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VNESIPGGRVAHLPPPHLNLVERLAWRARNQPDELAMVELRGMRGETDKATYARLDARARAIAFQLKSLG NQGDRVLLVMGNCLDYVVGFLACAYARRVAVNLPVPRRAKHLDRLAHVVADCGAEVLLTSGPEAKELTVS VAADLRLDFLTVLRLDWLLAIPDEDWQPVAPASKDVCLLQYTSGSTSAPRGVVVTHDNLMFNCAQIQYGF GLTAEDRALSWLPLYHDMGLILGVLTPIFAGFPVVLADPLSFVKRPDLWLRAISDYRITFTGGPNFAYDL CADAASYADLSGIDLSCWNVALNGAEPIRATTLERFNAALAPLGWAPTYMQPSYGLAENTLAVSTKIPAT EPTVVEIDVAALRQSQVCAPRGDSPSRRLVSSGRILAGTMVKIVDPETGHPVGPDRVGEIWLTGRSVAKG YWGRDIQTEEVFAARLPGDPARYLRTGDLGFCRDDELFVVGRLKDLVIVHGANHYPQDLEETAEGAHPAV RSHFVAVFAEEREDREALIVVAEIRREAERGLDPRDVGQRIARAITREHEVSVDAVFLARCGEVPKTTSG KIQRSLCRELLRQGGLALHGALEK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0468 | - | - | 100% (584) | fatty-acid-CoA ligase |
| M. marinum M | MMAR_1170 | fadD29_1 | 4e-94 | 39.31% (547) | fatty-acid-CoA ligase FadD29_1 |
| M. marinum M | MMAR_2341 | fadD25 | 1e-88 | 37.61% (545) | fatty acyl-AMP ligase FadD25 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1548 | fadD25 | 7e-92 | 36.33% (567) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_2901 | - | 1e-92 | 37.61% (585) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv1521 | fadD25 | 7e-92 | 36.33% (567) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_01234 | - | 2e-88 | 35.76% (576) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_1915 | - | 3e-93 | 38.21% (547) | acyl-CoA synthetase |
| M. avium 104 | MAV_1328 | - | 1e-90 | 36.63% (576) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_4301 | - | 8e-92 | 38.33% (540) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_4458 | - | 1e-102 | 39.86% (562) | PUTATIVE putative Fatty acyl-AMP ligase FadD28_1 and polyketide |
| M. ulcerans Agy99 | MUL_1117 | - | 0.0 | 98.78% (575) | fatty-acid-CoA ligase |
| M. vanbaalenii PYR-1 | Mvan_0999 | - | 1e-105 | 41.13% (564) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0468|M.marinum_M -----MNESIPGGRVAHLPPPHLNLVERLAWRARNQPDELAMVELRGMRG
MUL_1117|M.ulcerans_Agy99 --------------MAHLPPPHLNLVERLAWRARNQPDELAMVELRGMCG
