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M. leprae Br4923 MLBr_00015 (pabA)

annotation: para-aminobenzoate synthase component II
coordinates: 18321 - 19019
length: 232

MRILVIDNYDSFVFNLVQYLGQLGVDAEVWRNDDTRLSDESTIAAQFDGILLSPGPGTPERAGASINLVR
VCAAAHTPLLGVCLGHQAIGVSFGATVDRAPELLHGKTSSVFHTNNGVLQGLPNPFTATRYHSLTILPES
LPPVLEVVARTRSGVIMAVRHTELPIHGVQFHPESILTEGGHRLLANWLTYCGWLCDDALIRRLENEVDA
AVHPRLPVAAERTAAAIARTLA

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. leprae Br4923 MLBr_00015 pabA - 100% (232) para-aminobenzoate synthase component II
M. leprae Br4923 MLBr_00395 guaA 2e-07 27.46% (142) GMP synthase
M. leprae Br4923 MLBr_00535 carA 9e-06 26.43% (140) carbamoyl phosphate synthase small subunit

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb0013 trpG 1e-108 79.74% (232) para-aminobenzoate synthase component II
M. gilvum PYR-GCK Mflv_0813 - 5e-89 71.56% (225) para-aminobenzoate synthase component II
M. tuberculosis H37Rv Rv0013 trpG 1e-108 79.74% (232) para-aminobenzoate synthase component II
M. abscessus ATCC 19977 MAB_0032 - 2e-93 76.06% (213) para-aminobenzoate synthase component II
M. marinum M MMAR_0015 trpG 1e-109 82.89% (228) anthranilate synthase component II TrpG
M. avium 104 MAV_0018 - 1e-109 82.46% (228) para-aminobenzoate synthase component II
M. smegmatis MC2 155 MSMEG_0029 - 4e-95 74.12% (228) para-aminobenzoate synthase component II
M. thermoresistible (build 8) TH_0292 pabA 1e-95 79.07% (215) POSSIBLE ANTHRANILATE SYNTHASE COMPONENT II TRPG (GLUTAMINE
M. ulcerans Agy99 MUL_0017 trpG 1e-108 82.02% (228) para-aminobenzoate synthase component II
M. vanbaalenii PYR-1 Mvan_0022 - 2e-96 77.67% (215) para-aminobenzoate synthase component II

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_0015|M.marinum_M               MPILVVDNYDSFVFNLVQYLGQLGVRAEVWRNDDPRLSDEAAIA---AQF
MUL_0017|M.ulcerans_Agy99           MPILVVDNYDSFVFNLVQYLGQLGVRAEVWRNDDPRLCDEAAIA---AQF
Mb0013|M.bovis_AF2122/97            MRILVVDNYDSFVFNLVQYLGQLGIEAEVWRNDDHRLSDEAAVA---GQF
Rv0013|M.tuberculosis_H37Rv         MRILVVDNYDSFVFNLVQYLGQLGIEAEVWRNDDHRLSDEAAVA---GQF
MLBr_00015|M.leprae_Br4923          MRILVIDNYDSFVFNLVQYLGQLGVDAEVWRNDDTRLSDESTIA---AQF
MAV_0018|M.avium_104                MRILVVDNYDSFVFNLVQYLGQLGVDADVWRNDDSRLADHNAVA---RRF
Mflv_0813|M.gilvum_PYR-GCK          MQVLVVDNYDSFVFNLVQYLGQLGVEAKVWRNDDERLVTDADIAEVAGDF
Mvan_0022|M.vanbaalenii_PYR-1       MQVLVVDNYDSFVFNLVQYLGQLGVDAQVWRNDDDRLVTDADVSRVAEEF
MSMEG_0029|M.smegmatis_MC2_155      MQVLVVDNYDSFVFNLVQYLGQLGVHAQVWRNDDARLATEDAIAQAAADF
TH_0292|M.thermoresistible__bu      VQILVVDNYDSFVFNLVQYLGQLGVDAQVWRNDDARLGTEAAIADAVAAV
MAB_0032|M.abscessus_ATCC_1997      MRILVVDNYDSFVFNLVQYLGQLGVDATVWRNDDPRLADTDAVA---ADF
                                    : :**:******************: * ****** **     ::     .

