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M. leprae Br4923 MLBr_00628 (-)

annotation: putative metalloprotease
coordinates: 761203 - 761739
length: 178

MSVEVSNESGFDVSEVELVSVARFVIIKMDVNPAAELSMVLLDTAAMADLHMRWMDLPGPTDVMSFPMDE
FEPGGRPDAAEPGPSMLGDIVLCPEFAAQQAAAEGHSLGHELALLTIHGVLHLLGYDHGEPDEEKEMFAL
QGRLLEEWVAEQVRAYQHDRQNEKDCRLLYKSGYFGYL
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. leprae Br4923MLBr_00628--100% (178)putative metalloprotease

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2388c-2e-8889.14% (175) putative metalloprotease
M. gilvum PYR-GCKMflv_2707-1e-8487.43% (175) putative metalloprotease
M. tuberculosis H37RvRv2367c-2e-8889.14% (175) putative metalloprotease
M. abscessus ATCC 19977MAB_1669-6e-7274.29% (175) putative metalloprotease
M. marinum MMMAR_3677-4e-8889.71% (175) metal-dependent hydrolase
M. avium 104MAV_2026-2e-8788.57% (175) putative metalloprotease
M. smegmatis MC2 155MSMEG_4496-2e-8485.71% (175) putative metalloprotease
M. thermoresistible (build 8)TH_1055-1e-8283.15% (178) UNKNOWN
M. ulcerans Agy99MUL_3620-3e-8889.71% (175) putative metalloprotease
M. vanbaalenii PYR-1Mvan_3831-2e-8383.71% (178) putative metalloprotease

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_2707|M.gilvum_PYR-GCK          -----MSIEVSNESGIDVSESELVSVARFVIRKMDVNPAAELSMVLLDTA
Mvan_3831|M.vanbaalenii_PYR-1       -----MTIEVSNESGIDVSEEELISVARFVIGKMDVNPAAELSMLLLDTA
Mb2388c|M.bovis_AF2122/97           MREHLMSIEVANESGIDVSEAELVSVARFVIAKMDVNPCAELSMLLLDTA
Rv2367c|M.tuberculosis_H37Rv        MREHLMSIEVANESGIDVSEAELVSVARFVIAKMDVNPCAELSMLLLDTA
MLBr_00628|M.leprae_Br4923          -----MSVEVSNESGFDVSEVELVSVARFVIIKMDVNPAAELSMVLLDTA
MMAR_3677|M.marinum_M               -----MSIEVSNESGIDVSETELVSVARFVIGKMDVNPGAELSMVLLDTA
MUL_3620|M.ulcerans_Agy99           -----MSIEVSNESGIDVSETELVSVARFVIGKMDVNPGAELSMVLLDTA
MAV_2026|M.avium_104                -----MSIEVSNESGIDVSEAELISVARFVIAKMDVNPAAELSMVLLDTA
MSMEG_4496|M.smegmatis_MC2_155      -----MSIEVSNESGYDVSEPELISVARFVIEKMDVHPAAELSMVLLDSA
TH_1055|M.thermoresistible__bu      -----MSIEVSNESGIDVCEEELISVARFVIEKMNVHPAAELSMVLLDPA
MAB_1669|M.abscessus_ATCC_1997      -----MSIEVVNESGIDVAEGELVSVARFAIAAMDVHPAAELSMMLVDLA
                                         *::** **** **.* **:*****.*  *:*:* *****:*:* *

Mflv_2707|M.gilvum_PYR-GCK          AMADLHMRWMDLPGPTDVMSFPMDELEPGGRPDTPEPGPSMLGDIVLCPE
Mvan_3831|M.vanbaalenii_PYR-1       AMADLHMRWMDLPGPTDVMSFPMDELEPGGRPDAPEPGPSMLGDIVLCPE
Mb2388c|M.bovis_AF2122/97           AMADLHMRWMDLPGPTDVMSFPMDELEPGGRPDAPEPGPSMLGDIVLCPE
Rv2367c|M.tuberculosis_H37Rv        AMADLHMRWMDLPGPTDVMSFPMDELEPGGRPDAPEPGPSMLGDIVLCPE
MLBr_00628|M.leprae_Br4923          AMADLHMRWMDLPGPTDVMSFPMDEFEPGGRPDAAEPGPSMLGDIVLCPE
MMAR_3677|M.marinum_M               AMADLHMRWMDLPGPTDVMSFPMDELEPGGRPDAPEPGPAMLGDIVLCPE
MUL_3620|M.ulcerans_Agy99           AMADLHMRWMDLPGPTDVMSFPMDELEPGGRPDAPEPGPAMLGDIVLCPE
MAV_2026|M.avium_104                AMADLHMRWMDLPGPTDVMSFPMDELEPGGRPDAPEPGPAMLGDIVLCPE
MSMEG_4496|M.smegmatis_MC2_155      AMADLHMRWMDLPGPTDVMSFPMDELEPGGRPDAPEPGPAMLGDIVLCPE
TH_1055|M.thermoresistible__bu      AMADLHMRWMDLPGPTDVMSFPMDELEPGGRPDAAEPGPAMLGDIVLCPE
MAB_1669|M.abscessus_ATCC_1997      AMADLHMRWMDLPGPTDVMSFPMDELEPGGRPDAPEPGPSMLGDIVLCPQ
                                    *************************:*******:.****:*********:

