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M. thermoresistible (build 8) TH_0779 (rmlA2)

annotation: D-ALPHA-D-MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE MANB (D-ALPHA-D-HEPTOSE-1-PHOSPHATE GUANYLYLTRANSFERASE)
coordinates: 1630118 - 1631197
length: 360

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0779rmlA2-100% (360)D-ALPHA-D-MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE MANB (D-ALPHA-D-HEPTOSE-1-PHOSPHATE GUANYLYLTRANSFERASE)
M. thermoresistible (build 8)TH_0549glgC7e-2527.57% (370) glucose-1-phosphate adenylyltransferase
M. thermoresistible (build 8)TH_1924rmlA2e-1829.80% (245) ALPHA-D-GLUCOSE-1-PHOSPHATE THYMIDYLYLTRANSFERASE RMLA

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3292cmanC1e-17385.63% (355) mannose-1-phosphate guanyltransferase
M. gilvum PYR-GCKMflv_4734-1e-17884.40% (359) nucleotidyl transferase
M. tuberculosis H37RvRv3264cmanB1e-17385.63% (355) D-alpha-D-mannose-1-phosphate guanylyltransferase MANB
M. leprae Br4923MLBr_00753rmlA21e-17083.66% (355) putative sugar-phosphate nucleotidyl transferase
M. abscessus ATCC 19977MAB_3611c-1e-17179.94% (359) putative sugar-phosphate nucleotidyl transferase
M. marinum MMMAR_1277manB1e-17485.88% (354) d-alpha-D-mannose-1-phosphate guanylyltransferase ManB
M. avium 104MAV_4228-1e-17283.84% (359) nucleotidyl transferase
M. smegmatis MC2 155MSMEG_5078glgC8e-2627.87% (366) glucose-1-phosphate adenylyltransferase
M. ulcerans Agy99MUL_2610manB1e-17485.88% (354) d-alpha-D-mannose-1-phosphate guanylyltransferase ManB
M. vanbaalenii PYR-1Mvan_1729-0.085.52% (359) nucleotidyl transferase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4734|M.gilvum_PYR-GCK          MVNPAQVDAVVLVGGMGTRLRPLTLSAPKPMLPTAG-LPFLTHLLSRIAA
Mvan_1729|M.vanbaalenii_PYR-1       MVNPAEVDAVVLVGGMGTRLRPLTLSAPKPMLPTAG-LPFLTHLLSRIAD
MLBr_00753|M.leprae_Br4923          -MATLQVDAVVLVGGKGTRLRPLTLSAPKPMLPTAG-LPFLTHLLSRIAA
MAV_4228|M.avium_104                -MGTPEVDVVILVGGKGTRLRPLTLSAPKPMLPTAG-LPFLTHLLSRIAA
MMAR_1277|M.marinum_M               -MATNGVDAVVLVGGKGTRLRPLTLSAPKPMLPTAG-LPFLTHLLSRIAA
MUL_2610|M.ulcerans_Agy99           -MATNGVDAVVLVGGKGTRLRPLTLSAPKPMLPTAG-LPFLTHLLSRIAA
Mb3292c|M.bovis_AF2122/97           -MATHQVDAVVLVGGKGTRLRPLTLSAPKPMLPTAG-LPFLTHLLSRIAA
Rv3264c|M.tuberculosis_H37Rv        -MATHQVDAVVLVGGKGTRLRPLTLSAPKPMLPTAG-LPFLTHLLSRIAA
TH_0779|M.thermoresistible__bu      MVNPAQVDAVVLVGGQGTRLRPLTLSAPKPMLPTAG-LPFLTHLLSRIAE
MAB_3611c|M.abscessus_ATCC_199      MSGTVKADAVILVGGQGTRLRPLTLSAPKPMLPIAG-FPFLTHVLSRVAA
MSMEG_5078|M.smegmatis_MC2_155      MRELPHVLGIVLAGGEGKRLYPLTADRAKPAVPFGGAYRLIDFVLSNLVN
                                          .  ::*.** *.** *** . .** :* .*   :: .:**.:. 

