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MLHQLDKKNWDYTMALLNKLDSATLAGRLSPWLADTLAVSGEVTLNNIEIPTASGMSSETVLFEAVWDND GQRNTRGLVVRIPPSGEGLFPDYDIAREGRVMAVVAAHSEAAVPGVVAAELTGEVLGGPFLLLERAYGRV PSDDPPFVTGGWVVDLTPEQRATMFDNALRTIAAIQKVDPAAVGLDDLGRSGVGKTVLHREVEYWRNFYL WAADGRPNPTIDAAFEKLSQAIPTQTGPLVISWGDARFGNLMFADDLTVSGVFDWEMATLGPSEVDFGYF LFFDRVYSSGLGLPRLDGFPERAHAIARFEELTGRRTENLEWYEAWGALRGAILLQRVGNLLISQGLLPP EADMPFNNPASQVLASLLELPPPAGQTGWITGNR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5060 | - | - | 100% (384) | putative phosphotransferase |
| M. avium 104 | MAV_1929 | - | 4e-43 | 31.71% (328) | putative phosphotransferase |
| M. avium 104 | MAV_4058 | - | 7e-39 | 31.40% (328) | phosphotransferase enzyme family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3193 | - | 3e-39 | 32.12% (330) | hypothetical protein Mb3193 |
| M. gilvum PYR-GCK | Mflv_4497 | - | 9e-37 | 30.38% (339) | aminoglycoside phosphotransferase |
| M. tuberculosis H37Rv | Rv3168 | - | 8e-41 | 32.42% (330) | hypothetical protein Rv3168 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4482 | - | 4e-47 | 33.43% (347) | putative phosphotransferase |
| M. marinum M | MMAR_1393 | - | 2e-37 | 31.10% (328) | hypothetical protein MMAR_1393 |
| M. smegmatis MC2 155 | MSMEG_2042 | - | 8e-37 | 28.53% (375) | phosphotransferase enzyme family protein |
| M. thermoresistible (build 8) | TH_2648 | - | 1e-42 | 34.33% (335) | PUTATIVE putative phosphotransferase enzyme family protein, |
| M. ulcerans Agy99 | MUL_2483 | - | 2e-36 | 30.79% (328) | hypothetical protein MUL_2483 |
| M. vanbaalenii PYR-1 | Mvan_1869 | - | 2e-35 | 30.35% (346) | aminoglycoside phosphotransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3193|M.bovis_AF2122/97 -MANEPA-IGAIDRLQRSSRDVTTLPAVISRWLSSVLPGGAAP---EVTV
Rv3168|M.tuberculosis_H37Rv -MANEPA-IGAIDRLQRSSRDVTTLPAVISRWLSSVLPGGAAP---EVTV
MMAR_1393|M.marinum_M -MANETP-VEDVAHLQRSSRDMTTLPAVMARWLAGVLPGNAAP---EVTV
MUL_2483|M.ulcerans_Agy99 -MANETP-VEDVAHLQRSSRDMTTLPAVMARWLAGVLPGNAAP---EVTV
MSMEG_2042|M.smegmatis_MC2_155 -MANEPA-VEDVSHLQLSSRDVSTVPVALADWLSTVLPAGAEP---RVTV
Mflv_4497|M.gilvum_PYR-GCK -MTSEPA-VDNVDRLQRSSRDLSDVPAALSRWLSTKLPGVTPDAPVDITV
Mvan_1869|M.vanbaalenii_PYR-1 -MTSEPA-VDNVDRLQRSSRDMSNVPAALSQWLSTLIPDITP----EITV
MAB_4482|M.abscessus_ATCC_1997 -MTEQTATHEDVARPAESQRDPETLRGALTDWISGQLPADAAL---SVDH
MAV_5060|M.avium_104 MLHQLDKKNWDYTMALLNKLDSATLAGRLSPWLADTLAVSGEV---TLNN
TH_2648|M.thermoresistible__bu ---------MATPGTEDIRPTEAELPARLEPVIHRRLPDTAGT----RIT
: : : :.
