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M. leprae Br4923 MLBr_02680 (dnaB)

annotation: replicative DNA helicase
coordinates: 3230183 - 3231997
length: 604

AVVDDLAHSGMDAVPPSEDFGRQPPQDLAAEQSVLGGMLLSKDAIADVLERLRSGDFYRPAHQNVYDAIL
DLYGRGEPADAVTVAAELDRRGLLRRIGGAPYLHTLISTVPTAANAGYYAGIVAEKALLRRLVEAGTRVV
QYGYAGAEGADVAEVVDRAQAEIYDVAECRLSENYVPLEDLLQPTMDDLDAIASNGGISRGAPTGFTELD
EVTNGLHPGQMIIVAARPGVGKALALDTPLPTPTGWTAMGDVAVGDELLAVDEAPTRVVAATEVMLGRPC
YEIEFSDGTVIVADAQHQWPTSYGIRTSAQLRCGLDIIAAAGSTPRHAGRLTTAAFMAPVLCIDSVRRVR
SVPVRCVEVDNAAHLYLAGRGMVPTHNSTLGLDFMRSCSIKHRLASVIFSLEMSKSEIVMRLLSAEAKIK
LADMRSGRMTDDDWTRLARRMSEISEAPLYIDDSPNLTMMEIRAKARRLRQKTNLKLVVVDYLQLMTSGK
RFESRQVEVSEFSRHLKLLAKELELPVVAISQLNRSPEQRTDKKPMLSDLRESGSLEQDADVVILLHRPD
AFDRDDPRGGEADLILAKHRNGPTKTVTVAHQLHLSRFTNMAR*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. leprae Br4923MLBr_02680dnaB-100% (604)replicative DNA helicase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0059dnaB1e-11890.38% (239) replicative DNA helicase
M. gilvum PYR-GCKMflv_0878-1e-14069.09% (385) DnaB domain-containing protein
M. tuberculosis H37RvRv0058dnaB1e-11890.38% (239) replicative DNA helicase
M. abscessus ATCC 19977MAB_4895c-1e-11385.36% (239) replicative DNA helicase
M. marinum MMMAR_0076dnaB1e-12292.92% (240) replicative DNA helicase DnaB
M. avium 104MAV_0079-1e-15462.62% (503) replicative DNA helicase
M. smegmatis MC2 155MSMEG_6892-0.080.36% (555) replicative DNA helicase
M. thermoresistible (build 8)TH_2096dnaB0.086.64% (509) PROBABLE REPLICATIVE DNA HELICASE DNAB
M. ulcerans Agy99MUL_0075dnaB1e-12392.92% (240) replicative DNA helicase DnaB
M. vanbaalenii PYR-1Mvan_6030-1e-14178.26% (322) DnaB domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


MSMEG_6892|M.smegmatis_MC2_155      --MDDLGHPDGPADIDGPPPSGDFGRQPPQDMAAEQAVLGGMLLSKDAIA
TH_2096|M.thermoresistible__bu      -----------------------------------------MLLSKDAIA
MLBr_02680|M.leprae_Br4923          ---MAVVDDLAHSGMDAVPPSEDFGRQPPQDLAAEQSVLGGMLLSKDAIA
Mb0059|M.bovis_AF2122/97            MAVVDDLAP--GMD--SSPPSEDYGRQPPQDLAAEQSVLGGMLLSKDAIA
Rv0058|M.tuberculosis_H37Rv         MAVVDDLAP--GMD--SSPPSEDYGRQPPQDLAAEQSVLGGMLLSKDAIA
MMAR_0076|M.marinum_M               MAVVDDLAHSDNMD--APPPSEDFGRQPPQDLAAEQSVLGGMLLSKDAVA
MUL_0075|M.ulcerans_Agy99           MAVVDDLAHSDNMD--APPPSEDFGRQPPQDLAAEQSVLGGMLLSKDAVA
Mflv_0878|M.gilvum_PYR-GCK          MAVVDDRGRSGDRSDLEPPPSEDFGRQPPQDAAAEQAVLGGMLLSKDAVA
Mvan_6030|M.vanbaalenii_PYR-1       ---------------MEPPPSEDFGRQPPQDAAAEQAVLGGMLLSKDAVA
MAV_0079|M.avium_104                MAVVDDLTSGMD----SSSPSEDFGRQPPQDLAAEQAVLGGMLLSKDAIA
MAB_4895c|M.abscessus_ATCC_199      MAIVDDLGQSGP----AAPPEEDFGRQPPQDVAAEQSVLGGMMLSKDAIA
                                                                             *:*****:*

