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AVQSSARRLEKASGLGKGERQLNGPQTTGREYANLSEPQYNTMRENNVAIPVRDGTVLLADVHRPDAQGR FPALIAASPYPRQIQDLGAPMGFIEAGVTDFWVPRGYVHVIANVRGTGGSGGTFGFFDATERRDMHDLVE WAAAQPWCDGNVGMIGISYFAMTQLEAAVERPPHLKAIFPVAATTDLYEAAVHHGLFSSSFVSPFLTMVG ITSERSDALWRGKLVGLVRRVLNTPRLHQKFATMNGEAALTMLRQLTKIHHNPRPWDQLWLSAAVEHPTR DEWWDERDLNPLLDRIDVPVYLGCDWQNVPLHLPSTFAAWKALADGPSTRMGMLGEFGLTWPWESLHLEA LAWFDHWLKSRDTGILAGPAIRYVLPGAEGWRTTETWPPPGVVYREFALRADGQLGDDEGEPGAREYLVL GGGLNRAAASAIDPPSMLTWTSAPLTRDLDVVGDIELRLVAAATAMDTAWIATLHEVARDGTVSDVTAGW LRASMRRVDEKASRRGAPILPCREMEAVPIGEDVVYRIPLVANARRFKAGCRIRLILTSDDQDPATPAIM SFRHASVGTSSRNTIRSSSRLHLPVLPAQSSELQS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_5521 | - | - | 100% (596) | peptidase S15 |
| M. marinum M | MMAR_1269 | - | 3e-41 | 27.52% (556) | Acyl esterase |
| M. marinum M | MMAR_1910 | - | 2e-30 | 28.49% (530) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2823 | - | 9e-34 | 28.98% (528) | hydrolase |
| M. gilvum PYR-GCK | Mflv_4032 | - | 5e-23 | 25.00% (588) | peptidase S15 |
| M. tuberculosis H37Rv | Rv2800 | - | 9e-34 | 28.98% (528) | hydrolase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2222c | - | 5e-43 | 27.44% (605) | peptidase |
| M. avium 104 | MAV_3687 | - | 3e-32 | 28.08% (584) | hydrolase CocE/NonD family protein |
| M. smegmatis MC2 155 | MSMEG_5283 | - | 3e-37 | 27.51% (567) | hydrolase, CocE/NonD family protein |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3980 | - | 0.0 | 98.66% (596) | peptidase S15 |
| M. vanbaalenii PYR-1 | Mvan_2322 | - | 2e-28 | 26.83% (589) | peptidase S15 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5521|M.marinum_M MAVQSSARRLEKASGLGKGERQLNGPQTTGREYANLSEPQYNTMRENNVA
MUL_3980|M.ulcerans_Agy99 MAVQSSARRLEKTSGLGKGERQLNGPQTTGREYANLSEPQYNTMRENNAA
Mb2823|M.bovis_AF2122/97 ----MSTTSARPERPKLRALTGRVGGQALGGLLG-LPRATTRYTVG-HVR
Rv2800|M.tuberculosis_H37Rv ----MSTTSARPERPKLRALTGRVGGQALGGLLG-LPRATTRYTVG-HVR
MAV_3687|M.avium_104 ----MSLTSLRPAQPALHTLR-HLGGRAAGRLLG-LPPATTDYTVR-RVA
Mflv_4032|M.gilvum_PYR-GCK ----MSSELARRAR------------RALSRVFD-LPPPVCDFVVHRELR
Mvan_2322|M.vanbaalenii_PYR-1 ----MSSELSRLAR------------HALSRALH-LPPPVCDYAVNRHVR
MAB_2222c|M.abscessus_ATCC_199 ------------------------------------------------MP
MSMEG_5283|M.smegmatis_MC2_155 ----MAALDRPWRRPGAARYALSRLRGFVRTPVEVYEPEPGSVTVRHDVP
MMAR_5521|M.marinum_M IPVRDGTVLLADVHRPDAQGRFPALIAASPYPRQIQDLGAPMG-------
MUL_3980|M.ulcerans_Agy99 IPVRDGTVLLADVHRPDAQGRFPALIAASPYPRQIQDLGAPMG-------
Mb2823|M.bovis_AF2122/97 VPMRDGVQLVADHYAPATSQPVGTLLVRGPYGRRFP--------------
Rv2800|M.tuberculosis_H37Rv VPMRDGVQLVADHYAPATSQPVGTLLVRGPYGRRFP--------------
