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STFVVPGAELAVELSDEGGHPVVQLHGLTSSRARDRVLNLDLGRGLSGTRLLRYDARGHGKSTGRKVPQD YRWERLAEDLLRLLDKWFPGEQVHGVGPSMGTGTLLHAAAREPDRFAGLTLMVPATAWHTRPAQAANYRV AAEIIETEGVGAFIAWGRAATPPPATVGAPETVPDVADALLPSLFRGAALSDLPTSEALARIDVPTTILA WINDPAHPLSTAESLAALLPQSTLTVAHTPADVETWPKILSQDVARRG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0086 | - | - | 100% (259) | hydrolase |
| M. marinum M | MMAR_2019 | - | 2e-07 | 29.71% (175) | hypothetical protein MMAR_2019 |
| M. marinum M | MMAR_1120 | - | 3e-07 | 25.66% (226) | hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2714 | - | 1e-06 | 29.45% (146) | hypothetical protein Mb2714 |
| M. gilvum PYR-GCK | Mflv_1348 | - | 5e-13 | 32.18% (202) | 3-oxoadipate enol-lactonase |
| M. tuberculosis H37Rv | Rv2695 | - | 1e-06 | 29.45% (146) | hypothetical protein Rv2695 |
| M. leprae Br4923 | MLBr_01030 | - | 5e-06 | 26.06% (165) | hypothetical protein MLBr_01030 |
| M. abscessus ATCC 19977 | MAB_1875c | - | 2e-10 | 26.69% (251) | putative hydrolase (alpha/beta fold) |
| M. avium 104 | MAV_4371 | - | 1e-07 | 26.01% (223) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_1897 | pcaD | 2e-12 | 34.10% (173) | 3-oxoadipate enol-lactonase |
| M. thermoresistible (build 8) | TH_2963 | - | 1e-10 | 32.98% (191) | PUTATIVE putative 3-oxoadipate enol-lactonase |
| M. ulcerans Agy99 | MUL_0077 | - | 1e-118 | 99.04% (208) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_1865 | - | 3e-06 | 27.24% (257) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0086|M.marinum_M ---------------------------------------MSTFVVPGAEL
MUL_0077|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1348|M.gilvum_PYR-GCK --------------------------------------------MSAVDV
MSMEG_1897|M.smegmatis_MC2_155 --------------------------------------------MSSVAV
Mb2714|M.bovis_AF2122/97 ---------------------------------------------MAVDL
Rv2695|M.tuberculosis_H37Rv ---------------------------------------------MAVDL
MLBr_01030|M.leprae_Br4923 ---------------------------------------------MAVDL
TH_2963|M.thermoresistible__bu ---------------------------------------MPRFSRAGTTI
Mvan_1865|M.vanbaalenii_PYR-1 --------------MAPGTSTRSRSRGFAPAQALPPGRIVDVRSKDGVRL
MAV_4371|M.avium_104 MTAVATIVGASARRSMTQRATIEDPYADEDFNTFDGDRALVVTTPDGVPL
MAB_1875c|M.abscessus_ATCC_199 ----------------------------------MSEHRRTSISVDGHRL
MMAR_0086|M.marinum_M AVELSDEGGHPVVQLHGL-TSSRARDR--VLNLDLGRGLSGTRLLRYDAR
MUL_0077|M.ulcerans_Agy99 -------------------------------------------MLRYDAR
Mflv_1348|M.gilvum_PYR-GCK HVIESGLPDGPAVVLS---NSLGATHR--MWDAQLDALERRFRVLRYDTR
MSMEG_1897|M.smegmatis_MC2_155 HHVVTGRSDGPAVVFS---NSLGSTHR--MWDPQLAAFEERFRVVRYDTR
Mb2714|M.bovis_AF2122/97 DGVTTVLLPG-----------TGSDN------------DYVRRAFSAPLR
Rv2695|M.tuberculosis_H37Rv DGVTTVLLPG-----------TGSDN------------DYVRRAFSAPLR
MLBr_01030|M.leprae_Br4923 RNVTTVLLPG-----------TGSDD------------DYVYRAFSGPLH
TH_2963|M.thermoresistible__bu DYTDTGAPAGRLEAPTIL-FGHGLLFSGWQFNLQIYALRRYYRCLAIDWR
Mvan_1865|M.vanbaalenii_PYR-1 HAEVFGPEDGYPIVLA-----HGITCSLRVWAYQIAELARDHRVIAFDHR
MAV_4371|M.avium_104 AVREAGPPDAPLTMVFVHGFCLQMGAFHFQRTRLPEQLGPDVRMVFYDQR
MAB_1875c|M.abscessus_ATCC_199 AYRQFGSGDRVVVLSH-----AFLTSHYLEHAWAQELAARGFRVICLDLL
.
