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IDSQVKSGDAIERWARNLNRLGAQSAQEDSHLKSLLRQAAPTADQVNDVFNDVRESLPQTLANLEVVIDL LKRYHTGVEQVLVFLPQGASIAQTVAAPFPNMAALDLALSINQPPPCLTGFIPASEWRSPADTSLQPLPT GTYCKIPMDTPANSVRGSRNIPCTDIPGKRAATPRECRDPKPYVPAGTNPWYGDPNQILTCPAPAARCDQ PVKPGMVIPAPSVDNGLNPAPSDRVAGTPPPVSDPLSRPGSGTVQCNGQQPNPCVYKPSGPPTAVYSPQS GELVGPDGVKYSVENSTRTGDDGWKEMLAPAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_5010 | - | - | 100% (313) | mce-family protein mce1f |
| M. avium 104 | MAV_4546 | - | e-132 | 70.93% (313) | mce-family protein mce2f |
| M. avium 104 | MAV_1807 | - | 7e-44 | 34.78% (322) | virulence factor mce family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0180 | mce1F | 1e-145 | 75.96% (312) | MCE-family protein MCE1F |
| M. gilvum PYR-GCK | Mflv_0706 | - | 1e-128 | 67.50% (320) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv0174 | mce1F | 1e-144 | 75.64% (312) | MCE-family protein MCE1F |
| M. leprae Br4923 | MLBr_02594 | mce1F | 1e-164 | 84.03% (313) | putative secreted protein |
| M. abscessus ATCC 19977 | MAB_4148c | - | 2e-42 | 37.28% (287) | MCE-family protein |
| M. marinum M | MMAR_0417 | mce1F | 1e-163 | 84.44% (315) | MCE-family protein Mce1F |
| M. smegmatis MC2 155 | MSMEG_0139 | - | 1e-127 | 68.45% (317) | mce-family protein mce1f |
| M. thermoresistible (build 8) | TH_2681 | - | 1e-136 | 72.29% (314) | PUTATIVE virulence factor Mce family protein |
| M. ulcerans Agy99 | MUL_1067 | mce1F | 1e-161 | 83.81% (315) | MCE-family protein Mce1F |
| M. vanbaalenii PYR-1 | Mvan_0139 | - | 1e-126 | 66.56% (320) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_5010|M.avium_104 --------------------------------------------------
MLBr_02594|M.leprae_Br4923 -MLTPLIRRQLVLFAILTVISLTVLGVYYLQIPSLVGIGRYSLKAELSAT
MMAR_0417|M.marinum_M -MLTPFIKRQLIMFGTLTVLSLLVLGVYYLQIPALLGVGRYPLKAELPAS
MUL_1067|M.ulcerans_Agy99 -MLTPFIKRQLIMFGTLTVLSLLVLGVYYLQIPALLGVGRYPLKAELPAS
Mb0180|M.bovis_AF2122/97 -MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIPSLVGIGQYTLKADLPAS
Rv0174|M.tuberculosis_H37Rv -MLTRFIRRQLILFAIVSVVAIVVLGWYYLRIPSLVGIGQYTLKADLPAS
Mflv_0706|M.gilvum_PYR-GCK -MLTRFIKIQLIIFTILTVVALGVLGLYYLRLPSLVGVGQYTLYAELPRS
Mvan_0139|M.vanbaalenii_PYR-1 -MLTRFIKFQLITFTILTVVALGVLGLYYLRLPSLAGIGEYKLYAELERS
