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FPGAVIRKLAFSEEIYARYQAFTSFTAHVRGPVDIDAMSEAFDALLQAHPVFAAHLEEGPDGNHHIVAND LLHSGLVVIDGRRAENPHVQLDQRDSLFRLQLTLGESENLVTAYVHHSLADAHHLGSLLDELLSRYTDVV TTGDPGPITPEPAPQPAEDLLKRRGIKQSALTGFERFLPLLFAYDLPPIAEEMRKFEAPEPVPVTRCRLT SQETADLVSFSRDNGLSFNAVLAAAILLAEWRLRETPHVPIPYCYAVDLRFLLSPPVGATESTNPVGLAT YLAEIGPDTDITELAADIVATFRADLSDGMIHQSALRSGRILEGTPPGLPPFVLCTNVSTLPPIRTPEDV ELVDFHSRIHCAMDVPFGFYACSIATDRLSIELHGSIPAPQLLLDAIRDILCSVPSEYGLFME*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1768 | papA5 | - | 100% (414) | polyketide synthase associated protein PapA5 |
| M. marinum M | MMAR_3268 | - | 5e-05 | 24.23% (194) | non-ribosomal peptide synthetase |
| M. marinum M | MMAR_3271 | - | 9e-05 | 24.35% (193) | non-ribosomal peptide synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2964 | papA5 | 1e-132 | 54.48% (424) | acyltransferase PapA5 |
| M. gilvum PYR-GCK | Mflv_3386 | - | 1e-104 | 48.15% (405) | acyltransferase PapA5 |
| M. tuberculosis H37Rv | Rv2939 | papA5 | 1e-132 | 54.48% (424) | acyltransferase PapA5 |
| M. leprae Br4923 | MLBr_02349 | - | 1e-131 | 54.85% (423) | acyltransferase PapA5 |
| M. abscessus ATCC 19977 | MAB_2035 | - | 2e-24 | 29.66% (327) | acyltransferase PapA5 |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_4455 | - | 2e-06 | 23.12% (333) | PUTATIVE putative syringomycin synthetase |
| M. ulcerans Agy99 | MUL_2011 | papA5 | 0.0 | 99.76% (414) | acyltransferase PapA5 |
| M. vanbaalenii PYR-1 | Mvan_3119 | - | 1e-100 | 46.08% (408) | acyltransferase PapA5 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_1768|M.marinum_M ---------------------------MFPGAVIRKLAFSEEIYAR-YQA
MUL_2011|M.ulcerans_Agy99 ---------------------------MFPGAVIRKLAFSEEIYAR-YQA
Mb2964|M.bovis_AF2122/97 ---------------------------MFPGSVIRKLSHSEEVFAQ-YEV
Rv2939|M.tuberculosis_H37Rv ---------------------------MFPGSVIRKLSHSEEVFAQ-YEV
MLBr_02349|M.leprae_Br4923 ---------------------------MFAGSVIRKLSHSEEVFAR-YEV
Mflv_3386|M.gilvum_PYR-GCK ---------------------------MFPSSGIRKLARSEEMFAE-TQN
Mvan_3119|M.vanbaalenii_PYR-1 ---------------------------MFPSSGIRKLARSEEMFAE-THN
MAB_2035|M.abscessus_ATCC_1997 ----------------MTDTRPHQDTVDAPGEPIRPLSRLETYFTFGFGH
TH_4455|M.thermoresistible__bu MTLSSTDLAALTPEQKRALLARLLKQRAEASASVHPLSYGQRSMWFLYQL
.. :: *: :
MMAR_1768|M.marinum_M FTS-------FTAHVRGPVDIDAMSEAFDALLQAHPVFAAHLEEGPDGNH
MUL_2011|M.ulcerans_Agy99 FTS-------FTAHVRGPVDIDAMSEAFDALLQAHPVFAAHLEEGPDGNH
Mb2964|M.bovis_AF2122/97 FTS-------MTIQLRGVIDVDALSDAFDALLETHPVLASHLEQSSDGGW
Rv2939|M.tuberculosis_H37Rv FTS-------MTIQLRGVIDVDALSDAFDALLETHPVLASHLEQSSDGGW
MLBr_02349|M.leprae_Br4923 FTS-------MTIQLRGVLDIDALSEAFDALVQAHPVLASHLETSSDGGW
Mflv_3386|M.gilvum_PYR-GCK FVG-------LAAHVRGTVDETALADAFDALLQAHPVLNGHLEQLPDGKW
Mvan_3119|M.vanbaalenii_PYR-1 FIG-------LAAHVKGSMDADALSDAFDLLLQAHPVLGGHLEQLPDGKW
MAB_2035|M.abscessus_ATCC_1997 FGG-------QSMLISGDLDIEALNDTCIEMQLRHESLRSIIRK-NDQVP
TH_4455|M.thermoresistible__bu APGSPAYNISFAGRIRGPLDMGALHRAAQALVDRHAILRTTYAVRDGRPV
. : : * :* *: : : * : .
