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MTYVITQPDILTTAAADIADIRSAIGVANAAAASPTTAMMAAAGDEVSQLIAKLFSAYGQECQAVITDAA VFHDHFAATLAAAGSVYTQAEAAGTATLSQALTTLSSPIRALLGGTAASTSGAMAAAAPMAAAGDPIYTL VVGGSGNPIPSPAYISNVVSKFVAPYFPVDPALVQGLFTPAQFYIDTGIKTLPLNVSVPQGVAILTNTLV GTNPPYLGLLTSGNTVNVTGDSQSAMIASLVMRALNPTNSGAAGSPYFDDLTFSLFGNPMNPNGGLFARF PGLSLPSMGLDFYGSTPDNSFPTNVFTLEYDGAADFPRYPINFLADLNAFLGIQSLHGQYPSLTPEQLDT AIPLTNTVGPTSTNYYMIPSPHLPLLDPVRAIPVIGTPIADLIEPDLRYLVNWGYGDPAYGWSTSPPNVP TPFGVLPPLQATTSLPGYLAIGTQQGVNAFVSDINAEISAYSNLPSTLLSAPLGASGAGGTLLAGLSPAT FSPNDFIHFLQSANTTIVNDISNTAANTYAFLLPTADIANALVTSVPSYDLNLFLSGIEQAINGDPAGGL VYAFGAPIAANIALGTLAGGFELRAFLGVASQFL
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_3984 | - | - | 100% (594) | PPE family protein |
M. marinum M | MMAR_0369 | - | e-163 | 53.57% (603) | PE family protein |
M. marinum M | MMAR_3467 | - | e-149 | 49.33% (596) | PE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0156c | PE1 | 1e-116 | 43.27% (587) | PE family protein |
M. gilvum PYR-GCK | Mflv_1918 | - | 2e-26 | 31.86% (317) | hypothetical protein Mflv_1918 |
M. tuberculosis H37Rv | Rv0151c | PE1 | 1e-116 | 43.27% (587) | PE family protein |
M. leprae Br4923 | MLBr_01232 | - | 6e-10 | 27.54% (236) | hypothetical protein MLBr_01232 |
M. abscessus ATCC 19977 | MAB_4141 | - | 2e-22 | 29.14% (350) | PE/PPE family protein |
M. avium 104 | MAV_0534 | - | 2e-13 | 39.80% (98) | PE family protein |
M. smegmatis MC2 155 | MSMEG_2737 | - | 5e-30 | 31.08% (399) | PPE family protein |
M. thermoresistible (build 8) | TH_3724 | - | 5e-38 | 36.42% (335) | PUTATIVE putative PE-PPE, C-terminal domain protein |
M. ulcerans Agy99 | MUL_0967 | - | 1e-125 | 47.15% (562) | PE family protein |
M. vanbaalenii PYR-1 | Mvan_4726 | - | 1e-30 | 32.46% (305) | hypothetical protein Mvan_4726 |
CLUSTAL 2.0.9 multiple sequence alignment Mflv_1918|M.gilvum_PYR-GCK ------------------MGKGDFGLKASEFTGRSSTRFADSVRRRPGGA Mvan_4726|M.vanbaalenii_PYR-1 ------------------------------------------MRRRLRSA TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_3984|M.marinum_M --------------------------------------MTYVITQPDILT MUL_0967|M.ulcerans_Agy99 ------------------------------------MAVIDLLASPQAMT Mb0156c|M.bovis_AF2122/97 MAPFGFTPKARHNRGVALRSTYRLDRWVMGPVDKEGWGLSYVFAQPSVLA Rv0151c|M.tuberculosis_H37Rv MAPFGFTPKARHNRGVALRSTYRLDGWVMGPVDKEGWGLSYVFAQPSVLA MAV_0534|M.avium_104 --------------------------------------MSFLMVRPEILD