Mvan_0999|M.vanbaalenii_PYR-1 -----------------MFLEDL-LSRRLRRHADEFPDERILSFLDDRLE
TH_4458|M.thermoresistible__bu ------------------------LLSLLRQRSERYGDKIAFDYCTGEQ-
Mb1548|M.bovis_AF2122/97 -----------------MSVVESSLPGVLRERASFQPNDKALTFIDYERS
Rv1521|M.tuberculosis_H37Rv -----------------MSVVESSLPGVLRERASFQPNDKALTFIDYERS
MLBr_01234|M.leprae_Br4923 -------------------MQNSSVLSFLRERAGLQPDDEAFSFTDYEQD
MAV_1328|M.avium_104 -------------------MHGSSVVSLLRERAGLQPDDVAFRYTDYEQD
MAB_1915|M.abscessus_ATCC_1997 --MKLRVEEYLDGKGAITLPDGYTVNYYLERAVEELGDTFAYRYLDFNAN
MSMEG_4301|M.smegmatis_MC2_155 ----MKIEDYLDADGNIAIPDGVTLTSYFDRNVAELADTPAYRYLDFEH-
Mflv_2901|M.gilvum_PYR-GCK MSPELRLDDYLDHEGNIVIPPGTTLTSFLGRNAAEFGDTPAYRYLDFEH-
: : :
MMAR_0468|M.marinum_M ---ETDKATYARLDARARAIAFQLKSLGNQGDRVLLVMGNCLDYVVGFLA
MUL_1117|M.ulcerans_Agy99 ---ETDKATYARLDARARAIAFQLKSLGNQGDRVLLVMGHCLDYVVGFLA
Mvan_0999|M.vanbaalenii_PYR-1 ---VADSLTFGRLDDRARSVAAGLLDRGMGGAPVVLSYPPGLDFVSAFCG
TH_4458|M.thermoresistible__bu ---EHSRLTYQELDIRARAIAAHLQDQGVAGERVLVLCPSGLDFITAMFG
Mb1548|M.bovis_AF2122/97 WDGVEETLTWSQLYRRTLNLAAQLREHGSTGDRALILAPQILDYVVSFIA
Rv1521|M.tuberculosis_H37Rv WDGVEETLTWSQLYRRTLNLAAQLREHGSTGDRALILAPQSLDYVVSFIA
MLBr_01234|M.leprae_Br4923 WAGVRKTLTWAQLYQRTLNVAHELRRHGSIRDRAVILAPQGLDYIIAFLG
MAV_1328|M.avium_104 WAGVAETLTWAQLYQRTSNLAREVARHGDTGDRAVILAPQGLSYIVAFLA
MAB_1915|M.abscessus_ATCC_1997 SDGEPNDLNWTQLGQRSRAVAARLQQVTKPGDRVAILAPQGIDYVVGFFA
MSMEG_4301|M.smegmatis_MC2_155 -DGRVVELTWKELDTRVRAVGARLQQVTKLGDRVAILCPQGVDYVVSFFA
Mflv_2901|M.gilvum_PYR-GCK --DRTIELTWAQLRTRLDAVGARLQQVTRPGDRVAILTPQGVEYVIGFFA
.: .* * :. : . : :.:: .: .
MMAR_0468|M.marinum_M CAYARRVAVNLPVPRRAKHLDRLAHVVADCGAEVLLTSGPEAKELTVSVA
MUL_1117|M.ulcerans_Agy99 CAYARRVAVNLPVPRRAKHLDRLAHVVADCGAEVLLTSGPEAKELTASVA
Mvan_0999|M.vanbaalenii_PYR-1 CLYAGAIAVPAALPQSRRTAERLAAVLKDSAARCVLTSAAHRAELYSHAG
TH_4458|M.thermoresistible__bu CFYVGAVAVPVHPPVHNRLLSRVASIVADVRATSVLTTAATRADLKEILD
Mb1548|M.bovis_AF2122/97 SLQAGIVAVPLSIPQGGAHDERTVSVFADTAPAIVLTASSVVDNVVEYVQ