MMAR_0015|M.marinum_M               DGVLLSPGPGTPERAGASVSLVRACAAARTPLLGVCLGHQAIGVAFGATV
MUL_0017|M.ulcerans_Agy99           DGVLLSPGPGTPERAGASVSLVRACAEARTPLLGVCLGHQAIGVAFGATV
Mb0013|M.bovis_AF2122/97            DGVLLSPGPGTPERAGASVSMVHACAAAHTPLLGVCLGHQAIGVAFGATV
Rv0013|M.tuberculosis_H37Rv         DGVLLSPGPGTPERAGASVSIVHACAAAHTPLLGVCLGHQAIGVAFGATV
MLBr_00015|M.leprae_Br4923          DGILLSPGPGTPERAGASINLVRVCAAAHTPLLGVCLGHQAIGVSFGATV
MAV_0018|M.avium_104                DGVLLSPGPGTPERAGASIAVVRACAAEHTPLLGVCLGHQAIGVAFGATV
Mflv_0813|M.gilvum_PYR-GCK          DGVLLSPGPGTPERAGASIPLVHACAEAGTPLLGVCLGHQAIGVAFGGTV
Mvan_0022|M.vanbaalenii_PYR-1       DGVLLSPGPGTPERAGASIGLVHACAAARTPLLGVCLGHQAIGVAFGGTV
MSMEG_0029|M.smegmatis_MC2_155      DGVLLSPGPGTPERAGASIALVKACAAAGTPLLGVCLGHQAIGVAFGGTV
TH_0292|M.thermoresistible__bu      DGVLLSPGPGTPERAGASIPVVRACAAAGTPLLGVCLGHQAIGVAFGATV
MAB_0032|M.abscessus_ATCC_1997      DGVLISPGPGTPESAGASIAMVHSCAKTGTPLLGVCLGHQAIGVAFGGTV
                                    **:*:******** ****: :*: **   ***************:**.**

MMAR_0015|M.marinum_M               DRAPELLHGKTSSVYHTNVGVLQGLPDPFTATRYHSLTILPDSLPAELEA
MUL_0017|M.ulcerans_Agy99           DRAPELLHGKTSSVYHTNVGVLQGLPDPFTATRYHSLTILPDSLPAELEA
Mb0013|M.bovis_AF2122/97            DRAPELLHGKTSSVFHTNVGVLQGLPDPFTATRYHSLTILPKSLPAVLRV
Rv0013|M.tuberculosis_H37Rv         DRAPELLHGKTSSVFHTNVGVLQGLPDPFTATRYHSLTILPKSLPAVLRV
MLBr_00015|M.leprae_Br4923          DRAPELLHGKTSSVFHTNNGVLQGLPNPFTATRYHSLTILPESLPPVLEV
MAV_0018|M.avium_104                DRAPELLHGKTSSVHHTNAGVLQGLPNPFTATRYHSLTILPESLPPVLEV
Mflv_0813|M.gilvum_PYR-GCK          DRAPELLHGKTSTVHHADEGVLKGLPDPFTATRYHSLTILPETVPDELEV
Mvan_0022|M.vanbaalenii_PYR-1       DRAPELLHGKTSTVHHTNQGVLKGLPDPFTATRYHSLTILPETMPAELEV
MSMEG_0029|M.smegmatis_MC2_155      DRAPELLHGKTSVVHHNDSGVLKGLPDPFTATRYHSLTILPETLPAALEV
TH_0292|M.thermoresistible__bu      DRAPELLHGKTSTVHHTDVGVLQGLPDPFTATRYHSLTILPQTLPAELEV
MAB_0032|M.abscessus_ATCC_1997      DRAPELLHGKTSTVEHEDAGVLRGLPNPFTATRYHSLTILPDTVPEGLRV
                                    ************ * * : ***:***:**************.::*  *..