Mb3193|M.bovis_AF2122/97 ESGVDSTGMSSETIILTARRQQ-DGRSIQQKLVARVAPAAEDVPVFPTYR
Rv3168|M.tuberculosis_H37Rv ESGVDSTGMSSETIILTARWQQ-DGRSIQQKLVARVAPAAEDVPVFPTYR
MMAR_1393|M.marinum_M ESGVDSTGMSSETIILTARWHE-DHRPVQQKLVARVAPAAGDVPVFPSYR
MUL_2483|M.ulcerans_Agy99 ESGVDSTGMSSETIILTARWHE-DHRPVQQKLVARVAPAAGDVPVFPSYR
MSMEG_2042|M.smegmatis_MC2_155 EDGVDSNGMSSETLLLTAEWTE-DGAPVQQRLVARVAPAPGDVPVFSSYR
Mflv_4497|M.gilvum_PYR-GCK EDGIDANGMSSETILLRGRWSD-GGDPVEHRWVARVAPTDADIPVFEHYR
Mvan_1869|M.vanbaalenii_PYR-1 ESGIDANGMSSETILLRGRWLQ-AGDPVEQRWVARVAPAEADIPVFEHYR
MAB_4482|M.abscessus_ATCC_1997 AELPSANGMSSETILADAQWTE-NGQRTAHRLVIRTAPQPDSSPVFPSYD
MAV_5060|M.avium_104 IEIPTASGMSSETVLFEAVWDN-DGQRNTRGLVVRIPPSGEG--LFPDYD
TH_2648|M.thermoresistible__bu NWRAAERGMSTETFLFDLQRDGPDGPVTVRRLVFRRPP---AVSLFPDYD
***:**.: : * * .* :* *
Mb3193|M.bovis_AF2122/97 LDHQFEVIRLVGELTDVPVPRVRWIETTGDVLGTPFFLMDYVEGVVPPDV
Rv3168|M.tuberculosis_H37Rv LDHQFEVIRLVGELTDVPVPRVRWIETTGDVLGTPFFLMDYVEGVVPPDV
MMAR_1393|M.marinum_M LDHQFEVIKLVGELSDVPVPRVRWMEPTGEVLGTPFFLMDYVEGVVPPDV
MUL_2483|M.ulcerans_Agy99 LDHRFEVIKLVGELSDVPVPRVRWMVPTGEVLGTPFFLMDYVEGVVPPDV
MSMEG_2042|M.smegmatis_MC2_155 LDHQFELMRQIGELTDVPVPRVRWLESTGSVLGTPFFLMDRVDGIVPPDV
Mflv_4497|M.gilvum_PYR-GCK LDHQHEVMRLVAESTDVAVPAVRWLEDTGDVLGRPFFLMDRVDGVVPPDV
Mvan_1869|M.vanbaalenii_PYR-1 LDHQHEVMRLVAELTDVAVPPVRWLERRGDVLGRPFFLMDRVEGIVPPDV
MAB_4482|M.abscessus_ATCC_1997 MRRQFDVMDTLGRHSSAVVPPVRWYCDDTAVLGGEFFVMDRVDGDVPPDR
MAV_5060|M.avium_104 IAREGRVMAVVAAHSEAAVPGVVAAELTGEVLGGPFLLLERAYGRVPSDD
TH_2648|M.thermoresistible__bu LLRQVLVMNRLRDT-EVPVPTVCWLDRDGMELGTPYYVMEQIPTIGSPGD
: :. :: : .. ** * ** : ::: ...
