For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
SLFDISDRAKQYQSDLLEFMDSQVYPAEAIYDEQMRAAGDPHFHPPILEELKAAARNRGLWNLFHPHPEW GPGLTNLEYAPLAEILGRSHIASEACNCSAPDTGNMEVLTLFGTDEHQQRYLKPLLEGKIRSAFAMTEPA VASSDATNVEMSMVRDGDSYILNGRKWFASNGMHRNCKVLIVMGKTDPTAPVHRQQSMMVVPIDAPGLTV RRNLPVFGYQDREGHAEIDFVDVRVPVKDVLKGEGEGFAISQARLGPGRIHHCMRAIGMAERALELMCKR AQSRVTFGKPISENANVRDWIAEARIEIEMIRLLTLKAAYLMDTVGNKQARTEIAAIKVAAPNIALKIVD RAIQVHGGGGVTDDFPLAMAWAHLRTLRLADGPDEVHKRAIATQELRKYRNGAHGS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0156 | fadE2_1 | - | 100% (407) | acyl-CoA dehydrogenase FadE2_1 |
| M. marinum M | MMAR_0374 | fadE2 | e-125 | 56.36% (401) | acyl-CoA dehydrogenase FadE2 |
| M. marinum M | MMAR_0331 | fadE1 | 1e-74 | 39.85% (399) | acyl-CoA dehydrogenase FadE1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0159c | fadE2 | 1e-127 | 56.89% (399) | acyl-CoA dehydrogenase FADE2 |
| M. gilvum PYR-GCK | Mflv_0734 | - | 1e-127 | 56.82% (403) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0154c | fadE2 | 1e-127 | 56.89% (399) | acyl-CoA dehydrogenase FADE2 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 1e-21 | 24.43% (397) | putative acyl-CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_0255 | - | 1e-114 | 51.96% (408) | putative acyl-CoA dehydrogenase |
| M. avium 104 | MAV_5144 | - | 1e-124 | 56.72% (402) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_0102 | - | 1e-126 | 57.36% (401) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3848 | - | 1e-133 | 56.39% (399) | PUTATIVE acyl-CoA dehydrogenase FadE2_1 |
| M. ulcerans Agy99 | MUL_4790 | fadE1 | 6e-74 | 39.85% (399) | acyl-CoA dehydrogenase FadE1 |
| M. vanbaalenii PYR-1 | Mvan_0116 | - | 1e-128 | 57.57% (403) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0734|M.gilvum_PYR-GCK -------------MDFAMSAKAQDYHDRLTDFMTEHVFPAE----ESYHS
Mvan_0116|M.vanbaalenii_PYR-1 MDLTVYTCHIVAVMDFSMSAKAQDYHDRLTDFMTESVFPAE----ESYHA
MSMEG_0102|M.smegmatis_MC2_155 ----------MAGMDFAMSAKAADYHKRLTDFMVEFVFPAE----AEYHA
Mb0159c|M.bovis_AF2122/97 -----------------MSAKAIDYRTRLSDFMTEHVFGAE----ADYDD
Rv0154c|M.tuberculosis_H37Rv -----------------MSAKAIDYRTRLSDFMTEHVFGAE----ADYDD
MAV_5144|M.avium_104 -------------MDFAMSAKASDYHKRLTDFMTEHVFAAE----AEYDK
MMAR_0156|M.marinum_M ------------MSLFDISDRAKQYQSDLLEFMDSQVYPAE----AIYDE
TH_3848|M.thermoresistible__bu -------------MDFEYSPRTRELLTRVRDFMEEYVYPAE----PVYDA
MAB_0255|M.abscessus_ATCC_1997 -------------MDFAPSARAAELIAAVREFIDAEVMPVERAVLAHHDE
MUL_4790|M.ulcerans_Agy99 ------------MWDFETDPEYQAKLDWVQEFMVNELEPLD---------
MLBr_00737|M.leprae_Br4923 ---MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHA---------
. : : :
Mflv_0734|M.gilvum_PYR-GCK YR---AEAGPKDHTVPPVVEELK--KQAKERGLWNLFLPS---VSGLSNL
Mvan_0116|M.vanbaalenii_PYR-1 YR---AEAGPDDHTVPPVVEELK--KLAKARGLWNLFLPS---ESGLSNL
MSMEG_0102|M.smegmatis_MC2_155 YR---EEKGPKDHTVPPVVEELK--VKAKDRGLWNLFLPA---ESGLTNL
Mb0159c|M.bovis_AF2122/97 YR---RAAGPADHTAPPIIEELK--TKAKDRGLWNLFLSA---ESGLTNL
Rv0154c|M.tuberculosis_H37Rv YR---RAAGPADHTAPPIIEELK--TKAKDRGLWNLFLSA---ESGLTNL
MAV_5144|M.avium_104 YR---HEAGPHDHTVPPVVEQLK--VKAKQQGLWNLFLPA---ESGLTNL
MMAR_0156|M.marinum_M QM---RAAG-DPHFHPPILEELK--AAARNRGLWNLFHPHPEWGPGLTNL
TH_3848|M.thermoresistible__bu QV---AEND-NFHEQPQIMRDLQ--AKAREQGLWNLFMTHGDYGAGLTNL
MAB_0255|M.abscessus_ATCC_1997 LLGARAGTTAELWHVPPELDSLK--AKARAAGLWNLFLPDPELGGGLSNS
MUL_4790|M.ulcerans_Agy99 ----LVALDPYDKKNPEMMAVLRPLQQVKNQGLWAAHLRPEVGGQGFGQV
MLBr_00737|M.leprae_Br4923 -----ADVDQRARFPEEALAALN------ASGFNAIHVPEEYGGQGADSV
: *. *: . * .