MMAR_1768|M.marinum_M HIVANDL---LHSGLVVIDG-------RRAENPHVQLDQRDSLFRLQLTL
MUL_2011|M.ulcerans_Agy99 HIVANDL---LHSGLVVIDG-------RRAENPHVQLDQRDSLFRLQLTL
Mb2964|M.bovis_AF2122/97 NLVADDL---LHSGICVIDG-TAATNGSPSGNAELRLDQSVSLLHLQLIL
Rv2939|M.tuberculosis_H37Rv NLVADDL---LHSGICVIDG-TAATNGSPSGNAELRLDQSVSLLHLQLIL
MLBr_02349|M.leprae_Br4923 NLVADDL---LHPGICVVDANNGAQSGCGGIQSETRLDQSVSLLNLRLTP
Mflv_3386|M.gilvum_PYR-GCK EIVLDDL---MHEGLEVVEC------HGDQEPPPLLFDQTAALTHLRLTR
Mvan_3119|M.vanbaalenii_PYR-1 EIVLDDL---MHPGIEVVEL------TGDEPAPPLIFDQTVSLVHLRLTI
MAB_2035|M.abscessus_ATCC_1997 EFVATHR---PPKSIRVFEG---EDLGARSTGREAVFDQTQQLFYVDLLL
TH_4455|M.thermoresistible__bu QLVHPHWPVQIDQHDIGSDDTEFDRWLRRESNQPFDLETGPVFRLSVVRR
.:* . : :: : :
MMAR_1768|M.marinum_M GESENLVTAYVHHSLADAHHLGSLLDELLSRYTDVVTTGDPGPITPEPAP
MUL_2011|M.ulcerans_Agy99 GESENLVTAYVHHSLADAHHLGSLLDELLSRYTDVVTTGDPGPITPEPAP
Mb2964|M.bovis_AF2122/97 REGGAELTLYLHHCMADGHHGAVLVDELFSRYTDAVTTGDPGPITPQPTP
Rv2939|M.tuberculosis_H37Rv REGGAELTLYLHHCMADGHHGAVLVDELFSRYTDAVTTGDPGPITPQPTP
MLBr_02349|M.leprae_Br4923 REGGGELVLYIHHSMADGHHGAVLVDELFSRYTDVVTTGDPGPIIPQATP
Mflv_3386|M.gilvum_PYR-GCK RDDETHLTLYIHHSLADGHHQFSLVEELFSTYTDLVTTGTARQAPVAPAP
Mvan_3119|M.vanbaalenii_PYR-1 RDGQAQPTLYIHHSLADGHHQFSLVEELFSTYTDLVTTGTTKPVEVHPAP
MAB_2035|M.abscessus_ATCC_1997 GDGQARVTFFVHHSIADGRHGSAILIEFWSLYVQRVEEGQFPPILTQKFP
TH_4455|M.thermoresistible__bu ASGEQLLVLVVHHIAVDFWSIDVILDELRRLYAAEHGAERPEPCPQRYVD
.. . :** .* :: *: *.
