For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
REETEFRPKPMVEVGGRPVLWHIMKVLGHHGISDFVVCTGYKSEYIKDYFSNYGVSNLDFTITLGDQSSI KYHGSHDEFNWRVTVADTGLSTMTGGRIKRIHKYVGDEPFLCTYGDGIADVDIPALLKFHRSHGKIATVT ATQPMSRFGVIDLEQDGAVAKFREKPKTEDWINIGYFIFERGVFDYLEGDETVLEDQPLRRLAEDRQIAA FPHHGFWQPMDTFRESQLLNNLWNSGNPPWKVWE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_2334 | - | - | 100% (245) | nucleotidyltransferase |
| M. marinum M | MMAR_1277 | manB | 2e-09 | 24.68% (231) | d-alpha-D-mannose-1-phosphate guanylyltransferase ManB |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3292c | manC | 1e-11 | 24.78% (230) | mannose-1-phosphate guanyltransferase |
| M. gilvum PYR-GCK | Mflv_4734 | - | 3e-12 | 25.65% (230) | nucleotidyl transferase |
| M. tuberculosis H37Rv | Rv3264c | manB | 1e-11 | 24.78% (230) | D-alpha-D-mannose-1-phosphate guanylyltransferase MANB |
| M. leprae Br4923 | MLBr_00753 | rmlA2 | 3e-11 | 25.97% (231) | putative sugar-phosphate nucleotidyl transferase |
| M. abscessus ATCC 19977 | MAB_3611c | - | 1e-10 | 22.61% (230) | putative sugar-phosphate nucleotidyl transferase |
| M. avium 104 | MAV_4228 | - | 4e-09 | 23.38% (231) | nucleotidyl transferase |
| M. smegmatis MC2 155 | MSMEG_5979 | - | 1e-37 | 32.22% (239) | transferase |
| M. thermoresistible (build 8) | TH_0779 | rmlA2 | 8e-11 | 23.91% (230) | D-ALPHA-D-MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE MANB |
| M. ulcerans Agy99 | MUL_2610 | manB | 2e-09 | 24.68% (231) | d-alpha-D-mannose-1-phosphate guanylyltransferase ManB |
| M. vanbaalenii PYR-1 | Mvan_0216 | - | 6e-65 | 46.91% (243) | glucose-1-phosphate cytidylyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00753|M.leprae_Br4923 -MATLQVDAVVLVGGKGTRLRP-LTLSAPKPMLPTAGLPFLTHLLSRIAA
MAV_4228|M.avium_104 -MGTPEVDVVILVGGKGTRLRP-LTLSAPKPMLPTAGLPFLTHLLSRIAA
MUL_2610|M.ulcerans_Agy99 -MATNGVDAVVLVGGKGTRLRP-LTLSAPKPMLPTAGLPFLTHLLSRIAA
Mb3292c|M.bovis_AF2122/97 -MATHQVDAVVLVGGKGTRLRP-LTLSAPKPMLPTAGLPFLTHLLSRIAA
Rv3264c|M.tuberculosis_H37Rv -MATHQVDAVVLVGGKGTRLRP-LTLSAPKPMLPTAGLPFLTHLLSRIAA
