For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
RPLRLRIKGLRSFRSEVEINFSELALVAIVGDTGAGKSSILEAITYALYNATTWEQRGVKQLISDGATTM TVQLDFACDGQRYRITRSTSRGQYPPPGHLLEYLSDPTIRPLDGEEAIKREIFRLVGLDWKGFTSAVILP QGSFQTLLQAPPADRTEILKGIFRLHELGLVREQAQTLAGEYRGSLEKLQADRVQLLPDPKAAANEAAGR KRKAEKFANKLREFRTQVTEQQKAANMQTEAAARLRDTATLVEQANTHPAAALQALRPVLEELDKRAVGL DRDERKLQRSDERASAAIERAEAAGESEATLARAQTVLSRLLSDLPELAAEKTRLEEERQALELEAKQLV SDEESLQLLRAAALEKERALKTIEKEVLAASNALQKASERLEEYRRLALEERTAAKTLAALEVEQQGAEK NLAKARAAEHQARSEAETAAAALAHIQRKHAAAHAAQGLGPGDGCPICGQTIPAGFKPPRAQRERAASKT NEDARRVQTEARDVRVKLEERCRQLGESIDQARTTSQTASRATKNAFRGLRAALGDADADPDVSKAALLE ELTTRLHKQEAAAAKARGKAEAARLAFERRAAALQPRRDALSTRRQALERSNVKHSKQAEALAADRLTLP ERFRPAANASVDRMGSVAERLRKRLDEVSGIRLERERIQRRFAELRSERNALAERRQEDFESPRRRLEQA ALMLHSRLSDAAEIAHTEAPSFPESDIDFGAFVEAVAALEASAARVLDGLHGRASDADQAAERARQTIGT LLAKADAPTIDALDEQLIAARATFTRAKDDEVYAREQIPKVVALEEKLGPLREAIGTLDTLASMLTDGRF IGFVVARRQRALLGVASEIFGSMTGMRYGFAEDFRIIDRISGQPRGARTLSGGETFLASLSLALGLVELA ARSGGRLEALFLDEGFGSLDADALQEALGELERRAATGRLVAVISHIRAVAESIESVLRVNYRPEGSEIL LMTGTEREEFVSEEIEHGLLA*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. marinum M | MMAR_3599 | - | - | 100% (1002) | chromosome partition ATPase protein |
M. marinum M | MMAR_1785 | smc | 2e-13 | 21.63% (920) | chromosome partition protein Smc |
M. marinum M | MMAR_4142 | - | 5e-07 | 24.95% (517) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2946c | smc | 2e-12 | 23.19% (854) | chromosome partition protein Smc |
M. gilvum PYR-GCK | Mflv_4188 | - | 1e-15 | 22.15% (939) | chromosome segregation protein SMC |
M. tuberculosis H37Rv | Rv2922c | smc | 2e-12 | 23.07% (854) | chromosome partition protein Smc |
M. leprae Br4923 | MLBr_01629 | smc | 3e-10 | 21.85% (691) | putative cell division protein |
M. abscessus ATCC 19977 | MAB_1421 | - | 2e-11 | 21.84% (792) | hypothetical protein MAB_1421 |
M. avium 104 | MAV_3777 | smc | 2e-16 | 22.66% (940) | chromosome segregation protein SMC |
M. smegmatis MC2 155 | MSMEG_2423 | smc | 3e-15 | 22.86% (923) | chromosome segregation protein SMC |
M. thermoresistible (build 8) | TH_1853 | - | 3e-10 | 22.37% (903) | conserved hypothetical protein |
M. ulcerans Agy99 | MUL_2033 | smc | 4e-14 | 22.51% (893) | chromosome partition protein Smc |
M. vanbaalenii PYR-1 | Mvan_4435 | - | 2e-14 | 23.37% (736) | hypothetical protein Mvan_4435 |
CLUSTAL 2.0.9 multiple sequence alignment MAV_3777|M.avium_104 MYLKSLTLKGFKSFASPTTLRF-EPGITAVVGPNGSGKSNVVDALAWVMG MUL_2033|M.ulcerans_Agy99 MYLKSLTLKGFKSFAAPTTLRF-EPGITAVVGPNGSGKSNVVDALAWVMG Mb2946c|M.bovis_AF2122/97 MYLKSLTLKGFKSFAAPTTLRF-EPGITAVVGPNGSGKSNVVDALAWVMG Rv2922c|M.tuberculosis_H37Rv MYLKSLTLKGFKSFAAPTTLRF-EPGITAVVGPNGSGKSNVVDALAWVMG MLBr_01629|M.leprae_Br4923 MYLKSLTLKGFKSFASPTTLRF-EPGITAVVGPNGSGKSNVVDALAWVMG Mflv_4188|M.gilvum_PYR-GCK MHLKSLTLKGFKSFASPTTLRF-EPGITCVVGPNGSGKSNVVDALTWVMG MSMEG_2423|M.smegmatis_MC2_155 MHLKSLTLKGFKSFASPTTLRF-EPGITCVVGPNGSGKSNVVDALTWVMG TH_1853|M.thermoresistible__bu MRLHRLALTNYRGIARREVEFP-DRGVVVVSGANEIGKSSMIEALDLLFH