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SPAAAGGRFGASIRNAGYLQKWFLLGITIGGIAGLGAVVFYLALKYTGEFLLGYLADYHIPTPVGEGGSH GSSGFVRPWAIPLITTGGALLSAFIVARFAPEATGHGTDEAIEAVHTNPRSIRSRAVLVKMVASALTIGS GGSGGREGPTAQISAGFCSFLTRRLGLSDEDGRTAVALGIGAGIGAIFAAPLGGAVLAASITYRDDFDYR SLLPGFITSGTAYAVLGAFMGFDPLFGYIDAEYRFEKAWPLLWFVVIGVVAAAIGYLYARVFHASVGLAH RLPGGPVIKPAVGGLLVGLMGLLIPQILSSGYGWAQLAADRNALMAIPLWIIIVLPVAKILATSLSIGTG GSGGLFGPGIVIGAFVGAAIWRLGELTGLPGVPDAPGIFVVVAMMTCFGSVSRAPLAVMIMVAEMTGSFS VVPGAILAVGIASLLMSRTNVTIYEAQRLNRETAEAERAARAADRGN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0353 | - | - | 100% (468) | hypothetical protein MMAR_0353 |
| M. marinum M | MMAR_0501 | - | 2e-18 | 27.94% (383) | transmembrane protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0148c | - | 0.0 | 87.69% (455) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_2009 | - | 8e-24 | 28.68% (380) | Cl- channel, voltage-gated family protein |
| M. tuberculosis H37Rv | Rv0143c | - | 0.0 | 87.91% (455) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. avium 104 | MAV_4918 | - | 6e-19 | 29.75% (279) | chloride transporter, chloride channel (ClC) family protein |
| M. smegmatis MC2 155 | MSMEG_6465 | - | 0.0 | 69.33% (450) | chloride channel |
| M. thermoresistible (build 8) | TH_2100 | - | 0.0 | 68.70% (460) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_1164 | - | 2e-18 | 28.08% (381) | transmembrane protein |
| M. vanbaalenii PYR-1 | Mvan_4538 | - | 7e-21 | 28.08% (317) | Cl- channel, voltage-gated family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0148c|M.bovis_AF2122/97 MAPGDWSVFAWHAANLPTMPEAEDIGNEAAGGRLGVSIRSAGYLRKWFLL
Rv0143c|M.tuberculosis_H37Rv MAPGDWSVFAWHAANLPTMPEAEDIGNEAAGGRFGVSIRSAGYLRKWFLL
MMAR_0353|M.marinum_M MSP------------------------AAAGGRFGASIRNAGYLQKWFLL
MSMEG_6465|M.smegmatis_MC2_155 ----------------------MRTRPRIDGG-LGNFVRNSGYVRKWLIL
TH_2100|M.thermoresistible__bu ------------------------MREVAGGGRIGGYVNRLGYLPRWLLL
MAV_4918|M.avium_104 ------------------------MPAP----------RSDRNALDFFCA
MUL_1164|M.ulcerans_Agy99 ------------------------MPASFSGRFASVLRRASRRDVDFFCA
Mvan_4538|M.vanbaalenii_PYR-1 --------------------------------------------MQFGCA
Mflv_2009|M.gilvum_PYR-GCK ---------------------------------MPLRLRPGGPVRSLLVV
Mb0148c|M.bovis_AF2122/97 G---ITIGVIAGLGAVVFYLALKYTSEFLLGYLADYQIPTPVGEGGHRGS
Rv0143c|M.tuberculosis_H37Rv G---ITIGVIAGLGAVVFYLALKYTSEFLLGYLADYQIPTPVGEGGHRGS
MMAR_0353|M.marinum_M G---ITIGGIAGLGAVVFYLALKYTGEFLLGYLADYHIPTPVGEGGSHGS
MSMEG_6465|M.smegmatis_MC2_155 G---IAIGVIAGLGAVVFYLALDGAGRVLLGYLGGYDIPKPSGDGGNPGS
TH_2100|M.thermoresistible__bu G---VVIGVIAGLGAVVFYLALDYSTRLLLGHLGGYDIPEAVGDGGDPGS
MAV_4918|M.avium_104 V---IIVGVLAGIAGVATTLVLRVVQHATYHYSFGALLAGVAASSPIRRV
MUL_1164|M.ulcerans_Agy99 V---VIVGLLAGVAGLSTTVVLRFVEHLTYHYAFGSLLEGITGSSPVRRA
Mvan_4538|M.vanbaalenii_PYR-1 I---AVIGLIAGVAGAATTLLLHAIEHLTFHYSFGTLLSGIEGSNPVRRA
Mflv_2009|M.gilvum_PYR-GCK VGTAALAGAVIGIVGAAFQWCLRAAEGLRLDVVEWAQRLPGPG-------
* : *: . * .
