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NRNHRIEHWDPEDAQAWEASNHAVARRNLLWITACDHVAFGVWTLWPVLVLFMPYDVYGFSAADKFLLGA TATFVAACLRIPYSLGIATFGGRNWTVFSIAVLAIPTIGTIWLLSHPGLPLWPYLACAALTGCGGANYAA SMTNTNAFYPHRRKGFALGFNAGAGNLGVPMIQLVGLLVIAIAGYHQPYWVCGLYLLLLTVVAVGAARQM DNLAHATYDVGHLRAILTQRDTWVLALLYLGTFGSWIGFSFAFGQVLQINFVGSGQSHAQAALHAAEFAF IGPALGSLARIYGGRLADRVGGSRVTLAVFITMALFTGLLVAISTHGDHTPGPATVAMTAGYIGGFLALF ALAGLGNGSVYKMIPSVFEALSHRNQITEFERRRWSQAMSGAVIGFVAAFGALGGVGINLALRQSYLSTG TDTSAYWVFLLFYVGAALLTWSRYGRRAVPVAGTAGTASGSRLARV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0521 | narK3_2 | - | 100% (467) | integral membrane nitrite extrusion protein NarK3_2 |
| M. marinum M | MMAR_2079 | narK3 | e-159 | 58.99% (456) | integral membrane nitrite extrusion protein NarK3 |
| M. marinum M | MMAR_3637 | narK1 | e-156 | 59.48% (459) | integral membrane nitrite extrusion protein NarK1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0267c | narK3 | 1e-179 | 64.98% (454) | integral membrane nitrite extrusion protein NarK3 |
| M. gilvum PYR-GCK | Mflv_3015 | - | 1e-133 | 52.80% (447) | nitrite extrusion protein |
| M. tuberculosis H37Rv | Rv0261c | narK3 | 1e-179 | 64.98% (454) | integral membrane nitrite extrusion protein NarK3 |
| M. leprae Br4923 | MLBr_00844 | narK | 1e-161 | 61.32% (455) | putative nitrite extrusion protein |
| M. abscessus ATCC 19977 | MAB_3523c | - | 1e-136 | 52.12% (472) | integral membrane nitrite extrusion protein NarK3 |
| M. avium 104 | MAV_4899 | - | 1e-166 | 62.72% (456) | transporter, major facilitator family protein |
| M. smegmatis MC2 155 | MSMEG_0433 | - | 1e-178 | 65.71% (452) | nitrite extrusion protein |
| M. thermoresistible (build 8) | TH_2968 | - | 5e-05 | 26.63% (199) | PUTATIVE putative major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_3265 | narK3 | 1e-158 | 58.11% (456) | integral membrane nitrite extrusion protein NarK3 |
| M. vanbaalenii PYR-1 | Mvan_3492 | - | 1e-70 | 35.71% (462) | nitrite transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3015|M.gilvum_PYR-GCK ------------------------------MTWAFTGVMAKRTRDIDTWD
MAB_3523c|M.abscessus_ATCC_199 -----------------------------MANNTATAPIARRGRWIENWD
Mb0267c|M.bovis_AF2122/97 ---------------------------------------MGRSHQISDWD
Rv0261c|M.tuberculosis_H37Rv ---------------------------------------MGRSHQISDWD
MSMEG_0433|M.smegmatis_MC2_155 ------------------------------------MPTLLKPKRITNWD