Mvan_4435|M.vanbaalenii_PYR-1 MKLHRLALTNYRGITHRDIEFP-DRGVVVVSGPNEAGKSSMLEALDLLLE MAB_1421|M.abscessus_ATCC_1997 MKLHRLSVTNYRGITHRDITFP-ERGVVVVGGANEVGKTSMIEALDLLIE MMAR_3599|M.marinum_M MRPLRLRIKGLRSFRSEVEINFSELALVAIVGDTGAGKSSILEAITYALY * * :.. :.: : .:. : * . **:.:::*: : MAV_3777|M.avium_104 EQGAKTLRGGKMEDVIFAGTSSRAPLGRAEVTVTIDNSDNALPIEYSEVS MUL_2033|M.ulcerans_Agy99 EQGAKTLRGGKMEDVIFAGTSLRAPLGRAEVTVTIDNSDNALPIEYTEVS Mb2946c|M.bovis_AF2122/97 EQGAKTLRGGKMEDVIFAGTSSRAPLGRAEVTVSIDNSDNALPIEYTEVS Rv2922c|M.tuberculosis_H37Rv EQGAKTLRGGKMEDVIFAGTSSRAPLGRAEVTVSIDNSDNALPIEYTEVS MLBr_01629|M.leprae_Br4923 EQGAKTLRGSKMEDVIFAGTLSRAPLGRAEVTLIIDNSDNVLPIEYSEVS Mflv_4188|M.gilvum_PYR-GCK EQGAKTLRGGKMEDVIFAGTSSRAPLGRAEVTLTIDNSDNALPIEYSEVS MSMEG_2423|M.smegmatis_MC2_155 EQGAKTLRGGKMEDVIFAGTSSRAPLGRAEVTLTIDNSDNALPIEYSEVS TH_1853|M.thermoresistible__bu AKDRSTKKEVKQVKPTHADVG-------AEITAEISTGP-------YRFV Mvan_4435|M.vanbaalenii_PYR-1 SKDRSSKKEVKQVKPTHADVG-------AEVTAEISAGP-------YRFV MAB_1421|M.abscessus_ATCC_1997 SKDRSTKKDVKQVKPTFADVG-------SEVEAEISCGP-------YRFV MMAR_3599|M.marinum_M NATTWEQRGVKQLISDGATTMT------VQLDFACDGQRYRITRSTSRGQ : * * . :: . . MAV_3777|M.avium_104 ITRR----MFRDGASEYEINGSSCRLMDVQELLSDSGIGREMHVIVGQGK MUL_2033|M.ulcerans_Agy99 ITRR----MFRDGASEYEINGSSCRLMDVQELLSDSGIGREMHVIVGQGK Mb2946c|M.bovis_AF2122/97 ITRR----MFRDGASEYEINGSSCRLMDVQELLSDSGIGREMHVIVGQGK Rv2922c|M.tuberculosis_H37Rv ITRR----MFRDGASEYEINGSSCRLMDVQELLSDSGIGREMHVIVGQGK MLBr_01629|M.leprae_Br4923 ITRR----MFRDGASEYEINGSSCRLMDVQELLSDSGIGREMHVIVGQGK Mflv_4188|M.gilvum_PYR-GCK ITRR----MFRDGAGEYEINGSRCRLADVQELLSDSGIGREMHVIVGQGK MSMEG_2423|M.smegmatis_MC2_155 ITRR----MFRDGAGEYEINGASCRLMDVQELLSDSGIGREMHVIVGQGK TH_1853|M.thermoresistible__bu YHKR----FHKKCATQLTILAPRR-----EELSGDEAHERALAMLSETVD Mvan_4435|M.vanbaalenii_PYR-1 YRKR----FHKRPETELTVLTPRR-----EQLTGDEAHERVRAILAESVD MAB_1421|M.abscessus_ATCC_1997 YRKR----FHKRAETHLTVIEPRR-----EQLSGDEAHQRVLDMLDQSID MMAR_3599|M.marinum_M YPPPGHLLEYLSDPTIRPLDGEEAIKREIFRLVGLDWKGFTSAVILPQGS . : .* . . :: . MAV_3777|M.avium_104 LDEILQSRPEDRRAFIEEAAGVLKHRKRKEKALRKLDAMSANLARLTDLT MUL_2033|M.ulcerans_Agy99 LDEILQSRPEDRRAFIEEAAGVLKHRKRKEKALRKLDAMSANLARLTDLT Mb2946c|M.bovis_AF2122/97 LEEILQSRPEDRRAFIEEAAGVLKHRKRKEKALRKLDTMAANLARLTDLT Rv2922c|M.tuberculosis_H37Rv LEEILQSRPEDRRAFIEEAAGVLKHRKRKEKALRKLDTMAANLARLTDLT MLBr_01629|M.leprae_Br4923 LDQILQSRPEDRRTFIEEAAGILKYRRRKEKALRKLDAMSANLARLTDLT Mflv_4188|M.gilvum_PYR-GCK LSEILESRPEDRRAFIEEAAGVLKHRKRKEKAVRKLDSMAANLARLTDLT MSMEG_2423|M.smegmatis_MC2_155 LSEILESRPEDRRAFIEEAAGVLKHRKRKEKAVRKLDSMAANLARLTDLT TH_1853|M.thermoresistible__bu MELWRTQR-------------VLQAGSTAPVDLSGCDALSRALDAVAGEA Mvan_4435|M.vanbaalenii_PYR-1 LDLWQAQR-------------VLQSAPTSAADLSGCNALSRALDVVAGEV MAB_1421|M.abscessus_ATCC_1997 MNLWKAQR-------------VLQSAGAGVLDLSSSDALTRALDLAAGQS MMAR_3599|M.marinum_M FQTLLQAPPADRTEILKGIFRLHELGLVREQAQTLAGEYRGSLEKLQADR :. : : . * MAV_3777|M.avium_104 TELRRQLKPLGRQAEVARRAQTIQADLRDARLRLAADDLVNRRGEREAIF