MAB_4141|M.abscessus_ATCC_1997 ---------------------------------------------MAGQY MSMEG_2737|M.smegmatis_MC2_155 -------------------------------------------MGTHARS MLBr_01232|M.leprae_Br4923 ---------------------------------------------MKRLL Mflv_1918|M.gilvum_PYR-GCK TYGLYRHDGLGVGTWAWVFARSSRSFPRSRRCWRYPRGVPTPVAVLVANT Mvan_4726|M.vanbaalenii_PYR-1 AWGLLSLVIAVLFAWGSVVTSTS-----------------------AGAG TH_3724|M.thermoresistible__bu ------VVAVGALTWGGXGVASPAG--------------------QPERA MMAR_3984|M.marinum_M TAAADIADIRSAIGVANAAAASPTTAMMAAAGDEVSQLIAKLFSAYGQEC MUL_0967|M.ulcerans_Agy99 ATATEVAEIGLAINQADLAVAGPTTGLAAAAAAEVSEAIATLFDNYAQGY Mb0156c|M.bovis_AF2122/97 AAATDLAGIGSAINQATAAVAAPTTGLAAAAADEVSTALATLFGAYGQQF Rv0151c|M.tuberculosis_H37Rv AAATDLAGIGSAINQATAAVAAPTTGLAAAAADEVSTALATLFGAYGQQF MAV_0534|M.avium_104 AAARELHGINAAVLQSNSAAVTPTTALAPAAADVVSLVTAARFSRHGLAF MAB_4141|M.abscessus_ATCC_1997 SVPGKRHSLRRYVATITAVAAT------------------------CTVL MSMEG_2737|M.smegmatis_MC2_155 VSRTLLITLVVVIGTVALAFAST-----------------------ISSA MLBr_01232|M.leprae_Br4923 ATTLAALTVGTVSGFGSTVASSEPG---------------EPWLPPSPVP Mflv_1918|M.gilvum_PYR-GCK TALVMGGTFHPLTGPRDSPEFVTAYLDNAVDNQIS-AAYGY--------- Mvan_4726|M.vanbaalenii_PYR-1 TALVMGGNGHPLSVPQDTPDYINKYVTAADDAFIAPSGLCG--------- TH_3724|M.thermoresistible__bu AALRLTATADAIIMPGTKIGYIPSQDEFTAYATAVIGATAG--------- MMAR_3984|M.marinum_M QAVITDAAVFHDHFAATLAAAGSVYTQAEAAGTATLSQALTTLSSPIRAL MUL_0967|M.ulcerans_Agy99 QAVSRQTAAFHDAFAQTLFAASDSYVRAEAAAVKALAGLTEPVANLFAPV Mb0156c|M.bovis_AF2122/97 QAISAQVAAFHNEFTQRLAAAANAFVNAEATNTSALVQEAT--------- Rv0151c|M.tuberculosis_H37Rv QAISAQVAAFHNEFTQRLAAAANAFVNAEATNTSALVQEAT--------- MAV_0534|M.avium_104 QEVSAQAAQLRDQFATTLGISAGSYAAAEIANTAAVG------------- MAB_4141|M.abscessus_ATCC_1997 APLAMESRTIASTLASYVIGIGGNNDGASANIPRKLGGAYS--------- MSMEG_2737|M.smegmatis_MC2_155 ARLVATYALIVPGTGTPNPAVVQNYMENAVNHYLVPGGDCVG-------- MLBr_01232|M.leprae_Br4923 VRENSPAKIVYALGGARPPTFDWDYYTIRAGDEFFPDVNRK--------- Mflv_1918|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_4726|M.vanbaalenii_PYR-1 -------------------------------------------------- TH_3724|M.thermoresistible__bu -------------------------------------------------- MMAR_3984|M.marinum_M LGG--TAASTSGAMAAAAPMAAAGDPIYTLVVGGSGNPIPSPAYISNVVS MUL_0967|M.ulcerans_Agy99 LSGPESVAASATALLSGAPLKPVEA---ALILSESGVPTPSASYISDVYT Mb0156c|M.bovis_AF2122/97 --------AGLFKPTSPPVLPPMFNQNTAIIMGGTGSPIPTPSYVNAITT