Mflv_4734|M.gilvum_PYR-GCK          AGIEHVVMGTSYKAAVFESEFGDGSKLG-LQIDYVVEDEALGTGG-----
Mvan_1729|M.vanbaalenii_PYR-1       AGIEHVVLGTSYKANVFESEFGDGSKLG-LQIDYVVEDEPLGTGG-----
MLBr_00753|M.leprae_Br4923          AGIEHVILSTSYRDAVFEAEFGDGSKLG-LQIDYVIEESPLGTGG-----
MAV_4228|M.avium_104                AGIEHVILSTSYQAAVFEAEFGDGSKLG-LQIEYVTEERPLGTGG-----
MMAR_1277|M.marinum_M               AGIEHVVLSTSYQAGVFEAEFGDGSKLG-LQIDYVTEDKPLGTGG-----
MUL_2610|M.ulcerans_Agy99           AGIEHVVLSTSYQAGVFEAEFGDGSKLG-LQIDYVTEDKPLGTGG-----
Mb3292c|M.bovis_AF2122/97           AGIEHVILGTSYKPAVFEAEFGDGSALG-LQIEYVTEEHPLGTGG-----
Rv3264c|M.tuberculosis_H37Rv        AGIEHVILGTSYKPAVFEAEFGDGSALG-LQIEYVTEEHPLGTGG-----
TH_0779|M.thermoresistible__bu      AGIEHVVLGTSYKAHVFEAEFGDGSKFG-LNIEYVTETEPLGTGG-----
MAB_3611c|M.abscessus_ATCC_199      AGIDHVVLGTSYKADVFESEFGDGSKLG-LQITYVYEEEPLGTGG-----
MSMEG_5078|M.smegmatis_MC2_155      ARYLRICVLTQYKSHSLDRHISQNWRLSGLAGEYITPVPAQQRLGPRWYT
                                    *   :: : *.*:   :: .:.:.  :. *   *:    .    *     

Mflv_4734|M.gilvum_PYR-GCK          -------GIANVSSKLRHDTAVVFNGDVLSGCDLGALLDSHEERGADVTL
Mvan_1729|M.vanbaalenii_PYR-1       -------GIANVASKLRYDTAVVFNGDVLSGCDLRALLDSHVSRDADVTL
MLBr_00753|M.leprae_Br4923          -------GIANVIDQLRHDTVMVFNGDVLSGVDLGQLLGFQRTNFADVTL
MAV_4228|M.avium_104                -------GIANVAGQLRHDTVMVFNGDVLSGADLGQMLDFHAAQQADVTL
MMAR_1277|M.marinum_M               -------GIVNVAGKLHHDTVMVFNGDVLSGADLGQLLDYHHQNQADVTL
MUL_2610|M.ulcerans_Agy99           -------GIVNVAGKLHHDTVMVFNGDVLSGADLGQLLDYHHQNQADVTL
Mb3292c|M.bovis_AF2122/97           -------GIANVAGKLRNDTAMVFNGDVLSGADLAQLLDFHRSNRADVTL
Rv3264c|M.tuberculosis_H37Rv        -------GIANVAGKLRNDTAMVFNGDVLSGADLAQLLDFHRSNRADVTL
TH_0779|M.thermoresistible__bu      -------AIANVADKLRFDTVMVFNGDVLSGADLQGLLDTHERSGADLTL
MAB_3611c|M.abscessus_ATCC_199      -------AIRNVLEHLRYDTALIFNGDVLSGLDLKDLLAQHEQTQADLTL
MSMEG_5078|M.smegmatis_MC2_155      GSADAIYQSLNLIYDEDPDYIIIFGADHVYRMDPEQMMQFHIESGAGATV
                                              *:  .   *  ::*..* :   *   ::  :    *. *:

Mflv_4734|M.gilvum_PYR-GCK          HLVRVG--DPRAFGCVPTDSDGVVTAFLEKTQDPP-------TDQINAGC
Mvan_1729|M.vanbaalenii_PYR-1       HLVRVG--DPRAFGCVPTDSDGNVTAFLEKTQDPP-------TDQINAGC
MLBr_00753|M.leprae_Br4923          HLVRVG--DPRAFGCVST-EDGRVTAFLEKTQDPP-------TDQINAGC
MAV_4228|M.avium_104                HLVRVS--DPRAFGCVTT-EDGRVTAFLEKTQDPP-------TDQINAGC
MMAR_1277|M.marinum_M               HLVRVG--DPRAFGCVPT-EDGRVTAFLEKTQDPP-------TDQINAGC
MUL_2610|M.ulcerans_Agy99           HLVRVG--DPRAFGCVPT-EDGRVTAFLEKTQDPP-------TDQINAGC
Mb3292c|M.bovis_AF2122/97           QLVRVG--DPRAFGCVPTDEEDRVVAFLEKTEDPP-------TDQINAGC
Rv3264c|M.tuberculosis_H37Rv        QLVRVG--DPRAFGCVPTDEEDRVVAFLEKTEDPP-------TDQINAGC
TH_0779|M.thermoresistible__bu      HLVRVG--DPRAFGCVPTDAHGVVTAFLEKTQDPP-------TDQINAGC
MAB_3611c|M.abscessus_ATCC_199      HLVRVG--DPRAFGCVPTDSDGKVTAFLEKTEDPP-------TDQINAGC
MSMEG_5078|M.smegmatis_MC2_155      AGIRVPRSEASAFGCIDADESGRIREFIEKPADPPGTPDDPEQTFVSMGN
                                      :**   :. ****: :   . :  *:**. ***          :. * 