Rv1521|M.tuberculosis_H37Rv SLQAGIVAVPLSIPQGGAHDERTVSVFADTAPAIVLTASSVVDNVVEYVQ
MLBr_01234|M.leprae_Br4923 AMQAGFIAVPLSVPQAGSHDERVGAVLADTSPSVVLTTSAVADAIAKYVD
MAV_1328|M.avium_104 AIQAGLIAVPLSVPQPGSHDERVSAVLADTGPAVVLTTAAAAATVTEYLR
MAB_1915|M.abscessus_ATCC_1997 AIEAGNIAVPLFAPELPGHSERLDAVLTDAQPTVVLTNNAAAESVSRFVR
MSMEG_4301|M.smegmatis_MC2_155 AIQAGAIAVPLFSPELPGHAERLEAVLADATPSVVLTTTAAAEAVGAFVR
Mflv_2901|M.gilvum_PYR-GCK AIEAGAIAVPLFAPELPGHSERLHAVLADAQPSVVLTTTATAEPVREFLR
. . :** * .* :. * . :** . :
MMAR_0468|M.marinum_M ADLRLDFLTVLRLDWLLAIPDE--DWQPVAPASKDVCLLQYTSGSTSAPR
MUL_1117|M.ulcerans_Agy99 ADLRLDFLTVLRLDWLLAIPDE--DWQPVAPASKDVCLLQYTSDSTSAPR
Mvan_0999|M.vanbaalenii_PYR-1 AAP--SVVDVIATDVLPSRPG---DGRVALPDPDQVAFLQYTSGSTRSPR
TH_4458|M.thermoresistible__bu GLHDGDPLRWLAVDTIEADDET--SWTPTTVDTDSVAFVQYTSGSTSTPK
Mb1548|M.bovis_AF2122/97 PQPGQNAPAVIEVDRLDLDARPSSGSRSAAHGHPDILYLQYTSGSTRTPA
Rv1521|M.tuberculosis_H37Rv PQPGQNAPAVIEVDRLDLDARPSSGSRSAAHGHPDILYLQYTSGSTRTPA
MLBr_01234|M.leprae_Br4923 HSDTDTVPAILEVDSPNLDVENKSNIR--LTDAPSTAYLQYTSGSTRLPA
MAV_1328|M.avium_104 RPDTGPAPAVVEIDSLDLDEPNSASIR--ISGAPDIAYLQYTSGSTRLPA
MAB_1915|M.abscessus_ATCC_1997 GLPRDRRPRVVAVDSVPDSVA--ATYAKVTPDTDDIAYLQYTSGSTRVPA
MSMEG_4301|M.smegmatis_MC2_155 KLPHAGRPRMIAVDAVPAAVG--ATFTPAQLHTDGIAYLQYTSGSTRTPA
Mflv_2901|M.gilvum_PYR-GCK ALPHNRRPRLIAVDAVPDSVG--VGFQRAPLQTDDVAYLQYTSGSTRAPA
: * :****.** *
MMAR_0468|M.marinum_M GVVVTHDNLMFNCAQIQYGFG------LTAEDRALSWLPLYHDMGLILGV
MUL_1117|M.ulcerans_Agy99 GVVVTHDNLMFNCAQIQYGFG------LTAEDRALSWLPLYHDMGLILGV
Mvan_0999|M.vanbaalenii_PYR-1 GVMVRHGDLAANLNSLREILA------FDDHATGVSWLPVFHDMGLIAGV
TH_4458|M.thermoresistible__bu GVVLTHHNLLANLESISRDAG------QGDEARVVSWLPLHHDMGLIGGI
Mb1548|M.bovis_AF2122/97 GVMVSNKNLFANFEQIMTSYYGVYGKVAPPGSTVVSWLPFYHDMGFVLGL
Rv1521|M.tuberculosis_H37Rv GVMVSNKNLFANFEQIMTSYYGVYGKVAPPGSTVVSWLPFYHDMGFVLGL
MLBr_01234|M.leprae_Br4923 GVMVTHRNLMVNFQQLMADYFAPTNGVAPLDLTIVSWLPFYHDMGLVLGV
MAV_1328|M.avium_104 GVMVSHRNLQVNFQQLMAAFFPDVDGVAPRDTVCVSWLPFYHDMGLVQGV