Mb0148c|M.bovis_AF2122/97 TGFARPWAIPLVTTGGAVLSALIVAKLAPEATGHGTDEAIESVHGDPRAI
Rv0143c|M.tuberculosis_H37Rv TGFARPWAIPLVTTGGAVLSALIVAKLAPEATGHGTDEAIESVHGDPRAI
MMAR_0353|M.marinum_M SGFVRPWAIPLITTGGALLSAFIVARFAPEATGHGTDEAIEAVHTNPRSI
MSMEG_6465|M.smegmatis_MC2_155 PGFDRPWAIPLISCGGALVSAWFVAKFAPEAEGHGTDDAIEAVHTDPRKI
TH_2100|M.thermoresistible__bu AGFQRPWAIPLIACTGALVSAWLIARFAPEAEGHGTDDAIEAVHTDPRRI
MAV_4918|M.avium_104 LG-------PMVGAALAGLGWWLLRRRTDVPP-------LAETIARSERV
MUL_1164|M.ulcerans_Agy99 LG-------PMVGGALAGLGWWLLRRRTDVPP-------LAGTIADHARI
Mvan_4538|M.vanbaalenii_PYR-1 VG-------PLLGGALAGWGWWALRRRQDRPP-------LTG--------
Mflv_2009|M.gilvum_PYR-GCK ------WLIPVALVAFCAAVARTLVRWEPQAAGSGIPHVEAVFLGETSPP
*: . : : .
Mb0148c|M.bovis_AF2122/97 RGRAVLVKMVASALTIGSGGSGGREGPTAQISAGFCSLLTRRLN-LSNED
Rv0143c|M.tuberculosis_H37Rv RGRAVLVKMVASALTIGSGGSGGREGPTAQISAGFCSLLTRRLN-LSNED
MMAR_0353|M.marinum_M RSRAVLVKMVASALTIGSGGSGGREGPTAQISAGFCSFLTRRLG-LSDED
MSMEG_6465|M.smegmatis_MC2_155 RVRAIVVKTIASALTIGSGGSGGREGPAAHISAGFGSLLTRWLN-LSDED
TH_2100|M.thermoresistible__bu RGRAIVVKTVASALTIGSGGSGGREGPAAQISAGFGSLLTRRLD-LSDDD
MAV_4918|M.avium_104 PRLAWSIDAVLQVLLVGSGASLGREGAPRQFASALGDFGIGWLRRLSSRD
MUL_1164|M.ulcerans_Agy99 PRRTWSIDALLQVVLVGSGASLGREGAPRQFAAALSDFATTWLRRLSPGD
Mvan_4538|M.vanbaalenii_PYR-1 -----TADAGLQVLLVGSGASLGREGAPRQLAAAWGDIGVSRLA-LTAAD
Mflv_2009|M.gilvum_PYR-GCK RLRVLPARFVGGVLGIGSGLVLGREGPTVHMGAAIGAQAARRSC-LSDGD
.: :*** ****.. ::.:. *: *
Mb0148c|M.bovis_AF2122/97 GRTAVALGIGAGIGAIFAAPLGGAALGASIPYRDDFDYRNLLPGFIASGT
Rv0143c|M.tuberculosis_H37Rv GRTAVALGIGAGIGAIFAAPLGGAALGASIPYRDDFDYRNLLPGFIASGT
MMAR_0353|M.marinum_M GRTAVALGIGAGIGAIFAAPLGGAVLAASITYRDDFDYRSLLPGFITSGT
MSMEG_6465|M.smegmatis_MC2_155 GRLAVSLGIGAGIGAIFGAPLGGAVLAASIVYRDDFDYRALIPGFITSAS
TH_2100|M.thermoresistible__bu GRIAVSLGIGAGIGAIFGAPLGGAVLAASIGYRKDFDYTVLVPGFIASAA
MAV_4918|M.avium_104 REILLACAAGAGLGAVYAVPLAGALFAARILLR-TWRLRAVGAAFLSSGV