MMAR_0521|M.marinum_M ---------------------------------------MNRNHRIEHWD
MLBr_00844|M.leprae_Br4923 MDQLVLLQAEESLYGPGRRSKTVPIDHRHSLKSSFFRLRLRRACRISHWD
MAV_4899|M.avium_104 ---------------------------------------MGRDHRITDWN
MUL_3265|M.ulcerans_Agy99 ---------------------------------------MGRSRHIAHWD
Mvan_3492|M.vanbaalenii_PYR-1 ------------------MTVTDSESTGALATAAPAPERHRGKHWIDDWR
TH_2968|M.thermoresistible__bu --------------------------------------------------
Mflv_3015|M.gilvum_PYR-GCK PEDVQAWEGTGGKAPGKEIAKRNLIWSIVAEHVGFSVWSIWSVMVLFMPQ
MAB_3523c|M.abscessus_ATCC_199 PEDVVAWD-NG----GAKIARRNLIWSVVAEHVGFSVWSIWSVMVLFMPQ
Mb0267c|M.bovis_AF2122/97 PEDSVAWEAGN-----KFIARRNLIWSVAAEHVGFSVWSLWSVMVLFMPT
Rv0261c|M.tuberculosis_H37Rv PEDSVAWEAGN-----KFIARRNLIWSVAAEHVGFSVWSLWSVMVLFMPT
MSMEG_0433|M.smegmatis_MC2_155 PEDVAAWEAGN-----KYVARRNLIWSVVAEHIGFSIWSIWSVMVLFMPE
MMAR_0521|M.marinum_M PEDAQAWEASN-----HAVARRNLLWITACDHVAFGVWTLWPVLVLFMPY
MLBr_00844|M.leprae_Br4923 PEDQAAWEAGN-----KTIARLNLLWSVLTVHLGYSVWTLWPVMELFMPK
MAV_4899|M.avium_104 PEDAAAWEAGN-----KRIARRNLLCTIAGDHVAFSIWTLWPVMALFMPA
MUL_3265|M.ulcerans_Agy99 PEDVQAWEAGN-----KAIARRNLVFSIATMHVGFSIWTLWSVMVLFMPQ
Mvan_3492|M.vanbaalenii_PYR-1 PEDPEFWATTG-----KPVARRNLIFSIFAEHIGFSVWLLWSIVVVQMTA
TH_2968|M.thermoresistible__bu ----VRRDAPS-----GTPVRRPFLLVTALAVVVLTVAVLQTAVVPVLGI
. .: :: : : : . : :
Mflv_3015|M.gilvum_PYR-GCK DVYGIDAAG--------KFYLVAVPTLVGAFMRIPYTIAPARFGGRNWTI
MAB_3523c|M.abscessus_ATCC_199 NVYHIDAAG--------KFFLVAMPTLVGAVLRLPYTFATAWFGGRNWTV
Mb0267c|M.bovis_AF2122/97 SVYGFSAGD--------KFLLGATATLVGACLRFPYTFATAKFGGRNWTI
Rv0261c|M.tuberculosis_H37Rv SVYGFSAGD--------KFLLGATATLVGACLRFPYTFATAKFGGRNWTI
MSMEG_0433|M.smegmatis_MC2_155 AVYGFSAGD--------KFLLGATATLVGSCLRIPYTLATATFGGRNWTV
MMAR_0521|M.marinum_M DVYGFSAAD--------KFLLGATATFVAACLRIPYSLGIATFGGRNWTV
MLBr_00844|M.leprae_Br4923 DVYGFSAGD--------KFLLATTATLVGACLRVPYSLATALFGGRNWAI
MAV_4899|M.avium_104 AVYGFSAGD--------KLLLGAVATLVGGCARIPYTLGIAAFGGRKWTT
MUL_3265|M.ulcerans_Agy99 SVYGISAAN--------KLLLGATATLVGGCVRIPYVMATARFGGRNWAT
Mvan_3492|M.vanbaalenii_PYR-1 GADGSPAASGFALTTTQALWLVAVPSGVGAFLRLPYTFAVPVFGGRNWTV
TH_2968|M.thermoresistible__bu MAEQLHTSAT-------AVSWAVTANLLAAAAATPLLGRLADLYSKRRVL
. :. . . .. :.. * . : .:. .
Mflv_3015|M.gilvum_PYR-GCK VSALLLLIPTVLAYYYMKNPAS-YTTYMVIAAFAGLGGGNFASSMTNINA
MAB_3523c|M.abscessus_ATCC_199 FSALVLAVPTALTLYFMAHPETSYTTFMIVAAVAGFGGGNFASSMTNINA
Mb0267c|M.bovis_AF2122/97 FSALVLLIPTVGSILLLANPGLPLWPYLVCGALAGLGGGNFAASMTNINA