MSMEG_6892|M.smegmatis_MC2_155      DVLERLRPGDFYRPAHQSVYDAILDLYGRGEPADAVTVAAELDRRGLLRR
TH_2096|M.thermoresistible__bu      DVLEKLRPGDFYKPAHQNVYDAILDLYGRGEPADAVTVAAELDRRGLLRR
MLBr_02680|M.leprae_Br4923          DVLERLRSGDFYRPAHQNVYDAILDLYGRGEPADAVTVAAELDRRGLLRR
Mb0059|M.bovis_AF2122/97            DVLERLRPGDFYRPAHQNVYDAILDLYGRGEPADAVTVAAELDRRGLLRR
Rv0058|M.tuberculosis_H37Rv         DVLERLRPGDFYRPAHQNVYDAILDLYGRGEPADAVTVAAELDRRGLLRR
MMAR_0076|M.marinum_M               DVLERLRPGDFYRPAHQNIYDAILDLYGRGEPADAVTVAAELDRRGLLRR
MUL_0075|M.ulcerans_Agy99           DVLERLRPGDFYRPAHQNIYDAILDLYGRGEPADAVTVAAELDRRGLLRR
Mflv_0878|M.gilvum_PYR-GCK          DVLEKLRPGDFYKPANQLVYDAILDLYGRGEPADAVTVAAELDRRGLLRR
Mvan_6030|M.vanbaalenii_PYR-1       DVLEKLRPGDFYKPANQLVYDAILDLYGRGEPADAVTVAAELDRRGLLRR
MAV_0079|M.avium_104                DVLERLRPGDFYRPAHQNVYDAILDLYGRGEPADAVTVAAELDRRNLLRR
MAB_4895c|M.abscessus_ATCC_199      DVLEKLRPHDFYRPNHQSVYEAILDLYGRGEPADAVTVAAELDRRGQLRR
                                    ****:**. ***:* :* :*:************************. ***

MSMEG_6892|M.smegmatis_MC2_155      IGGAPYLHTLISTVPTAANAGFYAGIVAEKALLRRLVEAGTRVVQYGYAG
TH_2096|M.thermoresistible__bu      IGGAPYLHTLISTVPTAANAGYYAGIVAEKALLRRLVEAGTRVVQYGYAG
MLBr_02680|M.leprae_Br4923          IGGAPYLHTLISTVPTAANAGYYAGIVAEKALLRRLVEAGTRVVQYGYAG
Mb0059|M.bovis_AF2122/97            IGGAPYLHTLISTVPTAANAGYYASIVAEKALLRRLVEAGTRVVQYGYAG
Rv0058|M.tuberculosis_H37Rv         IGGAPYLHTLISTVPTAANAGYYASIVAEKALLRRLVEAGTRVVQYGYAG
MMAR_0076|M.marinum_M               IGGAPYLHTLISTVPTAANAGYYAGIVGEKALLRRLVEAGTRVVQYGYAG
MUL_0075|M.ulcerans_Agy99           IGGAPYLHTLISTVPTAANAGYYAGIVGEKALLRRLVEAGTRVVQYGYAG
Mflv_0878|M.gilvum_PYR-GCK          VGGAPYLHTLISTVPTAANAGYYAEIVAEKSLLRRLVEAGTRVVQYGYAG
Mvan_6030|M.vanbaalenii_PYR-1       VGGAPYLHTLISTVPTAANAGYYAEIVAEKSLLRRLVEAGTRVVQYGYAG
MAV_0079|M.avium_104                IGGAPYLHTLISTVPTAANAGYYATIVAEKALLRRLVEAGTRVVQYGYAG
MAB_4895c|M.abscessus_ATCC_199      VGGAPYLHTLISTVPTAANAGYYAGIVAEKALLRRLVEAGTRVVQYGYAG
                                    :********************:** **.**:*******************

MSMEG_6892|M.smegmatis_MC2_155      ADGADVADIVDRAQAEIYDVTERRASEDFVPLEDLLQPTMDEIDAIASQG
TH_2096|M.thermoresistible__bu      ADGADVNEVVDRAQAEIYDVTERRASEDFVPLEDLLQPTMDEIDAIASQG
MLBr_02680|M.leprae_Br4923          AEGADVAEVVDRAQAEIYDVAECRLSENYVPLEDLLQPTMDDLDAIASNG
Mb0059|M.bovis_AF2122/97            AEGADVAEVVDRAQAEIYDVADRRLSEDFVALEDLLQPTMDEIDAIASSG
Rv0058|M.tuberculosis_H37Rv         AEGADVAEVVDRAQAEIYDVADRRLSEDFVALEDLLQPTMDEIDAIASSG
MMAR_0076|M.marinum_M               AEGADVAEVVDRAQAEIYDVADRRLSEDFVPLEDLLQPTMDEIDAIASNG
MUL_0075|M.ulcerans_Agy99           AEGADVAEVVDRAQAEIYDVADRRLSEDFVPLEDLLQPTMDEIDAIASNG
Mflv_0878|M.gilvum_PYR-GCK          ADGADVNEIVDRAQAEIYDVTERKSSEDYVILEEILQPAMDEIDAIASQG
Mvan_6030|M.vanbaalenii_PYR-1       ADGADVNEIVDRAQAEIYDVTERKSSEDFVILEEILQPAMDEIDAIASEG
MAV_0079|M.avium_104                AEGADVAEVVDRAQAEIYEVAERRTTEDFVPLEDLLQPTMDEIDAIASNG
MAB_4895c|M.abscessus_ATCC_199      AEGADVAEVVDRAQAEVYDVTDRRMSEDYVPLEELLQPTMDEIDAIASAG
                                    *:**** ::*******:*:*:: : :*::* **::***:**::***** *