Rv0151c|M.tuberculosis_H37Rv --------AGLFKPTSPPVLPPMFNQNTAIIMGGTGSPIPTPSYVNAITT MAV_0534|M.avium_104 -------------------------------------------------- MAB_4141|M.abscessus_ATCC_1997 -------------------------------------------------- MSMEG_2737|M.smegmatis_MC2_155 -------------------------------------------------- MLBr_01232|M.leprae_Br4923 -------------------------------------------------- Mflv_1918|M.gilvum_PYR-GCK ---------AVTNAVAVYTPEEFFPLG---GLTFDDSVAEGLANLGRCLR Mvan_4726|M.vanbaalenii_PYR-1 ---------PQCSLVATYTPAQIRFVNGIFDMTYDESVAVGQANLNDCIQ TH_3724|M.thermoresistible__bu ---------APGAVDYLGVPGEFWPATGLDSLTFDASVAXGQAMLTPMVD MMAR_3984|M.marinum_M KFVAPYFPVDPALVQGLFTPAQFYIDTGIKTLPLNVSVPQGVAILTNTLV MUL_0967|M.ulcerans_Agy99 KYVEPNFPSATAP-QGVSTPNGLYPFTGIKDLSLDISLARGATILNDAIL Mb0156c|M.bovis_AF2122/97 LFIDP--VVSNPVVKALVTPEELYPITGVKSLPFQTSVQLGLQILDGAIW Rv0151c|M.tuberculosis_H37Rv LFIDP--VVSNPVVKALVTPEELYPITGVKSLPFQTSVQLGLQILDGAIW MAV_0534|M.avium_104 -------------------------------------------------- MAB_4141|M.abscessus_ATCC_1997 -----------VDYHPVSYPGAIWPVSGLTAPTFKTSVAQGRTNLNDEIV MSMEG_2737|M.smegmatis_MC2_155 ----GCEPPIAVPYIAQFWPIPLPGWGGLEGAKWNVSVGSGVTSLTTRYN MLBr_01232|M.leprae_Br4923 -------LIDYPARAPFRYVPTFLVPGPRDEVTIGEAIAVATKNLNQAIH Mflv_1918|M.gilvum_PYR-GCK AEPGCVFNADPAVAARVGTVAPRHDDTFVVFGYSQSAAVASLLKRQLIDA Mvan_4726|M.vanbaalenii_PYR-1 GSD-CTATLAPYSETGPHTVA---DSTYVIYAYSQSATVAANQKLQLIAH TH_3724|M.thermoresistible__bu GAIES-------------------DTPIVVFGHSQSAVIATKEKQRLLAE MMAR_3984|M.marinum_M GTNPPYLGLLTSGN------------TVNVTGDSQSAMIASLVMRALNPT MUL_0967|M.ulcerans_Agy99 QQ----LAALPAGS------------SVAVLGYSQSAVLSSRVMPKLLAE Mb0156c|M.bovis_AF2122/97 EQ-------INAGN------------HVTVFGYSQSAVIASLEMQHLISL Rv0151c|M.tuberculosis_H37Rv EQ-------INAGN------------HVTVFGYSQSAVIASLEMQHLISL MAV_0534|M.avium_104 -------------------------------------------------- MAB_4141|M.abscessus_ATCC_1997 TAG---------------------NQPITIVGYSLGAVVVSKSHSDLLQR MSMEG_2737|M.smegmatis_MC2_155 NVLVN--------------PDFTDTDDISIFGYSQGATVASIVKGNLDNP MLBr_01232|M.leprae_Br4923 RG----------------------TEPAAVVGLSQGSLALDTEQEQLATD Mflv_1918|M.gilvum_PYR-GCK PGP-----EPAATTFMLAANPMRPNGGVLGRFPAL-----TIPILGITFH Mvan_4726|M.vanbaalenii_PYR-1 P-------VASTVSFLLVANPNRPDGGILERFVGA-----YIPLLGITFN TH_3724|M.thermoresistible__bu YPDPD---TAPDVTFVMVANPNRPNGGLLARFPGL-----YIPILGVTFN MMAR_3984|M.marinum_M NSGAAGSPYFDDLTFSLFGNPMNPNGGLFARFPGL-----SLPSMGLDFY