MAB_1915|M.abscessus_ATCC_1997 GVEITHRAVMTNVLQMIISVG------LDDSIRSVSWLPLYHDMGLLM-I
MSMEG_4301|M.smegmatis_MC2_155 GVEITHRGVCTNVLQMIISVG------LDWNIRSVSWLPLFHDMGLLM-I
Mflv_2901|M.gilvum_PYR-GCK GVKITHRSACTNVVQMVLSVG------LDPDINSVSWLPLFHDMGLLM-I
** : : * .: :****..****:: :
MMAR_0468|M.marinum_M LTPIFAGFPVVLADPLSFVKRPDLWLRAISDYRIT---FTGGPNFAYDLC
MUL_1117|M.ulcerans_Agy99 LTPIFAGFPVVLADPLSFVKRPDLWLRAISDYRIT---FTGGPNFAYDLC
Mvan_0999|M.vanbaalenii_PYR-1 LLPIWSARPQFLMAPATFVRNPLSWLEAISRYGGT---HQGAPNFGYQAC
TH_4458|M.thermoresistible__bu FGVVHFGGTAYLMPPSSFIQRPMSWLEAISWHGAN---ISVGPNFGYQLC
Mb1548|M.bovis_AF2122/97 ILPILAGIPAVLTSPIGFLQRPARWIQMLASNTLA---FTAAPNFAFDLA
Rv1521|M.tuberculosis_H37Rv ILPILAGIPAVLTSPIGFLQRPARWIQMLASNTLA---FTAAPNFAFDLA
MLBr_01234|M.leprae_Br4923 VAPILGGWRSELTSPISFLQRPARWIQAMATSSHP---FSAGPNFAFELA
MAV_1328|M.avium_104 IAPILGGYPADLTSPVAFLQRPARWIQAMSRADPV---FSAAPNFAFELA
MAB_1915|M.abscessus_ATCC_1997 LFP-LCGGRITLMSPVSFVRRPGRWIKELAAEGHLGRTFAAAPNFAFELA
MSMEG_4301|M.smegmatis_MC2_155 MFPALCGGHITLMSPVSFVRRPYRWIKELGASDVP--TFAAAPNFAYELA
Mflv_2901|M.gilvum_PYR-GCK MFPALAGGYLTLMSPVAFVRRPYRWIKELGADDRP--MFAAAPNFAFALA
. . * * *::.* *:. :. .***.: .
MMAR_0468|M.marinum_M ADAASYADLSGIDLSCWNVALNGAEPIRATTLERFNAALAPLGWAPTYMQ
MUL_1117|M.ulcerans_Agy99 ADAASYTDLSGIDLSCWNVALNGAEPIRATTLERFNAALAPLGWAPTCMQ
Mvan_0999|M.vanbaalenii_PYR-1 VDAARAAGATTFDLRNWRVAWNGAEPVRPDTLHQFRDQFALNGFGSECLS
TH_4458|M.thermoresistible__bu VERSTPEERATLDLSTWVRAYCGAEPVRAATMRRFTEAFAPAGFRADAFH
Mb1548|M.bovis_AF2122/97 SRKTKDEDMEGLDLGGVHGILNGSERVQPVTLKRFIDRFAPFNLDPKAIR
Rv1521|M.tuberculosis_H37Rv SRKTKDEDMEGLDLGGVHGILNGSERVQPVTLKRFIDRFAPFNLDPKAIR
MLBr_01234|M.leprae_Br4923 ARRTSDADIAGLDLGACQGIISGSERIHPATLNRFSDRFARINFRDDMML
MAV_1328|M.avium_104 VRKTTDADLAGVNLGNIISIVSGAERIHPATLRRFCKRFAPYNFREHMMQ
MAB_1915|M.abscessus_ATCC_1997 AERGLPKDGEELDLSNVAGLINGSEPVSISSIRKFNDAFGPYGLPPTTIK
MSMEG_4301|M.smegmatis_MC2_155 AHRGLPPAGDELDLSNVAGLINGSEPVSMASINVFNEAFAPYGLPPTAVK
Mflv_2901|M.gilvum_PYR-GCK AQRGLPPEGEELDLSNVAGLINGSEPISVAAVEAFNAAFAPYGLKQTVIK
.:* *:* : ::. * :. . .