MAV_3687|M.avium_104 VPMRDGVELVADHYAPATSAPAGTLLVRAPYGRGFP--------------
Mflv_4032|M.gilvum_PYR-GCK VPMRDRVELVADHYAPHTASPAGTLLVRGPYGRGLP--------------
Mvan_2322|M.vanbaalenii_PYR-1 VPMRDGVELVADHYTPRTADPAGTLLVRGPYGRGFP--------------
MAB_2222c|M.abscessus_ATCC_199 ATMRDGTILRADIYRPKLKDPVPVILMRTQYGKDTAQIQP----------
MSMEG_5283|M.smegmatis_MC2_155 VTTRDGTVLRVNVHLPAGENPVPVLLCAHPYGKDKVPVRKKRGRGYALPF
. ** . * .: : * .:: * :
MMAR_5521|M.marinum_M -----------------FIEAGVTDFWVPRGYVHVIANVRGTGGSGGTFG
MUL_3980|M.ulcerans_Agy99 -----------------FIEAGVTDFWVPRGYVHVIANVRGTGGSGGTFG
Mb2823|M.bovis_AF2122/97 ------------------FSLVFARIYAARGYHVVLQSVRGTFGSGGVFE
Rv2800|M.tuberculosis_H37Rv ------------------FSLVFARIYAARGYHVVLQSVRGTFGSGGVFE
MAV_3687|M.avium_104 ------------------FALVFGGLYAARGYHVVLQSVRGTFGSGGVFE
Mflv_4032|M.gilvum_PYR-GCK ------------------FATMFASFYAARGYHVVFQSVRGTFGSGGEFD
Mvan_2322|M.vanbaalenii_PYR-1 ------------------ISVLFGSIYAARGYHVVLQSVRGTFGSGGEFD
MAB_2222c|M.abscessus_ATCC_199 ------------------SRFRTPDWFASHCYLVVVQDVRGQGTSDGIFT
MSMEG_5283|M.smegmatis_MC2_155 QYRVLRQPARVRFSSLTTWEAPDPAWWTKQGFAVVNCDLRGAGTSGGVGS
:. : : * .:** *.*
MMAR_5521|M.marinum_M FFDATERRDMHDLVEWAAAQPWCDGNVGMIGISYFAMTQLEAAVERPPHL
MUL_3980|M.ulcerans_Agy99 FFDATERRDMHDLVEWAAAQPWCDGNVGMIGISYFAMTQLEAAVERPPHL
Mb2823|M.bovis_AF2122/97 PMVN-EAADGADTVAWLREQPWFTGRFGTIGLPYLGFTQWALLHDPPPEL
Rv2800|M.tuberculosis_H37Rv PMVN-EAADGADTVAWLREQPWFTGRFGTIGLPYLGFTQWALLHDPPPEL
MAV_3687|M.avium_104 PMAH-EVADGADTVAWLREQPWFTGRFATIGMSYLGFTQWALLQDPPPDM
Mflv_4032|M.gilvum_PYR-GCK PFVN-EVDDGADTAAWLRDQPWFTGTFATIGLSYLGFTQWALLTDPPPEL
Mvan_2322|M.vanbaalenii_PYR-1 PFVN-EVADGADTAAWLRDQPWFTGTFATMGLSYLGFTQWALLTDPPPEL
MAB_2222c|M.abscessus_ATCC_199 EFGN-DGDDGYDTVEWAAGLPGATGKVGMYGSSYVGATQWLAATTTPPHL
MSMEG_5283|M.smegmatis_MC2_155 PLSDQEGEDVYDLVEWAAAQPWSTGAVGMIGVSYLAISQWKSAALRPPHL
: : * * . * * * .. * .*.. :* **.:
MMAR_5521|M.marinum_M KAIFPVAATTDLYE-AAVHHGLFSSSFVSPFLTMVGITSERSDALWRGKL
MUL_3980|M.ulcerans_Agy99 KAIFPVAATTDLYE-AAVHHGLFSSSFVSPFLTMVGITSERSDALWRGKL
Mb2823|M.bovis_AF2122/97 AAAVITVGPHDFRA-SVWGTGSFT---VNDFLGWSDLVSHQEDPGR----
Rv2800|M.tuberculosis_H37Rv AAAVITVGPHDFRA-SVWGTGSFT---VNDFLGWSDLVSHQEDPGR----
MAV_3687|M.avium_104 ATAVIMVGPHDFNE-STWGTGSFA---VNDFLGWSDMVSHQEDPVR----
Mflv_4032|M.gilvum_PYR-GCK AAAVITVGPDDVSG-PRWGAGSFG---LNDFLGWSDLVGRQEDPNR----
Mvan_2322|M.vanbaalenii_PYR-1 KAAVITVGPDDVSG-PRWGRGSFG---LNDFLGWSHLVGGQEDPNR----
MAB_2222c|M.abscessus_ATCC_199 TTIVPSNTASDYYDGWTYEGGAFR---LGFVQPWAMGTIATTAAKN----
MSMEG_5283|M.smegmatis_MC2_155 RAIVPWEGMTDPYR---------------DLLHPGGIAETGFIKLWS---
: . * . .