Mflv_4734|M.gilvum_PYR-GCK          YVFKRSIIEAIPKG------RALSVEREVFPKLLSDG-KKVCGY------
Mvan_1729|M.vanbaalenii_PYR-1       YVFKRSVIDAIPKG------RALSVEREIFPQLLSDG-KRVCGY------
MLBr_00753|M.leprae_Br4923          YVFERNVIDRIPRG------REVSVEREVFPTLLSDADVKVCGY------
MAV_4228|M.avium_104                YVFARRVIDRIPRG------REVSVEREVFPALLSDPDVTVCGY------
MMAR_1277|M.marinum_M               YVFKREIIDRIPRG------REVSVEREVFPSLLSDPDIKIYGY------
MUL_2610|M.ulcerans_Agy99           YVFKREIIDRIPRG------REVSVEREVFPSLLSDPDIKIYGY------
Mb3292c|M.bovis_AF2122/97           YVFERNVIDRIPQG------REVSVEREVFPALLADGDCKIYGY------
Rv3264c|M.tuberculosis_H37Rv        YVFERNVIDRIPQG------REVSVEREVFPALLADGDCKIYGY------
TH_0779|M.thermoresistible__bu      YVFQRHVIDRIPRG------RAVSVEREVFPQLLSEG-LRICGH------
MAB_3611c|M.abscessus_ATCC_199      YVFRRELIEQIPSG------RPVSVEREVFPGLLSSG-AKVCGY------
MSMEG_5078|M.smegmatis_MC2_155      YIFTTKVLIDAIRADADDDHSDHDMGGDIIPRLVADGMAAVYDFKNNEVP
                                    *:*   ::     .         .:  :::* *::.    : ..      

Mflv_4734|M.gilvum_PYR-GCK          ----VDATYWRDMGTPEDFVRGSADLVRGIAPSPALTHQRGEKLVHDGAS
Mvan_1729|M.vanbaalenii_PYR-1       ----VDATYWRDMGTPEDFVRGSADLVRGIAPSPALHGHRGESLVHDGAS
MLBr_00753|M.leprae_Br4923          ----VDATYWRDMGTPEDFVRGSADLVRGIAPSPALGGHRGEHLVHDGAA
MAV_4228|M.avium_104                ----VDATYWRDMGTPEDFVRGSADLVRGIAPSPALHGHRGEQLVHDGAA
MMAR_1277|M.marinum_M               ----VDATYWRDMGTPEDFVRGSADLVRGIAPSPALQGQRGEQLVHDGAA
MUL_2610|M.ulcerans_Agy99           ----VDATYWRDMGTPEDFVRGSADLVRGIAPSPALQGQRGEQLVHDGAA
Mb3292c|M.bovis_AF2122/97           ----VDASYWRDMGTPEDFVRGSADLVRGIAPSPALRGHRGEQLVHDGAA
Rv3264c|M.tuberculosis_H37Rv        ----VDASYWRDMGTPEDFVRGSADLVRGIAPSPALRGHRGEQLVHDGAA
TH_0779|M.thermoresistible__bu      ----VDASYWRDMGTPEDFVRGSADLVRGIAPSPALRGQRGESLVHDGAA
MAB_3611c|M.abscessus_ATCC_199      ----VDTSYWRDMGTPEDFVRGSADLVRGIAPSPAIPEHPGEALVHDGAS
MSMEG_5078|M.smegmatis_MC2_155      GATERDHGYWRDVGTLDAFYDAHMDLVS-VHPVFNLYNKR-WPIRGESEN
                                         *  ****:** : *  .  ***  : *   :  :    :  :.  