TH_2681|M.thermoresistible__bu -MLTRFIKMQLVIFTVLTVIALVALGWYYLRVPSLIGIGQYTLHAELPRS
MSMEG_0139|M.smegmatis_MC2_155 MLLTRFIKMQLVIFLTLTLVALVVLALFYLRLPTWAGLGMYKLNADLPNS
MAB_4148c|M.abscessus_ATCC_199 --MERLIKIQLAIFAAVTVISVALMAIFYLRVPTALGIGKHDVKAQFVAS
MAV_5010|M.avium_104 --------------------------------------------------
MLBr_02594|M.leprae_Br4923 GGLYPTANVTYRGIAIGKVTDVEPTATGAEATMSIDSRYKIPIDSAANVH
MMAR_0417|M.marinum_M GGLYPTANVTYRGITIGKVTGVEPTATGVEATMSIDSRYKIPVDASANVH
MUL_1067|M.ulcerans_Agy99 GGLYPTANVTYRGITIGKVTGVEPTATGVEATMSIDSRYKIPVDASANVH
Mb0180|M.bovis_AF2122/97 GGLYPTANVTYRGITIGKVTAVEPTDQGARVTMSIASNYKIPVDASANVH
Rv0174|M.tuberculosis_H37Rv GGLYPTANVTYRGITIGKVTAVEPTDQGARVTMSIASNYKIPVDASANVH
Mflv_0706|M.gilvum_PYR-GCK GGLYPTGNVTYRGTQIGKVTEVEPTETGARATMSIDNEYKVPADATANVH
Mvan_0139|M.vanbaalenii_PYR-1 GGLYPTGNVTYRGTQIGKVTEVEPTETGARVTMSIGDEYKIPADVSANVH
TH_2681|M.thermoresistible__bu GGLYATANVTYRGQTIGKVTAVEPTPRGARATMSIGSEYKIPIDSTANVH
MSMEG_0139|M.smegmatis_MC2_155 GGLYATANVTYRGTTIGKVTSVEPSESGARVEMNIYDRYKIPADATANVH
MAB_4148c|M.abscessus_ATCC_199 GGLYQNANVTFRGVQIGRVTDVELTPEGVTATMRLNDNVKVPGNVVAAVK
MAV_5010|M.avium_104 --------------------------------------------------
MLBr_02594|M.leprae_Br4923 SVSAVGEQYLDLVSS-GNPGKYLAPGQTITKS--KIPIEIGPALDSVNRG
MMAR_0417|M.marinum_M SVSAVGEQYLDLVST-GAPAKFLSPGQTITKG--TVPSEIGPALDTANRG
MUL_1067|M.ulcerans_Agy99 SVSAVGEQYLDLVST-GAPAKFLSPGQTITKG--TVPSEIGPALDTANRG
Mb0180|M.bovis_AF2122/97 SVSAVGEQYIDLVST-GAPGKYFSSGQTITKG--TVPSEIGPALDNSNRG
Rv0174|M.tuberculosis_H37Rv SVSAVGEQYIDLVST-GAPGKYFSSGQTITKG--TVPSEIGPALDNSNRG
Mflv_0706|M.gilvum_PYR-GCK SVSAIGEQYLDLVST-SGTTQYLSPGQTITEG--TVPSEVGPTIDAANDG
Mvan_0139|M.vanbaalenii_PYR-1 SVSAIGEQYLDLVSE-TGTDQYLSAGQTITKS--TVPAEVGPALDAANNG
TH_2681|M.thermoresistible__bu SVSAIGEQYLDLVPA-GTTDVYFSDGDTITES--TVPSEVGPALDAANEG
MSMEG_0139|M.smegmatis_MC2_155 SVSAVGEQFIDLTSD-SGGGAYFQPGDTITKA--TVPAEVGPALDAAEKG
MAB_4148c|M.abscessus_ATCC_199 SVSAIGEQYVDLIPPPTGAAGTLRSGDVIGADRTSIPTDVSTLLRQADGL
MAV_5010|M.avium_104 --------------------------------------------------
MLBr_02594|M.leprae_Br4923 LAALPKEKIGSLLDETAQAVGGLGPALQRLVSSTQAIVDAFKTNITDVND
MMAR_0417|M.marinum_M LEVLPADKIPVLLDETAQAVGGLGPALQRLVDATQAIVGDFHTQINDVND
MUL_1067|M.ulcerans_Agy99 LEVLPADKIPVLLDETAQAVGGLGPALQRLVDATQAIVGDFHTQINDVND
Mb0180|M.bovis_AF2122/97 LAALPTEKIGLLLDETAQAVGGLGPALQRLVDSTQAIVGDFKTNIGDVND