MMAR_0015|M.marinum_M               TAHT------RSG----VIMGVRHTELPIHGVQFHPESILTEGGHRMLAN
MUL_0017|M.ulcerans_Agy99           TAHT------RSG----VIMGVRHTELPIHGVQFHPESILTEGGHRMLAN
Mb0013|M.bovis_AF2122/97            TART------SSG----VIMAVQHTGLPIHGVQFHPESILTEGGHRILAN
Rv0013|M.tuberculosis_H37Rv         TART------SSG----VIMAVQHTGLPIHGVQFHPESILTEGGHRILAN
MLBr_00015|M.leprae_Br4923          VART------RSG----VIMAVRHTELPIHGVQFHPESILTEGGHRLLAN
MAV_0018|M.avium_104                TAHT------DSG----VIMGVRHTQLPIHGVQFHPESILTEGGHRMLAN
Mflv_0813|M.gilvum_PYR-GCK          IAWTGRGERSDGGEQRGVIMGVRHRDLPIHGVQFHPESILTQGGHRMLAN
Mvan_0022|M.vanbaalenii_PYR-1       TAKT------EGG----VIMGVRHVELPIHGVQFHPESILTQGGHRMLAN
MSMEG_0029|M.smegmatis_MC2_155      VGQT------DNG----IIMAVRHTELPIHGVQFHPESILTQGGHRMLAN
TH_0292|M.thermoresistible__bu      TART------AGG----VIMGVRHRELPIHGVQFHPESILTEGGHRMLAN
MAB_0032|M.abscessus_ATCC_1997      IART------ASG----VIMGVMHTEHPIHGVQFHPESILTEGGHRMLAN
                                     . *       .*    :**.* *   **************:****:***

MMAR_0015|M.marinum_M               WLAYCGWARDDTLVRRLENEVASAIRPHLPVEAG----TTDRTSA---
MUL_0017|M.ulcerans_Agy99           WLAYCGWARDDTLVRRLENEVASAIRPHLPVEAG----TTDRTSA---
Mb0013|M.bovis_AF2122/97            WLTCCGWTQDDTLVRRLENEVLTAISPHFPTSTASAGEATGRTSA---
Rv0013|M.tuberculosis_H37Rv         WLTCCGWTQDDTLVRRLENEVLTAISPHFPTSTASAGEATGRTSA---
MLBr_00015|M.leprae_Br4923          WLTYCGWLCDDALIRRLENEVDAAVHPRLPVAAERTAAAIARTLA---
MAV_0018|M.avium_104                WLTECGWVRDDTLVRRLENDVHAAVRPYLPADPA----ATDRTSA---
Mflv_0813|M.gilvum_PYR-GCK          WLGDCGDAPDEALIRALEEEVETAVAA-----------ATTRNSA---
Mvan_0022|M.vanbaalenii_PYR-1       WLGFCGAAPDEALVRRLEDEVADAVAA-----------ATTRNSA---
MSMEG_0029|M.smegmatis_MC2_155      WLGFCGAAPDETLVRRLEDEVARAVAA-----------ATQRSSA---
TH_0292|M.thermoresistible__bu      WLGFCGAAPDDALVRRLEDEVAETVRA-----------ATTRSSA---
MAB_0032|M.abscessus_ATCC_1997      WLTYCGAPLDEPLVRSLEAEVAAALNG-----------VTGRVAALGG
                                    **  **   *:.*:* ** :*  ::             .  *  *

species	id	gene	e-value	identity (len)	annotation
M. leprae Br4923	MLBr_00015	pabA	-	100% (232)	para-aminobenzoate synthase component II
M. leprae Br4923	MLBr_00395	guaA	2e-07	27.46% (142)	GMP synthase
M. leprae Br4923	MLBr_00535	carA	9e-06	26.43% (140)	carbamoyl phosphate synthase small subunit