MMAR_5521|M.marinum_M VGLVRRVLNTPRLHQKFATMNGEAALTMLRQLTKIHHNPRPWDQLWLSAA
MUL_3980|M.ulcerans_Agy99 VGLVRRVLNTPRLHQKFATMNGEAALTMLRQLTKIHHNPRPWDQLWLSAA
Mb2823|M.bovis_AF2122/97 ---IRAGIRQLTAPRRVARTA--ATLPLGESARTLLGTGAPWFESWVEHT
Rv2800|M.tuberculosis_H37Rv ---IRAGIRQLTAPRRVARTA--ATLPLGESARTLLGTGAPWFESWVEHT
MAV_3687|M.avium_104 ---ARAALHQLRARRKVAEAA--AGVPLGEAARALLGTGAPWFESWIEHA
Mflv_4032|M.gilvum_PYR-GCK ---VRTLLRQARAQRRVTSAS--LRLPLAAASRELLGDGALWFESWLDHP
Mvan_2322|M.vanbaalenii_PYR-1 ---LRSLLRQAGAQRRVTEAS--LGLPLGPASRTLLGDGAPWFESWLEHP
MAB_2222c|M.abscessus_ATCC_199 ----RADLAALEQLRAAAAERGRWLNHLPYQDLPPMQPGDPRVAPWYFDW
MSMEG_5283|M.smegmatis_MC2_155 -----RSLRDTRLKYDLGKEN----------------SSRPRYDDWWR--
: *
MMAR_5521|M.marinum_M VEHPTRDEWWDERDLNPLLDRIDVPVYLGCDWQNVPLHLPSTFAAWKALA
MUL_3980|M.ulcerans_Agy99 VEHPTRDEWWDERDINPLLDRIDVPVYLGCDWQNVPLNLPSTFAAWKALA
Mb2823|M.bovis_AF2122/97 DRD---DPFWDRLRFPAALDRVQVPVLLVGGWQ--DIFLRQTLQQYRHLR
Rv2800|M.tuberculosis_H37Rv DRD---DPFWDRLRFPAALDRVQVPVLLVGGWQ--DIFLRQTLQQYRHLR
MAV_3687|M.avium_104 DPS---DPFWNSLRCNEALDRVRVPVLLVGGWQ--DLFIRQTLQQYAHLR
Mflv_4032|M.gilvum_PYR-GCK DTD---DPFWTRLRLRDGLERAEVPVLLLTGWQ--DLFVDQTVEHYRMLA
Mvan_2322|M.vanbaalenii_PYR-1 ETD---DPFWSGLRLRDALADVDVPVLLLTGWQ--DLFVEQTLEHYRMLT
MAB_2222c|M.abscessus_ATCC_199 IRHSTRDDYWKRWSIRDRYQNVTVPVLHFEGWY--DAFLRGGLENFAGMT
MSMEG_5283|M.smegmatis_MC2_155 -------------SLVPALDRIEVPALICGSFSDNNLHTRGSVRGFEQIG
**. .: . : :
MMAR_5521|M.marinum_M DGP------STRMGMLGEFG----LTWPWES--------------LHLEA
MUL_3980|M.ulcerans_Agy99 DGP------STRMGMLGEFG----LTWPWES--------------LHLEA
Mb2823|M.bovis_AF2122/97 DRG------VHVALTVGPWTHTQMLTKGLAT--------------GARES
Rv2800|M.tuberculosis_H37Rv DRG------VHVALTVGPWTHTQMLTKGLAT--------------GARES
MAV_3687|M.avium_104 ARG------VDVALTVGPWTHTQLLTTGLGV--------------CTRES
