2_155 PIIPDEARTFGMDSWFPSLKIYNRNGQLYTSVDSELMLAYKESEVGQILH Mflv_2781|M.gilvum_PYR-GCK PIIPDEARTFGMDSWFPSLKIYNRNGQLYTAVDAELMLAYKESEVGQILH Mvan_3752|M.vanbaalenii_PYR-1 PIIPDEARTFGMDSWFPSLKIYNRNGQLYTAVDAELMLAYKESEIGQILH Mb2265|M.bovis_AF2122/97 PIIPDEARTFGMDSWFPSLKIYNRNGQLYTAVDADLMLAYKESEVGQILH Rv2241|M.tuberculosis_H37Rv PIIPDEARTFGMDSWFPSLKIYNRNGQLYTAVDADLMLAYKESEVGQILH MLBr_01651|M.leprae_Br4923 PIIPDEARTFGMDSWFPSLKIYNHNGQLYTAVDAQLMLAYKESEVGQILH MAV_2196|M.avium_104 PIIPDEARTFGMDSWFPSLKIYNRNGQLYTAVDAELMLAYKESEVGQILH MMAR_3334|M.marinum_M PIIPDEARTFGMDSWFPSLKIYNRNGQLYTAVDAELMLAYKESHVGQILH MUL_1308|M.ulcerans_Agy99 PIIPDEARTFGMDSWFPSLKIYNRNGQLYTAVDAELMLAYKESHVGQILH *********************** ******:**::******** ***** MAB_1884c|M.abscessus_ATCC_199 EGINEAGSTASFTAVGTAYSTHDEPMIPLYIFYSMFGFQRTGDGLWAAAD TH_1339|M.thermoresistible__bu EGINEAGSSASFIAAGTSYATHNEPMIPIYIFYSMFGFQRTGDNLWAAGD MSMEG_4323|M.smegmatis_MC2_155 EGINEAGSTSSFTAVGTSYSTHDEPMIPIYIFYSMFGFQRTGDGLWAAAD Mflv_2781|M.gilvum_PYR-GCK EGINEAGSTASFTAVGTSYATHNEPMIPIYIFYSMFGFQRTGDGLWAAAD Mvan_3752|M.vanbaalenii_PYR-1 EGINEAGSTASFTAVGTSYATHNEPMIPIYIFYSMFGFQRTGDGLWAAAD Mb2265|M.bovis_AF2122/97 EGINEAGSVGSFIAAGTSYATHNEPMIPIYIFYSMFGFQRTGDSFWAAAD Rv2241|M.tuberculosis_H37Rv EGINEAGSVGSFIAAGTSYATHNEPMIPIYIFYSMFGFQRTGDSFWAAAD MLBr_01651|M.leprae_Br4923 EGIDEAGSVGSFIAAGTSYSTHNEPMIPIYIFYSMFGFQRTGDGLWAAAD MAV_2196|M.avium_104 EGINEAGSVGSFIAAGTSYATHNEPMIPIYIFYSMFGFQRTGDGLWAAAD MMAR_3334|M.marinum_M EGINEAGSVGSFTAAGTSYATHNEPMIPIYIFYSMFGFQRTGDSFWAAAD MUL_1308|M.ulcerans_Agy99 EGINEAGSVGSFTAAGTSYATHNEPMIPIYIFYSMFGFQRTGDSFWAAAD ***:**** .** *.**:*:**:*****:**************.:***.* MAB_1884c|M.abscessus_ATCC_199 QMARGFVLGATAGRTTLTGEGLQHADGHSLLLASTNPAVVAYDPAFAYEI TH_1339|M.thermoresistible__bu QMARGFLLGATAGRTTLVGEGLQHADGHSLLLASTNPAVVAYDPAFAYEI MSMEG_4323|M.smegmatis_MC2_155 QMARGFVLGATAGRTTLTGEGLQHADGHSLLLASTNPAAVTYDPAFAYEI Mflv_2781|M.gilvum_PYR-GCK QMARGFVLGATAGRTTLVGEGLQHADGHSLLLAATNPAVVSYDPAFAFEI Mvan_3752|M.vanbaalenii_PYR-1 QMARGFVLGATAGRTTLVGEGLQHADGHSLLLASTNPAVVAYDPAFAYEI Mb2265|M.bovis_AF2122/97 QMARGFVLGATAGRTTLTGEGLQHADGHSLLLAATNPAVVAYDPAFAYEI Rv2241|M.tuberculosis_H37Rv QMARGFVLGATAGRTTLTGEGLQHADGHSLLLAATNPAVVAYDPAFAYEI MLBr_01651|M.leprae_Br4923 QMARGFLLGATAGRTTLTGEGLQHADGHSLLLAATNPAVVTYDPAFAYEI MAV_2196|M.avium_104 QMTRGFLLGATAGRTTLTGEGLQHADGHSLLLAATNPAVVAYDPAFAYEI MMAR_3334|M.marinum_M QMARGFVLGATAGRTTLTGEGLQHADGHSLLLAATNPAVVSYDPAFAYEL MUL_1308|M.ulcerans_Agy99 QMARGFVLGATAGRTTLTGEGLQHADGHSLLLAATNPAVVSYDPAFAYEL **:***:**********.