MUL_2033|M.ulcerans_Agy99 TELRRQLKPLGRQAEVARRAQTIQADLRDARLRLAADDVVSRRAEREAIF Mb2946c|M.bovis_AF2122/97 TELRRQLKPLGRQAEAAQRAAAIQADLRDARLRLAADDLVSRRAEREAVF Rv2922c|M.tuberculosis_H37Rv TELRRQLKPLGRQAEAAQRAAAIQADLRDARLRLAADDLVSRRAEREAVF MLBr_01629|M.leprae_Br4923 TELRRQLKPLSRQAEVARRAATIQADLRDARLRLAADDLVSRQGQRDAIV Mflv_4188|M.gilvum_PYR-GCK TELRRQLKPLGRQAEMARRAQTIQADLRDARLRLAADDLVARKAEFDDTD MSMEG_2423|M.smegmatis_MC2_155 TELRRQLKPLGRQAEMARRAATIQADLRDARLRLAADDLVRRQVEFQNTN TH_1853|M.thermoresistible__bu VQTSGT--------------EPLLIDRIDAEYRKYFTATGRPTGEWLAAT Mvan_4435|M.vanbaalenii_PYR-1 DDVSATGAGN---------VESLLVDRVEEEYRRYFTSTGRATGEWAAAT MAB_1421|M.abscessus_ATCC_1997 VALSGS--------------EPDLVERIDAEYALYFTGTGRPTGEWARAG MMAR_3599|M.marinum_M VQLLPDPKAAAN----EAAGRKRKAEKFANKLREFRTQVTEQQKAANMQT : . MAV_3777|M.avium_104 EAEAAMRREHDEASARLAVASEELAAHEKALGELSGRAESVQQTWFALSA MUL_2033|M.ulcerans_Agy99 EAEATMRREHDEAAARLTVAAEELAAHEATLAELTSRAESVQHTWFGLSA Mb2946c|M.bovis_AF2122/97 QAEAAMRREHDEAAARLAVASEELAAHESAVAELSTRAESIQHTWFGLSA Rv2922c|M.tuberculosis_H37Rv QAEAAMRREHDEAAARLAVASEELAAHESAVAELSTRAESIQHTWFGLSA MLBr_01629|M.leprae_Br4923 EAETMMRRDHDEAAARLAVASEELAAHEAALTELSGRAESVQQIWFGLST Mflv_4188|M.gilvum_PYR-GCK QAETTLRREHDELTERLQERAAELDAHETAVEDLSERADAAQQRWFRLSA MSMEG_2423|M.smegmatis_MC2_155 QAETALRKEHEELTVRLQSATVELQAHEAAVAELTRRAEAAQQTWFRASA TH_1853|M.thermoresistible__bu KRLQAADEQVARCAARVAEVEDAVRRHATLTESLAELEDGRRTADAQLAA Mvan_4435|M.vanbaalenii_PYR-1 ARLRAADEEVARCAAAMAEVDEAVRRHAALTTDMAQLAVETASAAERLQS MAB_1421|M.abscessus_ATCC_1997 ARLTAAEDALASARAAMAEVDQQVREHDELTQELASVIADRAEVNRRLAP MMAR_3599|M.marinum_M EAAARLRDTATLVEQANTHPAAALQALRPVLEELDKRAVGLDRDERKLQR : .: MAV_3777|M.avium_104 LAERVAATVRIASERAQHLDLGPVTAGDTDP---DALDAEAERVAAAEQQ MUL_2033|M.ulcerans_Agy99 LAERVGTTVRIANERAQHLDVEPVTNSDTDP---DALDAEAEQVAIAEQQ Mb2946c|M.bovis_AF2122/97 LAERVDATVRIASERAHHLDIEPVAVSDTDPRKPEELEAEAQQVAVAEQQ Rv2922c|M.tuberculosis_H37Rv LAERVDATVRIASERAHHLDIEPVAVSDTDPRKPEELEAEAQQVAVAEQQ MLBr_01629|M.leprae_Br4923 LVERVSATIRIAGERAYHLDVDPATPSDTDP---DVLEAEAQQMEVAEQQ Mflv_4188|M.gilvum_PYR-GCK LAERVSATVRIASERAQHLDGDPDFSAGPDP---DELEAQADAVAEQEQQ MSMEG_2423|M.smegmatis_MC2_155 LAERVGATVRIATDRAQMLDSEPEMSSGRDP---DALEAEAEEVAELEAQ TH_1853|M.thermoresistible__bu AREAAEAVERLTRQLAEAQ----------------LAAEAAEATHTASVA Mvan_4435|M.vanbaalenii_PYR-1 ARNAAAAVAVLQGELDQAT----------------ARAEAARSVHAASKA MAB_1421|M.abscessus_ATCC_1997 LEEASQAVTTLVQQHDNAV----------------VVAEAAQAAAVAAQT MMAR_3599|M.marinum_M SDERASAAIERAEAAGESE----------------ATLARAQTVLSRLLS : :. * MAV_3777|M.avium_104 LLAELAAARSRLETARAELAEREREAAEADRAHMAAVRAEADRREGLARL MUL_2033|M.ulcerans_Agy99 LLVELAEARDRLDAARAELADREHRAAEADRAHLAAVRAEADRREGLARL Mb2946c|M.bovis_AF2122/97 LLAELDAARARLDAARAERADRERRAAEADRAHLAAVREEADRREGLARL Rv2922c|M.tuberculosis_H37Rv LLAELDAARARLDAARAELADRERRAAEADRAHLAAVREEADRREGLARL MLBr_01629|M.leprae_Br4923 LLAELAVARTQLEAARAELADRERHAVEADKAHLEAVRAEADRREGLALL Mflv_4188|M.gilvum_PYR-GCK LLDELAESQERLEAAREELAEREQAAAEAERAHMAAARAEADRREGLARL