MMAR_0086|M.marinum_M GHGKSTGRKVPQDYRWERLAEDLLRLLD-KWFPGEQVHGVGPSMGTGTLL
MUL_0077|M.ulcerans_Agy99 GHGKSTGRKVPQDYRWERLAEDLLRLLD-KWFPGEQVHGVGPSMGTGTLL
Mflv_1348|M.gilvum_PYR-GCK GHGASPVPDGP--YSIDDLADDVVGILD-RRG-IDTAHLVGLSLGGMTAM
MSMEG_1897|M.smegmatis_MC2_155 GHGQSPVPEGP--YTIDDLADDVVALLD-TLG-IERAHVVGLSLGGMTAM
Mb2714|M.bovis_AF2122/97 RAGAVLVTPVP---HPGRLIDGYRAALD-DAARDGPVVVGGVSLGAAVAA
Rv2695|M.tuberculosis_H37Rv RAGAVLVTPVP---HPGRLIDGYRAALD-DAARDGPVVVGGVSLGAAVAA
MLBr_01030|M.leprae_Br4923 RVGAAVLTPPP---QPNRLIDGYLSALD-DAARAGPIGVGGVSIGAAVAA
TH_2963|M.thermoresistible__bu GQGASSGAARP--YDMDTLTEDAAHLVR-SLG-VAPAHYVGLSMGGFVGI
Mvan_1865|M.vanbaalenii_PYR-1 GHGRSAIPPRRGGYSLDYLAGDLDAVLEATLAPGERAVIAGHSMGGIAIS
MAV_4371|M.avium_104 GHGRS-GEAAPESYTLTQLGRDLQTVLQ-VVAPRGLVVLVGHSMGGMTVL
MAB_1875c|M.abscessus_ATCC_199 GTTADERPLEPDRYNSQALGRQLIGALD--ALGIERAVLGGTSVGANISI
* : * *:*
MMAR_0086|M.marinum_M HAAAREPD----RFAGLTLMVPATAW--------------HTR----PAQ
MUL_0077|M.ulcerans_Agy99 HAAAREPD----RFAGLTLMVPATAW--------------HTR----PAQ
Mflv_1348|M.gilvum_PYR-GCK RVAARNPD----RVNRMVLLCTAAEL--------------APAQAWTDRA
MSMEG_1897|M.smegmatis_MC2_155 RLSARNPQ----RVDRIALLCTATHL--------------PPSSAWTERA
Mb2714|M.bovis_AF2122/97 AWALEHPD----RAVAVLAALPAWTG--------------EPE---LAPA
Rv2695|M.tuberculosis_H37Rv AWALEHPD----RAVAVLAALPAWTG--------------EPE---LAPA
MLBr_01030|M.leprae_Br4923 AWALAHPE----RAVAVLAALPAWNG--------------APE---SAPA
TH_2963|M.thermoresistible__bu RLAARHPE----LVRSLVLMNTSAGPEDP-----------AKADRYRTMA
Mvan_1865|M.vanbaalenii_PYR-1 SWSERLPHRVEQRADAVALINTTTGDLLRNVN-LLPVPPALADVRVRAAG
MAV_4371|M.avium_104 SHARQFPEQYGRRIVGAALISSAAEGVSRSPLGEILKNPALEAVRVAARS
MAB_1875c|M.abscessus_ATCC_199 EAAALAPE----RVAGLLLEGPFLEHG------------IGAAGYLWSAG
: *. .