***************:****.*:******:*: MAB_1884c|M.abscessus_ATCC_199 AHIVEHGLQRMYGENSENVYFYITLYNEPYVQPAEPENVDTEGILRGIYK TH_1339|M.thermoresistible__bu AHIVESGLHRMYGENPENVFFYLTIYNEPYRQPAEPEDLDVEGLLRGIYR MSMEG_4323|M.smegmatis_MC2_155 AHIIESGLQRMYGEDPENVFFYLTIYNEPYQQPAEPENLDVEALLKGLYL Mflv_2781|M.gilvum_PYR-GCK AYIIESGLQRMYGDNPENVYFYMTIYNEPYVQPAEPEGIDVEGLLRGMYR Mvan_3752|M.vanbaalenii_PYR-1 AYIIESGLHRMYGENPENVYFYMTIYNEPYVQPAEPDGLDVEGLLRGMYR Mb2265|M.bovis_AF2122/97 AYIVESGLARMCGENPENIFFYITVYNEPYVQPPEPENFDPEGVLRGIYR Rv2241|M.tuberculosis_H37Rv AYIVESGLARMCGENPENIFFYITVYNEPYVQPPEPENFDPEGVLRGIYR MLBr_01651|M.leprae_Br4923 AYIVESGLTRMFGEDPENVFFYITVYNEPYPQPPEPENFDPDGVLRGMYR MAV_2196|M.avium_104 AYIVESGLARMFGENPEDVYFYITVYNEPYVQPPEPENFDPEGLLRGLYR MMAR_3334|M.marinum_M AYIIENGLSRMFGENPENIYFYITVYNEPYVQPAEPENFDPEGVLRGMYR MUL_1308|M.ulcerans_Agy99 AYIIENGLSRMFGENPENIYFYITVYNEPYVQPAEPENFDPEGVLRGMYR *:*:* ** ** *::.*:::**:*:***** **.**:..* :.:*:*:* MAB_1884c|M.abscessus_ATCC_199 FRAAPEARTHRANILASGVSVPDALRAADLLAEQWDVAADVWSVTSWGEL TH_1339|M.thermoresistible__bu YRRAPQKRTHTAQILASGVAMPEALRAADLLAEDWDVAADVWSVTSWGEL MSMEG_4323|M.smegmatis_MC2_155 YRPAPEKRAKSAQILASGVAMPEALRAADLLASDWDVAADVWSVTSWGEL Mflv_2781|M.gilvum_PYR-GCK YQAAPQKKSNSAQILVSGVSMPSALKAAEMLAEEWDVSADVWSVTSWGEL Mvan_3752|M.vanbaalenii_PYR-1 YQAAPEKRTNAAQILVSGVGMPSALKAAELLAQEWDVAADVWSVTSWGEL Mb2265|M.bovis_AF2122/97 YHAATEQRTNKAQILASGVAMPAALRAAQMLAAEWDVAADVWSVTSWGEL Rv2241|M.tuberculosis_H37Rv YHAATEQRTNKAQILASGVAMPAALRAAQMLAAEWDVAADVWSVTSWGEL MLBr_01651|M.leprae_Br4923 YYTAKEQRSNKAHILASGVSMPAALTAAEMLSTQWDVAADVWSVTSWGEL MAV_2196|M.avium_104 YHVATEQRANKAQILASGVAMPSALSAAKMLADEWDVAADVWSVTSWGEL MMAR_3334|M.marinum_M YRAATKQCAHKAQLLASGVSMPDALKAAQMLADEWDVATDVWSVTSWSEL MUL_1308|M.ulcerans_Agy99 YRAATKQCAHKAQLLASGVSMPDALKAAQMLADEWDVATDVWSVTSWSEL : * : :: *::*.***.:* ** **.:*: :***::********.