MSMEG_2423|M.smegmatis_MC2_155 LLDELSEARIALETARAELAEREQIAADAERAHMAAARAEADRREGLARL TH_1853|M.thermoresistible__bu ALNERRRLRAEIEERTAAVAALQPEVDAALEAEATAREVQQEADTAAERA Mvan_4435|M.vanbaalenii_PYR-1 ALAQRRRARADLDERSATVTSLQTESDTAADELDTANEMQVAAEEAAGKA MAB_1421|M.abscessus_ATCC_1997 KRDERAQLVADIRARRVSIDMLAEQLSATAEAHGTAQQVCEAAEAAAAQA MMAR_3599|M.marinum_M DLPELAAEKTRLEEERQALELEAKQLVSDEESLQLLRAAALEKERALKTI : : . MAV_3777|M.avium_104 AGQVETMR---ARVESIDDSVARLSERIEAAAARAQQAKAEFETVQGRVG MUL_2033|M.ulcerans_Agy99 AGQVETMR---ARVESIDDSVARLSERIEHAAARAQQTRAEFETVQARVG Mb2946c|M.bovis_AF2122/97 AGQVETMR---ARVESIDESVARLSERIEDAAMRAQQTRAEFETVQGRIG Rv2922c|M.tuberculosis_H37Rv AGQVETMR---ARVESIDESVARLSERIEDAAMRAQQTRAEFETVQGRIG MLBr_01629|M.leprae_Br4923 AGQVETMR---ARIESIDDSVARLSERIEEVTARTQQILAEFETVQGRVG Mflv_4188|M.gilvum_PYR-GCK SGQVDTMR---TRVESVDETVARLTANIDDAAARAQLTQAEFETVQARVG MSMEG_2423|M.smegmatis_MC2_155 AGQVDTMR---TRVESIDEGVLRLSVSIEEAAAKAEHAQAEFEDVQSRVG TH_1853|M.thermoresistible__bu REAADAAR---ERVDTARQAVQRLADRAERDTLADRLRRIDAAATELARV Mvan_4435|M.vanbaalenii_PYR-1 RSALAACQ---ERVDAARVAVQRLADREEADRLTGRIATIERHGRELEAV MAB_1421|M.abscessus_ATCC_1997 TESVDAAR---VQLEAARGTLDRALARDEVDGLAARVSRIDLTNRQLASV MMAR_3599|M.marinum_M EKEVLAASNALQKASERLEEYRRLALEERTAAKTLAALEVEQQGAEKNLA : : . * : : MAV_3777|M.avium_104 ELDQGEVGLDEHHERTVAALRLADERVAELQAAERDAERKVASLRARIDA MUL_2033|M.ulcerans_Agy99 ELDQGEVGLDEQHERTVAALRLAEQRLAELQVAERDAERQVASLRARIGA Mb2946c|M.bovis_AF2122/97 ELDQGEVGLDEHHERTVAALRLADERVAELQSAERAAERQVASLRARIDA Rv2922c|M.tuberculosis_H37Rv ELDQGEVGLDEHHERTVAALRLADERVAELQSAERAAERQVASLRARIDA MLBr_01629|M.leprae_Br4923 ELDQSEVHLDEQHERAVAALRFANERVAELQSAERDAERQVVSLRARIDA Mflv_4188|M.gilvum_PYR-GCK ELDAGEVGLDEHHDRSVAALRLADERVAELLAAERAAERQVASLQARIDA MSMEG_2423|M.smegmatis_MC2_155 ELDAGEVGLDEHHDRTVAALRLADERVAELQAAERAAERQVASLRARIEA TH_1853|M.thermoresistible__bu DGELATLTVTEAALRQIEAAELAVERAAGQAELASAHIELTAAVDLELRV Mvan_4435|M.vanbaalenii_PYR-1 QRDLTAITLTDALLADIETAAAAVERATAAVEQTSAHIEVTAAADVEVRI MAB_1421|M.abscessus_ATCC_1997 GAELSSLVITAQSLGAIETAARAVGMAEAALETASAQVELRALVDVDIAV MMAR_3599|M.marinum_M KARAAEHQARSEAETAAAALAHIQRKHAAAHAAQGLGPGDGCPICGQTIP : MAV_3777|M.avium_104 LAVGLERKDGTAWLTENHSGAGILGPMAKLVKVRSGYEAAVAAVLGSAAD MUL_2033|M.ulcerans_Agy99 LSVGLDRKDGAAWLARNHSDAGLFGSVAQLVKVRSGYEAAVAAVLGSAAE Mb2946c|M.bovis_AF2122/97 LAVGLQRKDGAAWLAHNRSGAGLFGSIAQLVKVRSGYEAALAAALGPAAD Rv2922c|M.tuberculosis_H37Rv LAVGLQRKDGAAWLAHNRSGAGLFGSIAQLVKVRSGYEAALAAALGPAAD MLBr_01629|M.leprae_Br4923 LTMGLERKDGAAWLARNYSDTGLLGSIAKLVKVRPGYEAALAAVLGPAAD Mflv_4188|M.gilvum_PYR-GCK LSVGLDRRDGAAWLQENHSGAGLFGSIANLVKVRAGHEAAIAAMLGAAAD MSMEG_2423|M.smegmatis_MC2_155 LSVGLDRRDGAAWLQKNHSGGGLFGSIGDFLRVQPGYEVAVAAVLGAAAD TH_1853|M.thermoresistible__bu GDEQLTIPAGGSWTAGATAPTEIELPGLLTARIVPGAPAAQMQETLDVAR Mvan_4435|M.vanbaalenii_PYR-1 GDADMTLRAGDTWAAAVGTATGIDLPGVLSVQVIPGASAAATAAALDTAA MAB_1421|M.abscessus_ATCC_1997 NGEQLRVAAGDRWSSAATDTIEITAPGVAVARIIPGPNAAQLRDKLDTAR MMAR_3599|M.marinum_M AGFKPPRAQRERAASKTNEDARRVQTEARDVRVKLEERCRQLGESIDQAR . :: * MAV_3777|M.avium_104 ALAADGLGAARSALGALKQADGGRAALVLGDWP--ADPPAPQ--PAPAGA MUL_2033|M.ulcerans_Agy99 ALAADSFGAARSAVTALKQADGGRAALVLGDWPDAHDHRAAG--GLPSGT Mb2946c|M.bovis_AF2122/97 ALAVDGLTAAGSAVSALKQADGGRAVLVLSDWPAPQAPQSASGEMLPSGA Rv2922c|M.tuberculosis_H37Rv ALAVDGLTAAGSAVSALKQADGGRAVLVLSDWPAPQAPQSASGEMLPSGA MLBr_01629|M.leprae_Br4923 ALAVDSLGAARSALTALKEADAGRATLVLADWLADAGPACVT--GLPDGA Mflv_4188|M.gilvum_PYR-GCK ALAAEDFGAARAAVAALKESDGGRAALVLGDWP---AQEAVT-GQLPAGA MSMEG_2423|M.smegmatis_MC2_155 ALAAENFGAAAAAVAALKESDGGRAAIVLGDWN---AIGSSPQAALPPGA TH_1853|M.thermoresistible__bu AALADALQHAG--------------------------------------- Mvan_4435|M.vanbaalenii_PYR-1 ARLADALRAAG--------------------------------------- MAB_1421|M.abscessus_ATCC_1997 QTLSGALADAG--------------------------------------- MMAR_3599|M.marinum_M TTSQTASRATKNAFRGLRAALG---------------------------- : MAV_3777|M.avium_104 LWALDLIDAPERLRGAITAMLSGVAVVDDLDRALALVAEHPRLRAVTLDG MUL_2033|M.ulcerans_Agy99 LWALDLIEVPSRLRPAMTAMLSGVVVVNDLSEALDLVQAQPQLRAVTLDG Mb2946c|M.bovis_AF2122/97 QWALDLVESPPQLVGAMIAMLSGVAVVNDLTEAMGLVEIRPELRAVTVDG Rv2922c|M.tuberculosis_H37Rv QWALDLVESPPQLVGAMIAMLSGVAVVNDLTEAMGLVEIRPELRAVTVDG MLBr_01629|M.leprae_Br4923 QRALDLIEAPPWLQGALIAMLYGVVVVNYLAEALGVVDICPQLRVVTVDG Mflv_4188|M.gilvum_PYR-GCK AWAVDLVEPADRVRGAVTAMLSGVAVVENLTAALDLVAAQPRLRAVTADG MSMEG_2423|M.smegmatis_MC2_155 TWATDLVSVPDRLRGAVTAMLTGVAVVPDMAAGLALVSSRPELRAVTTEG TH_1853|M.thermoresistible__bu -------------------------------------------------- Mvan_4435|M.vanbaalenii_PYR-1 -------------------------------------------------- MAB_1421|M.abscessus_ATCC_1997 -------------------------------------------------- MMAR_3599|M.marinum_M -------------------------------------------------- MAV_3777|M.avium_104 DLVGAGWVSGGSDRKLSTLEVTSEIDKASAELAAAEAQVAQLSAALSGAL MUL_2033|M.ulcerans_Agy99 DLVGAGWVSGGSDRKPSTLEITSEIDKARRELAAAEVRVAELGAALSGAL Mb2946c|M.bovis_AF2122/97 DLVGAGWVSGGSDRKLSTLEVTSEIDKARSELAAAEALAAQLNAALAGAL Rv2922c|M.tuberculosis_H37Rv DLVGAGWVSGGSDRKLSTLEVTSEIDKARSELAAAEALAAQLNAALAGAL MLBr_01629|M.leprae_Br4923 DLVGAGWVSGGSGRRLSTLEVTSEIDKAGAELAAAEAHMAQLNAALSGAL Mflv_4188|M.gilvum_PYR-GCK DLVGAGWVSGGSDRKPSTLEIQSEVDRARSELVDAERRTGELSAALSGAL MSMEG_2423|M.smegmatis_MC2_155 DLVGPGWVSGGSDRKPSTLEIASEIDKARAELEQAERQTSELGAALSGAL TH_1853|M.thermoresistible__bu ---------------VADVASARSQVERRRELSTARETFAATVVALTGED Mvan_4435|M.vanbaalenii_PYR-1 ---------------VDDVEAARALDRRRHELSAAGRQIRAILEALAADD MAB_1421|M.abscessus_ATCC_1997 ---------------VADVGEAQKQFERRTELNAERDRLTALLDGLMGPE MMAR_3599|M.marinum_M ----DADADPDVSKAALLEELTTRLHKQEAAAAKARGKAEAARLAFERRA . .: MAV_3777|M.avium_104 AEQAARQDSAEQALAALNESDSAISGMYEQLGRLGQEARTSEDEWSRLLR MUL_2033|M.ulcerans_Agy99 TDQTARQDAAEQALAALNESDTAISAMYEQLGRIGQDARGAEEEWTRLLR Mb2946c|M.bovis_AF2122/97 TEQSAGQDAAEQALAALNESDTAISAMYEQLGRLGQEARAAEEEWNRLLQ Rv2922c|M.tuberculosis_H37Rv TEQSARQDAAEQALAALNESDTAISAMYEQLGRLGQEARAAEEEWNRLLQ MLBr_01629|M.leprae_Br4923 SEQVAHSDATEQALVALNESDTAILSMYDQLGRLGQEVRAAEAEWESLLA