Mb3193|M.bovis_AF2122/97 MPYTFGDNWFADAPAERQRQLQDATVAALATLHSIPNAQNTFSFLTQG-R
Rv3168|M.tuberculosis_H37Rv MPYTFGDNWFADAPAERQRQLQDATVAALATLHSIPNAQNTFSFLTQG-R
MMAR_1393|M.marinum_M MPYTFGNNWFADAPAERQRELQDATVGLLAMLHSIPKPQDTFGFLSDG-P
MUL_2483|M.ulcerans_Agy99 MPYTFGNNWFADAPAERQRELQDATVGLLAMLHSIPKPQDTFGFLSDG-P
MSMEG_2042|M.smegmatis_MC2_155 MPYTFGGNWFADAPADRRRLLQDGTVAVLAKLHSIPDALNRFGFLLDVDP
Mflv_4497|M.gilvum_PYR-GCK MPYTFGDNWLYDASPEQQRALQDRTVEVLAALHSIPDAQRTFGFLQEIDP
Mvan_1869|M.vanbaalenii_PYR-1 MPYTFGDNWLFDATAEQQRQLQDRTVEVLAKLHSIPNAQQVFGFLQDVDP
MAB_4482|M.abscessus_ATCC_1997 MPYTFG-SWVTEASEADRRKMQRLTVDQLARIHAAP--VERFAFLNDA-R
MAV_5060|M.avium_104 PPFVTG-GWVVDLTPEQRATMFDNALRTIAAIQKVDPAAVGLDDLGRS-G
TH_2648|M.thermoresistible__bu FPSYHCAGMYFDATSQQRTTMWTGCVRAMADVHTLDWRALRLDALLMP-D
* . : . : : : :* :: : *
Mb3193|M.bovis_AF2122/97 TSDTTLHRHFNWVRSWYDFAVEGIGRSPLLERTFEWLQSHWPDDAAAREP
Rv3168|M.tuberculosis_H37Rv TSDTTLHRHFNWVRSWYDFAVEGIGRSPLLERTFEWLQSHWPDDAAAREP
MMAR_1393|M.marinum_M SGDTALRRHFDWVRSWYDFAVPGIGNSALIERTFQWLQEHWPSEVAAREP
MUL_2483|M.ulcerans_Agy99 SGDTALRRHFDWVRSWYDFAVPGIGNSALIERTFQWLQEHWPSEVAAREP
MSMEG_2042|M.smegmatis_MC2_155 PGDTPLRRHFAWLKDWYEFAVTDIGRSPLVEHALAWLEDNFPSDVAAGEP
Mflv_4497|M.gilvum_PYR-GCK PGETALHRHFGWLTRWYAFSSADLGSSPLVERAISWLEEHFPHDVAASEP
Mvan_1869|M.vanbaalenii_PYR-1 PGPTALHRHFGWLKNWYEFSVPDIGRSPLVERALAWLEDRFPEDVAAAEP
MAB_4482|M.abscessus_ATCC_1997 EGETGLDAHVRRTHEFYEWVRGDGPTIPLIDRGFEWLRENWPEESLSGVG
MAV_5060|M.avium_104 VGKTVLHREVEYWRNFYLWAADGRPN-PTIDAAFEKLSQAIPTQTG---P
TH_2648|M.thermoresistible__bu RGRHPLEQVVDYYTDALHWASDGDPR-PELAAAAEWLRRHLYEPEH----
. * . : . . : *
Mb3193|M.bovis_AF2122/97 ----VLLWGDARVGNVLYRDFQPVA-VLDWEMVALGPRELDVAWMIFAHR
Rv3168|M.tuberculosis_H37Rv ----VLLWGDARVGNVLYRDFQPVA-VLDWEMVALGPRELDVAWMIFAHR
MMAR_1393|M.marinum_M ----VLLWGDARVGNVLYRDFRPVA-VLDWEMVTLGPRELDVAWMIFAHM
MUL_2483|M.ulcerans_Agy99 ----VLLWGDARVGNVLYRDFRPVA-VLDWEMVTLGPRELDVAWMIFAHM
MSMEG_2042|M.smegmatis_MC2_155 ----VLAWGDSRIGNVLYEDFEPVA-VLDWEMATVGPRELDVSWIIFAHM
Mflv_4497|M.gilvum_PYR-GCK ----VLVWGDSRIGNVIYRDFRPVA-VLDWEMATIGPREFDLAWISFAHM
Mvan_1869|M.vanbaalenii_PYR-1 ----VLVWGDSRIGNVIYQDFSPVA-VLDWEMATVGPREFDVAWISFAHM
MAB_4482|M.abscessus_ATCC_1997 RPIDVVSWGDSRPGNVIYRDFEPVA-LLDWEMASVGPRELDLGWIIFLHR
MAV_5060|M.avium_104 ---LVISWGDARFGNLMFADDLTVSGVFDWEMATLGPSEVDFGYFLFFDR
TH_2648|M.thermoresistible__bu ---LALCWGDSRLSNILYGEDFAVNAVVDWEIAYIGDHEADLAWFLFIDW
.: ***:* .*::: : .* :.***:. :* * *..:: * .