MMAR_0468|M.marinum_M PSYGLAENTLAVSTKIPATEPTVVEIDVAALRQSQVCAPRGDSP-SRRLV
MUL_1117|M.ulcerans_Agy99 PSYGLAENTLAVSTKIPATEPTVVEIYVAALRQSQVCAPRGDSP-SRRLV
Mvan_0999|M.vanbaalenii_PYR-1 PGYGLAEATLVVSGSDGSKPATELTVDESELHVGQVRPRIDDGPGVKRLV
TH_4458|M.thermoresistible__bu PVYGLAEATLFVSGRPENVLPTVRSLDNAALREHRVVPAAADDANAAAVV
Mb1548|M.bovis_AF2122/97 PSYGMAEATVYVATRKAGQPPKIVQFDPQKLPDGQAERTESD--GGTPLV
Rv1521|M.tuberculosis_H37Rv PSYGMAEATVYVATRKAGQPPKIVQFDPQKLPDGQAERTESD--GGTPLV
MLBr_01234|M.leprae_Br4923 PSYGLAEGTVYAASRPKGSSPEVVYFEPAKLSEGTVKRCEAR--TGAPLL
MAV_1328|M.avium_104 PSYGLAEATVYVASRAEAGAPEVVHFEPEKLSAGSAQRCPAQ--TGSPLL
MAB_1915|M.abscessus_ATCC_1997 PSYGMAEATLFVSTIPSDAEASVVYLDRRALGDGHAVRVEADDENAVPQV
MSMEG_4301|M.smegmatis_MC2_155 PSYGMAEATLFVSTIGPAAHPSAVYLDREELGAGRAVEVPEDDPRAIAQV
Mflv_2901|M.gilvum_PYR-GCK PSYGMAEATLFVSTTPPDSALKAVYVDRKQLTAGRAVIVDSDHPDATVQV
* **:** *: .: . * . :
MMAR_0468|M.marinum_M SSGRILAGTMVKIVDP--ETGHPVGPDRVGEIWLTGRSVAKGYWGRDIQT
MUL_1117|M.ulcerans_Agy99 SSGRILAGTMVKIVDP--ETGHPVGPDRVGEIWLTGRSVAKGYWGRDIQT
Mvan_0999|M.vanbaalenii_PYR-1 GSGRPAAGTEVQIVR---ADGRVAEPHTLGEIWVRSDSVAQGYWNNPGET
TH_4458|M.thermoresistible__bu GCGPAAYGEEIVIVDP--ATRREFPPDVVGEIWVAGENVAQGYLGKPSES
Mb1548|M.bovis_AF2122/97 SYG-IVDTQLVRIVDP--DTGIERPAGTIGEIWVHGDNVAIGYWQKPEAT
Rv1521|M.tuberculosis_H37Rv SYG-IVDTQLVRIVDP--DTGIERPAGTIGEIWVHGDNVAIGYWQKPEAT
MLBr_01234|M.leprae_Br4923 SYG-TPKSPIVRIVDS--DTCIECPTGRVGEIWLHGDNVAEGYWHKPEET
MAV_1328|M.avium_104 SYG-APTSPTVRIVDP--DTNTERADGTVGEIWVNGENVAQGYWRKPEET
MAB_1915|M.abscessus_ATCC_1997 SCGKIARSQWAVIVNPNADT--ELADGEVGEIWLHGDNIGRGYWGRPKET
MSMEG_4301|M.smegmatis_MC2_155 SCGKIARSQWAVIVDPNSDTGAELPDGHVGEIWLYGDNVGKGYWGRPHET
Mflv_2901|M.gilvum_PYR-GCK SCGNVARSQWAVIVDPATDC--ELPDGCVGEIWLHGDNIGNGYWERPEET
. * ** :****: . .:. ** . :
MMAR_0468|M.marinum_M EEVFAARLP------------GDPARYLRTGDLGFCRDDELFVVGRLKDL
MUL_1117|M.ulcerans_Agy99 EEVFAARLP------------GDPARYLRTGDLGFCRDDELFVVGRLKDL
Mvan_0999|M.vanbaalenii_PYR-1 SGTFGACLT------------TGEGPYLRTGDLGFVDDGELFVIGRLNDV
TH_4458|M.thermoresistible__bu AETFAAHLAD-----------SGRGPFLRTGDYGFLLDGELFVTGRLKDL
Mb1548|M.bovis_AF2122/97 ERTFSATIVN-------PSEGTPAGPWLRTGDSGFLSEGELFIMGRIKDL
Rv1521|M.tuberculosis_H37Rv ERTFSATIVN-------PSEGTPAGPWLRTGDSGFLSEGELFIMGRIKDL
MLBr_01234|M.leprae_Br4923 QRTFGGKLAN-------PSPGTPEGPWLRTGDLGFISEDELFIVGRMKDL
MAV_1328|M.avium_104 RRTFGGVLVN-------PSPGTPRQPWLRTGDLGFISAGELFIVGRMKDL