TH_0779|M.thermoresistible__bu MVNPAQVDAVVLVGGQGTRLRP-LTLSAPKPMLPTAGLPFLTHLLSRIAE
Mflv_4734|M.gilvum_PYR-GCK MVNPAQVDAVVLVGGMGTRLRP-LTLSAPKPMLPTAGLPFLTHLLSRIAA
MAB_3611c|M.abscessus_ATCC_199 MSGTVKADAVILVGGQGTRLRP-LTLSAPKPMLPIAGFPFLTHVLSRVAA
MMAR_2334|M.marinum_M -------------------MRE-ETEFRPKPMVEVGGRPVLWHIMKVLGH
Mvan_0216|M.vanbaalenii_PYR-1 ------MKAVILAGGRGTRISE-ESESRPKPMVDIGGRPILWHIMKIYET
MSMEG_5979|M.smegmatis_MC2_155 ------MKVVLFCGGYGMRMRNGPGDAVPKPMQMVGPRPLIWHVMRYYAH
: **** . *.: *::
MLBr_00753|M.leprae_Br4923 AGIEHVILSTSYRDAVFEAEFG-----------------------DGSKL
MAV_4228|M.avium_104 AGIEHVILSTSYQAAVFEAEFG-----------------------DGSKL
MUL_2610|M.ulcerans_Agy99 AGIEHVVLSTSYQAGVFEAEFG-----------------------DGSKL
Mb3292c|M.bovis_AF2122/97 AGIEHVILGTSYKPAVFEAEFG-----------------------DGSAL
Rv3264c|M.tuberculosis_H37Rv AGIEHVILGTSYKPAVFEAEFG-----------------------DGSAL
TH_0779|M.thermoresistible__bu AGIEHVVLGTSYKAHVFEAEFG-----------------------DGSKF
Mflv_4734|M.gilvum_PYR-GCK AGIEHVVMGTSYKAAVFESEFG-----------------------DGSKL
MAB_3611c|M.abscessus_ATCC_199 AGIDHVVLGTSYKADVFESEFG-----------------------DGSKL
MMAR_2334|M.marinum_M HGISDFVVCTGYKSEYIKDYFSNYGVSNLDFTITLGDQSSIKYHGSHDEF
Mvan_0216|M.vanbaalenii_PYR-1 AGITDFIVLVGYKGYMIKEYFMNYFLHTSDVTIDLATDS-VATIQSKTEP
MSMEG_5979|M.smegmatis_MC2_155 FGHKEFILCLGYGADHIKNYFLTYQEAASN---DFVMSGGQVQLMHSDIS
* ..:: .* :: *
MLBr_00753|M.leprae_Br4923 GLQIDYVIEESPLGTGGGIANVIDQLR-HDTVMVFNGDVLSGVDLGQLLG
MAV_4228|M.avium_104 GLQIEYVTEERPLGTGGGIANVAGQLR-HDTVMVFNGDVLSGADLGQMLD
MUL_2610|M.ulcerans_Agy99 GLQIDYVTEDKPLGTGGGIVNVAGKLH-HDTVMVFNGDVLSGADLGQLLD
Mb3292c|M.bovis_AF2122/97 GLQIEYVTEEHPLGTGGGIANVAGKLR-NDTAMVFNGDVLSGADLAQLLD
Rv3264c|M.tuberculosis_H37Rv GLQIEYVTEEHPLGTGGGIANVAGKLR-NDTAMVFNGDVLSGADLAQLLD
TH_0779|M.thermoresistible__bu GLNIEYVTETEPLGTGGAIANVADKLR-FDTVMVFNGDVLSGADLQGLLD
Mflv_4734|M.gilvum_PYR-GCK GLQIDYVVEDEALGTGGGIANVSSKLR-HDTAVVFNGDVLSGCDLGALLD
MAB_3611c|M.abscessus_ATCC_199 GLQITYVYEEEPLGTGGAIRNVLEHLR-YDTALIFNGDVLSGLDLKDLLA