MUL_0967|M.ulcerans_Agy99 GVTSS------QVNFVLLGNPMNPNGGVLARFPDL-----TLPSLGFTFY Mb0156c|M.bovis_AF2122/97 GPNAPSPS---QLNFILIGNEMNPNGGILARIPGL-----NVTTLGLPFY Rv0151c|M.tuberculosis_H37Rv GPNAPSPS---QLNFILIGNEMNPNGGILARIPGL-----NVTTLGLPFY MAV_0534|M.avium_104 -------------------------------------------------- MAB_4141|M.abscessus_ATCC_1997 YPGGN-----PNIQFVLMGSANTPNGGIFARFPWL-----KIPLADIESN MSMEG_2737|M.smegmatis_MC2_155 DNADH-------LNFFFIGNPQRPNGGFFERLAFLG----TVPVLDATFG MLBr_01232|M.leprae_Br4923 PTAPP----PDQLTFNTFGDPSGYHGFGKSVLASIFRPGDYIPLIDYTMP Mflv_1918|M.gilvum_PYR-GCK GATPTAGVDG---AYRTVDVVRQYDGLGGDFPVRPLNLLATVNALLGYGI Mvan_4726|M.vanbaalenii_PYR-1 GSTPTFSPQPR--PLTTVDVARQYDGWA-DFPTNPLNLLADLNAIMGTIL TH_3724|M.thermoresistible__bu GATPAPADGP----FDSYDVAREFDGWA-DFPRYPLNLVATANAILGIYY MMAR_3984|M.marinum_M GSTPDN-------SFPTNVFTLEYDGAA-DFPRYPINFLADLNAFLGIQS MUL_0967|M.ulcerans_Agy99 GATPDN-------AFPTVSYTLEYDGFA-DFPRYPINLLADINAVMGIPF Mb0156c|M.bovis_AF2122/97 GATPDN-------PYPTTTYTLEYDGFA-DFPRYPLNVLSDINAVFGILT Rv0151c|M.tuberculosis_H37Rv GATPDN-------PYPTTTYTLEYDGFA-DFPRYPLNVLSDINAVFGILT MAV_0534|M.avium_104 -------------------------------------------------- MAB_4141|M.abscessus_ATCC_1997 GAWEPD-------QFKTKVINTEYDTYG-DFPAY-FNPLALANSIAAIQY MSMEG_2737|M.smegmatis_MC2_155 NPTPTDTCEHSDGTHCATDFALMYDGVV-DFPAYPLNLLATANALAGFWY MLBr_01232|M.leprae_Br4923 QRMDSQ--------YDSNRVVAAYDGLS-EFPDRADNLLAQLNCFAGGAI Mflv_1918|M.gilvum_PYR-GCK MHG-ETVDVPFAQARFQG-----------------------------REG Mvan_4726|M.vanbaalenii_PYR-1 LHP-NYSDA--GTPQLQG-----------------------------QYQ TH_3724|M.thermoresistible__bu LHG-GYYELLTENPDILDDPERT---------------------IVQQYG MMAR_3984|M.marinum_M LHG-QYPSLTPEQLDTAIPLTN-----------------------TVGPT MUL_0967|M.ulcerans_Agy99 VHA-DYQDLTQAQLDSAVQLP------------------------TEGPT Mb0156c|M.bovis_AF2122/97 VHT-TYADLTPAQIASATQLP------------------------TQGTT Rv0151c|M.tuberculosis_H37Rv VHT-TYADLTPAQIASATQLP------------------------TQGTT MAV_0534|M.avium_104 -------------------------------------------------- MAB_4141|M.abscessus_ATCC_1997 AHPDAYYDRIDPAALDDPDNPNV---------------------VKTVQG MSMEG_2737|M.smegmatis_MC2_155 VHG-TYLAPDDDEPPTATPYGYTPDEVKTAIEAANAPDGCTAANHCQRHG MLBr_01232|M.leprae_Br4923 SHTPSGFFNPEDVPPQNIRTTVN-----------------------SRGA Mflv_1918|M.gilvum_PYR-GCK DTDYYLIGTDLLPLLQPL--LLFVP------RPILSALDAPLRVLVEDAY Mvan_4726|M.vanbaalenii_PYR-1 DSTYYLIPAPITPVLVPLTWVPIVG------KPLAIALDPAVRVLVEMGY