MMAR_1768|M.marinum_M QPAEDLLKRRGIKQSALTG--FERFLPLLFAYDLPP--IAEEMRKF----
MUL_2011|M.ulcerans_Agy99 QPAEDLLKRRGIKQSALTG--FERFLPLLFAYDLPP--IAEEMRKF----
Mb2964|M.bovis_AF2122/97 LSMEAVLAQRGIRKQGLSG--AERFMSVMYAYEIPATETPAVLAHP----
Rv2939|M.tuberculosis_H37Rv LSMEAVLAQRGIRKQGLSG--AERFMSVMYAYEIPATETPAVLAHP----
MLBr_02349|M.leprae_Br4923 LSMEAVLQQRGVKKHALSG--AERFMSVMYAYDLPATGTPAVLAEP----
Mflv_3386|M.gilvum_PYR-GCK AALETILSDRGVEKKLRSG--LERLLAAMFAYDVPPSRRAPAENNP----
Mvan_3119|M.vanbaalenii_PYR-1 EPLEVILANRGVEKRTRSG--LERLLAAMFVYDLPPSRRAPSDVNP----
MAB_2035|M.abscessus_ATCC_1997 QSGEYFLN-----RTQYPG--ADPSVKADEVLRVPLWDEAALAQKL----
TH_4455|M.thermoresistible__bu HAEHQIQMLESSEGERLWEYWRDRLAGDLPVIELPMDRPRRVAQTYRGAV
. . . : . :*
MMAR_1768|M.marinum_M --------------EAP-EPVPVTRCRLTSQETADLVSFSRDNGLSFNAV
MUL_2011|M.ulcerans_Agy99 --------------EAP-EPVPVTRCRLTSQETADLVSFSRDNGLSFNAV
Mb2964|M.bovis_AF2122/97 --------------GLP-QAVPVTRLWLSKQQTSDLMAFGREHRLSLNAV
Rv2939|M.tuberculosis_H37Rv --------------GLP-QAVPVTRLWLSKQQTSDLMAFGREHRLSLNAV
MLBr_02349|M.leprae_Br4923 --------------GLP-QAVPVTRLWLTKQETSDLAAFGREHRLSINAV
Mflv_3386|M.gilvum_PYR-GCK --------------VLP-QRVPMEFCKLSEAETENIIGFCRANKLGLNSL
Mvan_3119|M.vanbaalenii_PYR-1 --------------VLP-QLVPMAYCTLSEQDTEKIIAFCRANKLGLNSL
MAB_2035|M.abscessus_ATCC_1997 --------------PPPREPALAKQMTLEKLGRASLARLGNIESISINAL
TH_4455|M.thermoresistible__bu HRFTIDRRLTADLKQTARRAGATPYMTLLAAYIALLHRYSGQNDILIGSP
. . * : . : :.:
MMAR_1768|M.marinum_M LA------------------------------------------------
MUL_2011|M.ulcerans_Agy99 LA------------------------------------------------
Mb2964|M.bovis_AF2122/97 VA------------------------------------------------
Rv2939|M.tuberculosis_H37Rv VA------------------------------------------------
MLBr_02349|M.leprae_Br4923 VA------------------------------------------------
Mflv_3386|M.gilvum_PYR-GCK LS------------------------------------------------
Mvan_3119|M.vanbaalenii_PYR-1 LS------------------------------------------------
MAB_2035|M.abscessus_ATCC_1997 VS------------------------------------------------
TH_4455|M.thermoresistible__bu FAGREQSGLDGVVGYFANPLVLRFDVTGDTTFASLLGQTKQTVLDALAHQ
.:
MMAR_1768|M.marinum_M -------AAILLAEWRLRETPHVPIPYCYAVDLRFLLSPPVGATEST---
MUL_2011|M.ulcerans_Agy99 -------AAILLAEWRLRETPHVPIPYCYAVDLRFLLSPPVGATEST---