Rv0174|M.tuberculosis_H37Rv LAALPTEKIGLLLDETAQAVGGLGPALQRLVDSTQAIVGDFKTNIGDVND
Mflv_0706|M.gilvum_PYR-GCK LAVLPKEKIDALLTETSEAVGGLGPSLQRLVDSTTNLAEGFRDNLPQVTD
Mvan_0139|M.vanbaalenii_PYR-1 LAVLPKEKIDGLLTETSAAVGGLGPALQRLVDSTTNVAEGFRDNLPQVND
TH_2681|M.thermoresistible__bu LQALPAEKIDSLLTETAAAVGGLGPSLQRLVDSTTAIARDFRDNLEPVGD
MSMEG_0139|M.smegmatis_MC2_155 LAVLPKEKIGTLLDEAATAFGGLGPSLQRLVDSTQAIAGDFRANIDPVND
MAB_4148c|M.abscessus_ATCC_199 VNTVADTRLREVLAEAFKAFNGSGQELSRLIDSSRLLIQEANTNYDSTTK
MAV_5010|M.avium_104 -------MIDSQVKSGDAIERWARNLNRLGAQSAQEDSHLKSLLRQAAPT
MLBr_02594|M.leprae_Br4923 IIQNSGPILDSQVKSDNAIERWVHNLNVLAAQSARQDQHLKSILSQAAPT
MMAR_0417|M.marinum_M IIQNSGPILDSQVNSGDAISRWAHNLNVLATQTAERDQNVKSILTQAAPT
MUL_1067|M.ulcerans_Agy99 IIQNSGPILDSQVNSGDAISRWAHNLNVLATQTAERDQNVKSILTQAAPT
Mb0180|M.bovis_AF2122/97 IIENSGPILDSQVNTGDQIERWARKLNNLAAQTATRDQNVRSILSQAAPT
Rv0174|M.tuberculosis_H37Rv IIENSGPILDSQVNTGDQIERWARKLNNLAAQTATRDQNVRSILSQAAPT
Mflv_0706|M.gilvum_PYR-GCK IINNAAPILDSQVQSGDAIEQWSRNLNVIASQTAEQDAALRSGLQQAAPT
Mvan_0139|M.vanbaalenii_PYR-1 IITNSAPILQSQVTSGDAIEQWSRNLNVIASQTAEQDAALRSGLQQAAPT
TH_2681|M.thermoresistible__bu IIDNSAPILDSQVDSGDAIARWSRNVNILAAQAAQQDAALRSGLQQAAPT
MSMEG_0139|M.smegmatis_MC2_155 IIENSGPIIDSQVNSGDAIQRWAANLNTLAAQSAQNDEALRSGLQQAAPT
MAB_4148c|M.abscessus_ATCC_199 LIDQVGPLLDAQIRSGDNIRGSVSSLAALTEHFAKADPQLRQFLKVAPGA
::::*: :.: * .: : : * * ::. * *. :
MAV_5010|M.avium_104 ADQVNDVFNDVRESLPQTLANLEVVIDLLKRYHTGVEQVLVFLPQGASIA
MLBr_02594|M.leprae_Br4923 ADEVNTVFSDVRDSLPQTLANFEILIDMLKRYHHGVEQMLVFLPQGASIA
MMAR_0417|M.marinum_M ADQLNSVFSDVRDSLPQTLANLEVVFDLLKRYHKGLEQVLVFLPQGASIA
MUL_1067|M.ulcerans_Agy99 ADQLNSVFSDVRDSLPQTLANLEVVFDLLKRYHKGLEQVLVFLPQGASIA
Mb0180|M.bovis_AF2122/97 ADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHAGVEQLLVFLPQGAAIA
Rv0174|M.tuberculosis_H37Rv ADEVNAVFSGVRDSLPQTLANLEVVFDMLKRYHAGVEQLLVFLPQGAAIA
Mflv_0706|M.gilvum_PYR-GCK LDQVNTVFSDVQEALPQTLANLAVVNDMLKRYNKGIEQTLVIYPQGASLL
Mvan_0139|M.vanbaalenii_PYR-1 LDQVTTVFSDVRDALPQTLANLAVINDMLKRYNKGIEQTLVIYPQGASLL
TH_2681|M.thermoresistible__bu ADQLNAVFGGVRESLPQVLANLAVVSDMLKRYHKGLNQSLVILPQGAAIA
MSMEG_0139|M.smegmatis_MC2_155 ADQLNAVFSDVRESLPQTLANLEIVIDMLKRYNKNVEQVLVALPQGAAVA
MAB_4148c|M.abscessus_ATCC_199 SEQASQLFAGIRPSFPVLAASLANLGRVGVIYNKSIEQSLVILPALFSAL
:: . :* .:: ::* *.: : : *: .::* ** * :