MSMEG_6892|M.smegmatis_MC2_155      GIARGVPTGFTELDEVTNGLHAGQMIIIAARPGVGKALALDTPLPTPSGW
TH_2096|M.thermoresistible__bu      GLARGVPTGFIELDEVTNGLHPGQMIIIAARPGVGKALALDTPLPTPHGW
MLBr_02680|M.leprae_Br4923          GISRGAPTGFTELDEVTNGLHPGQMIIVAARPGVGKALALDTPLPTPTGW
Mb0059|M.bovis_AF2122/97            GLARGVATGFTELDEVTNGLHPGQMVIVAARPGVGK--------------
Rv0058|M.tuberculosis_H37Rv         GLARGVATGFTELDEVTNGLHPGQMVIVAARPGVGK--------------
MMAR_0076|M.marinum_M               GISRGVPTGFTELDEVTNGLHPGQMIIVAARPGVGK--------------
MUL_0075|M.ulcerans_Agy99           GISRGVPTGFTELDEVTNGLHPGQMIIVAARPGVGK--------------
Mflv_0878|M.gilvum_PYR-GCK          GISKGVPTGFTDLDELTNGLHPGQMIVVAARPGMGKALALDTPLPTPTGW
Mvan_6030|M.vanbaalenii_PYR-1       GVSKGVPTGFTDLDELTNGLHPGQMIVVAARPGMGKALALDTPLPTPTGW
MAV_0079|M.avium_104                GVARGVPTGFTELDEVTNGLHAGQMIIVAARPGVGKALALDTPLPTPTGW
MAB_4895c|M.abscessus_ATCC_199      GISKGVPTGFTDLDEITNGLHPGQMIIVAARPGVG---------------
                                    *:::*..*** :***:*****.***:::*****:*               