MMAR_2334|M.marinum_M NWRVTVADTGLSTMTGGRIKRIHKYVG-DEPFLCTYGDGIADVDIPALLK
Mvan_0216|M.vanbaalenii_PYR-1 -WTVTLLDTGLNTMTGGRLLRAKEYIG-DDTFCFTYGDGVSDLDVRNVID
MSMEG_5979|M.smegmatis_MC2_155 DWTISFVDTGLESPIGERLRRVRDYLDGDEYFLANYADVLTDAPLDHMIA
: * : . : : .* ::. : ::
MLBr_00753|M.leprae_Br4923 FQRTNFADVTLHLVRVGDPRAFGCVST-EDGRVTAFLEKTQDPPTDQINA
MAV_4228|M.avium_104 FHAAQQADVTLHLVRVSDPRAFGCVTT-EDGRVTAFLEKTQDPPTDQINA
MUL_2610|M.ulcerans_Agy99 YHHQNQADVTLHLVRVGDPRAFGCVPT-EDGRVTAFLEKTQDPPTDQINA
Mb3292c|M.bovis_AF2122/97 FHRSNRADVTLQLVRVGDPRAFGCVPTDEEDRVVAFLEKTEDPPTDQINA
Rv3264c|M.tuberculosis_H37Rv FHRSNRADVTLQLVRVGDPRAFGCVPTDEEDRVVAFLEKTEDPPTDQINA
TH_0779|M.thermoresistible__bu THERSGADLTLHLVRVGDPRAFGCVPTDAHGVVTAFLEKTQDPPTDQINA
Mflv_4734|M.gilvum_PYR-GCK SHEERGADVTLHLVRVGDPRAFGCVPTDSDGVVTAFLEKTQDPPTDQINA
MAB_3611c|M.abscessus_ATCC_199 QHEQTQADLTLHLVRVGDPRAFGCVPTDSDGKVTAFLEKTEDPPTDQINA
MMAR_2334|M.marinum_M FHRSHGKIATVTATQP--MSRFGVIDLEQDGAVAKFREKPK-TED-WINI
Mvan_0216|M.vanbaalenii_PYR-1 HHRAERTTVTVTAVQP--PARYGTLEFDE--RRVSFQEKPI-GDGGWVSG
MSMEG_5979|M.smegmatis_MC2_155 EFHLSGAVASMMVVPP--QSSFHCVEVSEAGEVKEIIAVSE--LTIWENG
:: . : : : . .
MLBr_00753|M.leprae_Br4923 GCYVFERNVIDRIPRGREVSVEREVFPTLLSDADVKVCGYVDATYWRDMG
MAV_4228|M.avium_104 GCYVFARRVIDRIPRGREVSVEREVFPALLSDPDVTVCGYVDATYWRDMG
MUL_2610|M.ulcerans_Agy99 GCYVFKREIIDRIPRGREVSVEREVFPSLLSDPDIKIYGYVDATYWRDMG
Mb3292c|M.bovis_AF2122/97 GCYVFERNVIDRIPQGREVSVEREVFPALLADGDCKIYGYVDASYWRDMG
Rv3264c|M.tuberculosis_H37Rv GCYVFERNVIDRIPQGREVSVEREVFPALLADGDCKIYGYVDASYWRDMG
TH_0779|M.thermoresistible__bu GCYVFQRHVIDRIPRGRAVSVEREVFPQLLSEG-LRICGHVDASYWRDMG
Mflv_4734|M.gilvum_PYR-GCK GCYVFKRSIIEAIPKGRALSVEREVFPKLLSDG-KKVCGYVDATYWRDMG
MAB_3611c|M.abscessus_ATCC_199 GCYVFRRELIEQIPSGRPVSVEREVFPGLLSSG-AKVCGYVDTSYWRDMG
MMAR_2334|M.marinum_M GYFIFERGVFDYLE-GDETVLEDQPLRRLAEDR--QIAAFPHHGFWQPMD
Mvan_0216|M.vanbaalenii_PYR-1 GFFVAQPSVLDYIS-GDDTVFEQAPLQRLATDG--ELSAYQHSGFWRGMD
MSMEG_5979|M.smegmatis_MC2_155 GFFVLSQGIFDLLPPGGDLVAD--VCGTLAGQG--KLFGYRYQGFWKPAD
* :: ::: : * : * . : .. :*: .