Mflv_4032|M.gilvum_PYR-GCK GRG------VPTGLTIGPWTHGDMMTKAAPT--------------MLRES
Mvan_2322|M.vanbaalenii_PYR-1 SRG------VTAGLTVGPWTHGHMMTTAAPT--------------VLGET
MAB_2222c|M.abscessus_ATCC_199 ARGGSPGARRYQRMVIGPWDHLAWGRESSSPSPLLKGLGPGANSPVNEMQ
MSMEG_5283|M.smegmatis_MC2_155 SAER----------HLYTHRGGKWAAFYSDD--------------ALRTQ
:
MMAR_5521|M.marinum_M LAWFDHWLKSRDTGILAGPA-IRYVLPGAEG---WRTTETWPPPGVVYRE
MUL_3980|M.ulcerans_Agy99 LAWFDHWLKSRDTGILAGPA-IRYVLPGAEG---WRTTETWPPPGVVYRK
Mb2823|M.bovis_AF2122/97 LDWLDAHLGRAPA--LRPSP-VRVFVTGQG----WRHLPDWPP-ATTERA
Rv2800|M.tuberculosis_H37Rv LDWLDAHLGRAPA--LRPSP-VRVFVTGQG----WRHLPDWPP-ATTERA
MAV_3687|M.avium_104 LQWLETHLGDAPG--RRAGR-VHVYVTGVDRARAWRRLPDWPP-ATTERA
Mflv_4032|M.gilvum_PYR-GCK LDWLATHLKGEPP--QRRSP-VRIHLSRRG----WLNLPDWPP-AMPSLV
Mvan_2322|M.vanbaalenii_PYR-1 LDWLATHLGGAAP--LRRSP-VRIHLGGRG----WLNLPDWPP-AMPDVV
MAB_2222c|M.abscessus_ATCC_199 LAWFDHFLKGSDNGVATESPRLDYYLMGANR---WKHASAWPLPQTNWTV
MSMEG_5283|M.smegmatis_MC2_155 LAFLVRHLRGGTAQELPRVR--LEVRESRDRVVAVRDEAQWPLPSTRWTP
* :: * **
MMAR_5521|M.marinum_M FAL-----RADGQLGDDEG-----------------EPGAREYLVLGGG-
MUL_3980|M.ulcerans_Agy99 FAL-----RADGQLGDDEG-----------------EPGAREYLVLGGG-
Mb2823|M.bovis_AF2122/97 WYL-----QPGGRLGESAP-ASGTPPATFRYHPADPTPTTGGPLLSSNG-
Rv2800|M.tuberculosis_H37Rv WYL-----QPGGRLGESAP-ASGTPPATFRYHPADPTPTTGGPLLSSNG-
MAV_3687|M.avium_104 LYL-----RPGGYLGETAPSLKGLAPATFRYDPAHPTPTTGGPLLSPNG-
Mflv_4032|M.gilvum_PYR-GCK LHP-----QPGGGLAPGAP--G-AADATFVYNPGDPTPTVGGRLLSPVG-
Mvan_2322|M.vanbaalenii_PYR-1 LHP-----QPAGRLGPAAP--EPDGTATFVYNPADPTPTVGGRLLSPAG-
MAB_2222c|M.abscessus_ATCC_199 YHLGGRGTQHNGTLRDSAA--AHDAPDVYLYDPANPVPSAGGHSCCAAES
MSMEG_5283|M.smegmatis_MC2_155 LYL------HDAGLRAAPP-------------------DAAGSISFDTR-
. * .