MSMEG_6892|M.smegmatis_MC2_155      TTMGDVAVGDHLLGPDGEPTRVVADTDVMLGRPCYVVEFSDGTAIVADAQ
TH_2096|M.thermoresistible__bu      TTMGDVAVGDELLGADGRPTRVVAATEVMLGRPCYEVEFSDGTVIVADAD
MLBr_02680|M.leprae_Br4923          TAMGDVAVGDELLAVDEAPTRVVAATEVMLGRPCYEIEFSDGTVIVADAQ
Mb0059|M.bovis_AF2122/97            --------------------------------------------------
Rv0058|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_0076|M.marinum_M               --------------------------------------------------
MUL_0075|M.ulcerans_Agy99           --------------------------------------------------
Mflv_0878|M.gilvum_PYR-GCK          TTMAEVKVGDFLIGADGKPTRVVAATNVMVDRPCFEVEFSDGTVLVADAE
Mvan_6030|M.vanbaalenii_PYR-1       TTMADVAVGDLLIGADGKPTRVVAATEVMVGRPCYEVEFSDGTVIVADAE
MAV_0079|M.avium_104                TTMGDVAVGDELLGDDGRPTRVVAATDVMLGRPCYEVEFSDGTVIVADAA
MAB_4895c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MSMEG_6892|M.smegmatis_MC2_155      HQWPTEHGVRITANLRAGMHTVVSAS------------------------
TH_2096|M.thermoresistible__bu      HQWPTGYGVRTTARLRAGLDTIAAAG------------------------
MLBr_02680|M.leprae_Br4923          HQWPTSYGIRTSAQLRCGLDIIAAAG------------------------
Mb0059|M.bovis_AF2122/97            --------------------------------------------------
Rv0058|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_0076|M.marinum_M               --------------------------------------------------
MUL_0075|M.ulcerans_Agy99           --------------------------------------------------
Mflv_0878|M.gilvum_PYR-GCK          HQWLTETRASRKSAQAAAVGYNRTKNQRTFAAVRTTREIAETLRCPTVDR
Mvan_6030|M.vanbaalenii_PYR-1       HQWLTETRASRKSAQAAAVGYNRYKNQRTFAAVRTTREIGETLRCPTADR
MAV_0079|M.avium_104                HQWLTETRVSRKSAQAAAVGYNRYKNQRTFAAVRTTAEIAETLRCPAQDR
MAB_4895c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MSMEG_6892|M.smegmatis_MC2_155      --------------------------------------------------
TH_2096|M.thermoresistible__bu      --------------------------------------------------
MLBr_02680|M.leprae_Br4923          --------------------------------------------------
Mb0059|M.bovis_AF2122/97            --------------------------------------------------
Rv0058|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_0076|M.marinum_M               --------------------------------------------------
MUL_0075|M.ulcerans_Agy99           --------------------------------------------------
Mflv_0878|M.gilvum_PYR-GCK          RLNHSIVNTAPIQGVEKDLLVPPYTLGAWLGDGTSAAAQITTADPEVLMR
Mvan_6030|M.vanbaalenii_PYR-1       RLNHSVVNAAPIEAPVADLLLPPYTLGAWLGDGTSRAAQITTADPEILMR
MAV_0079|M.avium_104                RLNHSVVNARALELPDREFLVPPYTLGAWLGDGTSAAAQITAADPEIIMR
MAB_4895c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MSMEG_6892|M.smegmatis_MC2_155      --------------------------------------------------
TH_2096|M.thermoresistible__bu      --------------------------------------------------
MLBr_02680|M.leprae_Br4923          --------------------------------------------------
Mb0059|M.bovis_AF2122/97            --------------------------------------------------
Rv0058|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_0076|M.marinum_M               --------------------------------------------------
MUL_0075|M.ulcerans_Agy99           --------------------------------------------------
Mflv_0878|M.gilvum_PYR-GCK          IEGEGLVTVPSKSAKMRYQILLPEAEPTGVRSCAVCGQDFVPQTSQVRTC
Mvan_6030|M.vanbaalenii_PYR-1       IEAEGLVTVPLPGARMRYGLQLPTEAPAGTRECVVCGASFTPSTSQVRTC
MAV_0079|M.avium_104                IEAE----------------------------------------------
MAB_4895c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MSMEG_6892|M.smegmatis_MC2_155      --------------------------------------------------
TH_2096|M.thermoresistible__bu      --------------------------------------------------
MLBr_02680|M.leprae_Br4923          --------------------------------------------------
Mb0059|M.bovis_AF2122/97            --------------------------------------------------
Rv0058|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_0076|M.marinum_M               --------------------------------------------------
MUL_0075|M.ulcerans_Agy99           --------------------------------------------------
Mflv_0878|M.gilvum_PYR-GCK          GRSCGGRVRFLTDPVPAPTCATCGGPSCGLRMCKSCRGAFGSVQARLRTI
Mvan_6030|M.vanbaalenii_PYR-1       GRSCGGRARFVSEPVAAPTCSHCGGPSCGLRLCQSCRNAVGTVQGRLRTI
MAV_0079|M.avium_104                ----------------------------------DSGAGVGTLQARLRTI
MAB_4895c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MSMEG_6892|M.smegmatis_MC2_155      --------------------------------------------------
TH_2096|M.thermoresistible__bu      --------------------------------------------------
MLBr_02680|M.leprae_Br4923          --------------------------------------------------
Mb0059|M.bovis_AF2122/97            --------------------------------------------------
Rv0058|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_0076|M.marinum_M               --------------------------------------------------
MUL_0075|M.ulcerans_Agy99           --------------------------------------------------
Mflv_0878|M.gilvum_PYR-GCK          GVLGAKHIPIDYLRASEEQRRALLAGLLDTDGTVPNGGSVQYTGTNARLI
Mvan_6030|M.vanbaalenii_PYR-1       GVLGNKHIPTEYLRASEAQRRALLAGLLDTDGTVTNGGAVQFSVTSRRLA
MAV_0079|M.avium_104                GVLGNKHIPTEYLRGSEAQRRALLAGLLDTDGTVTVGGAVQFSVTNQRLA
MAB_4895c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MSMEG_6892|M.smegmatis_MC2_155      ------------------------------------------------GG
TH_2096|M.thermoresistible__bu      ------------------------------------------------SM
MLBr_02680|M.leprae_Br4923          ------------------------------------------------ST
Mb0059|M.bovis_AF2122/97            --------------------------------------------------
Rv0058|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_0076|M.marinum_M               --------------------------------------------------
MUL_0075|M.ulcerans_Agy99           --------------------------------------------------
Mflv_0878|M.gilvum_PYR-GCK          GDVAELVVSLGYRCQIAKKAVNGRSADSSVAYTINFSTDDVVFGLHRKAV
Mvan_6030|M.vanbaalenii_PYR-1       ADVAELVVSLGYRCQVATKAVKGRTEASSTAYILNFSTTDSVFGLHRKDL
MAV_0079|M.avium_104                RDVNELIVSLGYRCQTSTKRVQGRSETSSIAYTLTFSTADKVFALERKAI
MAB_4895c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MSMEG_6892|M.smegmatis_MC2_155      R------GGTALLAPAVQITAVRRRPSVPVRCVEVDNPEHLYLAGPGMVP
TH_2096|M.thermoresistible__bu      ARYGEQPGGAALLAPVLQIDAVRRINSVPVRCVEVDNPAHLYLAGQGMVP
MLBr_02680|M.leprae_Br4923          PRHAGRLTTAAFMAPVLCIDSVRRVRSVPVRCVEVDNAAHLYLAGRGMVP
Mb0059|M.bovis_AF2122/97            --------------------------------------------------
Rv0058|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_0076|M.marinum_M               --------------------------------------------------
MUL_0075|M.ulcerans_Agy99           --------------------------------------------------
Mflv_0878|M.gilvum_PYR-GCK          LHKERRRSASTVRSGSRFITDVRPVPSVPVRCVEVDNDDHLYLAGRSMIP
Mvan_6030|M.vanbaalenii_PYR-1       SHKERR-SKSSVRSNTRFIVDVREIETVPVRCVEVDNDDHMYLASRSMIP
MAV_0079|M.avium_104                AHKERRAVTGTSRGGSRFIVDVRPIEPVAVRCVEVDNDSHMYLASRAMVP
MAB_4895c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MSMEG_6892|M.smegmatis_MC2_155      THNSTLGLDFMRSCSIKHRMASVIFSLEMSKSEIVMRLLSAEAKIKLGDM
TH_2096|M.thermoresistible__bu      THNSTLGLDFMRSCSIKHRMASIIFSLEMSKSEIVMRLLSAEAKIKLSDM
MLBr_02680|M.leprae_Br4923          THNSTLGLDFMRSCSIKHRLASVIFSLEMSKSEIVMRLLSAEAKIKLADM
Mb0059|M.bovis_AF2122/97            ---STLGLDFMRSCSIRHRMASVIFSLEMSKSEIVMRLLSAEAKIKLSDM
Rv0058|M.tuberculosis_H37Rv         ---STLGLDFMRSCSIRHRMASVIFSLEMSKSEIVMRLLSAEAKIKLSDM
MMAR_0076|M.marinum_M               ---STLGLDFMRSCSIKHQMASVIFSLEMSKTEIVMRLLSAEAKIKLADM
MUL_0075|M.ulcerans_Agy99           ---STLGLDFMRSCSIKHQMASVIFSLEMSKTEIVMRLLSAEAKIKLADM
Mflv_0878|M.gilvum_PYR-GCK          THNSTLGLDFMRSCSIKHQLPSIVFSLEMSKTEIVMRLLSAEAKIKLADM
Mvan_6030|M.vanbaalenii_PYR-1       THNSTLGLDFMRSCSIKHHLPSIVFSLEMSKTEIVMRLLSAEAKIKLADM
MAV_0079|M.avium_104                THNSTLGLDFLRSCSIKHRMASVIFSLEMSKSEIVMRLLSAEAKIKLSDM
MAB_4895c|M.abscessus_ATCC_199      --KSTLGLDFMRSCSIKHQLPSVIFSLEMSKTEIVMRLLSAEAKIKLGDM
                                       *******:*****:*::.*::*******:***************.**