Rv0261c|M.tuberculosis_H37Rv FSALVLLIPTVGSILLLANPGLPLWPYLVCGALAGLGGGNFAASMTNINA
MSMEG_0433|M.smegmatis_MC2_155 FSALVLLIPTVMTVVLMANPGLPLWPYLVCAALAGFGGGNFASSMTNINA
MMAR_0521|M.marinum_M FSIAVLAIPTIGTIWLLSHPGLPLWPYLACAALTGCGGANYAASMTNTNA
MLBr_00844|M.leprae_Br4923 FSVMVLLIPTIATMVLLAHPGLPLWPYLACAALTGLGGGNFAASMTNANA
MAV_4899|M.avium_104 FSAVVLLIPTVGTIVLLANPGLPLWLFVLCAALTGLGGGNYAASLANVNA
MUL_3265|M.ulcerans_Agy99 FSSLVLLVPTVGAIVLLANPGLPLWPYLVCAALSGVGGGNYSASLANVEA
Mvan_3492|M.vanbaalenii_PYR-1 ISALLLLIPCLGLAWAVSNPDINFAVLLLIAATAGFGGGNFASSMANISF
TH_2968|M.thermoresistible__bu LAVLVVVLAGS----VLAATTASLPLLITARVLQGASFALYPISIAILRD
.: :: :. : . : . * . . :. *::
Mflv_3015|M.gilvum_PYR-GCK FYPQRLKGWALGLNAGGGNIG-VPVIQLIGLMVIAAVGNTRPEIVCAIYL
MAB_3523c|M.abscessus_ATCC_199 FYPQRFKGWALGLNAGGGNIG-VPVIQVIGLLVIATVGNRSPHWVAAIYL
Mb0267c|M.bovis_AF2122/97 FFPQRLKGAALALNAGGGNLG-VPMVQLVGLLVIATAGDREPYWVCAIYL
Rv0261c|M.tuberculosis_H37Rv FFPQRLKGAALALNAGGGNLG-VPMVQLVGLLVIATAGDREPYWVCAIYL
MSMEG_0433|M.smegmatis_MC2_155 FYPQRLKGWALGLNAGGGNIG-VPMIQLVGLFVIATAGNRAPYWVCAVYL
MMAR_0521|M.marinum_M FYPHRRKGFALGFNAGAGNLG-VPMIQLVGLLVIAIAGYHQPYWVCGLYL
MLBr_00844|M.leprae_Br4923 FYPHRLKGAAFGLAGGAGNLG-VSVIQVVGMLVIASVGDRKPYIVCGLYV
MAV_4899|M.avium_104 FYPQRLKGAAMAVNAGVANLG-VAVIQLVGLLVLATAGHQAPYWVCAVYL
MUL_3265|M.ulcerans_Agy99 FYPQRLKGVALGLTGGIGNLG-VTAIQAVGLLVLATAGHEAPYWVCAVYL
Mvan_3492|M.vanbaalenii_PYR-1 FYPESEKGWALGLNAAGGNIG-VAVAQKIIPVVVTLGAGVALSLAGLFYI
TH_2968|M.thermoresistible__bu ELPPDRLGRAMAVMSGTLGFGGGAGLVVTGLLMTDGAVYQRVFWLCTAFT
* * *:.. .. .:* . .: :
Mflv_3015|M.gilvum_PYR-GCK VAISGAAVGAALFMDNLRNQKSNFGALV----EAMRFKHSWVMSFLYIGT
MAB_3523c|M.abscessus_ATCC_199 VLIAFAAVGAALFMDNLADQKTDGRSLI----DVMKYRDSWIIAFLYIGT
Mb0267c|M.bovis_AF2122/97 VLLAVAGLGAALYMDNLTEYRIELNTMR----AVVSEPHTWVISLLYIGT
Rv0261c|M.tuberculosis_H37Rv VLLAVAGLGAALYMDNLTEYRIELNTMR----AVVSEPHTWVISLLYIGT
MSMEG_0433|M.smegmatis_MC2_155 VALAVAGLGAALYMDNLEHHKIDLGAMK----AILGERDTWIISLLYIGT
MMAR_0521|M.marinum_M LLLTVVAVGAARQMDNLAHATYDVGHLR----AILTQRDTWVLALLYLGT
MLBr_00844|M.leprae_Br4923 VLLIIAGIGAMLFMNDIEHHRIGVNTIRPVLFVVVSTRDSWVLALLYLAS
MAV_4899|M.avium_104 VFLAAVAIAAAMFMDDINHG-TQLSTMR----SILFERDTHVISLLYIAT
MUL_3265|M.ulcerans_Agy99 VLIAIAGLGAALFMENLTHV-IEVGHVR----SVLAVPDTWSVSFLYMCA
Mvan_3492|M.vanbaalenii_PYR-1 PFTVAAAVCAFLFMNNLTEAKADVKPVW----ESLRHADTWIMSLLYIGT
TH_2968|M.thermoresistible__bu LAVIVIAVLIVPVRHRRATGTLDWFGAAG-----LALGLSLGLLAITQGS
.: . : : : : :