Mflv_4188|M.gilvum_PYR-GCK AEQAARQDAAEHALAALNESDAAISAIYEQLGRLGQDARAADDEWQRLIR MSMEG_2423|M.smegmatis_MC2_155 AEQSARQDAAEQALAALNESDAAISAIYEQLARLGQEARGAHQEWQRLIK TH_1853|M.thermoresistible__bu TLERLRARLAELDAAA--------SDDTGELG------------------ Mvan_4435|M.vanbaalenii_PYR-1 SVDQLRARLADLQARTPAEEGLFDTDTRGSLD------------------ MAB_1421|M.abscessus_ATCC_1997 SLEALREKLSRLRELVP-----EATGLWDAID------------------ MMAR_3599|M.marinum_M AALQPRRDALSTRRQALERSNVKHSKQAEALAADRLTLPER--------- : . : MAV_3777|M.avium_104 QREELEAGRTQTVAEVTELENRLRNAQETPQEPAAEP---VNRQQIAAAT MUL_2033|M.ulcerans_Agy99 QREELEVGRTQTLEEVLELESRLRNAQESQHVQAAEP---VDRQEIAAAA Mb2946c|M.bovis_AF2122/97 QRTEQEAVRTQTLDDVIQLETQLRKAQETQRVQVAQP---IDRQAISAAA Rv2922c|M.tuberculosis_H37Rv QRTEQEAVRTQTLDDVIQLETQLRKAQETQRVQVAQP---IDRQAISAAA MLBr_01629|M.leprae_Br4923 QREELEARRVSILEEVVELETRLHNVEQIQHVHALDENSAAARQLIVAAA Mflv_4188|M.gilvum_PYR-GCK QRDEMEAGRNRTVSELAELELRLQNAQREP-MFDAEV---VDRTEFTAAA MSMEG_2423|M.smegmatis_MC2_155 QRDELEAGRTKTVEELRELESRLSNAEQTP-MFDIEP---VDRQETVAAA TH_1853|M.thermoresistible__bu -------------------------------------------------V Mvan_4435|M.vanbaalenii_PYR-1 -------------------------------------------------P MAB_1421|M.abscessus_ATCC_1997 -------------------------------------------------P MMAR_3599|M.marinum_M -----------------------------------------------FRP MAV_3777|M.avium_104 DAARSAEVEARLAVRTAEERANAVRGRADSLRRAAAAEREARVRAQQARE MUL_2033|M.ulcerans_Agy99 ESARAIEVEARLTVRTAEERANALRGRADSLRRVAAAEREARVRAELARA Mb2946c|M.bovis_AF2122/97 DRARGVEVEARLAVRTAEERANAVRGRADSLRRAAAAEREARVRAQQARA Rv2922c|M.tuberculosis_H37Rv DRARGVEVEARLAVRTAEERANAVRGRADSLRRAAAAEREARVRAQQARA MLBr_01629|M.leprae_Br4923 EEARGVEVEALLAVRTAEERVNAVCGRANSLRRAAAAEREVRLRDQQAHA Mflv_4188|M.gilvum_PYR-GCK EAARSAEVEARLSVRTAEERANAVRGRADSLRRAAVAEREARVRAQRARE MSMEG_2423|M.smegmatis_MC2_155 EAARAVEVEARLAVRTAEERANAVRGRADSLRRAAAAEREARVRAQRARE TH_1853|M.thermoresistible__bu DDAQAELTAAERAYQQAHTDCETHR------KAAVLAARRLAEKSQTAAA Mvan_4435|M.vanbaalenii_PYR-1 AAQRLELVEATAAHQQAIRDCETHR------KVAEEAAKLSAKRGLHAAR MAB_1421|M.abscessus_ATCC_1997 AQARAEVARLVGEVERLQAEEVTHR------RAVQTAGQQLAEKAAEAMA MMAR_3599|M.marinum_M AANASVDRMGSVAERLRKRLDEVSGIRLERERIQRRFAELRSERNALAER . . : . : * MAV_3777|M.avium_104 ARLRAAAVAAAVADSGRLLATRLNAVVAAASRIRDALAAERQQRATAMTA MUL_2033|M.ulcerans_Agy99 VRLRSAAVAAAVAESGRLLAWRLNRVVDAASQLRDELAAERQQRSAAMSA Mb2946c|M.bovis_AF2122/97 ARLHAAAVAAAVADCGRLLAGRLHRAVDGASQLRDASAAQRQQRLAAMAA Rv2922c|M.tuberculosis_H37Rv ARLHAAAVAAAVADCGRLLAGRLHRAVDGASQLRDASAAQRQQRLAAMAA MLBr_01629|M.leprae_Br4923 ARIRAAAVAAAVTDCGQLLASRLTQAVDLAARHRDALATERQQRSVAIAA Mflv_4188|M.gilvum_PYR-GCK ARVHAAAVAAAVAESGRAVAQRLADAVSVASRIRDEVAAERQVRAGALTK MSMEG_2423|M.smegmatis_MC2_155 AREYAARVAAAVSECGRQIAGKLSAVVAAAARSRDELATERQLRVNALGE TH_1853|M.thermoresistible__bu LREKLTAARTELDTAAARLAAQRADVDDETLVVRAAAHG----------- Mvan_4435|M.vanbaalenii_PYR-1 LLEKLQAAQAELAAAGARLAEQRAATSDDELAVKAEADA----------- MAB_1421|M.abscessus_ATCC_1997 