MMAR_0086|M.marinum_M AANYRVAAEIIETEG---VGAFIAWGRAATPPPA--TVGAPETVPDVADA
MUL_0077|M.ulcerans_Agy99 AANYRVAAEIIETEG---VGAFIAWGRAATPPPA--TVGAPETVPDVADA
Mflv_1348|M.gilvum_PYR-GCK AAVRAGGAESVAPAV---IARWFTLSHLETHPAE--RAEWVDMIAATPAE
MSMEG_1897|M.smegmatis_MC2_155 AAVRTHGSAAVAESV---VGRWFTPGFLAADPGR--KAAYQQMIAATPAE
Mb2714|M.bovis_AF2122/97 AQAARYTAARLRCDG---LAATTTR-MRASSPVW--LAEELTRSWRVQWP
Rv2695|M.tuberculosis_H37Rv AQAARYTAARLRCDG---LAATTTR-MRASSPVW--LAEELTRSWRVQWP
MLBr_01030|M.leprae_Br4923 ALAARYSASHLRRDG---LAATTLQ-MQASSPPW--LADELARSWCGQWP
TH_2963|M.thermoresistible__bu RIYRFTGIGPLRRAV---LPLMFGPAFLADPDSEDVIDEWERRLRRYPRS
Mvan_1865|M.vanbaalenii_PYR-1 EVLRRFGGVPLVRAVDRPNRRFVSSIAVGRDADPAIADFVFELFNSTSPA
MAV_4371|M.avium_104 APKLMHRGRNVSRSL---IGPVLRAASFSDLQVSRSLDAFSQRMMNSTPI
MAB_1875c|M.abscessus_ATCC_199 LTLFTLGRPLVWLAG------AVARSFPETEQPT--LGLIRAFLTAPPAR
:
MMAR_0086|M.marinum_M LLPSLFRGAALSDLPTSEALARIDVPTTILAWINDPAHPLSTAESLAALL
MUL_0077|M.ulcerans_Agy99 LLPSLFRGAALSDLPTSEALARIDVPTTTLAWINDPAHPLSTAESLAALL
Mflv_1348|M.gilvum_PYR-GCK GYASCCEAIAELDLR--EQLPTITAPTLAIAGADDPATPPAKLEQIVSAI
MSMEG_1897|M.smegmatis_MC2_155 GYAGCCEAIAALDLR--ADLARITAPTLAIAGTDDPATPPDRLAEITAAV
Mb2714|M.bovis_AF2122/97 ELPDAMEEAAAYVAPSRAELARLVAPLAVAAAVDDPIHPLQVAADWVSVA
Rv2695|M.tuberculosis_H37Rv ELPDAMEEAAAYVAPSRAELARLVAPLAVAAAVDDPIHPLQVAADWVSVA
MLBr_01030|M.leprae_Br4923 LLPDAMEEAAAYIAPSCAELARLATPLGVAAAVDDPIHPLQVGVDWVTAA
TH_2963|M.thermoresistible__bu SVRDAVLAVAN-RAGVEDELAAIDVPTLVIGGAQDAATPPAHAQALAAGI
Mvan_1865|M.vanbaalenii_PYR-1 GRGGWARVLVDHLGPRHIALKNLTVPTLVIGSTKDRLLPMASARRIAATA
MAV_4371|M.avium_104 PTMVGFLDALEHHDETAGLWTLLRVPTLIACGDHDLLTPDEYSRKMAASL
MAB_1875c|M.abscessus_ATCC_199 SAAFMRGMLVGRMAPPRAVRRSVNVPTMILSLTADPLHPASDAHSLAVDI
: .* * * .
MMAR_0086|M.marinum_M PQSTLTVAH---TPADVET--WPKILSQDVARRG----------------
MUL_0077|M.ulcerans_Agy99 PQSTLTVAH---TPADVET--WPKILSQDLARRG----------------
Mflv_1348|M.gilvum_PYR-GCK PGARLLVVDGAAHLANAEQ--PEQITPAIIEHL--EQR------------
MSMEG_1897|M.smegmatis_MC2_155 RGARLVQVTPGAHLANVEQ--ADAITPTLLEHLGTEQS------------
Mb2714|M.bovis_AF2122/97 PHAALRTVTLDEIGADAAA--LGSACLAALAEVSGA--------------
Rv2695|M.tuberculosis_H37Rv PHAALRTVTLDEIGADAAA--LGSACLAALAEVSGA--------------
MLBr_01030|M.leprae_Br4923 PHAALQTVTLNQIGTNAAA--LGTACLAALALT-----------------
TH_2963|M.thermoresistible__bu RGARLEIIDDCGHSSPLER--PDVVTELLRGFLLEHT-------------
Mvan_1865|M.vanbaalenii_PYR-1 PNLARFVEVPGGHCAILER--PDDVNDHLRWLVRSVTGQGDATGATG---
MAV_4371|M.avium_104 PQSELVIVAGASHLALLDK--PEAINGGLVRLVRRATPSRAALALRRIGE
MAB_1875c|M.abscessus_ATCC_199 VGAQVVSAGTLATLRFWPRRVTPAIVSFLVETFGIDVTARQADA------
MMAR_0086|M.marinum_M ------
MUL_0077|M.ulcerans_Agy99 ------
Mflv_1348|M.gilvum_PYR-GCK ------
MSMEG_1897|M.smegmatis_MC2_155 ------
Mb2714|M.bovis_AF2122/97 ------
Rv2695|M.tuberculosis_H37Rv ------
MLBr_01030|M.leprae_Br4923 ------
TH_2963|M.thermoresistible__bu ------
Mvan_1865|M.vanbaalenii_PYR-1 ------
MAV_4371|M.avium_104 RLWRRG
MAB_1875c|M.abscessus_ATCC_199 ------