Mflv_3015|M.gilvum_PYR-GCK FGSFIGFSFAFGQVLQINYLAG--------GDTPAQASLHAAQIAFLGPL
MAB_3523c|M.abscessus_ATCC_199 FGSFIGFSFAFGQVLQLNFLAGLAHSGVTPAQAAAQASLHAAQIAFIGPL
Mb0267c|M.bovis_AF2122/97 FGSFIGFSFAFGQVLQINFIAS--------GQSTAQASLHAAQIAFLGPL
Rv0261c|M.tuberculosis_H37Rv FGSFIGFSFAFGQVLQINFIAS--------GQSTAQASLHAAQIAFLGPL
MSMEG_0433|M.smegmatis_MC2_155 FGSFIGFAFAFGQVLQINFISG--------GQTPAQASLHAAQIAFIGPL
MMAR_0521|M.marinum_M FGSWIGFSFAFGQVLQINFVGS--------GQSHAQAALHAAEFAFIGPA
MLBr_00844|M.leprae_Br4923 FGSFIGFSFAFGQVLETNFVAG--------GQSTAQAALHAAELAFIGPT
MAV_4899|M.avium_104 FGSWIGFSFAFGQVMQVNFLEN--------GESAKHAALHAAQLAFIGPL
MUL_3265|M.ulcerans_Agy99 SGSFIGFAFVFGQVLQFNLLAG--------GQSTAQASLHAAEIAFVGPL
Mvan_3492|M.vanbaalenii_PYR-1 FGSFIGYSAAFPTLLKAVFDRG----------------DIALMWAFLGAG
TH_2968|M.thermoresistible__bu HWGWTSPSTLGAAAASVVILVG----WWCWEQRAAHPLVSTRMLSRRPML
.: . : . . : :
Mflv_3015|M.gilvum_PYR-GCK LGSISRPFGGK-----------------LADRVGGGRITLYVFVAMIF-A
MAB_3523c|M.abscessus_ATCC_199 LGSLARPFGGW-----------------LSDRTGGGKISLYAFIAMIF-G
Mb0267c|M.bovis_AF2122/97 LGSLSRIYGGK-----------------LADRIGGGRVTLAAFCAMLL-A
Rv0261c|M.tuberculosis_H37Rv LGSLSRIYGGK-----------------LADRIGGGRVTLAAFCAMLL-A
MSMEG_0433|M.smegmatis_MC2_155 LGSLSRVYGGK-----------------LADRIGGGRVTLAVFAGMIL-G
MMAR_0521|M.marinum_M LGSLARIYGGR-----------------LADRVGGSRVTLAVFITMAL-F
MLBr_00844|M.leprae_Br4923 LAAVARFWGGR-----------------LADRLGGSRVTLVVFGAMVF-A
MAV_4899|M.avium_104 LGSVARIYGGR-----------------LADRVGGSRVTLGVLAAMTL-A
MUL_3265|M.ulcerans_Agy99 LGSLARIVGGK-----------------LGDRFGGGRVTLGVFVAMIL-S
Mvan_3492|M.vanbaalenii_PYR-1 IGSVARPLGGK-----------------LSDRVGGARITAVSFAMLAIGA
TH_2968|M.thermoresistible__bu LTNLATIFVGMGLYFAFLGITLFVQVPRDQAGFGFSATVLQASVVYLLPG
: :: * * . :
Mflv_3015|M.gilvum_PYR-GCK AGVLVATGVMDDAAAGAP---TSAQMIGYVAGFILLFILSGLGNGSTYKM
MAB_3523c|M.abscessus_ATCC_199 AGILVAAGTISDRGAGAP---SGSIMTAYVIGFIILFVVSGIGNGSVYKM
Mb0267c|M.bovis_AF2122/97 TGILISASTFGDHLAGP---MPTATMVGYVIGFTALFILSGIGNGSVYKM
Rv0261c|M.tuberculosis_H37Rv TGILISASTFGDHLAGP---MPTATMVGYVIGFTALFILSGIGNGSVYKM
MSMEG_0433|M.smegmatis_MC2_155 AGLLVAVSTVSDGSSEA---ATGLMMSGYVVGFIALFLLSGIGNGSVYKM
MMAR_0521|M.marinum_M TGLLVAISTHGDHTPGP---ATVAMTAGYIGGFLALFALAGLGNGSVYKM
MLBr_00844|M.leprae_Br4923 AGLLGVLGIIEGSRVCP---IRGVMMASYFAGFITLFILSGLGNGSVYKM
MAV_4899|M.avium_104 AGLLVIVSTVDDQHAGA---HSVSMIG-YVVGFMVLFILSGMGNGSVFKL
MUL_3265|M.ulcerans_Agy99 AALLVAVNTHADLNHGAGGRMTAATLIGYVSGFIALFIFCGMGKGTVFEL