MSMEG_6892|M.smegmatis_MC2_155      RSGRMTDDDWTRLARRMSEISEAPLYIDDSPNLTMMEIRAKARRLAQKSD
TH_2096|M.thermoresistible__bu      RSGRMTDDDWTRLARRMSEISEAPLYIDDSPNLTMMEIRAKARRLAQKAD
MLBr_02680|M.leprae_Br4923          RSGRMTDDDWTRLARRMSEISEAPLYIDDSPNLTMMEIRAKARRLRQKTN
Mb0059|M.bovis_AF2122/97            RSGRMSDDDWTRLARRMSEISEAPLFIDDSPNLTMMEIRAKARRLRQKAN
Rv0058|M.tuberculosis_H37Rv         RSGRMSDDDWTRLARRMSEISEAPLFIDDSPNLTMMEIRAKARRLRQKAN
MMAR_0076|M.marinum_M               RSGRMTDDDWTRLARRMSEISEAPLYIDDSPNLTMMEIRAKARRLRQKAN
MUL_0075|M.ulcerans_Agy99           RSGRMTDDDWTRLARRMSEISEAPLYIDDSPNLTTMEIRAKARRLRQKAN
Mflv_0878|M.gilvum_PYR-GCK          RSGRMNDDDWTKLARRMSEISEAPLYIDDSPNLTMMEIRAKARRLKQKAD
Mvan_6030|M.vanbaalenii_PYR-1       RSGRMNDDDWTRLARRMSEISEAPLYIDDSPNLTMMEIRAKARRLKQKAD
MAV_0079|M.avium_104                RSGRMSDEDWTRLARRMSEISEAPLYIDDSPNLTMMEIRAKARRLRQKAD
MAB_4895c|M.abscessus_ATCC_199      RSGRMSDDDWTRLARRMSEISEAPLYIDDSPNLTMMEIRAKARRLNQKAG
                                    *****.*:***:*************:******** ********** **:.