MLBr_00753|M.leprae_Br4923 TPEDFVRGSADLVRGIAPSPALGGHRGEHLVHDGAAVSPGAVLIGGTVVG
MAV_4228|M.avium_104 TPEDFVRGSADLVRGIAPSPALHGHRGEQLVHDGAAVSPGAVLIGGTVVG
MUL_2610|M.ulcerans_Agy99 TPEDFVRGSADLVRGIAPSPALQGQRGEQLVHDGAAIAPGAVLIGGTVVG
Mb3292c|M.bovis_AF2122/97 TPEDFVRGSADLVRGIAPSPALRGHRGEQLVHDGAAVSPGALLIGGTVVG
Rv3264c|M.tuberculosis_H37Rv TPEDFVRGSADLVRGIAPSPALRGHRGEQLVHDGAAVSPGALLIGGTVVG
TH_0779|M.thermoresistible__bu TPEDFVRGSADLVRGIAPSPALRGQRGESLVHDGAAVAPGALLIGGTVVG
Mflv_4734|M.gilvum_PYR-GCK TPEDFVRGSADLVRGIAPSPALTHQRGEKLVHDGASVAPGALLIGGTVVG
MAB_3611c|M.abscessus_ATCC_199 TPEDFVRGSADLVRGIAPSPAIPEHPGEALVHDGASVAPGALVIGGTVVG
MMAR_2334|M.marinum_M TFRESQLLNNLWNSGNPPWKVWE---------------------------
Mvan_0216|M.vanbaalenii_PYR-1 TLWDKIYLNDLWDNGKAPWKIWADQLV-----------------------
MSMEG_5979|M.smegmatis_MC2_155 TFKERAELEARYHDGDRPWMLWEKSVRAVPEAS-----------------
* : . * *
MLBr_00753|M.leprae_Br4923 RGAEIGPGVRLDGAVIFDGAKVEAGSVIERSILGFGVRIGPRALIRDGVI
MAV_4228|M.avium_104 RGAEIGPGVRLDGAVIFDGVKVEAGSVIERSIVGFGARIGPRALIRDGVI
MUL_2610|M.ulcerans_Agy99 RGAEIGPGVRLDGAVIFDGVKVEAGSVIERSIIGFGARIGPRALVRDGVI
Mb3292c|M.bovis_AF2122/97 RGAEIGPGTRLDGAVIFDGVRVEAGCVIERSIIGFGARIGPRALIRDGVI
Rv3264c|M.tuberculosis_H37Rv RGAEIGPGTRLDGAVIFDGVRVEAGCVIERSIIGFGARIGPRALIRDGVI
TH_0779|M.thermoresistible__bu RGAEIGPGARLDGAVIFDGVRVEAGSVIERSIIGFGARIGPRALIRDGVI
Mflv_4734|M.gilvum_PYR-GCK RGAEVAGGARLDGAVIFDGVKIGAGAVIERSIIGFGAHIGPRALIRDGVI
MAB_3611c|M.abscessus_ATCC_199 RGAEIGPGARLDGAVVFDGARIEAGAVVERSIIGFGARIGPRALVRDGVI
MMAR_2334|M.marinum_M --------------------------------------------------
Mvan_0216|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5979|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00753|M.leprae_Br4923 GDGADIGARCELLRGARVWPGVSIPDGGIRYSSDV
MAV_4228|M.avium_104 GDGADIGARCELLRGARVWPGVSIPDGGIRYSSDV
MUL_2610|M.ulcerans_Agy99 GDGADIGARCELLRGARVWPGVSIPDGGIRYSSDV
Mb3292c|M.bovis_AF2122/97 GDGADIGARCELLSGARVWPGVFLPDGGIRYSSDV
Rv3264c|M.tuberculosis_H37Rv GDGADIGARCELLSGARVWPGVFLPDGGIRYSSDV
TH_0779|M.thermoresistible__bu GDGADIGARCELLRGARVWPGVAIPDGGIRFSTDV
Mflv_4734|M.gilvum_PYR-GCK GDGADIGARCELLRGLRVWPGITIPDGGIRFSTDI
MAB_3611c|M.abscessus_ATCC_199 GDGADIGARCELLRGARVWPGITIPDGGIRYSSDV
MMAR_2334|M.marinum_M -----------------------------------
Mvan_0216|M.vanbaalenii_PYR-1 -----------------------------------
MSMEG_5979|M.smegmatis_MC2_155 -----------------------------------