Mb2964|M.bovis_AF2122/97 -------AAILLTEWQLRNTPHVPIPYVYPVDLRFVLAPPVAPTEAT---
Rv2939|M.tuberculosis_H37Rv -------AAILLTEWQLRNTPHVPIPYVYPVDLRFVLAPPVAPTEAT---
MLBr_02349|M.leprae_Br4923 -------AAILMTEWRLRETPHVPIPYVYPVDLRYVLAPPVAPTEST---
Mflv_3386|M.gilvum_PYR-GCK -------ASILMAEWQLRETPNIPVPYVYPVDLRYLLSPPVSATECT---
Mvan_3119|M.vanbaalenii_PYR-1 -------AAVLMAEWNVRRTPNIPVPYVYPVDLRYLLSPPVSATEST---
MAB_2035|M.abscessus_ATCC_1997 -------AALIRAHVRAGDP--VPL-YFYPVDLRDCVTPPVAPTEAT---
TH_4455|M.thermoresistible__bu EFPFTLLVERLKPVRDVGHAPLFQVSFAWEQHRRFRETRDSDTGIASGAE
. : . . . : : : . * : . .:
MMAR_1768|M.marinum_M --------------------------NPVGLATYLAEIGPDTDITELAAD
MUL_2011|M.ulcerans_Agy99 --------------------------NPVGLATYLAEIGPDTDITELAAD
Mb2964|M.bovis_AF2122/97 --------------------------NLLGAASYLAEIGPNTDIVDLASD
Rv2939|M.tuberculosis_H37Rv --------------------------NLLGAASYLAEIGPNTDIVDLASD
MLBr_02349|M.leprae_Br4923 --------------------------NLLGAAGYLAEIGQDTDIVDLATD
Mflv_3386|M.gilvum_PYR-GCK --------------------------NPVGIATYLAEISPDTDVVDLARD
Mvan_3119|M.vanbaalenii_PYR-1 --------------------------NPVGIATYLAEIEKGTDIAELARD
MAB_2035|M.abscessus_ATCC_1997 --------------------------NLLSNA-WFGDVEIGPDLVTLARK
TH_4455|M.thermoresistible__bu LDLQTVHIGQGGAPNELMMLMGERDGELVCALQYNTDLFDAATIERMAGH
: : : :: . : :* .
MMAR_1768|M.marinum_M IVATFRADLSDGMIHQSALRSGRILEG--------TPPGLPPFVLCTNVS
MUL_2011|M.ulcerans_Agy99 IVATFRADLSDGMIHQSALRSGRILEG--------TPPGLPPFILCTNVS
Mb2964|M.bovis_AF2122/97 IVATLRADLANGVIQQSGLHFGTAFEG--------TPPGLPPLVFCTDAT
Rv2939|M.tuberculosis_H37Rv IVATLRADLANGVIQQSGLHFGTAFEG--------TPPGLPPLVFCTDAT
MLBr_02349|M.leprae_Br4923 IVATLRADLANGVVQQSGLHFGTAFEG--------TPPGLPPLVFCTDAT
Mflv_3386|M.gilvum_PYR-GCK INDTFKADIADGVIQQSFLHFSPQYVG--------NPPGLPDVVMFTDNG
Mvan_3119|M.vanbaalenii_PYR-1 INDTYKKDIAEGVIQQSFLHFSPQYVG--------NPPGLPDVVMFTDNG
MAB_2035|M.abscessus_ATCC_1997 IHVQFDRDLADGTIHRTRVRNEPTKLL--------ADKSFGGAIHATQLG
TH_4455|M.thermoresistible__bu FVTMLSGIVAGPAAKVSELPLLTDAECRRLAQWNRTEVDFGAPECLHDLV
: :: : : : .: :
MMAR_1768|M.marinum_M TLPPIRTPEDVELVDFHSRIHC----------------------AMDVPF
MUL_2011|M.ulcerans_Agy99 TLPPIRTPEDVELVDFHSRIHC----------------------AMDVPF
Mb2964|M.bovis_AF2122/97 SFPTMRTPPGLEIEDIKGQFYC----------------------SISVPL
Rv2939|M.tuberculosis_H37Rv SFPTMRTPPGLEIEDIKGQFYC----------------------SISVPL