MSMEG_6892|M.smegmatis_MC2_155      LRLIVVDYMQLMTSGKKYESRQQEVSDFSRSLKLMAKELDVPVVAISQLN
TH_2096|M.thermoresistible__bu      LRLVVVDYMQLMTSGKKYESRQQEVSDFSRSLKLMAKELDLPVVAISQLN
MLBr_02680|M.leprae_Br4923          LKLVVVDYLQLMTSGKRFESRQVEVSEFSRHLKLLAKELELPVVAISQLN
Mb0059|M.bovis_AF2122/97            LKLIVVDYLQLMTSGKKYESRQVEVSEFSRHLKLLAKELEVPVVAISQLN
Rv0058|M.tuberculosis_H37Rv         LKLIVVDYLQLMTSGKKYESRQVEVSEFSRHLKLLAKELEVPVVAISQLN
MMAR_0076|M.marinum_M               LKLVVVDYLQLMTSGKKHESRQVEVSEFSRHLKLLAKEIEVPVVAISQLN
MUL_0075|M.ulcerans_Agy99           LKLVVVDYLQLMISGKKHESRQVEVSEFSRHLKLLAKEIEVPVVAISQLN
Mflv_0878|M.gilvum_PYR-GCK          LRLIVIDYLQLMTSGKKVESRQQEVSEFSRQIKLLAKELEVPVVAMSQLN
Mvan_6030|M.vanbaalenii_PYR-1       LRLVVIDYLQLMTSGKKVESRQQEVSEFSRQIKLLAKELEVPVVAMSQLN
MAV_0079|M.avium_104                LRLVVVDYLQLMSSGKKVESRQLEVSEFSRQLKLLAKELEVPVVAISQLN
MAB_4895c|M.abscessus_ATCC_199      LKLVVVDYLQLMTSGKKHESRQQEVSEFSRNLKLLAKELEVPVIAISQLN
                                    *:*:*:**:*** ***: **** ***:*** :**:***:::**:*:****

MSMEG_6892|M.smegmatis_MC2_155      RGPEQRTDKRPQVSDLRESGCMTANTRILRADTGAEVTFGELMATGERPL
TH_2096|M.thermoresistible__bu      RGPEQRTDKKPQVSDLRESGCLTANTRLLRADTGAEVTFGELMATGERPL
MLBr_02680|M.leprae_Br4923          RSPEQRTDKKPMLSDLRESGSLEQDADVVILLHRPDAFDRDDPRGGEADL
Mb0059|M.bovis_AF2122/97            RGPEQRTDKKPMLADLRESGCLTASTRILRADTGAEVAFGELMRSGERPM
Rv0058|M.tuberculosis_H37Rv         RGPEQRTDKKPMLADLRESGCLTASTRILRADTGAEVAFGELMRSGERPM
MMAR_0076|M.marinum_M               RGPEQRTDKKPMLSDLRESG------------------------------
MUL_0075|M.ulcerans_Agy99           RGPEQRTDKKPMLSDLRESG------------------------------
Mflv_0878|M.gilvum_PYR-GCK          RGPEQRTDKKPMLSDLRESG------------------------------
Mvan_6030|M.vanbaalenii_PYR-1       RGPEQRTDKKPMLSDLRESG------------------------------
MAV_0079|M.avium_104                RGPEQRTDKKPMLSDLRESG------------------------------
MAB_4895c|M.abscessus_ATCC_199      RGPEQRTDKRPQVSDLRESG------------------------------
                                    *.*******:* ::******                              

