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MIRDLYISDVTLRDGMHAVRHQYSIAQAVAIARALDDAGVDSIEVAHGDGLGGSSCCYGFGAHTDLQWIE AVAGAVDRARVATLLLPGIGSVANLEDAHRAGASVVRVGTHCTEADLAARYLGAARDLGMDAVGFLMMSH LTTPKRLAEQAKLLEGYGASCVYVVDSGGALTGAAVAQRFDALRQNLDPATELGIHAHHNLSLGVANSVV AVEHGARRIDASLAGMGAGAGNAPLEVLIAVVNRLGWTHGCELNALEDAADDLVRPLQDRPVRIDRETLT LGYAGVYSSFLRHAEVTAGRYGVDARSLLEEAGRRGLIGGQEDLLVDIALDLVGPAEPLAHGAP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_1506 | - | - | 100% (344) | 4-hydroxy-2-oxovalerate aldolase |
| M. marinum M | MMAR_5021 | - | 2e-88 | 49.85% (331) | 4-hydroxy-2-oxovalerate aldolase |
| M. marinum M | MMAR_1493 | - | 4e-05 | 28.35% (127) | hypothetical protein MMAR_1493 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3564c | - | 1e-89 | 50.46% (329) | 4-hydroxy-2-ketovalerate aldolase |
| M. gilvum PYR-GCK | Mflv_1522 | - | 3e-87 | 48.34% (331) | 4-hydroxy-2-ketovalerate aldolase |
| M. tuberculosis H37Rv | Rv3534c | - | 1e-89 | 50.46% (329) | 4-hydroxy-2-ketovalerate aldolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4375 | - | 1e-120 | 66.46% (328) | 4-hydroxy-2-ketovalerate aldolase |
| M. avium 104 | MAV_0627 | - | 3e-87 | 48.94% (329) | 4-hydroxy-2-ketovalerate aldolase |
| M. smegmatis MC2 155 | MSMEG_4150 | - | 1e-117 | 61.59% (328) | 4-hydroxy-2-ketovalerate aldolase |
| M. thermoresistible (build 8) | TH_0371 | - | 2e-86 | 48.63% (329) | PROBABLE 4-HYDROXY-2-OXOVALERATE ALDOLASE (HOA) |
| M. ulcerans Agy99 | MUL_2435 | - | 0.0 | 96.80% (344) | 4-hydroxy-2-ketovalerate aldolase |
| M. vanbaalenii PYR-1 | Mvan_0597 | - | 1e-152 | 77.54% (334) | 4-hydroxy-2-ketovalerate aldolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1522|M.gilvum_PYR-GCK MSTEDIYFNPIWDVRMTDTSLRDGSHHKRHQFTKDEVGSIVAALDAAGVP
MAV_0627|M.avium_104 -MTTDIFFNPMWDVRLTDTSLRDGSHHKRHQFTKDEVQAIVAALDVAGVP
TH_0371|M.thermoresistible__bu -MTTDIFFNPVWDVRITDTSLRDGSHHKRHQFTKDEVRSIVAALDTAGVP
Mb3564c|M.bovis_AF2122/97 -------MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIVAALDAAGVP
Rv3534c|M.tuberculosis_H37Rv -------MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIVAALDAAGVP
MMAR_1506|M.marinum_M ---------MIRDLYISDVTLRDGMHAVRHQYSIAQAVAIARALDDAGVD
MUL_2435|M.ulcerans_Agy99 ---------MIGDLYISDVTLRDGMHAVRHQDGIAQAVAIARALDDAGVD
Mvan_0597|M.vanbaalenii_PYR-1 ---------MIRDVYLSDVTLRDGMHAVRHQYSIEQVAMIATALDRAGVD
MAB_4375|M.abscessus_ATCC_1997 ----------MTQLYIQDVTLRDGMHAIRHQISPTAVARIASALEAAGVN
MSMEG_4150|M.smegmatis_MC2_155 --------MTMTRLFITDVTLRDGMHAIGHRYDRGQVREIAAALDEAGVD
: : : *.:**** * *: . *. **: ***
Mflv_1522|M.gilvum_PYR-GCK VIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKESKIAFLMLPGVGT
MAV_0627|M.avium_104 VIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKEAKIAFLMLPGVGT
TH_0371|M.thermoresistible__bu VIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAETAKESKIAFLMLPGVGT
Mb3564c|M.bovis_AF2122/97 VIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAATAKEARIAFLMLPGVGT
Rv3534c|M.tuberculosis_H37Rv VIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAATAKEARIAFLMLPGVGT
MMAR_1506|M.marinum_M SIEVAHGDGLGGSSCCYGFGAHTDLQWIEAVAGAVDRARVATLLLPGIGS
MUL_2435|M.ulcerans_Agy99 SIEVAHGDGLGGSSCCYGFGAHTDLEWIEAVAGAVDRARVATLLLPGIGG
Mvan_0597|M.vanbaalenii_PYR-1 SIEVAHGDGLAGGTCNYGFGAHTDLEWIETVATAVKRARVATLVLPGVGT
MAB_4375|M.abscessus_ATCC_1997 AIEVAHGDGLAGGSVNYGPGSNTDWEWIEAAADAVTTAKLTTLLLPGIGT
MSMEG_4150|M.smegmatis_MC2_155 AIEVGHGDGLNGSSLAYGFSRHSDLSYIHEAASVTRRAKLACVLLPGIGT
*** ***** *.: ** . .: . *. .* .. :::: ::***:*
Mflv_1522|M.gilvum_PYR-GCK KEDIKEAQNNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMSHT
MAV_0627|M.avium_104 KEDIKEAQNNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMSHT
TH_0371|M.thermoresistible__bu KDDIKEAQDNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMAHT
Mb3564c|M.bovis_AF2122/97 KDDIKEARDNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMAHT
Rv3534c|M.tuberculosis_H37Rv KDDIKEARDNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMAHT
MMAR_1506|M.marinum_M VANLEDAHRAGASVVRVGTHCTEADLAARYLGAARDLGMDAVGFLMMSHL
MUL_2435|M.ulcerans_Agy99 VAHLEDAHRAGATVVRVGTHCTEADLAARYLGAARDLGMDAVGFLMMSHL
Mvan_0597|M.vanbaalenii_PYR-1 VRDLRDARRAGATVVRVGTHCTEADISAEHITAARELGMDTVGFLMMSHM
MAB_4375|M.abscessus_ATCC_1997 VAELKRAYSLGVRSIRVAAHCTEADITAQHITMARELGMDVSGFLMLSHM
MSMEG_4150|M.smegmatis_MC2_155 IEDLKRARDSGIELVRIATHCTEADVSAQHISAAVELGFHVSGFLMMSSA
.:. * * *:.:******:: .:: * :**:.. ****::
Mflv_1522|M.gilvum_PYR-GCK ISPEKLAKQARIMADAGCQCVYVVDSAGALVLEGVADRVSALVAELGDDA
MAV_0627|M.avium_104 IPPEKLAQQARIMADAGCQCVYVVDSAGALVLEGVRDRVAALVAELGDDA
TH_0371|M.thermoresistible__bu IPPEKLAEQARIMADAGCQCVYVVDSAGALVLEGVRDRVAALVAELGDDA
Mb3564c|M.bovis_AF2122/97 IAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVSALVAELGEDA
Rv3534c|M.tuberculosis_H37Rv IAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVSALVAELGEDA
MMAR_1506|M.marinum_M TTPKRLAEQAKLLEGYGASCVYVVDSGGALTGAAVAQRFDALRQNLDPAT
MUL_2435|M.ulcerans_Agy99 TTPKLLAEQAKLLEGYGASCVYVVDSGGAMTGAAVAQRFDALRQNLDPAT
Mvan_0597|M.vanbaalenii_PYR-1 SSPSALAAQAKLMEGYGATCVYVVDSGGAMVMRDVAERVDALRQTLLPAT
MAB_4375|M.abscessus_ATCC_1997 ASAETLAEQAKLMETFGAHCVYVTDSGGRLTMPMVRDRVRAYRDVLDSHT
MSMEG_4150|M.smegmatis_MC2_155 TTPENIGVQAAKMESYGAQCVYIADSAGNLTPAGTTARFQALEAALDGAT
... :. ** : *. ***:.**.* :. . *. * * :
Mflv_1522|M.gilvum_PYR-GCK QVGFHGHENLGLGVANSIEAVRAGAKQIDGSCRRFGAGAGNAPVEALIGV
MAV_0627|M.avium_104 QVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGNAPVEALIGV
TH_0371|M.thermoresistible__bu QVGFHGHENLGLGVANSVEAVRAGAKQIDGSCRRFGAGAGNAPVEALIGV
Mb3564c|M.bovis_AF2122/97 QVGFHGHENLGLGVANSVAAVRAGAKQIDGSCRRFGAGAGNAPVEALIGV
Rv3534c|M.tuberculosis_H37Rv QVGFHGHENLGLGVANSVAAVRAGAKQIDGSCRRFGAGAGNAPVEALIGV
MMAR_1506|M.marinum_M ELGIHAHHNLSLGVANSVVAVEHGARRIDASLAGMGAGAGNAPLEVLIAV
MUL_2435|M.ulcerans_Agy99 ELGIHAHHNLSLGVANSVVAVEHGARRIDASLAGMGAGAGNVPLEVLIAV
Mvan_0597|M.vanbaalenii_PYR-1 EIGIHAHHNLSLGVANSITAVQHGAHRVDASLAGMGAGAGNAPLEVFVAA
MAB_4375|M.abscessus_ATCC_1997 EIGIHAHENLSLSVANSVVAVEEGATRIDASLAGHGAGAGNCPLEAFVAV
MSMEG_4150|M.smegmatis_MC2_155 QRGIHAHENLSLSVANTVVAVENGARRVDAALAGMGAGAGNCPIEAFIAV
: *:*.*.**.*.***:: **. ** ::*.: ****** *:*.::..