Mb3193|M.bovis_AF2122/97 VFQELAGLATLPGLPEVMREDDVRATYQALTGVELGDLHWFYVYSGVMWA
Rv3168|M.tuberculosis_H37Rv VFQELAGLATLPGLPEVMREDDVRATYQALTGVELGDLHWFYVYSGVMWA
MMAR_1393|M.marinum_M VFEELAGLATLPGLPTVMREDDVRRTYQRLTGTQLGDLHWFYVYSGVMWA
MUL_2483|M.ulcerans_Agy99 VFEELAGLATLPGLPTVMREDDVRRTYQRLTGTQLGDLHWFYVYSGVMWA
MSMEG_2042|M.smegmatis_MC2_155 VFQELAGLAGLPGLPDVLREDDVRATYTRLTGAQLGDLRWFYIYSGVIWC
Mflv_4497|M.gilvum_PYR-GCK VFQELTKLAGLPGMPDFLREDDVRDTYRKLTGVEVGDLHWFHVYSAVVWC
Mvan_1869|M.vanbaalenii_PYR-1 VFQELTKLAGLPGMPDFLREDDVRETYRELTGVEIGDLHWFHVYSAVVWC
MAB_4482|M.abscessus_ATCC_1997 FFQDLAEVATLPGLPDFCKREDIAAEYAALTGHHAADLDFYTAYAALQHA
MAV_5060|M.avium_104 VYSSGLGLPRLDGFP---ERAHAIARFEELTGRRTENLEWYEAWGALRGA
TH_2648|M.thermoresistible__bu AFSEYEGTPRLPGTP---GRDETIELYQRLSGLPVRNLRYNELLAVLALS
:.. . * * * . . : *:* :* : . : .
Mb3193|M.bovis_AF2122/97 CVFMRTGARRVHFGEIEKPDDVESLFYHAGLMKHLLGEEH----------
Rv3168|M.tuberculosis_H37Rv CVFMRTGARRVHFGEIEKPDDVESLFYHAGLMKHLLGEEH----------
MMAR_1393|M.marinum_M CVFMRTGARRVHFGEVEKPDDVESLFYHAGLMKRLIGDER----------
MUL_2483|M.ulcerans_Agy99 CVFMRTGARRVHFGEVEKPDDVESLFYHAGLMKRLIGDER----------
MSMEG_2042|M.smegmatis_MC2_155 CVFMRTGARRVRFGEIEKPEDVESLFYHASLLRRLIEEA-----------
Mflv_4497|M.gilvum_PYR-GCK CVFMRTGTRRVHFGEIERPDDIESLFYHASLLKRLIGEAD----------
Mvan_1869|M.vanbaalenii_PYR-1 CVFMRTGARRVHFGEIERPADIETLFYHASLLKRLIGETD----------
MAB_4482|M.abscessus_ATCC_1997 VIMARIQMRAMAFGQAQMPDDPDDLILHRATLEKMLNGTYWAGVKA----
MAV_5060|M.avium_104 ILLQRVGNLLISQGLLPPEADMPFNNPASQVLASLLELPPPAGQTGWITG
TH_2648|M.thermoresistible__bu VPVTRLETKLRSDGLLAEG--FDLLGFCVERARQLLG-------------
. * * ::
Mb3193|M.bovis_AF2122/97 --
Rv3168|M.tuberculosis_H37Rv --
MMAR_1393|M.marinum_M --
MUL_2483|M.ulcerans_Agy99 --
MSMEG_2042|M.smegmatis_MC2_155 --
Mflv_4497|M.gilvum_PYR-GCK --
Mvan_1869|M.vanbaalenii_PYR-1 --
MAB_4482|M.abscessus_ATCC_1997 --
MAV_5060|M.avium_104 NR
TH_2648|M.thermoresistible__bu --