AREKHAARAEELAAAEQRLAHVRSSASDDLLTERHERAV----------- MMAR_3599|M.marinum_M RQEDFESPRRRLEQAALMLHSRLSDAAEIAHTEAPSFPESD----IDFGA : . : . MAV_3777|M.avium_104 VRDEVNALSARVAALTDSLHRDEVANAQAALRIEQLEQMVLEQFGMAPAD MUL_2033|M.ulcerans_Agy99 VREETSSLSARVATLTDSLHRDEVANAQAALRIEQVEQMVLEQFGMAPSD Mb2946c|M.bovis_AF2122/97 VRDEVNTLSARVGELTDSLHRDELANAQAALRIEQLEQMVLEQFGMAPAD Rv2922c|M.tuberculosis_H37Rv VRDEVNTLSARVGELTDSLHRDELANAQAALRIEQLEQMVLEQFGMAPAD MLBr_01629|M.leprae_Br4923 VRYEVNTLRVRLATLTDSLHRDEVANVQAALRIEQLEQLVLEQFGIAPVD Mflv_4188|M.gilvum_PYR-GCK AREEVNELTARITALTDALHRDEVAKAQAALRIEQLEQQVLEQFGMAVAD MSMEG_2423|M.smegmatis_MC2_155 IREEVTALNNRINTLTDALHRDEMAKAQAQLRIEQLEAQVLEQFGMSAGD TH_1853|M.thermoresistible__bu --EEAERAAVRVAQLNAELSAAQPDQVAAALDTAARHAETVHAEHRRTAD Mvan_4435|M.vanbaalenii_PYR-1 --EAAAAAEAAVARVGAELAGHEPEAVAAALVDAERAAAEVGARHHEVGE MAB_1421|M.abscessus_ATCC_1997 --QAADLTSRRVTDLVSQLAALEADRVRAELAEVSARAQALDRRHEATRD MMAR_3599|M.marinum_M FVEAVAALEASAARVLDGLHGRASDADQAAERARQTIGTLLAKADAPTID . : * * : : MAV_3777|M.avium_104 LIAEYGPHIALPPSELEMAEYEQAKERGEQVFAPAPIPFDRPTQERRAKR MUL_2033|M.ulcerans_Agy99 LVAEYGPDVALPPTELEMAEFEQARERGEQVVAPAPMPFDRATQQRRAKR Mb2946c|M.bovis_AF2122/97 LITEYGPHVALPPTELEMAEFEQARERGEQVIAPAPMPFDRVTQERRAKR Rv2922c|M.tuberculosis_H37Rv LITEYGPHVALPPTELEMAEFEQARERGEQVIAPAPMPFDRVTQERRAKR MLBr_01629|M.leprae_Br4923 LIAEYGPQVALLPTELEMAEFQQARERGEQVTSPAPMPYDRATQERRAKR Mflv_4188|M.gilvum_PYR-GCK LVAEYGPDVALPPSELEMAEYEQARERGEQVTAPAPMPYDRPTQERRAKR MSMEG_2423|M.smegmatis_MC2_155 LVAEYGPQVALPPSELEMAEYEQAKERGEQVTAPAPMPFDRATQERRAKR TH_1853|M.thermoresistible__bu ALRELNAQLEVYGSEGRKGELDAAKA-------------EREQAEAEFLR Mvan_4435|M.vanbaalenii_PYR-1 ALREIAAQLKVYGTEGRKGGLDAAET-------------ERGRAEAEFVR MAB_1421|M.abscessus_ATCC_1997 RLRDISVRLEVFGRQGRQDQLDAAAS-------------EREYAATEFAR MMAR_3599|M.marinum_M ALDEQLIAARATFTRAKDDEVYAREQIP-----------KVVALEEKLGP : : . . . . MAV_3777|M.avium_104 AERELAELGRVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLGVVDEV MUL_2033|M.ulcerans_Agy99 AERELTELGRVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLDVVADV Mb2946c|M.bovis_AF2122/97 AERALAELGRVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLGVVADV Rv2922c|M.tuberculosis_H37Rv AERALAELGRVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLGVVADV MLBr_01629|M.leprae_Br4923 AERELAELGRVNPLALEEFAALEERYNFLSTQLEDVKGARKDLLDVVAEV Mflv_4188|M.gilvum_PYR-GCK AERELKELGRVNPLALEEFAALEERYNFLSTQLEDVKAARKDLLDVIAEV MSMEG_2423|M.smegmatis_MC2_155 AERELAELGRVNPLALEEFAALEERYNFLSTQLEDVKAARADLLDVIADV TH_1853|M.thermoresistible__bu IGRLARAVKLLRETMLRHRDASRRRY------------------------ Mvan_4435|M.vanbaalenii_PYR-1 VQRRARAAELLRSVMGRHRDAMRQRY------------------------ MAB_1421|M.abscessus_ATCC_1997 IGAKARAVDTLRSVMMRHRDGMRLRY------------------------ MMAR_3599|M.marinum_M LREAIGTLDTLASMLTDGRFIG---------------------------- : MAV_3777|M.avium_104 DARILQVFSEAYTDVEREFSDVFGVLFPGGEGRLRLTDPSN-MLTTGIEV MUL_2033|M.ulcerans_Agy99 DARILQVFSDAFVDVEREFQIVFSSLFPGGEGRLRLTAPED-MLTTGIEV Mb2946c|M.bovis_AF2122/97 