Mvan_3492|M.vanbaalenii_PYR-1 AGALWSVQAKN--------------MPVFFIAFMFLFVATGIGNGSTYRM
TH_2968|M.thermoresistible__bu ACTGFVVALVSGRFIDRYG-ARPVLMVGALAGIGGFVFIAVAHTHTWQVI
: . .: :. . : :
Mflv_3015|M.gilvum_PYR-GCK IPSIFEAKAQGRDDLDKEGKAAWSRAMSGALIGFAGAVGALG---GVFIN
MAB_3523c|M.abscessus_ATCC_199 IPSVFAAKARSAG-LDET----WSRTMSGALIGVAGAIGALG---GVAIN
Mb0267c|M.bovis_AF2122/97 IPSIFEARSHSLQ-ISEAERRQWSRSMSGALIGLAGAVGALG---GVGVN
Rv0261c|M.tuberculosis_H37Rv IPSIFEARSHSLQ-ISEAERRQWSRSMSGALIGLAGAVGALG---GVGVN
MSMEG_0433|M.smegmatis_MC2_155 IPSIFEARSHSLD-VSEDERRHWSRSMSGALIGFAGAVGALG---GVGIN
MMAR_0521|M.marinum_M IPSVFEALSHRNQ-ITEFERRRWSQAMSGAVIGFVAAFGALG---GVGIN
MLBr_00844|M.leprae_Br4923 IPTIFEACSHSLG-INDDECRDWSRVISGVVIGFVAEVGALG---GVGID
MAV_4899|M.avium_104 IPSVYEARSRGRD-TSEDERRQWARAMAGSLIGICSAVGAFG---GVAIN
MUL_3265|M.ulcerans_Agy99 IPSIFAERSQHLD-ISDMQRRQWARIVSGALIGFAGSVGALG---GVGIN
Mvan_3492|M.vanbaalenii_PYR-1 ISKIFRVKGEDAG--GDPLTMLHMRRQAAGALGIISSVGAFG---GFIVP
TH_2968|M.thermoresistible__bu AAAVLTNAYISLG--YGALPALVVGEAPPGATGIATGMNAIARTIGSSVA
. : . *. ..*:. * :
Mflv_3015|M.gilvum_PYR-GCK VVLRASYVGDAKSATAAFWVFLAFYVVCAFVTWFVFLRLQEH-------R
MAB_3523c|M.abscessus_ATCC_199 LVLRASYLSAAKSATMAFWVFLVFYVICAAVTWYAYVRRPMT-------V
Mb0267c|M.bovis_AF2122/97 LALRESYLTSG-TATSAFWAFGVFYLVASVLTWAIYVRRGLK-------S
Rv0261c|M.tuberculosis_H37Rv LALRESYLTSG-TATSAFWAFGVFYLVASVLTWAIYVRRGLK-------S
MSMEG_0433|M.smegmatis_MC2_155 MALRQSYLSSG-SATTAFWTFLAFYVLASVVTWFCYVRR----------P
MMAR_0521|M.marinum_M LALRQSYLSTG-TDTSAYWVFLLFYVGAALLTWSRYGRRAVP-------V
MLBr_00844|M.leprae_Br4923 LALRESYLNTG-GVTAAFWIFMLCYAAAGVLTWKMYVCRPLPGNLHDEAA
MAV_4899|M.avium_104 LALRQSYLSTG-TETSAYWTFMASYVVAAIMTWLVYVRRPVT--------
MUL_3265|M.ulcerans_Agy99 LALRQSYVHSG-TETPAFWAFLVCYLCAAALTWARYVRPRSP------VA
Mvan_3492|M.vanbaalenii_PYR-1 LAYAWSKSQFG-NIQPALQFYVGFFIVLLGVTWFFYMRKGTR--------
TH_2968|M.thermoresistible__bu AALVAVAVAGSTTAAPSEAGFTAIFAGGAVTALFAMLLIGLSR-----TG
. . : : : :
Mflv_3015|M.gilvum_PYR-GCK AHSGEHIGRTSAPVPVG----
MAB_3523c|M.abscessus_ATCC_199 SVP--AISSSKNEVAV-----
Mb0267c|M.bovis_AF2122/97 AGELVPATTAPAGLAYV----
Rv0261c|M.tuberculosis_H37Rv AGELVPATTAPAGLAYV----
MSMEG_0433|M.smegmatis_MC2_155 AAMPVTGTERHAPAIAG----
MMAR_0521|M.marinum_M AGTAGTASGSRLARV------
MLBr_00844|M.leprae_Br4923 NAFAASVGASRTHRG------
MAV_4899|M.avium_104 -APGVSLPETQAARL------
MUL_3265|M.ulcerans_Agy99 SAPRKPNEDPQLSGAAA----
Mvan_3492|M.vanbaalenii_PYR-1 --------MAQAGV-------
TH_2968|M.thermoresistible__bu RPAFETVEARQESRAMNHEWG