MMAR_5521|M.marinum_M ---LNRAAASAIDPPSMLTWTSAPLTRDLDVVGDIELRLVAAATAMDTAW
MUL_3980|M.ulcerans_Agy99 ---LNRAAASAIDPPSMLTWTSAPLTRDLDVVGDIELRLVAAATAMDTAW
Mb2823|M.bovis_AF2122/97 ---GYRDDSRLATRADVLCFTGAPLTHDLCVHGNPVVELVHSSDNPYVDV
Rv2800|M.tuberculosis_H37Rv ---GYRDDSRLATRADVLCFTGAPLTHDLCVHGNPVVELVHSSDNPYVDV
MAV_3687|M.avium_104 ---GYRDDTRLASRDDVLAFTSATLTEDVYVYGNPVVELAHGADHPHADL
Mflv_4032|M.gilvum_PYR-GCK ---GYRDDTALARRADVLTFTGTALASDLPVVGVPVLDVAHTCATPHNDL
Mvan_2322|M.vanbaalenii_PYR-1 ---GYRDDTALARRADVLTFTGTPLPADLYVVGHPVLELAHTCANPHNDL
MAB_2222c|M.abscessus_ATCC_199 APQGRYDQRAVEQRPDVLTYTTEPLSTNTEITGPISVDLWASSSAPDTDF
MSMEG_5283|M.smegmatis_MC2_155 ----RAAARFGWTLPEDTELTGPMALRLYLSADTDDVDLFVGVEKWDGAR
. * . : :
MMAR_5521|M.marinum_M IATLHEVARDGTVSDVTAGWLRASMRRVDEKASRRGAPILPCREMEAVPI
MUL_3980|M.ulcerans_Agy99 IATLHEVARDGTVSDVTAGWLRASMRRVDEKASRRGAPILPCRGMEAVPI
Mb2823|M.bovis_AF2122/97 FVRVSEVDAKGRSRNVSDGYRRLGDAP-----------------------
Rv2800|M.tuberculosis_H37Rv FVRVSEVDAKGRSRNVSDGYRRLGDAP-----------------------
MAV_3687|M.avium_104 FVRVSEVDAAGRSRNVTETYRRLSAAAKPKAD------------------
Mflv_4032|M.gilvum_PYR-GCK FVRISQVDAHGRSRNVSDGYVASAPDS-----------------------
Mvan_2322|M.vanbaalenii_PYR-1 FVRVSQVDEHGRSRNVSDGYLAAAPDS-----------------------
MAB_2222c|M.abscessus_ATCC_199 TAKLVAVQADGTAANLNNGIVRTSLAQSLSER-------------RLMPI
MSMEG_5283|M.smegmatis_MC2_155 YVPFEGSYGFGRDR-VTTGWLRASMRALDESRSRPFEPVPTFTDPRPLRP
. . * :. .
MMAR_5521|M.marinum_M GEDVVYRIPLVANARRFKAGCRIRLILTSDDQDPATPAIMSFRHASVGTS
MUL_3980|M.ulcerans_Agy99 GEDVVYRIPLVANARRFKAGCRIRLIFTSDDQDPATPAIMSFRHASVGTS
Mb2823|M.bovis_AF2122/97 ---ELVRVELDAIAHRFRADSRIRVLIAGSWFPRYARNLGTPEPILTGRQ
Rv2800|M.tuberculosis_H37Rv ---ELVRVELDAIAHRFRADSRIRVLIAGSWFPRYARNLGTPEPILTGRQ
MAV_3687|M.avium_104 ---KVIRLELDGTAHRFRAGSRIRLLIAGSWSPRYAHNLGSGEPVLTARR
Mflv_4032|M.gilvum_PYR-GCK ---GTVTVELDPVAWTFPAGSRIRVLIAGGSHPRFLRNLGTGEHAGTATD
Mvan_2322|M.vanbaalenii_PYR-1 ---GTARIELDPVAWTFPAGSRIRLLIAGGSHPRFLRNLGTGETATTATT
MAB_2222c|M.abscessus_ATCC_199 GQPHKYHIDIWPVSYQFRTGERIRLEISSSDFPQYAPNPNTAAPFGRNAE
MSMEG_5283|M.smegmatis_MC2_155 GEVVPVDIPLGPSSTLFRAGEQLRLVVAGRWLWPRNPLTGQFPAAYERRS
: : : * :. ::*: .:.
MMAR_5521|M.marinum_M SRNTI-----RSS--SRLHLPVLPAQSSELQS-------------
MUL_3980|M.ulcerans_Agy99 SRNTI-----RSS--SRLHLRVLPAQSSELQS-------------
Mb2823|M.bovis_AF2122/97 LKPAT-----HAVHFGR-SRLLLPVG-------------------
Rv2800|M.tuberculosis_H37Rv LKPAT-----HAVHFGR-SRLLLPVG-------------------
MAV_3687|M.avium_104 LTPVT-----HSVRYGR-SRLLLPVGPAEPSADGVADPVGDGG--
Mflv_4032|M.gilvum_PYR-GCK FATAR-----HTVHLGEGTRLTLPAGPPPPSAD------------
Mvan_2322|M.vanbaalenii_PYR-1 YKTAR-----HTVHLGEQSRLVLPAGSHPPSTD------------
MAB_2222c|M.abscessus_ATCC_199 LRTATQIILHDAAHPSTLTLPVIPAGDPGTETFPMPRRPDDPPGN
MSMEG_5283|M.smegmatis_MC2_155 RGTAT-----LHWGPDRQARLLVPVVGDAHR--------------
. . :*.