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VAVPKRTIVDDRWATESDLIAALQAGDGKAFRALVETLHAPLVRLAGIYVSRATAEDAVQNAWVSAVRSI GKFEGRASVRTWMFRVVLNQVHTLARKEANTVPFATAGPEVDPRPSVDPERLIDPELGPNHWRDVPVRWD LLPEQRLLSAEVRSVVVEALQQLPGAQREVVAMRDLEGWSSEETCEALGISAVNQRVLLHRGRTALRAIL EEYFHDN
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_3276 | - | - | 100% (217) | alternative RNA polymerase sigma factor |
| M. marinum M | MMAR_2997 | - | 3e-24 | 37.63% (194) | alternative RNA polymerase sigma factor |
| M. marinum M | MMAR_0426 | sigG | 2e-12 | 33.12% (154) | alternative RNA polymerase sigma factor SigG |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3941 | sigMa | 3e-12 | 29.50% (200) | RNA polymerase sigma factor SigM |
| M. gilvum PYR-GCK | Mflv_0519 | - | 3e-15 | 30.93% (194) | RNA polymerase factor sigma-70 |
| M. tuberculosis H37Rv | Rv0182c | sigG | 3e-12 | 30.77% (156) | RNA polymerase factor sigma-70 |
| M. leprae Br4923 | MLBr_01076 | sigE | 2e-08 | 29.49% (217) | RNA polymerase sigma factor SigE |
| M. abscessus ATCC 19977 | MAB_4553 | - | 2e-16 | 31.65% (158) | RNA polymerase factor sigma-70 |
| M. avium 104 | MAV_2488 | - | 1e-23 | 38.02% (192) | RNA polymerase sigma factor, sigma-70 family protein |
| M. smegmatis MC2 155 | MSMEG_0219 | - | 2e-14 | 33.33% (186) | RNA polymerase factor sigma-70 |
| M. thermoresistible (build 8) | TH_0604 | sigG | 4e-14 | 30.26% (195) | PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGG (RNA |
| M. ulcerans Agy99 | MUL_1353 | - | 1e-106 | 96.41% (195) | alternative RNA polymerase sigma factor |
| M. vanbaalenii PYR-1 | Mvan_0782 | - | 1e-32 | 41.15% (209) | ECF subfamily RNA polymerase sigma-24 factor |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3276|M.marinum_M --------------------------------MAVPKRTIVDDRWATESD
MUL_1353|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0782|M.vanbaalenii_PYR-1 --------------------------------MTGYHLAEMTTTSADEAD
MAV_2488|M.avium_104 ----------------------------------------MVTPVAVPPE
Rv0182c|M.tuberculosis_H37Rv -----MRTSPMPAKFRSVRVVVITGSVTAAPVRVSETLRRLIDVSVLAEN
MAB_4553|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_0519|M.gilvum_PYR-GCK ---------------------------------MSHPMRKLLFVTVLA--
MSMEG_0219|M.smegmatis_MC2_155 ---------------------------------MSVILRKLTTVTVLAH-
TH_0604|M.thermoresistible__bu ---------------------------------MSVMLRTLLHVTVLT--
Mb3941|M.bovis_AF2122/97 ---------------------------MPPPIGYCPAVGFGGRHERSDAE
MLBr_01076|M.leprae_Br4923 MGDGIGMEREGRWTGNTQCPLRVVPGDESPTLDGRASPEDLIITNLLSPT
MMAR_3276|M.marinum_M LIAALQAGDGKAFRALVETLHAPLVRLAGIYVS-RATAEDAVQNAWVSAV
MUL_1353|M.ulcerans_Agy99 ----MQAGDGQAFRALVETLHAPLVRLASIYVS-RATAEDAVQNAWVSAV
Mvan_0782|M.vanbaalenii_PYR-1 LIAALRARDEVAFARLVDQHTPAMLRVARGYVASHEVAEEVVQETWIALL