Mflv_0734|M.gilvum_PYR-GCK EYAPLAELTGWSMEIAPEATNCAAPDTGNMETLHLFATEEQRTQWLEPLL
Mvan_0116|M.vanbaalenii_PYR-1 EYAPLAELTGWSMEIAPEATNCAAPDTGNMETLHLFATEEQRKQWLEPLL
MSMEG_0102|M.smegmatis_MC2_155 EYAPLAEITGWSMEIAPEALNCQAPDTGNMETLHLFANEAQRKQWLEPLL
Mb0159c|M.bovis_AF2122/97 EYAPLAEMTGWSMEIAPEALNCAAPDTGNMEILHMFGTEQQRAQWLRPLL
Rv0154c|M.tuberculosis_H37Rv EYAPLAEMTGWSMEIAPEALNCAAPDTGNMEILHMFGTEQQRAQWLRPLL
MAV_5144|M.avium_104 EYAPLAEITGWSLEIAPEALNCAAPDTGNMETLHLFATEEQRKQWLEPLL
MMAR_0156|M.marinum_M EYAPLAEILGRS-HIASEACNCSAPDTGNMEVLTLFGTDEHQQRYLKPLL
TH_3848|M.thermoresistible__bu EYAPIAEEMGRS-IIGNEVFNCSAPDTGNMEILALYGTEKQRKQWLEPLL
MAB_0255|M.abscessus_ATCC_1997 EYAPLAEQMGRS-LFAPTVFNCNAPDSGNMEVLHRYGSQEQKEVWLEPLL
MUL_4790|M.ulcerans_Agy99 KLALLNEILGRS-RWAPSVFGCQAPDSGNAEILALFGTEDQKARYLQPLL
MLBr_00737|M.leprae_Br4923 AACIVIEEVARVDASASLIP---AVNKLGTMGLILRGSEELKKQVLPSLA
. : * . . * :. . * ..: : * .*
Mflv_0734|M.gilvum_PYR-GCK AGEIRSAFAMTEPAVASSDARNIETTMLRDGDDYVINGRKWWITGAADPR
Mvan_0116|M.vanbaalenii_PYR-1 AGEIRSAFAMTEPAVASSDARNIETTMLRDGDDYVINGRKWWITGAADPR
MSMEG_0102|M.smegmatis_MC2_155 AGEIRSAFAMTEPAVASSDARNIETTMLRDGDHYVINGRKWWITGAADPR
Mb0159c|M.bovis_AF2122/97 DGKIRSAFSMTEPAVASSDARNIETTISRDGADYVINGRKWWTSGAADPR
Rv0154c|M.tuberculosis_H37Rv DGKIRSAFSMTEPAVASSDARNIETTISRDGADYVINGRKWWTSGAADPR
MAV_5144|M.avium_104 AGEIRSAFSMTEPAVASSDARNIETSIVRDGADYVINGRKWWTSGAADPR
MMAR_0156|M.marinum_M EGKIRSAFAMTEPAVASSDATNVEMSMVRDGDSYILNGRKWFASNGMHRN
TH_3848|M.thermoresistible__bu NCEIRSAFAMTEPDVASSDARNITATIRRDGDEYVLNGRKWYTSGILDPD
MAB_0255|M.abscessus_ATCC_1997 EGDIRSAFCMTEPDVASSDATNMAATAVVEGDEVVINGRKWWSTGVGHPD
MUL_4790|M.ulcerans_Agy99 DGEITSCYSMTEPQGGS-DPGSFVTAATRDGDSWIINGEKWFSTNAKH--
MLBr_00737|M.leprae_Br4923 AEGAMASYALSE-REAGSDAASMRTRAKADGDDWILNGFKCWITNGGK--
:.:.::* .. *. .. :* ::** * : :. .