TH_3724|M.thermoresistible__bu DTTYYLIRTEQLPLLRPLR-DLGVP------EEFVDALEPYVRRIVDLGY MMAR_3984|M.marinum_M STNYYMIPSPHLPLLDPVRAIPVIG------TPIADLIEPDLRYLVNWGY MUL_0967|M.ulcerans_Agy99 QSTYYMIPTEHLPLLAPLRFIPYVG------DPLAELLEPNLRVLVNFGY Mb0156c|M.bovis_AF2122/97 SNTYYIIETEHLPLLAPLRAIPVIG------PPLAALVEPNLEVIVNLGY Rv0151c|M.tuberculosis_H37Rv SNTYYIIETEHLPLLAPLRAIPVIG------PPLAALVEPNLEVIVNLGY MAV_0534|M.avium_104 -------------------------------------------------- MAB_4141|M.abscessus_ATCC_1997 NTTYYLVRAEHLPLLQPLRDLTNPIGA----SFVLDAIEPTLRVFIDMAY MSMEG_2737|M.smegmatis_MC2_155 DTIYVTLPAKTLPIMQPLLDLGAATGTSALIIPIVDLISPLTQTLIETGY MLBr_01232|M.leprae_Br4923 KTTTYLIPVNHLPLTLPLRYLGWSD-------ALVDQIDAVLQPKIDAAY Mflv_1918|M.gilvum_PYR-GCK DR------DAGPGDPTTARWWP-VKDFAGTAAKLIASVPVAVDNLTEGFG Mvan_4726|M.vanbaalenii_PYR-1 DR------TVNPGQPTPARYLY-VPNLIKAALNFAMAIPTGWDDAISYLT TH_3724|M.thermoresistible__bu DR------NTPYGEPAPVRVLPPLTPAPGPATQHNAGQGITVASATS--- MMAR_3984|M.marinum_M GDPAYGWSTSPPNVPTPFGVLPPLQATTSLPGYLAIGTQQGVNAFVSDIN MUL_0967|M.ulcerans_Agy99 GDPAYGYDTGPANVPTPFGLFPPVSPLT-VAEHLAAGTQQGIVNSGAALQ Mb0156c|M.bovis_AF2122/97 GDPRFGYSTSPANVPTPFGLFPDVPASV-VADALVAGTQQGVNDFMVELP Rv0151c|M.tuberculosis_H37Rv GDPRFGYSTSPANVPTPFGLFPDVPASV-VADALVAGTQQGVNDFMVELP MAV_0534|M.avium_104 -------------------------------------------------- MAB_4141|M.abscessus_ATCC_1997 DR------DTGPGTTTQFSFFTPSKNIVDAFNKLPTAIAEGAHNVENGLA MSMEG_2737|M.smegmatis_MC2_155 DR-------TNYGRPTPAGLIP-RINLVKLVSDLINDIPEGINAALTPGL MLBr_01232|M.leprae_Br4923 AYN-----DNPLNKPISVDPVNGMDPIAGIDAELRDSILNVFAQLRSILP Mflv_1918|M.gilvum_PYR-GCK LG---RVLGTPVPG-VFGVGGP------DLPDVDEGGAVTSDIDEDAVAQ Mvan_4726|M.vanbaalenii_PYR-1 GDPDCRPFHTTVPASPFGVGGPPVYTGAIDPYGEPTPYLAPPVETHGEAA TH_3724|M.thermoresistible__bu ------------------------------TPDKRTPVVEAPVEEPPVQT MMAR_3984|M.marinum_M AEISAYSNLPSTLL---------------SAPLGASGAGGTLLAGLSPAT MUL_0967|M.ulcerans_Agy99 AQGPPSIPLSDIAH---------------TLTANPPWAGTPALPPSTSPA Mb0156c|M.bovis_AF2122/97 AALN-------------------------TLPQTPMPAFPPYVPTLLPPP Rv0151c|M.tuberculosis_H37Rv AALN-------------------------TLPQTPMPAFPPYVPTLLPPP MAV_0534|M.avium_104 -------------------------------------------------- MAB_4141|M.abscessus_ATCC_1997 GATPKQSASPEKPASPPVPQPGPTNPGSATTQIPAPEAPTPSVVSLSTAE MSMEG_2737|M.smegmatis_MC2_155 TPLPGSTGPTVTATVQAPAPKTGDTENRIQAVTDVVGKDTNKVDVKTTDT MLBr_01232|M.leprae_Br4923 PPPG---------------------------------------------- Mflv_1918|M.gilvum_PYR-GCK