Mflv_2707|M.gilvum_PYR-GCK          FAAKQAADAGHTLGQELALLTVHGVLHLLGYDHAEPDEEKEMFALQRELL
Mvan_3831|M.vanbaalenii_PYR-1       FAAKQAADAGHTLGQELALLTVHGVLHLLGYDHAEPDEEKEMFALQRELL
Mb2388c|M.bovis_AF2122/97           FAAEQAAAAGHSLGHELALLTIHGVLHLLGYDHAEPDEEKEMFALQDRLL
Rv2367c|M.tuberculosis_H37Rv        FAAEQAAAAGHSLGHELALLTIHGVLHLLGYDHAEPDEEKEMFALQDRLL
MLBr_00628|M.leprae_Br4923          FAAQQAAAEGHSLGHELALLTIHGVLHLLGYDHGEPDEEKEMFALQGRLL
MMAR_3677|M.marinum_M               FAAEQAAAAGHSLGHELALLTIHGVLHLLGYDHGEPDEEKEMFALQDRLL
MUL_3620|M.ulcerans_Agy99           FAAEQAAAAGHSLGHELALLTIHGVLHLLGYDHGEPDEEKEMFALQDRLL
MAV_2026|M.avium_104                FAADQAAAAGHSLGHELALLTIHGVLHLLGYDHGEPDEEKEMFALQDRLL
MSMEG_4496|M.smegmatis_MC2_155      FAEQQAAKAGHSLGHELALLTVHGVLHLLGYDHAEPDEEKEMFALQRQLL
TH_1055|M.thermoresistible__bu      FAAEQAAAAGHSLGQELALLTVHGVLHLLGYDHAEPEEEKEMFALQRRLL
MAB_1669|M.abscessus_ATCC_1997      FAAEQAEAAGHSLAHELALLTVHGVLHLLGYDHAEPEEEREMFALQNQLL
                                    ** .**   **:*.:******:***********.**:**:****** .**

Mflv_2707|M.gilvum_PYR-GCK          EEWVAEQVEAYHLDRQNEKDRRLLDKSRYF------DTP
Mvan_3831|M.vanbaalenii_PYR-1       EEWVADQVQAYHQDRQSQKDQRLLDKSRYFDELNHGDTP
Mb2388c|M.bovis_AF2122/97           EEWVADQVEAYQHDRQDEKDRRLLDKSRYFDL-------
Rv2367c|M.tuberculosis_H37Rv        EEWVADQVEAYQHDRQDEKDRRLLDKSRYFDL-------
MLBr_00628|M.leprae_Br4923          EEWVAEQVRAYQHDRQNEKDCRLLYKSGYFGYL------
MMAR_3677|M.marinum_M               EEWVAEQVQAYQQDRQDERDRRLLDKSRYFDEP------
MUL_3620|M.ulcerans_Agy99           EEWVAEQVQAYQQDRQDERDRRLLDKSRYFDEP------
MAV_2026|M.avium_104                EEWVADQVEAYHQDRQQERDRRLLDKSRYFDN-------
MSMEG_4496|M.smegmatis_MC2_155      EEWVADQVEAYHADRQSEKDRRLLDKSRYFDEP------
TH_1055|M.thermoresistible__bu      EEWVADQVEAYHQELQSEKDRRLLDKSRYFDQL------
MAB_1669|M.abscessus_ATCC_1997      QDWYEQQAQLY-------RDSRLLDKSRNFDE-------
                                    ::*  :*.. *       :* *** **  *