For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. marinum M MMAR_2320 (wecE)

annotation: pyridoxal phosphate-dependent enzyme, WecE
coordinates: 2788950 - 2790098
length: 382

VEHKIPFNRPYMTGQELNYIAEAHSCGHLAGDGPFTYRCHAWLEQQTGCRKALLTPSCTAALEMMALLLE
IEEGDEVILPSFTFVSTANAFVLRGGVPVFVDIRPDTLNVDETLIEAAITPRTRAIVPVHYAGVACEMDT
IMSIARRHKLAVVEDAAQGTMAYYRGRALGSIGDLGALSFHETKNVISGEGGALLVNSEEYIYRAEILRD
KGTNRSRFLRKEVDKYTWQDKGSSYLSSELIAAFLWAQFEDAERITRSRLDLWNYYHAGFESLEQRGLLR
RPIIPEGCSHNAHMYYVLLAPGTDRAGVLAALAKEDINAVFHYVPLHDSPAGRRYGRTSGDLTVTNDSSS
RLIRLPMWVGLQEADQNRVVDALTRILTFGA*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_2320wecE-100% (382)pyridoxal phosphate-dependent enzyme, WecE
M. marinum MMMAR_2335-8e-2126.73% (333) pyridoxal phosphate-dependent enzyme

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1542c-0.086.05% (380) TDP-4-oxo-6-deoxy-D-glucose transaminase
M. gilvum PYR-GCK-----
M. tuberculosis H37RvRv1504c-1e-10089.85% (197) hypothetical protein Rv1504c
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_2610-5e-2231.12% (331) putative aminotransferase
M. avium 104-----
M. smegmatis MC2 155MSMEG_0688-6e-0530.19% (106) aminotransferase AlaT
M. thermoresistible (build 8)-----
M. ulcerans Agy99-----
M. vanbaalenii PYR-1-----

CLUSTAL 2.0.9 multiple sequence alignment


Mb1542c|M.bovis_AF2122/97           ---------------------------------MSDHKVPFNRPYMTGRE
Rv1504c|M.tuberculosis_H37Rv        ---------------------------------MSDHKVPFNRPYMTGRE
MMAR_2320|M.marinum_M               ---------------------------------MVEHKIPFNRPYMTGQE
MAB_2610|M.abscessus_ATCC_1997      MSIAESANASVRTGPAPSSKTREFARAILSGTAVHPEEIPAGRAYTTLRD
MSMEG_0688|M.smegmatis_MC2_155      -MERVTTHQLPWQSTGEHRKPRTFTQSTKLQDVLYEIRGPVHEHASRLEA
                                                                     :   . *  .     . 

Mb1542c|M.bovis_AF2122/97           LAYIAEAHSCGHLAGD----------------------------------
Rv1504c|M.tuberculosis_H37Rv        LAYIAEAHSCGHLAGD----------------------------------
MMAR_2320|M.marinum_M               LNYIAEAHSCGHLAGD----------------------------------
MAB_2610|M.abscessus_ATCC_1997      LATHPGLRDVTDVLIPGSAPDTVDFLPLARLVNAAELPAIRAAIDSVLPS
MSMEG_0688|M.smegmatis_MC2_155      EGHRILKLNIGNPAPFG---------------------------------
                                            .  .                                      

Mb1542c|M.bovis_AF2122/97           -----GPFTRRSHAWLEQQTGCRKALLTPSCTAALEMMALLLDIEEGDEV
Rv1504c|M.tuberculosis_H37Rv        -----GPFTRRSHAWLEQQTGCRKALLTPSCTAALEMMALLLDIEEGDEV
MMAR_2320|M.marinum_M               -----GPFTYRCHAWLEQQTGCRKALLTPSCTAALEMMALLLEIEEGDEV
MAB_2610|M.abscessus_ATCC_1997      GKFTSGPHVDAFEDEIATYLGIDHVIGASSGTDAMTAVLLALGAGPGTEV
MSMEG_0688|M.smegmatis_MC2_155      ----FEAPDVIMRDIIQALPTAQGYSDSKGILSARRAVFTRYELVEGFPK
                                          .     .  :           : .   *   :        *   

Mb1542c|M.bovis_AF2122/97           ILPSYTFVSTANAFVLRGGVPVFVDIRPDTLNIDETRIVDAITPRTKAIV
Rv1504c|M.tuberculosis_H37Rv        ILPSYTFVSTANAFVLRGGVPVFVDIRPDTLNIDETRIVDAITPRTKAIV
MMAR_2320|M.marinum_M               ILPSFTFVSTANAFVLRGGVPVFVDIRPDTLNVDETLIEAAITPRTRAIV
MAB_2610|M.abscessus_ATCC_1997      ILPANSFAATENAVFLTGARPVLVDTRADDHLLDPTEVEAAITSRTVAVL
MSMEG_0688|M.smegmatis_MC2_155      FDVDDVYLGNGVSELITMTLQALLDNGDQVLIPAPDYPLWTASTSLAGGT
                                    :     : ..  : .:     .::*   :           : :.   .  