MAB_1915|M.abscessus_ATCC_1997 DFSFRNKLQARLDHGSHATGTEPGATWFRTGDLGVYLDGELYITGRVKDL
MSMEG_4301|M.smegmatis_MC2_155 EVSFHNKLQSRLPQGSHAAGAPDGAAWFRTGDLGMYLGGELYITGRIKDM
Mflv_2901|M.gilvum_PYR-GCK ELTFRNKLQSRLARGSHAERSADSALWLRTGDLGVYLDGELYITGRIKDL
* : ::**** *. .**:: **::*:
MMAR_0468|M.marinum_M VIVHGANHYPQDLEETAEGAHPAVRSHFVAVFAE--EREDREALIVVAEI
MUL_1117|M.ulcerans_Agy99 VIVHGANHYPQDLEETAEGAHPAVRSHFVAVFAE--EREDREALIVVAEI
Mvan_0999|M.vanbaalenii_PYR-1 IVIRGVNYYPHDIEYTVERSHPALQPDAGAVIGV--ERSGRVDLVSVSEI
TH_4458|M.thermoresistible__bu IIIRGRNYHPNDIEATVQEVHPALMSGRGAAFAVSPDPSGTEQLVIVQEV
Mb1548|M.bovis_AF2122/97 LIVYGRNHSPDDIEATIQTIS----PGRCAAIAVS--EHGAEKLVAIIEL
Rv1521|M.tuberculosis_H37Rv LIVYGRNHSPDDIEATIQTIS----PGRCAAIAVS--EHGAEKLVAIIEL
MLBr_01234|M.leprae_Br4923 LIVYGRNHYPEDIESTVQEIT----GGRVAAISVP--VDETEKLVTIIEV
MAV_1328|M.avium_104 LIVYGRNHYPEDIESTVQAVT----GGRVAAISVP--ADETEKLVTIIEL
MAB_1915|M.abscessus_ATCC_1997 VIIDGRNHYPQDIEATVEEASPAVRRGFVAAFSVP--AEGSGEQLVIVAE
MSMEG_4301|M.smegmatis_MC2_155 VIVDGRNHYPQDLEATVAEASSQVRAGYIAAFSVP--SEH-GERLVIVAE
Mflv_2901|M.gilvum_PYR-GCK IIVDGRNHYPQDIEATAAAASPSVRAGFVAAFSVP--GEG-REEVVIVAE
::: * *: *.*:* * *.:. : :
MMAR_0468|M.marinum_M RREAERGLDPRDVGQRIA----RAITREHEVSVDAVFLARCGEVPKTTSG
MUL_1117|M.ulcerans_Agy99 RREAERGLDPRDVGQRIA----RAITREHEVSVDAVFLARCGEVPKTTSG
Mvan_0999|M.vanbaalenii_PYR-1 RRDLVDSIVGDDIVDAIR----RAVARDHQLALQRVVLLRPGGMPKTSSG
TH_4458|M.thermoresistible__bu DRGRLGEVDTDELIAAIR----TAVTSQHDIGVHTVVLVDPLRIPTTSSG
Mb1548|M.bovis_AF2122/97 KKKDESDDEAAERLGFVKREVTSAISKSHGLSVADLVLVSPGSIPITTSG
Rv1521|M.tuberculosis_H37Rv KKKDESDDEAAERLGFVKREVTSAISKSHGLSVADLVLVSPGSIPITTSG
MLBr_01234|M.leprae_Br4923 KKRGDSDAEAMQKLVAVKNNITAAISKSHGLNVADLVLVPPGSIPTTTSG
MAV_1328|M.avium_104 KRRGDSDEDARRKLDAVKNEVTAAISIAHGLNVADLVPVAPGSIPTTTSG
MAB_1915|M.abscessus_ATCC_1997 RAAGAGRAEPEPIIDAIR----AAVSRRHNLPIADVQLVQAGAIPRTTSG
MSMEG_4301|M.smegmatis_MC2_155 RAPGAGRADPAPIVDAIR----AAISKRHAVAVHDIKLVAAGSIPRTTSG
Mflv_2901|M.gilvum_PYR-GCK RAPGAGRAEAAPIQEAIR----AEVSRKHAIPVRDVKLVRSGVIPRTTSG
: :: * : : : :* *:**
MMAR_0468|M.marinum_M KIQRSLCRELLRQGG-----------------------LALHGALEK---
MUL_1117|M.ulcerans_Agy99 KIQRSLCRELLRQGG-----------------------LALHGALEK---
Mvan_0999|M.vanbaalenii_PYR-1 KIQRARCRDELGRSGLPVVHDWQASPARQATIDFDLESLSQPGMLERQ--
TH_4458|M.thermoresistible__bu KIRRRTCRQRFLDGELDAFAEWRLATPRPAQPVPAADEQADEQAGAGPGA
Mb1548|M.bovis_AF2122/97 KIRRAQCVELYRQDEFTRLDA-----------------------------
