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MTTLATDIATSTMAADLGGTWLRLRVGGPGTEVKRHMAPSLLNFPEQSVAQLRERLVDELCAAAPAGAHA AISCGAALDHRRGILYGSGPLWGAEAAPFDLAEALRLRRPDVTWLLVNDLTAGLADFTARWAGPSTRRIG YLTISSGIALRIADLRTSEIPVDEWGLQGEVGHLPTQADPVLRGLMCECGVPDHLAAHASGPGIGRIAGR LGVLPPNTSLLQWFPRALAAGDAAAVSVLQAAVAPIAALIRMLWCVDPHLDLLGIGGGVVEGLGSHYERE LREQLRGGSCYADRGFSESWLDERLVFCADSSADIDCLRGAQLMCDERLKATA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0581 | - | - | 100% (333) | glucose kinase |
| M. marinum M | MMAR_0987 | - | 3e-07 | 25.48% (263) | carbohydrate kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0669 | - | 8e-10 | 28.46% (267) | sugar kinase |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv0650 | - | 8e-10 | 28.46% (267) | sugar kinase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. avium 104 | MAV_4510 | - | 2e-05 | 27.50% (280) | sugar kinase |
| M. smegmatis MC2 155 | MSMEG_1363 | - | 8e-08 | 27.78% (288) | glucokinase |
| M. thermoresistible (build 8) | TH_4374 | - | 4e-07 | 26.82% (261) | PUTATIVE glucokinase |
| M. ulcerans Agy99 | MUL_0546 | - | 1e-151 | 99.24% (264) | glucose kinase |
| M. vanbaalenii PYR-1 | Mvan_1251 | - | 2e-05 | 26.87% (268) | ROK family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_1363|M.smegmatis_MC2_155 -MTLTLALDIGGTKIAAGL--------VDDDGALVHQAQLPTPD-GDGEL
Mvan_1251|M.vanbaalenii_PYR-1 MNDLVLALDIGGTKIAAGL--------VDADGTLVHRAQQPTPD-GDAET
Mb0669|M.bovis_AF2122/97 --MLTLCLDIGGTKIAAGL--------ADPAGTLVHTAQRPTPAYGGAEQ
Rv0650|M.tuberculosis_H37Rv --MLTLCLDIGGTKIAAGL--------ADPAGTLVHTAQRPTPAYGGAEQ
MAV_4510|M.avium_104 --MLTLGLDIGGTKIAAAL--------VDSSGTLVHTAVRPTPNPAPADD
TH_4374|M.thermoresistible__bu --VLTLTLDIGGTKLAAGL--------VDGDGGLVHHTHAATPG-GDAEA
MMAR_0581|M.marinum_M --MTTLATDIATSTMAADLGGTWLRLRVGGPGTEVKRHMAPSLLNFPEQS
MUL_0546|M.ulcerans_Agy99 --MTTLATDIATSTMAADLGGTWLRLRVGGPGTEVKRHMAPSLLNFPEQS
.* **. :.:** * .. * *: .: :
MSMEG_1363|M.smegmatis_MC2_155 IWNVVDELVTGALRVADGAVDGVGIAAAGPIDLPGGTIS---PINIVEWQ
Mvan_1251|M.vanbaalenii_PYR-1 VWDTAAALLAETRDAAPGPVSAVGIGSAGPIDVPGGTVS---PINIAEWS
Mb0669|M.bovis_AF2122/97 VWAAVAEMIADALGVAGGAVGGVGIASAGPIDLHSGRVS---PINIGSWG
Rv0650|M.tuberculosis_H37Rv VWAAVAEMIADALGVAGGAVGGVGIASAGPIDLHSGRVS---PINIGSWG
MAV_4510|M.avium_104 VWDVVHALIAEVVRAADAPIAAVGIASAGPVDLPSGSVS---PINIAGWH
TH_4374|M.thermoresistible__bu VWTVLAGLIDDALTRAGGRVRAVGVGSAGPIDLTAGTVS---PINLTAWS
MMAR_0581|M.marinum_M VAQLRERLVDELCAAAPAGAHAA-ISCGAALDHRRGILYGSGPLWGAEAA
MUL_0546|M.ulcerans_Agy99 VAQLRERLVDELCAAAPAGAHAA-ISCGAALDHRRGILYGSGPLWGAEAA
: :: * . .. :.....:* * : *:
MSMEG_1363|M.smegmatis_MC2_155 RFPIVDRVAAAT-GLPVRLGGDGLCMALGEHWRGAGRGAQFLLGMVVSTG
Mvan_1251|M.vanbaalenii_PYR-1 HFPIVRRVADLT-GLPVRLGGDGLCMALGEWWRGAGRGAGFLLGMVVSTG
Mb0669|M.bovis_AF2122/97 GFPLRDRVAAAVPGVPVRLGGDGVCMALGEHWLGAGRGARFLLGLVVSTG
Rv0650|M.tuberculosis_H37Rv GFPLRDRVAAAVPGVPVRLGGDGVCMALGEHWLGAGRGARFLLGLVVSTG