MSMEG_6892|M.smegmatis_MC2_155      VWSLDEHKRMVARPMTNVFPSGRKEVFTLRMASGREVEATANHPFLTLDG
TH_2096|M.thermoresistible__bu      VWSLDDRNRMVARPVSNVFYSGRKEVFKVRLASGRGXAVRADA-------
MLBr_02680|M.leprae_Br4923          ILAKHRNGPTKTVTVAHQLHLSR---FTN-MAR-----------------
Mb0059|M.bovis_AF2122/97            VWSLDERLRMVARPMINVFPSGRKEVFRLRLASGREVEATGSHPFMKFEG
Rv0058|M.tuberculosis_H37Rv         VWSLDERLRMVARPMINVFPSGRKEVFRLRLASGREVEATGSHPFMKFEG
MMAR_0076|M.marinum_M               --------------------------------------------------
MUL_0075|M.ulcerans_Agy99           --------------------------------------------------
Mflv_0878|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_6030|M.vanbaalenii_PYR-1       --------------------------------------------------
MAV_0079|M.avium_104                --------------------------------------------------
MAB_4895c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MSMEG_6892|M.smegmatis_MC2_155      WVPLGELKPGDRLATPRLVPEPVNTQRMHDSEVVMLAHMIGDGSCVKRQP
TH_2096|M.thermoresistible__bu      --------------------------------------------------
MLBr_02680|M.leprae_Br4923          --------------------------------------------------
Mb0059|M.bovis_AF2122/97            WTPLAQLKVGDRIAAPRRVPEPIDTQRMPESELISLARMIGDGSCLKNQP
Rv0058|M.tuberculosis_H37Rv         WTPLAQLKVGDRIAAPRRVPEPIDTQRMPESELISLARMIGDGSCLKNQP
MMAR_0076|M.marinum_M               --------------------------------------------------
MUL_0075|M.ulcerans_Agy99           --------------------------------------------------
Mflv_0878|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_6030|M.vanbaalenii_PYR-1       --------------------------------------------------
MAV_0079|M.avium_104                --------------------------------------------------
MAB_4895c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MSMEG_6892|M.smegmatis_MC2_155      IRYASIDEGNLLAVETAAEHFGVTPIRDEYAAAQVTTLRLPAPYRLTRGK
TH_2096|M.thermoresistible__bu      --------------------------------------------------
MLBr_02680|M.leprae_Br4923          --------------------------------------------------
Mb0059|M.bovis_AF2122/97            IRYEPVDEANLAAVTVSAAHSDGAAIRDDYLAARVPSL-RPARQRLPRGR
Rv0058|M.tuberculosis_H37Rv         IRYEPVDEANLAAVTVSAAHSDRAAIRDDYLAARVPSL-RPARQRLPRGR
MMAR_0076|M.marinum_M               --------------------------------------------------
MUL_0075|M.ulcerans_Agy99           --------------------------------------------------
Mflv_0878|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_6030|M.vanbaalenii_PYR-1       --------------------------------------------------
MAV_0079|M.avium_104                --------------------------------------------------
MAB_4895c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MSMEG_6892|M.smegmatis_MC2_155      RNPIAEWLDKLGLFGKRSYEKFVPAQVFALPNDQVALFLRHLWATDGSVR
TH_2096|M.thermoresistible__bu      --------------------------------------------------
MLBr_02680|M.leprae_Br4923          --------------------------------------------------
Mb0059|M.bovis_AF2122/97            CTPIAAWLAGLGLFTKRSHEKCVPEAVFRAPNDQVALFLRHLWSAGGSVR
Rv0058|M.tuberculosis_H37Rv         CTPIAAWLAGLGLFTKRSHEKCVPEAVFRAPNDQVALFLRHLWSAGGSVR
MMAR_0076|M.marinum_M               --------------------------------------------------
MUL_0075|M.ulcerans_Agy99           --------------------------------------------------
Mflv_0878|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_6030|M.vanbaalenii_PYR-1       --------------------------------------------------
MAV_0079|M.avium_104                --------------------------------------------------
MAB_4895c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MSMEG_6892|M.smegmatis_MC2_155      WDAKVGQGRVYYATTSRQLADDVVQLLLRVGVYARIKRAKKAGYRDCWHV
TH_2096|M.thermoresistible__bu      --------------------------------------------------
MLBr_02680|M.leprae_Br4923          --------------------------------------------------
Mb0059|M.bovis_AF2122/97            WDPTNGQGRVYYGSTSRRLIDDVAQLLLRVGIFSWITHAPKLGGHDSWRL
Rv0058|M.tuberculosis_H37Rv         WDPTNGQGRVYYGSTSRRLIDDVAQLLLRVGIFSWITHAPKLGGHDSWRL
MMAR_0076|M.marinum_M               --------------------------------------------------
MUL_0075|M.ulcerans_Agy99           --------------------------------------------------
Mflv_0878|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_6030|M.vanbaalenii_PYR-1       --------------------------------------------------
MAV_0079|M.avium_104                --------------------------------------------------
MAB_4895c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MSMEG_6892|M.smegmatis_MC2_155      LIYGRENQKRFVAHVGVHGARGAAARDLLAELESVTQDTNLDTVPKEVWS
TH_2096|M.thermoresistible__bu      --------------------------------------------------
MLBr_02680|M.leprae_Br4923          --------------------------------------------------
Mb0059|M.bovis_AF2122/97            HIHGAKDQVRFLRHVGVHGAEAVAAQEMLRQLKGPVRNPNLDSAPKKVWA
Rv0058|M.tuberculosis_H37Rv         HIHGAKDQVRFLRHVGVHGAEAVAAQEMLRQLKGPVRNPNLDSAPKKVWA
MMAR_0076|M.marinum_M               --------------------------------------------------
MUL_0075|M.ulcerans_Agy99           --------------------------------------------------
Mflv_0878|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_6030|M.vanbaalenii_PYR-1       --------------------------------------------------
MAV_0079|M.avium_104                --------------------------------------------------
MAB_4895c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MSMEG_6892|M.smegmatis_MC2_155      QVKAALIERGMSHRAFAKAMGTQFCGSALWKHAPSRSRLHRAASLLEDAA
TH_2096|M.thermoresistible__bu      --------------------------------------------------
MLBr_02680|M.leprae_Br4923          --------------------------------------------------
Mb0059|M.bovis_AF2122/97            QVRNRLSAK--------QMMDIQLHEPTMWKHSPSRSRPHRAEARIEDRA
Rv0058|M.tuberculosis_H37Rv         QVRNRLSAK--------QMMDIQLHEPTMWKHSPSRSRPHRAEARIEDRA
MMAR_0076|M.marinum_M               --------------------------------------------------
MUL_0075|M.ulcerans_Agy99           --------------------------------------------------
Mflv_0878|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_6030|M.vanbaalenii_PYR-1       --------------------------------------------------
MAV_0079|M.avium_104                --------------------------------------------------
MAB_4895c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