Rv1521|M.tuberculosis_H37Rv KIRRAQCVELYRQDEFTRLDA-----------------------------
MLBr_01234|M.leprae_Br4923 KVRRTACVEQYRRQQFSRLDG-----------------------------
MAV_1328|M.avium_104 KIRRAACVERYLRGAFIRLDG-----------------------------
MAB_1915|M.abscessus_ATCC_1997 KLARRACRQEYLDNKLGVRA------------------------------
MSMEG_4301|M.smegmatis_MC2_155 KLARRACQAQYLAELQTS--------------------------------
Mflv_2901|M.gilvum_PYR-GCK KLARRSCRASYLDGTL----------------------------------
*: * *
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 ----------LADWLRQELSIS--DLTWSTPLTELGIDSLKGVELVNVLS
TH_4458|M.thermoresistible__bu GPGADEIRAWFVAQLAGELGLSPDDIDTGQPFAYYGLDSVRAIQLMTALE
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 AAFDFTFPPTSMLDHPSIASLAGLIR-------------DAKLGAG----
TH_4458|M.thermoresistible__bu AWSGIKVAPTLAYDHPTIDLAAEHLAGLTHTATSTAADAGVSTGAGRRPE
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 HRAASNRPDAGVYSAGQ----IDALDEAALVDLLQQR-------------
TH_4458|M.thermoresistible__bu HGPAPDRADEPIAIIGIGCRFPGADGPAAYWRLLREGRDAITATPPERWD
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 VDDILDGGRS----------------------------------------
TH_4458|M.thermoresistible__bu TDSVGDGTRWGGFLERIDGFDAGFFGISPREAVRIDPQQRLLLEVAWEAL
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4458|M.thermoresistible__bu EDAGLVPDRLAGSRTGVFTGVSTYDYLHLQLSHPELIDAYSGTGTASSIA
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4458|M.thermoresistible__bu ANRLSYVFDFRGPSLTLDSACSSSLVAVHQACRSLRDGECDLALAGGVNI
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4458|M.thermoresistible__bu MLSAGIGLNFTRAGVMATDGRCKTFDARADGWVRGEGAGIVVLKPLREAL
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4458|M.thermoresistible__bu ADEDPIYAVIRGSAVNQDGRTNGLMAPSRTAQEVVLTDAYRRAGVSPGVV
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4458|M.thermoresistible__bu QYVEAQGIGTPVGDAIEVGALGTVLAEDRPPDSPCLIGSVKTNIGHLEAA
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4458|M.thermoresistible__bu AGIAGLIKVALALRHRMIPPTLNFTEPNPTIEFDKLPVRVAQTLTPWPDD
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4458|M.thermoresistible__bu SGRAVAGVSAFGFGGTNAHVVLAEAPQVRAAATADDHADGFVEILPLSAR
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4458|M.thermoresistible__bu SQAALDALAERYESALTGGVPPADLCHTAGARRAHHDHRLAVVGASRAEL
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4458|M.thermoresistible__bu IGALAAYRRGEPHPGVFTGRSQSGHRSGVVFVFSDEGSQWRGMAQRLYAE