Mflv_0734|M.gilvum_PYR-GCK CKILIVMGRTNPDGPSHRQQSMILVPTDTPGVSIERSLPVFGWQDQHG-H
Mvan_0116|M.vanbaalenii_PYR-1 CKILIVMGRTNPDGPSHRQQSMILVPADTPGVDIQRSLPVFGWQDQHG-H
MSMEG_0102|M.smegmatis_MC2_155 CKILIVMGRTNPDAAAHQQQSMILVPVDTPGVDIQRSLPVFGWQDQHG-H
Mb0159c|M.bovis_AF2122/97 CKILIVMGRTNPDAAAHQQQSMVLVPIDTPGVTIVRSTPVFGWQDRHG-H
Rv0154c|M.tuberculosis_H37Rv CKILIVMGRTNPDAAAHQQQSMVLVPIDTPGVTIVRSTPVFGWQDRHG-H
MAV_5144|M.avium_104 CKILIVMGRTNPDAASHQQQSMVLVPMDTPGVTVVRSTPVFGWQDQHG-H
MMAR_0156|M.marinum_M CKVLIVMGKTDPTAPVHRQQSMMVVPIDAPGLTVRRNLPVFGYQDREG-H
TH_3848|M.thermoresistible__bu CKLIIFMGKSDPDAPTYKQQSMILVPADAPGIEVLRDLPMFGYKDRLG-H
MAB_0255|M.abscessus_ATCC_1997 CKVIIFMGLTDPNAHRYARHSMVLVPMDTPGITVERMLPTMGFYDEPGGH
MUL_4790|M.ulcerans_Agy99 ASFFIVMAVTNPQARTYEKMSLFIVPAETPGIEIVRNVGVGTESSKHASH
MLBr_00737|M.leprae_Br4923 STWYTVMAVTDPDKGANG-ISAFIVHKDDEGFSIGPKEKKLGIKGSPT--
.. .*. ::* * .:* : *. : .
Mflv_0734|M.gilvum_PYR-GCK CEITFDNVRVPASNLLDEEGSGFAIAQARLGPGRIHHCMRAIGAAERALA
Mvan_0116|M.vanbaalenii_PYR-1 CEIVFDNVRVPASNLLDEEGSGFAIAQARLGPGRIHHCMRAIGAAERALA
MSMEG_0102|M.smegmatis_MC2_155 CEIVFNDVRVPAENLLDVEGSGFAIAQARLGPGRIHHCMRAIGAAERALT
Mb0159c|M.bovis_AF2122/97 CEIDYHNVRVPATNLLGEEGSGFAIAQARLGPGRIHHCMRALGAAERALA
Rv0154c|M.tuberculosis_H37Rv CEIDYHNVRVPATNLLGEEGSGFAIAQARLGPGRIHHCMRALGAAERALA
MAV_5144|M.avium_104 CEIVYDNVRVPVTNLLGEEGSGFAIAQARLGPGRIHHCMRALGGAERALA
MMAR_0156|M.marinum_M AEIDFVDVRVPVKDVLKGEGEGFAISQARLGPGRIHHCMRAIGMAERALE
TH_3848|M.thermoresistible__bu GEVQFTDVRVPAENMLGNEGDGFAIAQGRLGPGRMHYAMRAIGFAERALD
MAB_0255|M.abscessus_ATCC_1997 GVVSFDNVRLPADAFIAGPGKGFEIAQGRLGPGRVHHAMRLIGLAEVALE
MUL_4790|M.ulcerans_Agy99 GYVRYHDVRVPADHVLGGEGQAFMTAQTRLGGGRIHHAMRTIALARRAFD
MLBr_00737|M.leprae_Br4923 TELYFDKCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALD
: : . *:* .: * .* : *. * : :. *. *:
Mflv_0734|M.gilvum_PYR-GCK LMVDRVQTRIAFGKPLAEQGVVREAIAKSRNDIEQTRMLCHKAAWTIDQH
Mvan_0116|M.vanbaalenii_PYR-1 LMIDRVQTRIAFGKPLAEQGVVREAIAKSRNEIEQTRLLCHKAAWTIDQQ
MSMEG_0102|M.smegmatis_MC2_155 LMVDRVQKRVAFGKPLAEQGVVREAIAKSRNEIDQARLLCEKAAWTIDLQ
Mb0159c|M.bovis_AF2122/97 LMVNRVRNRVAFGRPLAEQGVVQQAIAQSRNEIDQARLLCEKAAWTIDQH
Rv0154c|M.tuberculosis_H37Rv LMVNRVRNRVAFGRPLAEQGVVQQAIAQSRNEIDQARLLCEKAAWTIDQH
MAV_5144|M.avium_104 LMVDRAQKRVAFGRPLAEQGVVRESIAKSRNEIDQARLLCEKAAWTIDQH
MMAR_0156|M.marinum_M LMCKRAQSRVTFGKPISENANVRDWIAEARIEIEMIRLLTLKAAYLMDTV
TH_3848|M.thermoresistible__bu LMCRRALTREAFGGPLAQRGVVREWIARSRMEIDQIRLLTFKAAWLMDTR