MLBr_02349|M.leprae_Br4923 AFPTMRTPPDLAIEDIQGRFYC----------------------SISVPL
Mflv_3386|M.gilvum_PYR-GCK IVPPMRMPPDMELAASHGELYF----------------------AVGAGI
Mvan_3119|M.vanbaalenii_PYR-1 IVPPLRTPPDMEVAASHGEFYF----------------------AVGAGI
MAB_2035|M.abscessus_ATCC_1997 RIRVPRLPGNLVVDDITSSHAS----------------------ALGPAI
TH_4455|M.thermoresistible__bu TTAARRDPAAVALSSADGELTYGELDRRSETLALRLQRLSVGPDTIVPVL
* * : : . :: :
MMAR_1768|M.marinum_M GFYACSIATDRLSIELHGSIPAP---QLLLDAIRDILCSVPSEYGLFME-
MUL_2011|M.ulcerans_Agy99 GFYACSIATDRLSIELHGSIPAP---QLLLDAIRDILCSVPSEYGLFME-
Mb2964|M.bovis_AF2122/97 DLYSCAVYAGQLIIEHHGHIAEP---GKSLEAIRSLLCTVPSEYGWIME-
Rv2939|M.tuberculosis_H37Rv DLYSCAVYAGQLIIEHHGHIAEP---GKSLEAIRSLLCTVPSEYGWIME-
MLBr_02349|M.leprae_Br4923 DLYSCGVYEGQLIIEHHGHIEEP---AKALEAIRSLLCTVPSEYGWIME-
Mflv_3386|M.gilvum_PYR-GCK EIYTSKIFAGRLMIEYHSHGPAP---EKSVQTIETLLRGIAARQAAARVS
Mvan_3119|M.vanbaalenii_PYR-1 EIYTSKIFNGQLMIEYHSHGPDR---EKSVAAIEEQLRAVVARQSGVG--
MAB_2035|M.abscessus_ATCC_1997 YTFLYGREVSVYTIDSLNQRLRVGFLAGSYEKSDELLAYIEDELTAAIDA
TH_4455|M.thermoresistible__bu LDRSADLVVAWLGVLKAGGAFMPIDPAQPVHRIAAILSGASDAPVCVTHR
: . *
MMAR_1768|M.marinum_M --------------------------------------------------
MUL_2011|M.ulcerans_Agy99 --------------------------------------------------
Mb2964|M.bovis_AF2122/97 --------------------------------------------------
Rv2939|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02349|M.leprae_Br4923 --------------------------------------------------
Mflv_3386|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3119|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_2035|M.abscessus_ATCC_1997 RI------------------------------------------------
TH_4455|M.thermoresistible__bu RHTDLLREFRGEQVFLDVGSPVPPRLPAPPAPPATTWRMSSTPRVPPGPR
MMAR_1768|M.marinum_M ----------------------------------
MUL_2011|M.ulcerans_Agy99 ----------------------------------
Mb2964|M.bovis_AF2122/97 ----------------------------------
Rv2939|M.tuberculosis_H37Rv ----------------------------------
MLBr_02349|M.leprae_Br4923 ----------------------------------
Mflv_3386|M.gilvum_PYR-GCK ----------------------------------
Mvan_3119|M.vanbaalenii_PYR-1 ----------------------------------
MAB_2035|M.abscessus_ATCC_1997 ----------------------------------
TH_4455|M.thermoresistible__bu RARSTPTAASATGCCGCSRPIRSPPPTGCCNRHR