MAV_4510|M.avium_104 RFPLRDKVAAAVPATPVVLGGDGLCMALGEQWLGAGRGARFLLGMVVSTG
TH_4374|M.thermoresistible__bu RFPLTERVSAALPGVPVRLGGDGLCMAMGEQWRGAGRGARFVLGIVVSTG
MMAR_0581|M.marinum_M PFDLAEALRLRRPDVTWLLVNDLTAGLADFTARWAGPSTRRIGYLTISSG
MUL_0546|M.ulcerans_Agy99 PFDLAEALRLRRPDVTWLLVNDLTAGLADFTARWAGPSTRRIGYLTISSG
* : : . * .* . . ** .: : :.:*:*
MSMEG_1363|M.smegmatis_MC2_155 VGG---GLVLDGAPYDGR--TGNAGHAGHVIVELEDGDLCTCGGHGCVET
Mvan_1251|M.vanbaalenii_PYR-1 IGG---GLVLDGAPYHGR--SGNAGHVGHVVVEP-GGAPCTCGGRGCVET
Mb0669|M.bovis_AF2122/97 VGG---GLVLDGAPCLGR--TGNAGHVGHVVVDP-DGSPCPCGGRGCVET
Rv0650|M.tuberculosis_H37Rv VGG---GLVLDGAPCLGR--TGNAGHVGHVVVDP-DGSPCPCGGRGCVET
MAV_4510|M.avium_104 VGG---GLVLDGAPYPGR--TGNAGHVGHVVVEL-DGRPCTCGGHGCVET
TH_4374|M.thermoresistible__bu VGG---GLVLDGMPYQGR--TGNAGHVGHVVVDP-RGVACSCGGRGCVET
MMAR_0581|M.marinum_M IALRIADLRTSEIPVDEWGLQGEVGHLPTQADPVLRGLMCECGVPDHLAA
MUL_0546|M.ulcerans_Agy99 IALRIADLRTSEIPVDEWGLQGEVGHLPTQADPVLRGLMCECGVPDHLAA
:. .* . * *:.** * * ** . : :
MSMEG_1363|M.smegmatis_MC2_155 VASGPNMTRWARRQGWQAPADADAKELADAANAGDAVALAAYRRGARAVA
Mvan_1251|M.vanbaalenii_PYR-1 VASGPHLARWAHDNGWAAAPDADAKDLAEAAGRGDPVALRAFARGADAVA
Mb0669|M.bovis_AF2122/97 IASGPSLARWARANGWSAPPGAGAKELAEAAGAGDPVALRAFRRGAAALA
Rv0650|M.tuberculosis_H37Rv IASGPSLARWARANGWSAPPGAGAKELAEAAGAGDPVALRAFRRGAAALA
MAV_4510|M.avium_104 VASGPSMVRWARENGWSAAPGAGARDLAAAAAS-DPLAQKAFHRSADALA
TH_4374|M.thermoresistible__bu MAAGPAMVRWARANGWNAPPDADAEDLAAAAAAGVPVAVRAYRRGADALA
MMAR_0581|M.marinum_M HASGPGIGRIAGRLGVLPPNTSLLQWFPRALAAGDAAAVSVLQAAVAPIA
MUL_0546|M.ulcerans_Agy99 HASEPGIGRIAGRLGALPPNTSLLQWFPRALAAGDAAAVSVLQAAVAPIA
*: * : * * * .. : . :. * . * . .. .:*
MSMEG_1363|M.smegmatis_MC2_155 AMIASVGAVC-DLDLVVIGGGVAKS-GALLFDPIREALKNYAGLDFLRT-
Mvan_1251|M.vanbaalenii_PYR-1 RTIASVAAVC-DLDLVVVGGGVAKA-GALLFDPLRQALTMYAGLEFLRG-
Mb0669|M.bovis_AF2122/97 AMIASVGAVC-DLDLAVIGGGVAKS-GRLLFEPLRAALADHARLDFLAG-
Rv0650|M.tuberculosis_H37Rv AMIASVGAVC-DLDLAVIGGGVAKS-GRLLFEPLRAALADHARLDFLAG-
MAV_4510|M.avium_104 AMIASVGAVC-DLDVVVIGGGVAQS-GPLLFDPLRERLAHYAGLDFLSG-
TH_4374|M.thermoresistible__bu AAISSVAAVC-DLDLVVIGGGVARS-GPVLFDPLAEALTTYTGLSFLRG-
MMAR_0581|M.marinum_M ALIRMLWCVDPHLDLLGIGGGVVEGLGSHYERELREQLRGGSCYADRGFS
MUL_0546|M.ulcerans_Agy99 ALIRMLWCVDPHLDLLGR---------------HRWRSGGRSGFALRA--
* : .* .**: :
MSMEG_1363|M.smegmatis_MC2_155 ------LQVVPAELGGDAGLIGAAALARA-------
Mvan_1251|M.vanbaalenii_PYR-1 ------LRVVPAELGGDAGLVGAAALVHDSVRFG--
Mb0669|M.bovis_AF2122/97 ------LRVVPAELGGAAGLVGAARLAAIA------
Rv0650|M.tuberculosis_H37Rv ------LRVVPAELGGAAGLVGAARLAAIA------
MAV_4510|M.avium_104 ------LTVVPGELGGNAGLIGAARLATLARPAGS-
TH_4374|M.thermoresistible__bu ------LRVVPARLGATAGLIGAARLAISAC-----
MMAR_0581|M.marinum_M ESWLDERLVFCADSSADIDCLRGAQLMCDERLKATA
MUL_0546|M.ulcerans_Agy99 ------------------------------------