MAB_0255|M.abscessus_ATCC_1997 HACRRGLDRTAFGKPLVNLGGNRERIADARIAINQTRLLVLHAAWLLDTV
MUL_4790|M.ulcerans_Agy99 MMCERAVSRQTRHGRLSDLQMTQEKVADSWIQIEQFRLLVLRTAWLIDKH
MLBr_00737|M.leprae_Br4923 AAIVYTKDRKQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERG
* : : :* :: *:: :* :
Mflv_0734|M.gilvum_PYR-GCK GNKSKDAQLLVAQIKAVAPQMACDVIDRAIQVHGGAGVSDDFPLARLYSW
Mvan_0116|M.vanbaalenii_PYR-1 GNKSKDAQLLVAQIKAVAPQMACDVIDRAIQVHGGAGVCDDFPLARLYSW
MSMEG_0102|M.smegmatis_MC2_155 GNK--AAHVLVSQIKSVAPQVACNVLDRAIQVHGAAGVGDDFPLARLYAW
Mb0159c|M.bovis_AF2122/97 GNK--EARHLVAMIKAVAPRVACDVIDRAIQVHGAAGVSDDTPLARLYGW
Rv0154c|M.tuberculosis_H37Rv GNK--EARHLVAMIKAVAPRVACDVIDRAIQVHGAAGVSDDTPLARLYGW
MAV_5144|M.avium_104 GNK--AAHLLVSQIKAVAPKVACDVIDRAIQVHGAAGVSDDTVLARLYGW
MMAR_0156|M.marinum_M GNK--QARTEIAAIKVAAPNIALKIVDRAIQVHGGGGVTDDFPLAMAWAH
TH_3848|M.thermoresistible__bu GNA--AARSEVAAIKVAAMETAHQVVNRAVQTFGAAGVSDDTVLARLFAI
MAB_0255|M.abscessus_ATCC_1997 GIMG--ALSAVSEIKVAAPNMAQQVIDMAIQIHGGGGLSNDFPLAAAWVN
MUL_4790|M.ulcerans_Agy99 HDYQ-KVRRDIAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMVA
MLBr_00737|M.leprae_Br4923 EPD---LGFISAASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRD
: * .: *:: .*. * .: .
Mflv_0734|M.gilvum_PYR-GCK HRAMRLFDGPDEVHMRTIARAELGREKSALATAACRVSHPGAAG------
Mvan_0116|M.vanbaalenii_PYR-1 HRAMRLFDGPDEVHMRTIARAELGREKSAMATAASRQSDTAASRQSNPAA
MSMEG_0102|M.smegmatis_MC2_155 HRAMRLFDGPDEVHMRTIARSELGREKSPLALAVTK--------------
Mb0159c|M.bovis_AF2122/97 HRAMRIFDGPDEVHLRSIARAELSREKSTFAAAVT---------------
Rv0154c|M.tuberculosis_H37Rv HRAMRIFDGPDEVHLRSIARAELSREKSTFAAAVT---------------
MAV_5144|M.avium_104 HRAMRIFDGPDEVHMRTIARAELGREKSALAAAVTAHA------------
MMAR_0156|M.marinum_M LRTLRLADGPDEVHKRAIATQELRKYRNGAHGS-----------------
TH_3848|M.thermoresistible__bu TRALQIADGPNEVHLRTIARLELERYRDE---------------------
MAB_0255|M.abscessus_ATCC_1997 ARALRLADGPDEVHRGVVARIELAKYAND---------------------
MUL_4790|M.ulcerans_Agy99 AESLGIADGATELHKMTVARRTLRQYEPVATPFPSQHIPTRRAAAEARLA
MLBr_00737|M.leprae_Br4923 AKITQIYEGTNQIQRVVMSRALLR--------------------------
. : :*. ::: :: *
Mflv_0734|M.gilvum_PYR-GCK ----------
Mvan_0116|M.vanbaalenii_PYR-1 SRQSETAVTG
MSMEG_0102|M.smegmatis_MC2_155 ----------
Mb0159c|M.bovis_AF2122/97 ----------
Rv0154c|M.tuberculosis_H37Rv ----------
MAV_5144|M.avium_104 ----------
MMAR_0156|M.marinum_M ----------
TH_3848|M.thermoresistible__bu ----------
MAB_0255|M.abscessus_ATCC_1997 ----------
MUL_4790|M.ulcerans_Agy99 ERLEHSIAEF
MLBr_00737|M.leprae_Br4923 ----------