DARILQVFNDAFVDVEREFRGVFTALFPGGEGRLRLTEPDD-MLTTGIEV Rv2922c|M.tuberculosis_H37Rv DARILQVFNDAFVDVEREFRGVFTALFPGGEGRLRLTEPDD-MLTTGIEV MLBr_01629|M.leprae_Br4923 DARILQVFSDAFVDVEREFRGVFTSLFPGGEGRLRLTDPDD-MLTTGIEV Mflv_4188|M.gilvum_PYR-GCK DTRILQVFTEAYMDVEREFTQVFSTLFPGGEGRLLLTNPSD-MLTTGIEV MSMEG_2423|M.smegmatis_MC2_155 DNRILQVFTEAYADVEREFEQVFATLFPGGEGRLLLTDPSD-MLTTGIEV TH_1853|M.thermoresistible__bu -------VDPFRAEVERLGRIVFGDSFEVEIDSDLCIRSRT-LAGRTVDY Mvan_4435|M.vanbaalenii_PYR-1 -------VDPFRGEVERLGRIVFGDSFEVDVDSSLCIGNRT-LSGRTVPY MAB_1421|M.abscessus_ATCC_1997 -------VDPFRAELERLGRMVFGPTFEVDIDSDLSIRSRT-LEGRTVPY MMAR_3599|M.marinum_M -----FVVARRQRALLGVASEIFGSMTGMRYGFAEDFRIIDRISGQPRGA . : :* . : MAV_3777|M.avium_104 EARPPGKKITRLSLLSGGEKALTAVAMLVAIFRARPSPFYIMDEVEAALD MUL_2033|M.ulcerans_Agy99 EARPPGKKVSRLSLLSGGEKALTAVAILVAIFRARPSPFYIMDEVEAALD Mb2946c|M.bovis_AF2122/97 EARPPGKKITRLSLLSGGEKALTAVAMLVAIFRARPSPFYIMDEVEAALD Rv2922c|M.tuberculosis_H37Rv EARPPGKKITRLSLLSGGEKALTAVAMLVAIFRARPSPFYIMDEVEAALD MLBr_01629|M.leprae_Br4923 EARPSGKKVSRLSLLSGGEKSLIAVAMLVAIFKARPSPFYIMDEVEAALD Mflv_4188|M.gilvum_PYR-GCK EARPPGKKIKRLSLLSGGEKSLTAVAMLVAIFRARPSPFYVMDEVEAALD MSMEG_2423|M.smegmatis_MC2_155 EARPPGKKIKRLSLLSGGEKSLTAVAMLVAIFRARPSPFYVMDEVEAALD TH_1853|M.thermoresistible__bu ESLSGG---------AKEQLGIVARLAGAALVARDDTVPVVIDDALGFTD Mvan_4435|M.vanbaalenii_PYR-1 ESLSGG---------AKEQLGIVARLAGAALVAKEDSVPVVIDDALGFTD MAB_1421|M.abscessus_ATCC_1997 ESLSGG---------AKEQLGIVARLASAALVAPQDAVPVIIDDALGFTD MMAR_3599|M.marinum_M RTLSGGE-------TFLASLSLALGLVELAARSGGRLEALFLDEGFGSLD .: . * . .: * .:*: . * MAV_3777|M.avium_104 DTNLRRLISLFELLRARS-QLIIITHQKPTMEVADALYGVTMQGDGITAV MUL_2033|M.ulcerans_Agy99 DTNLRRLIGLFEMLRDRS-QLIIITHQKPTMEVADALYGVTMQGDGITAV Mb2946c|M.bovis_AF2122/97 DVNLRRLLSLFEQLREQS-QIIIITHQKPTMEVADALYGVTMQNDGITAV Rv2922c|M.tuberculosis_H37Rv DVNLRRLLSLFEQLREQS-QIIIITHQKPTMEVADALYGVTMQNDGITAV MLBr_01629|M.leprae_Br4923 DVNLCRLIGVFEQLRGQS-QLIIITHQKPTMEVADTLYGVTMQGDGITAV Mflv_4188|M.gilvum_PYR-GCK DVNLRRLISLFEQLRERS-QLIVITHQKPTMEVADALYGVTMQGDGITTV MSMEG_2423|M.smegmatis_MC2_155 DVNLRRLISLFEQLREKS-QLIVITHQKPTMEIADALYGVTMRGDGITTV TH_1853|M.thermoresistible__bu AERLVKMGAVFDAVGGDG-QVIVLTCSPDRYAGISDAHRIELTA------ Mvan_4435|M.vanbaalenii_PYR-1 TERLTKMAEVFDAVAGDG-QVIILTCSPQRYAGVRTAQHIELIAG----- MAB_1421|M.abscessus_ATCC_1997 SDRLERMGEVFGAVGTET-QVIVLTCSPDRYRAVTGAQRISLSA------ MMAR_3599|M.marinum_M ADALQEALGELERRAATGRLVAVISHIRAVAESIESVLRVNYRPEGSEIL * . : : ::: : MAV_3777|M.avium_104 ISQRMRGQQVDQLVTT----- MUL_2033|M.ulcerans_Agy99 ISQRIRGQQVDRLVANSS--- Mb2946c|M.bovis_AF2122/97 ISQRMRGQQVDQLVTNSS--- Rv2922c|M.tuberculosis_H37Rv ISQRMRGQQVDQLVTNSS--- MLBr_01629|M.leprae_Br4923 ISQRMRGQQVESLVTSSS--- Mflv_4188|M.gilvum_PYR-GCK ISQRMRGQ---ELVTSSS--- MSMEG_2423|M.smegmatis_MC2_155 ISQRMRGQ---ELVSNPS--- TH_1853|M.thermoresistible__bu --------------------- Mvan_4435|M.vanbaalenii_PYR-1 --------------------- MAB_1421|M.abscessus_ATCC_1997 --------------------- MMAR_3599|M.marinum_M LMTGTEREEFVSEEIEHGLLA