MAV_2488|M.avium_104 GTDAGRLVGGVPLARLVRDFHRPMLNFARTMVDSPAVAEEAVQEAWLQVL
Rv0182c|M.tuberculosis_H37Rv SGREPADERRGDFSAHTEPYRRELLAHCYRMTGSLHDAEDLVQETLLRAW
MAB_4553|M.abscessus_ATCC_1997 ---MTAHAIEDEFLSHTEQYRREILAHCYRMTGSIHDAEDLVQETYLRGW
Mflv_0519|M.gilvum_PYR-GCK ---LDEGGAKDAFLADAQKYRRELLAHCYRMTGSLHDAEDLVQETYLRAW
MSMEG_0219|M.smegmatis_MC2_155 --KLDDDSPADAFLAEAQTYRRELLAHCYRMTGSLHDAEDLVQETYLRAW
TH_0604|M.thermoresistible__bu ---APPDGGSDAFLADAEQYRRELLAHCYRMTGSLHDAEDLVQETFLRAW
Mb3941|M.bovis_AF2122/97 LLAAHVAGDRYAFDQLFRRHHRQLHRLARLTSRTSEDADDALQDAMLSAH
MLBr_01076|M.leprae_Br4923 IMSHPPPSRDDDWVEPFDALQGTAVFDATGDKATMPSWEELVRQHAARVY
. :: :::
MMAR_3276|M.marinum_M RSIGKFEGRASVRTWMFRVVLNQVHTLAR-KEANTVPFATAGPEVDPRPS
MUL_1353|M.ulcerans_Agy99 RSIGKFEGRASIRTWMFRVVLNQVHTLAR-KEANTVPFANAGPEVDPRPS
Mvan_0782|M.vanbaalenii_PYR-1 KGIDRFEGRSSLRTWLFTVMINIAKTRGL-RDRTDADVQIAAYTGG---T
MAV_2488|M.avium_104 RSSDSFQGRSSVGTWLFGIVKHTAARHRR-RESRIRRHEVLADADIEAVD
Rv0182c|M.tuberculosis_H37Rv KAYEGFAGKSSLRTWLHRIATNTCLTALEGRRRRPLPTGLGRPSADPSGE
MAB_4553|M.abscessus_ATCC_1997 KAYARFEGKSSVRTWLYRIATNTCLTALEGKQRRPLPTGLGAPSADPLDE
Mflv_0519|M.gilvum_PYR-GCK KSYDRFEGKSSVRTWLYRIATNTCLTALDGRKRRPLPSGLGGPSADPYAD
MSMEG_0219|M.smegmatis_MC2_155 KSYQGFQGRSSVRTWLYRIATNTCLTSLEGRSRRPLPSGLGTPSSAPTDQ
TH_0604|M.thermoresistible__bu KSHHKFEGKASVRTWLYKIATNACLTALDGRQRRPLPTGLGAPSSDPTDD
Mb3941|M.bovis_AF2122/97 RGAGSFRYDAAVSSWLHRIVVNACLDRLRRAKAHPT--------------
MLBr_01076|M.leprae_Br4923 WLAYRLSGNQHDAEDLTQETFIRVFRSVQNYQPGTFEGWLHRITTNLFLD
: :
MMAR_3276|M.marinum_M VDPERLIDP-ELGPNHWR--DVPVRWDLLPEQRLLSAEVRSVVVEALQQL
MUL_1353|M.ulcerans_Agy99 VDPERLIDP-ELGPNHWR--DVPVRWDLLPEQRLLSAEVRSVVVEALQKL
Mvan_0782|M.vanbaalenii_PYR-1 VDPKRFRDSDDPWPGHWKADEVPSPFPDTPEGSVLGGELLAVTRRELAKL
MAV_2488|M.avium_104 PLSGRMHPAGHPDAGHWR---VPPSRRFLPEDQTVHRELLGYLREALDAL
Rv0182c|M.tuberculosis_H37Rv LVERREVSWLEPLPDVT---DDPADPSTIVGN---RESVRLAFVAALQHL
MAB_4553|M.abscessus_ATCC_1997 LDERSEIPWLEPLP------DDATDPASIVGA---RESVRLAFVAALQHL
Mflv_0519|M.gilvum_PYR-GCK LTERHEIAWLEPIPDDPH--EDPADPSVIAES---RESVRLALIAALQHL
MSMEG_0219|M.smegmatis_MC2_155 ITEHHEVPWLEPLPDG----DDPADPSQIVGT---RESVRLAFVAALQHL
TH_0604|M.thermoresistible__bu IVAREEVPWLEPLPDD------AADPSTIVGS---RESVRLAFVAALQHL
Mb3941|M.bovis_AF2122/97 ---------------------APLEDVYPVADRTAQVETAIAVQRALMRL
MLBr_01076|M.leprae_Br4923 MVRRRARIRMDALPDDYDR--VPADEP-NPEQIYHDSRLGPDLQAALDSL
. * *
MMAR_3276|M.marinum_M PGAQREVVAMRDLEGWSSEETCEALGISAVNQRVLLHRGRTALRAILEEY
MUL_1353|M.ulcerans_Agy99 PGAQREVVAMRDLERWSSEETCEALGISAVNQRVLLHRGRTALRAILEEY
Mvan_0782|M.vanbaalenii_PYR-1 PERQRLVVTMRDVLDMDSAEVSRLLDLSPANQRVLLHRGRAAVRQALENY
MAV_2488|M.avium_104 PARQRQLVILRDLVGISAEEAAELLQLSAEAQRALLYRARGNLRNELEKR
Rv0182c|M.tuberculosis_H37Rv SPRQRAVLLLRDVLQWKSAEVADAIGTSTVAVNSLLQRARSQLQTVRPSA
MAB_4553|M.abscessus_ATCC_1997 PAKQRAVLVLREVLQWKAQEVAEAIGSTTAAVNSLLQRARAQLHEVSP-H