Mflv_1522|M.gilvum_PYR-GCK FDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMGYSGVYSSFL
MAV_0627|M.avium_104 FDKIGVKTGIDFFDIADAAEEVVAPAMPAECLLDRNALIMGYSGVYSSFL
TH_0371|M.thermoresistible__bu FDKVGVKTGIDFFDIADAAEEVVAPAMPSECLLDRNALIMGYSGVYSSFL
Mb3564c|M.bovis_AF2122/97 FDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMGYSGVYSSFL
Rv3534c|M.tuberculosis_H37Rv FDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMGYSGVYSSFL
MMAR_1506|M.marinum_M VNRLGWTHGCELNALEDAADDLVRPLQDRPVRIDRETLTLGYAGVYSSFL
MUL_2435|M.ulcerans_Agy99 VNRLGWTHGCELNALEDAADDLVRPLQDRPVRIDRETLTLGYAGVYSSFL
Mvan_0597|M.vanbaalenii_PYR-1 AERLDWTHGCDLHALQDAADDLVRPLQDRPVRVDRETLTLGYAGVYSSFL
MAB_4375|M.abscessus_ATCC_1997 ADLHGWGHSCDLFALQDAADDLVRPLHDRPVRVDRETLTLGYAGVYSSFL
MSMEG_4150|M.smegmatis_MC2_155 ANKYGWEHGCELFKLQDAAEDLVRPLQDRPVRVDRQTLTLGYAGVYSSFL
: . . :: : ***:::* * :**::* :**:*******
Mflv_1522|M.gilvum_PYR-GCK KHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEIKREQEAEAT
MAV_0627|M.avium_104 KHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEIKREQESGAA
TH_0371|M.thermoresistible__bu KHAIRQSERYGVPAHQLLHRAGQRKLIGGQEDQLIDIALEIKRELEEQAG
Mb3564c|M.bovis_AF2122/97 KHAVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEIKRELDSGAA
Rv3534c|M.tuberculosis_H37Rv KHAVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEIKRELDSGAA
MMAR_1506|M.marinum_M RHAEVTAGRYGVDARSLLEEAGRRGLIGGQEDLLVDIALDLVGPAEPLAH
MUL_2435|M.ulcerans_Agy99 RHAEITAGRYGVDARSLLEEAGRRGLIGGQEDLLVDIALDLVGPAEPLAH
Mvan_0597|M.vanbaalenii_PYR-1 RHAEAAAARYHIDARTLLEEAGRRGMVGGQEDMLVDIALDLTGADRS---
MAB_4375|M.abscessus_ATCC_1997 RHAEAAAQRYDVDVRSILIEAGRRRLVGGQEDMLVDIALSLST-------
MSMEG_4150|M.smegmatis_MC2_155 RHAERAANEFDIDVREIILEIGRRELIGGQEDMIIDVALDLAAHQSAQSP
:** : .: : . :: . *:* ::***** ::*:**.:
Mflv_1522|M.gilvum_PYR-GCK RA--
MAV_0627|M.avium_104 AAR-
TH_0371|M.thermoresistible__bu STA-
Mb3564c|M.bovis_AF2122/97 VTH-
Rv3534c|M.tuberculosis_H37Rv VTH-
MMAR_1506|M.marinum_M GAP-
MUL_2435|M.ulcerans_Agy99 GAP-
Mvan_0597|M.vanbaalenii_PYR-1 ----
MAB_4375|M.abscessus_ATCC_1997 ----
MSMEG_4150|M.smegmatis_MC2_155 NRTG