** MAB_1884c|M.abscessus_ATCC_199 NRDGLAIDHQALRHPDRPKGVPYVTKALEGAQ----GPKVAVSDWMHAVP TH_1339|M.thermoresistible__bu NRDGVTIEKQRLRHPDQPADTPYVTRALADAS----GPVVAVSDWMRAVP MSMEG_4323|M.smegmatis_MC2_155 NREGVAIEKHRLRHPDEPAGTPHVTSALADAA----GPVIAVSDWMRAVP Mflv_2781|M.gilvum_PYR-GCK NREGVAIEKERLRHPDREVATPYVTEALAGAE----GPVVAVSDWMRAVP Mvan_3752|M.vanbaalenii_PYR-1 NRDGVAIEREKLRHPELPAATPYVTKMLAEAA----GPVVAVSDWMRAVP Mb2265|M.bovis_AF2122/97 NRDGVAIETEKLRHPDRPAGVPYVTRALENAR----GPVIAVSDWMRAVP Rv2241|M.tuberculosis_H37Rv NRDGVAIETEKLRHPDRPAGVPYVTRALENAR----GPVIAVSDWMRAVP MLBr_01651|M.leprae_Br4923 NRDGMSIETARLRYPDQPTSVPYVTQVLSEARSDNAGPVIAVSDWMRAVP MAV_2196|M.avium_104 NRDGVAIDRARLRHPDRPAGVPYVTQALSDAS----GPVVAVSDWMRAVP MMAR_3334|M.marinum_M NRDGVSVERHRLRHPGEPAGVAYVTTALEGTS----GPVVAVSDWMRAVP MUL_1308|M.ulcerans_Agy99 NRDGVSVERHRLRHPGEPAGVAYVTTALEGTS----GPVVAVSDWMRAVP **:*:::: **:* ..:** * : ** :******:*** MAB_1884c|M.abscessus_ATCC_199 EQIRPWVPGMYRTLGADGFGISDTRPAARRFFNTDAESVVVAVLEALADE TH_1339|M.thermoresistible__bu EQIRAWVPGTYITLGTDGFGFSDTRPAARRYFNTDAESVAVAVLEGLARD MSMEG_4323|M.smegmatis_MC2_155 EQIRPWVPGTYVTLGTDGFGFSDTRPAARRYFNTDAESVVVAVLQGLARD Mflv_2781|M.gilvum_PYR-GCK EQIRPWVPGTYVTLGTDGFGFSDTRPAARRYYNTDAESIVVAVLEGLARD Mvan_3752|M.vanbaalenii_PYR-1 EQIRPWVPGTYITLGTDGFGFSDTRPAARRYYNTDAESVVVAVLEGLARD Mb2265|M.bovis_AF2122/97 EQIRPWVPGTYLTLGTDGFGFSDTRPAARRYFNTDAESQVVAVLEALAGD Rv2241|M.tuberculosis_H37Rv EQIRPWVPGTYLTLGTDGFGFSDTRPAARRYFNTDAESQVVAVLEALAGD MLBr_01651|M.leprae_Br4923 EQIRPWVPGTYVTLGTDGFGFSDTRTATRRYFNTDAESQVVAVLEALARD MAV_2196|M.avium_104 EQIRPWVPGTYVTLGTDGFGFSDTRPAARRYFNTDAESQVVAVLEALARD MMAR_3334|M.marinum_M EQIRPWVPGTYVTLGTDGFGFSDTRPAARRYFNTDAESQVVAVLEALARD MUL_1308|M.ulcerans_Agy99 EQIRPWVPGTYVTLGTDGFGFSNTRPAARRYFNTDAESQVVAVLEALARD ****.**** * ***:****:*:**.*:**::****** .****:.** : MAB_1884c|M.abscessus_ATCC_199 GSVDRQVAVTAAAQYKIDDVSAADVSYKDTGSA--- TH_1339|M.thermoresistible__bu GNLDRSVAVEAARRYRIDDVMAAPEQTSDPGVA--- MSMEG_4323|M.smegmatis_MC2_155 GEIDASVAAQAAEQYRIDDVSAAGVSYADTGSA--- Mflv_2781|M.gilvum_PYR-GCK GNIDISAAVDAARRYEIDDVMAAPEQTSDPGVA--- Mvan_3752|M.vanbaalenii_PYR-1 GNIDISVAVEAAKKYEIDDVMAAPEQTSDPGVA--- Mb2265|M.bovis_AF2122/97 GEIDPSVPVAAARQYRIDDVAAAPEQTTDPGPGA-- Rv2241|M.tuberculosis_H37Rv GEIDPSVPVAAARQYRIDDVAAAPEQTTDPGPGA-- MLBr_01651|M.leprae_Br4923 GEIDPSVPVAATRQYQIDDVQAAPEQTSDPGPGVQN MAV_2196|M.avium_104 GEIDPSVPVAAARQYRIDDVLAAPEQTSDPGVA--- MMAR_3334|M.marinum_M GEIDESVAVTAARQYRIDDVQAAPKQTSDSGVA--- MUL_1308|M.ulcerans_Agy99 GEIDESMAVTAARQYRIDDVQAAPKQTSDSGVA--- *.:* . .. *: :*.**** ** . *.* .