RDSASSTERSAPAEESRSAVGGADSDGRD-----------DVVDPEPAAP Mvan_4726|M.vanbaalenii_PYR-1 PGSGSPAAHPAGTEPPETVTFSPTTESTP-----------STLLPETPAE TH_3724|M.thermoresistible__bu GRSTLKREKPVSARHLVRNSLRAVPGLRR-----------GEP------- MMAR_3984|M.marinum_M FSPNDFIHFLQSANTTIVNDISNTAANTY-----------AFLLPTADIA MUL_0967|M.ulcerans_Agy99 SSIEDFILAVQAANSSISRGFVKTLSTAY-----------ATLLPTTDIA Mb0156c|M.bovis_AF2122/97 PPPQ------PATLINIADTFASVVSTGY-----------SILLPTADLG Rv0151c|M.tuberculosis_H37Rv PPPQ------PATLINIADTFASVVSTGY-----------SILLPTADLG MAV_0534|M.avium_104 -------------------------------------------------- MAB_4141|M.abscessus_ATCC_1997 PPAPPASAKAADPTAISVSTAGASTARDQDFQPDTKPDPKSTPPPTKDSV MSMEG_2737|M.smegmatis_MC2_155 GTEPVQPTDQPTDQGTVTGDVTAAAAPEVTAP----ADTDAVETPKANGK MLBr_01232|M.leprae_Br4923 -------------------------------------------------- Mflv_1918|M.gilvum_PYR-GCK ---------EAETSEAETVTETEADDADDAD------------------- Mvan_4726|M.vanbaalenii_PYR-1 SEDMPPDFVENDTPDSDEVSPTEDDALKDTETINESQDGPTESASGVSGE TH_3724|M.thermoresistible__bu ----------AATPTPDVTPDVTPDAPAGQP------------------- MMAR_3984|M.marinum_M NALVTSVPSYDLNLFLSGIEQAINGDPAGGL---------------VYAF MUL_0967|M.ulcerans_Agy99 SELVFTLPSYNLNLFLDGVIQAINGQPIGD-------------------- Mb0156c|M.bovis_AF2122/97 LAFVTILPAYDLTLFVNQLAAGNLRAAIELP---------------LAAT Rv0151c|M.tuberculosis_H37Rv LAFVTILPAYDLTLFVNQLAAGNLRAAIELP---------------LAAT MAV_0534|M.avium_104 -------------------------------------------------- MAB_4141|M.abscessus_ATCC_1997 GEADKSKNTLKPTLRLPKLPVAQPGTAPKSPKFPSLKN-HLKSVPGLSEK MSMEG_2737|M.smegmatis_MC2_155 PLIRISPIAKPNEGMTAGTGTSGKAQPPSLRKALGIKGHPVRDLVKSVSK MLBr_01232|M.leprae_Br4923 -------------------------------------------------- Mflv_1918|M.gilvum_PYR-GCK DGADADDEDIDADGADADGEDTAGNTAEAA------- Mvan_4726|M.vanbaalenii_PYR-1 DAADADSRSADADSLSADAGDSAPADAAAADTAA--- TH_3724|M.thermoresistible__bu --EPAEPNESAAPPAAAEADDASE------------- MMAR_3984|M.marinum_M GAPIAANIALGTLAGGFELRAFLGVASQFL------- MUL_0967|M.ulcerans_Agy99 ------------------------------------- Mb0156c|M.bovis_AF2122/97 IGLAALGGMIEFIAIVVTLADITQQLQSFSI------ Rv0151c|M.tuberculosis_H37Rv IGLAALGGMIEFIAIVVTLADITQQLQSFSI------ MAV_0534|M.avium_104 ------------------------------------- MAB_4141|M.abscessus_ATCC_1997 KNPAADASSKHSQPANAPAHTSDKTSDHASETGRGAA MSMEG_2737|M.smegmatis_MC2_155 ALGIDRPAKGGSNPKKATTDAKDTKAASDAKDAA--- MLBr_01232|M.leprae_Br4923 -------------------------------------