Mflv_0519|M.gilvum_PYR-GCK SPRQRAVLVLREVLQWKAAEVGEVIGASTAAVNSLLQRARAQLDEVAPSR
MSMEG_0219|M.smegmatis_MC2_155 SPRQRAVLVMREVLQWKASEVGEAIGASTAAVNSLLQRARAQLEAVGPNE
TH_0604|M.thermoresistible__bu PPRQRAVLLLREVLQWRAAEVAEVLNTSTAAVNSLLQRARAQLDQVGPSE
Mb3941|M.bovis_AF2122/97 PVEQRAAVVAVDMQGYSIADTSRMLGVAEGTVKSRCARARARLARLLGYL
MLBr_01076|M.leprae_Br4923 PPEFRAAVVLCDIEGLSYEEIGATLGVKLGTVRSRIHRGRQALRDYLLTA
. * : :: : : . *.* :
MMAR_3276|M.marinum_M FHDN----------------------------------------------
MUL_1353|M.ulcerans_Agy99 FHDH----------------------------------------------
Mvan_0782|M.vanbaalenii_PYR-1 LKEPV---------------------------------------------
MAV_2488|M.avium_104 YQP-----------------------------------------------
Rv0182c|M.tuberculosis_H37Rv ADRLSAPDSPEAQDLLARYIAAFEAYDIDRLVELFTAEAIWEMPPYTGWY
MAB_4553|M.abscessus_ATCC_1997 EETLLEPEDPMLREQLRQYINAFERYDVEAIAKMFTTEAIWEMPPFTGWY
Mflv_0519|M.gilvum_PYR-GCK DDQPVSPESPQAAEALAKYIAAFEDYDMDRLVELFTADAVWEMPPFDGWY
MSMEG_0219|M.smegmatis_MC2_155 DDKIEAPDSPQAQATLDRYIAAFEAYDIDKLVELFTEEAIWEMPPFDSWY
TH_0604|M.thermoresistible__bu DDELVPPESPEAQELLTRYIDAFESYDIDKLVELFTADAVWEMPPFDGWY
Mb3941|M.bovis_AF2122/97 NTGVNIRR------------------------------------------
MLBr_01076|M.leprae_Br4923 HPRDGATTDATHVKSA----------------------------------
MMAR_3276|M.marinum_M --------------------------------------------------
MUL_1353|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0782|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2488|M.avium_104 --------------------------------------------------
Rv0182c|M.tuberculosis_H37Rv QGAQAIVTLIHQQCPAYSPGDMRLISLIANGQPAAAMYMRAGD--VHLPF
MAB_4553|M.abscessus_ATCC_1997 QGGPSIAALIKEQCPAEHAGDMRLVETSANGQPAIGLYMREGDG-VHRPF
Mflv_0519|M.gilvum_PYR-GCK SGPADIIALSKYHCPAAGAGDMRFLRTTANGQPVAALYMRNPETNVHEAF
MSMEG_0219|M.smegmatis_MC2_155 QGPQAIGDLSRYKCPAEEPGDMRFLQTTANGQPAAAMYMLNRETGRHEAF
TH_0604|M.thermoresistible__bu QGPQNIVTLSKTHCPAERPGDMRLIPTTANGQPAGAMYLRNPETGTHEAF
Mb3941|M.bovis_AF2122/97 --------------------------------------------------
MLBr_01076|M.leprae_Br4923 --------------------------------------------------
MMAR_3276|M.marinum_M -----------------------------------
MUL_1353|M.ulcerans_Agy99 -----------------------------------
Mvan_0782|M.vanbaalenii_PYR-1 -----------------------------------
MAV_2488|M.avium_104 -----------------------------------
Rv0182c|M.tuberculosis_H37Rv QLHVLDMAADRVSHVVAFLDTTLFPKFGLPDSL--
MAB_4553|M.abscessus_ATCC_1997 QMHVLDVTQDGVAHVVCFFDISLFEKFGLPAELTD
Mflv_0519|M.gilvum_PYR-GCK QLHVLDLRTRGIAHVVAFMDVSLFRKFGLPETL--
MSMEG_0219|M.smegmatis_MC2_155 QLHVLDITADGISHVVAFMGEGLFKKFGLPETL--
TH_0604|M.thermoresistible__bu QMHVLAIGPGGISHVVAFH-MPSFAPFGLPDSL--
Mb3941|M.bovis_AF2122/97 -----------------------------------
MLBr_01076|M.leprae_Br4923 -----------------------------------