MUL_1164|M.ulcerans_Agy99 REILLACAAGAGLGAVYAVPLAGALFALRIMLN-TWNIRALGAALITSSL
Mvan_4538|M.vanbaalenii_PYR-1 RRILLACAAGAGLGAVYSVPLGGALFATRILLR-TWHPRALGTALITSSI
Mflv_2009|M.gilvum_PYR-GCK VRLVQTALAGAGLAVAFNAPIAGVLFTLEEVTR-SLRARTVLATVAATVT
. : ***:.. : .*:.*. : . : . . ::
Mb0148c|M.bovis_AF2122/97 AYAVLGAFLGFDPLFGYIDAEYRFEKAWPLLWFVVIGLIAAAVGYLYARV
Rv0143c|M.tuberculosis_H37Rv AYAVLGAFLGFDPLFGYIDAEYRFEKAWPLLWFVVIGLIAAAVGYLYARV
MMAR_0353|M.marinum_M AYAVLGAFMGFDPLFGYIDAEYRFEKAWPLLWFVVIGVVAAAIGYLYARV
MSMEG_6465|M.smegmatis_MC2_155 AYAVLGSILGFDPLFGFLVGDYRFGQALDLAWFVVLGVIAGGVGWLYARV
TH_2100|M.thermoresistible__bu AYAVFGSILGFDPLFGHVAADFRFDHAALLLWFVVLGVLSAGVGYLYART
MAV_4918|M.avium_104 AVAVGSAVTGDQPNLRWPVEESTY---LLTAHGLLLAPVALAVGLVFNRL
MUL_1164|M.ulcerans_Agy99 AVAIGSLVTHDRPELDWPSAESTY---LLSAHALALAPVAFVVGVAFNRI
Mvan_4538|M.vanbaalenii_PYR-1 AVMVAAPVTHLEHPLSWPDSRLSY---LFVFLALALAPVATAVGLVFDRM
Mflv_2009|M.gilvum_PYR-GCK AVLASRLILADQPDFDVHAVVAPG--LAWLPLFVVFGVLTGLLGAAYNVV
* . : : :. :: :* :
Mb0148c|M.bovis_AF2122/97 FHASVAITRRLPGG-PVLKPAIGGLLVGLLGLPIPQILSSGYGWAQLAAD
Rv0143c|M.tuberculosis_H37Rv FHASVAITRRLPGG-PVLKPAIGGLLVGLLGLPIPQILSSGYGWAQLAAD
MMAR_0353|M.marinum_M FHASVGLAHRLPGG-PVIKPAVGGLLVGLMGLLIPQILSSGYGWAQLAAD
MSMEG_6465|M.smegmatis_MC2_155 FYGTVAVTKMLPGG-KIVKPALGGLAVGLMALAIPQVLASGYGWAEKAAA
TH_2100|M.thermoresistible__bu FYGIRAVTADLPGG-RIVKPALGGLAVGLLGLALPQVLSSGYGWAQKATV
MAV_4918|M.avium_104 MAVARPARPMRTWT-LIPALAGAGLVTGVCSHWWPELPGNGRSILTVSLA
MUL_1164|M.ulcerans_Agy99 MAAARPASLVRSWT-LIPGLAAAGLAIGICSHWWPELPGNGKSILTVSLP
Mvan_4538|M.vanbaalenii_PYR-1 MHGA-PRLTLRSWM-VIPGIAAAGLLTGVCSIWLPELPGNGRSILQVSMG
Mflv_2009|M.gilvum_PYR-GCK VVWSTDRVAAIPRVPTELKAAAIGAAVGALLWVAPLTVGDGDTLTQMILD
. . * * * * ..*
Mb0148c|M.bovis_AF2122/97 RGTLLSIPLWIVIVLPIAKILATSLSIGTGGSGGLFGPGIVIGAFVGAAI
Rv0143c|M.tuberculosis_H37Rv RGTLLSIPLWIVIVLPIAKILATSLSIGTGGSGGLFGPGIVIGAFVGAAI
MMAR_0353|M.marinum_M RNALMAIPLWIIIVLPVAKILATSLSIGTGGSGGLFGPGIVIGAFVGAAI