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4458|M.thermoresistible__bu DQVFRTALAECDRALRRHMEISPLSELLADPSHSRMDEVTIASPALFAVQ
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4458|M.thermoresistible__bu VALAALWQSWGVEPAAVIGHRMGEVAAAHVAGVLGLDDAAALLCGRTRLS
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4458|M.thermoresistible__bu RLASTGAVREGLDGLLANLRPDDPRIPLYSTVTGDAVTGRGFGAAHWMEN
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4458|M.thermoresistible__bu LHSPVRFSAAVRRLLGRGHDAFLEISAHPMLLSAVQEDAADLGRSCTTLV
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4458|M.thermoresistible__bu SMRRGECGRDVLMTSLAALYASGHAVDWARVHPHGSHCTAAPTYPWQRQR
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4458|M.thermoresistible__bu FWLDIDRCDTGDGAGTGGTAERTVVPAPLPAPSASAAPTVDEVLLCADQR
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4458|M.thermoresistible__bu ERRELLESYLRDRVAAELGVLPPLLDVAAPLSTLGIDSLTAAELRARVER
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M --------------------------------------------------
MUL_1117|M.ulcerans_Agy99 --------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_4458|M.thermoresistible__bu DLGIVIPVAQLLNGPSVSDLAEWISTTMVGFGSTTPEPESAGVPGRSRPP
Mb1548|M.bovis_AF2122/97 --------------------------------------------------
Rv1521|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01234|M.leprae_Br4923 --------------------------------------------------
MAV_1328|M.avium_104 --------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 --------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_0468|M.marinum_M -------------------------------------------------
MUL_1117|M.ulcerans_Agy99 -------------------------------------------------
Mvan_0999|M.vanbaalenii_PYR-1 -------------------------------------------------
TH_4458|M.thermoresistible__bu DGAVASGSGDGGRWIELLNQMPEVSDDTVDELLRQLLAAGENHDDTQLH
Mb1548|M.bovis_AF2122/97 -------------------------------------------------
Rv1521|M.tuberculosis_H37Rv -------------------------------------------------
MLBr_01234|M.leprae_Br4923 -------------------------------------------------
MAV_1328|M.avium_104 -------------------------------------------------
MAB_1915|M.abscessus_ATCC_1997 -------------------------------------------------
MSMEG_4301|M.smegmatis_MC2_155 -------------------------------------------------
Mflv_2901|M.gilvum_PYR-GCK -------------------------------------------------