MSMEG_6892|M.smegmatis_MC2_155      LHDLATNDVFWDEIVEITSIGEHDVYDGTVPGTHNFVAQGISAHNSLEQD
TH_2096|M.thermoresistible__bu      --------------------------------------------------
MLBr_02680|M.leprae_Br4923          --------------------------------------------------
Mb0059|M.bovis_AF2122/97            IHELARGDAYWDTVVEITSIGDQHVFDGTVSGTHNFVANGISLHNSLEQD
Rv0058|M.tuberculosis_H37Rv         IHELARGDAYWDTVVEITSIGDQHVFDGTVSGTHNFVANGISLHNSLEQD
MMAR_0076|M.marinum_M               ---------------------------------------------SLEQD
MUL_0075|M.ulcerans_Agy99           ---------------------------------------------SLEQD
Mflv_0878|M.gilvum_PYR-GCK          ---------------------------------------------SIEQD
Mvan_6030|M.vanbaalenii_PYR-1       ---------------------------------------------SIEQD
MAV_0079|M.avium_104                ---------------------------------------------SLEQD
MAB_4895c|M.abscessus_ATCC_199      ---------------------------------------------SLEQD
                                                                                      

MSMEG_6892|M.smegmatis_MC2_155      ADMVMLLHRPDAFDRDDPRGGEADIILGKHRNGPTANITVAHQLHFSRFT
TH_2096|M.thermoresistible__bu      --------------------------------------------------
MLBr_02680|M.leprae_Br4923          --------------------------------------------------
Mb0059|M.bovis_AF2122/97            ADVVILLHRPDAFDRDDPRGGEADFILAKHRNGPTKTVTVAHQLHLSRFA
Rv0058|M.tuberculosis_H37Rv         ADVVILLHRPDAFDRDDPRGGEADFILAKHRNGPTKTVTVAHQLHLSRFA
MMAR_0076|M.marinum_M               ADMVILLNRPDAFERDDPRGGEADFILAKHRNGPTKTVTVAHQLHLSRFA
MUL_0075|M.ulcerans_Agy99           ADMVILLNRPDAFERDDPRGGEADFILAKHRNGPTKTVTVAHQLHLSRFA
Mflv_0878|M.gilvum_PYR-GCK          ADMVILLHRPDAFESDDPRGGEADLIVAKHRAGPTRTVTVAHQLHLSRFS
Mvan_6030|M.vanbaalenii_PYR-1       ADMVILLHRPDAFESDDPRGGEADLIVAKHRAGPTRTITVAHQLHLSRFS
MAV_0079|M.avium_104                ADMVILLNRPDAFERDDPRGGEADFILAKHRNGPTKTVTVAHQLHLSRFA
MAB_4895c|M.abscessus_ATCC_199      ADMVILLHRPDAFERDDPRGGEADLILGKHRNGPTATITVAHQLHLSRFT
                                                                                      

MSMEG_6892|M.smegmatis_MC2_155      NMAR
TH_2096|M.thermoresistible__bu      ----
MLBr_02680|M.leprae_Br4923          ----
Mb0059|M.bovis_AF2122/97            NMAR
Rv0058|M.tuberculosis_H37Rv         NMAR
MMAR_0076|M.marinum_M               NMAR
MUL_0075|M.ulcerans_Agy99           NMAR
Mflv_0878|M.gilvum_PYR-GCK          NMAK
Mvan_6030|M.vanbaalenii_PYR-1       NMAK
MAV_0079|M.avium_104                NMAR
MAB_4895c|M.abscessus_ATCC_199      NMAR