MSMEG_6465|M.smegmatis_MC2_155 TETLMNIPLWIVLVLPVAKIVATSLSIGTGGSGGIFGPGVVIGAFVGAAL
TH_2100|M.thermoresistible__bu TDTLMALPLWLVLVVPFAKILATGLSIGTGGSGGIFGPGVVIGAFVGAAL
MAV_4918|M.avium_104 SGMTLASALAILLLKP----VLTALFLRAGGAGGLLTPSLATGAAAGTAL
MUL_1164|M.ulcerans_Agy99 SGMTLSAAAVILVLKP----LLTALVLRVGGAGGMLTPSLATGAAAGSLL
Mvan_4538|M.vanbaalenii_PYR-1 SGLTLTSAALILLLKP----LLTMLFLRAGAAGGLLTPALATGAAAGSLA
Mflv_2009|M.gilvum_PYR-GCK GHGFVLLAAVGLLAAR---FFTGPMSYAAAVPGGLFAPLLAVGALWGYVF
: . :: . : .. .**:: * :. ** *
Mb0148c|M.bovis_AF2122/97 WRLGELTELPGVPHEPGIFVVVAMMACFGSVSRAPLAVMIMVAEMTGSFS
Rv0143c|M.tuberculosis_H37Rv WRLGELTELPGVPHEPGIFVVVAMMACFGSVSRAPLAVMIMVAEMTGSFS
MMAR_0353|M.marinum_M WRLGELTGLPGVPDAPGIFVVVAMMTCFGSVSRAPLAVMIMVAEMTGSFS
MSMEG_6465|M.smegmatis_MC2_155 WRLGDALALPGIPDSPAIFVVVGMMACFGCVAHAPLAVMIMVCEMTSSFA
TH_2100|M.thermoresistible__bu WRLGEAVDAPGLPESPGVFVVVGMMACFGSVAHVPLAVLLMVAEMTGSFS
MAV_4918|M.avium_104 VLT--INWATGSQLHVPAVSLAGAAGVLAVTQGSPIWAAIFVWELAR---
MUL_1164|M.ulcerans_Agy99 VLA--ILAVAGTHLHGPVISLAAAAGVLAVTQGSPIWAAIFVWELAR---
Mvan_4538|M.vanbaalenii_PYR-1 ALA--LNHWAGTQLHVAAVSLSCAAGLLAITQRSPLFAALFVWELAR---
Mflv_2009|M.gilvum_PYR-GCK VTCLGAIAPESASALVIPMALVGMAAFFGATVRAPLTGVVIVLEMTATTT
. . : :. . *: ::* *::
Mb0148c|M.bovis_AF2122/97 VVPGAIIAVGIAALLLSRTNVTIYETQRLNRQTAEAERGGSDRPTTA
Rv0143c|M.tuberculosis_H37Rv VVPGAIIAVGIAALLLSRTNVTIYETQRLNRQTAEAERGGSDRPTTA
MMAR_0353|M.marinum_M VVPGAILAVGIASLLMSRTNVTIYEAQRLNRETAEAERAARAADRGN
MSMEG_6465|M.smegmatis_MC2_155 VIPCAMVGVGVACLTISRSDVAIYRAQRARREPEPA-----------
TH_2100|M.thermoresistible__bu VVPGAMVAVGLAYLLITRTDVSIYAAQRMDRESAAAERARRGAGGDS
MAV_4918|M.avium_104 --PPLWLFLLFLLTATAAHGLKVLAQGR-----TTTHAG--------
MUL_1164|M.ulcerans_Agy99 --PPIWMLVVFLVTAVGAHGLKTLVLGRRLPL-RDHRAG--------
Mvan_4538|M.vanbaalenii_PYR-1 --PPLWLLLVFAVGAYAAYGLAALRRRHQKEAGREITAAA-------
Mflv_2009|M.gilvum_PYR-GCK VALPMLAACVSAVLAARAVGSAPIYASLRDRMLVEPVAAPGVDEGR-
.