Mb1542c|M.bovis_AF2122/97           PVHYAGVACE------MDAIMKIATHHNLAVVEDAAQGAMASYRGRALGS
Rv1504c|M.tuberculosis_H37Rv        PVHYAGVACE------MDAIMKIATHHNLAVVEDAAQGAMASYRGRALGS
MMAR_2320|M.marinum_M               PVHYAGVACE------MDTIMSIARRHKLAVVEDAAQGTMAYYRGRALGS
MAB_2610|M.abscessus_ATCC_1997      PVHLYGAFAD------IHALTEVTSRHGIPVVEDGCQGIGLDG----LGH
MSMEG_0688|M.smegmatis_MC2_155      PVHYLCDETQGWNPDVADIESKITERTKAIVVINPNNPTGAVYSRETLEQ
                                    ***      :       .   .:: :    ** :  :          *  

Mb1542c|M.bovis_AF2122/97           IGDLG---ALSFHETKNV-ISGEGGALLVNSEDFLLRAEILREKGTNRSR
Rv1504c|M.tuberculosis_H37Rv        IGDLG---ALSFHETKNV-ISGEGGALLVNS-------------------
MMAR_2320|M.marinum_M               IGDLG---ALSFHETKNV-ISGEGGALLVNSEEYIYRAEILRDKGTNRSR
MAB_2610|M.abscessus_ATCC_1997      HSDAA---ILSFNPYKNLGAVGKAGAVATRLPGLARRVTELLYHG-----
MSMEG_0688|M.smegmatis_MC2_155      IVDLARKHQLLLLADEIYDKILYDDAKHISLATLAPDLLCLTFNGLSKAY
                                      * .    * :   :        .*                        

Mb1542c|M.bovis_AF2122/97           FLRNEVDKYTWQDKGSSYLPSELVAAFLWAQFEEAERITRIRLDLWNRYH
Rv1504c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_2320|M.marinum_M               FLRKEVDKYTWQDKGSSYLSSELIAAFLWAQFEDAERITRSRLDLWNYYH
MAB_2610|M.abscessus_ATCC_1997      -FAAGQKNVKAAGYGLNSRLDNLQAAVLRARLDWLGENNLARSILARRYV
MSMEG_0688|M.smegmatis_MC2_155      RVAGYRSGWLVITGPKEHATSFIEGISLLANMRLCP--NVPAQHAIQVAL
                                                                                      

Mb1542c|M.bovis_AF2122/97           ESFESLEQRGLLRRPIIPQGCSHNAHMYYVLLAPSADREEVLARLTSKG-
Rv1504c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_2320|M.marinum_M               AGFESLEQRGLLRRPIIPEGCSHNAHMYYVLLAPGTDRAGVLAALAKED-
MAB_2610|M.abscessus_ATCC_1997      DGLADLAESGLLR---LPHWDTDHVWHLFTVEVTKHDRDKVTESLRAAG-
MSMEG_0688|M.smegmatis_MC2_155      GGHQSIDALVLPGGRLLEQRDVAWEKLNEIPGVSCVKPRGALYAFPRLDP
                                                                                      

Mb1542c|M.bovis_AF2122/97           -IGAVFHYVPLHDSPAGRRYGRTNG--NLTVTNDVASRLIRLPMWVGLQE
Rv1504c|M.tuberculosis_H37Rv        --------------------------------------------------
MMAR_2320|M.marinum_M               -INAVFHYVPLHDSPAGRRYGRTSG--DLTVTNDSSSRLIRLPMWVGLQE
MAB_2610|M.abscessus_ATCC_1997      -VATDLYYPVLTHRHRVPLVADLFEGVRLPRTEAAHARMFQLPLYPTLTL
MSMEG_0688|M.smegmatis_MC2_155      EVYDIHDDEQLVLDLLLQEKILLTQGTGFNWPTPDHLRIVTLP-WARDLA
                                                                                      

Mb1542c|M.bovis_AF2122/97           VDQSRVVEALTRILTLRA
Rv1504c|M.tuberculosis_H37Rv        ------------------
MMAR_2320|M.marinum_M               ADQNRVVDALTRILTFGA
MAB_2610|M.abscessus_ATCC_1997      AEQDRVIGVLHDVLG---
MSMEG_0688|M.smegmatis_MC2_155      SAIERLGNFLASYRQ---