Mflv_4734|M.gilvum_PYR-GCK          VAPGALLIGG----TVVGRGAEVAGGARLDGAVIFDGVKIGAGAVIERSI
Mvan_1729|M.vanbaalenii_PYR-1       VAPGALLIGG----TVVGRGAEVAGGARLDGAVIFDGVKIGAGAVIERSI
MLBr_00753|M.leprae_Br4923          VSPGAVLIGG----TVVGRGAEIGPGVRLDGAVIFDGAKVEAGSVIERSI
MAV_4228|M.avium_104                VSPGAVLIGG----TVVGRGAEIGPGVRLDGAVIFDGVKVEAGSVIERSI
MMAR_1277|M.marinum_M               IAPGAVLIGG----TVVGRGAEIGPGVRLDGAVIFDGVKVEAGSVIERSI
MUL_2610|M.ulcerans_Agy99           IAPGAVLIGG----TVVGRGAEIGPGVRLDGAVIFDGVKVEAGSVIERSI
Mb3292c|M.bovis_AF2122/97           VSPGALLIGG----TVVGRGAEIGPGTRLDGAVIFDGVRVEAGCVIERSI
Rv3264c|M.tuberculosis_H37Rv        VSPGALLIGG----TVVGRGAEIGPGTRLDGAVIFDGVRVEAGCVIERSI
TH_0779|M.thermoresistible__bu      VAPGALLIGG----TVVGRGAEIGPGARLDGAVIFDGVRVEAGSVIERSI
MAB_3611c|M.abscessus_ATCC_199      VAPGALVIGG----TVVGRGAEIGPGARLDGAVVFDGARIEAGAVVERSI
MSMEG_5078|M.smegmatis_MC2_155      LAPAKFVNGGSAQESVVGAGSIIS-AASVRNSVLSSNVVVDDGAIVEGSV
                                    ::*. .: **    :*** *: :. .. : .:*: ... :  *.::* *:

Mflv_4734|M.gilvum_PYR-GCK          IGFGAHIGPRALIRDGVIGDGADIG-ARCELLRGLRVWPGITIPDGGIRF
Mvan_1729|M.vanbaalenii_PYR-1       IGFGARIGPRALIRDGVIGDGADIG-ARCELLRGARVWPGITIPDGGIRF
MLBr_00753|M.leprae_Br4923          LGFGVRIGPRALIRDGVIGDGADIG-ARCELLRGARVWPGVSIPDGGIRY
MAV_4228|M.avium_104                VGFGARIGPRALIRDGVIGDGADIG-ARCELLRGARVWPGVSIPDGGIRY
MMAR_1277|M.marinum_M               IGFGARIGPRALVRDGVIGDGADIG-ARCELLRGARVWPGVSIPDGGIRY
MUL_2610|M.ulcerans_Agy99           IGFGARIGPRALVRDGVIGDGADIG-ARCELLRGARVWPGVSIPDGGIRY
Mb3292c|M.bovis_AF2122/97           IGFGARIGPRALIRDGVIGDGADIG-ARCELLSGARVWPGVFLPDGGIRY
Rv3264c|M.tuberculosis_H37Rv        IGFGARIGPRALIRDGVIGDGADIG-ARCELLSGARVWPGVFLPDGGIRY
TH_0779|M.thermoresistible__bu      IGFGARIGPRALIRDGVIGDGADIG-ARCELLRGARVWPGVAIPDGGIRF
MAB_3611c|M.abscessus_ATCC_199      IGFGARIGPRALVRDGVIGDGADIG-ARCELLRGARVWPGITIPDGGIRY
MSMEG_5078|M.smegmatis_MC2_155      LMPGVRIGRGAVVRHAILDKNVVVGPGEMVGVDLDKDRERFAISAGGVVA
                                    :  *.:**  *::*..::.... :* ..   :   :    . :. **:  

Mflv_4734|M.gilvum_PYR-GCK          STDI---
Mvan_1729|M.vanbaalenii_PYR-1       STDI---
MLBr_00753|M.leprae_Br4923          SSDV---
MAV_4228|M.avium_104                SSDV---
MMAR_1277|M.marinum_M               SSDV---
MUL_2610|M.ulcerans_Agy99           SSDV---
Mb3292c|M.bovis_AF2122/97           SSDV---
Rv3264c|M.tuberculosis_H37Rv        SSDV---
TH_0779|M.thermoresistible__bu      STDV---
MAB_3611c|M.abscessus_ATCC_199      SSDV---
MSMEG_5078|M.smegmatis_MC2_155      VGKGVWI
                                      .