MAV_5010|M.avium_104 QTVA--APFPNMAALDLALSINQPPPCLTGFIPASEWRSPADTSLQPLPT
MLBr_02594|M.leprae_Br4923 QTAS--ATFPNMAALDLALSINQPPPCLTGFIPAAEWRSPADTSLQPLPV
MMAR_0417|M.marinum_M QTVA--APFPNMAALDMALAINQPPPCLTGFIPAEQWRSFADTSLQPLPK
MUL_1067|M.ulcerans_Agy99 QTVA--APFPNMAALDMALAINQPPPCLTGFIPAEQWRSFADTSLQPLPK
Mb0180|M.bovis_AF2122/97 QTVL--TPTPGAAQLPLAPAINYPPPCLTGFLPASEWRSPADTSPRPLPS
Rv0174|M.tuberculosis_H37Rv QTVL--TPTPGAAQLPLAPAINYPPPCLTGFLPASEWRSPADTSPRPLPS
Mflv_0706|M.gilvum_PYR-GCK QMG---SIFQDGGLLHFGLSINQPPPCMTGFLPASEWRSPADTSQAPLPS
Mvan_0139|M.vanbaalenii_PYR-1 QMG---SIFEDGGLLHFGLSINQPPPCMTGFLPASEWRSPADTSTAPLPS
TH_2681|M.thermoresistible__bu QTTT--APFPGEALLHLALGINIPPPCLTGFLPPSQWRSPADTSPQPLPE
MSMEG_0139|M.smegmatis_MC2_155 QTG---TIFAPEGLLHFGLGINAPPPCLTGFLPASQWRSPADTRTEPLPS
MAB_4148c|M.abscessus_ATCC_199 LTVAGGAPMDEGAKLDFRLNLGDPPPCLTGFVPPPLMRTPADETLRELPR
: . * : :. ****:***:*. *: ** **
MAV_5010|M.avium_104 GTYCKIPMDTPANSVRGSRNIPCTDIPGKRAATPRECRDPKPYVPAGTNP
MLBr_02594|M.leprae_Br4923 GTYCKIPMDTPANSVRGSRNIPCVDVPGKRAASPRECRDSKPYVPLGTNP
MMAR_0417|M.marinum_M GTYCKIPMDTPANSVRGSRNIPCVDVPGKRAATPRECRDPKPYVPAGTNP
MUL_1067|M.ulcerans_Agy99 GTYCKIPMDTPANSVRGSRNIPCVDVPGKRAATPRECRDPKPYVPAGTNP
Mb0180|M.bovis_AF2122/97 GTYCKIPQDAQLQ-VRGARNIPCVDVPGKRAATPKECRSKDPYVPLGTNP
Rv0174|M.tuberculosis_H37Rv GTYCKIPQDAQLQ-VRGARNIPCVDVLGKRAATPKECRSKDPYVPLGTNP
Mflv_0706|M.gilvum_PYR-GCK GMYCKIPKDYQGNSVRGARNYPCPDVPGKRAASPKECRSDEPYVPLGTNP
Mvan_0139|M.vanbaalenii_PYR-1 GMYCKIPKDYQGNAVRGARNYPCVDVPGKRAASPKECRSDEPYVPLGTNP
TH_2681|M.thermoresistible__bu GTYCKIPKDTQGNVVRGGRNYPCVDVPGKRAATPRECRSDEPYVPLGTNP
MSMEG_0139|M.smegmatis_MC2_155 GLYCKIPKDAP-NAVRGARNYPCADVPGKRAATPRECRSDEPYQPLGTNP
MAB_4148c|M.abscessus_ATCC_199 DMYCKTAQNDP-SAVRGARNYPCQEFPGKRAPTIQLCRDPRGYVPIGSNP
. *** . : . ***.** ** :. ****.: : **. * * *:**
MAV_5010|M.avium_104 WYGDPNQILTCPAPAARCDQPVKPGMVIPAPSVDNGLNPAPSDRVA---G
MLBr_02594|M.leprae_Br4923 WFGDPNQLLTCPAPGARCDQPVKPGLVIPAPTVDNGLNPAPADRLP---G
MMAR_0417|M.marinum_M WYGDPNQLLTCPAPGARCDQPVKPGLVAQAPSVNNGMNPAPADKLPPG-G
MUL_1067|M.ulcerans_Agy99 WYGDPNQLLTCPAPGARCDQSVKPGLVAQAPSVNNGMNPAPADKLPPG-G
Mb0180|M.bovis_AF2122/97 WFGDPNQILTCPAPGARCDQPVKPGLVIPAPSINTGLNPAPADQVQ---G
Rv0174|M.tuberculosis_H37Rv WFGDPNQILTCPAPGARCDQPVKPGLVIPAPSINTGLNPAPADQVQ---G
Mflv_0706|M.gilvum_PYR-GCK WYGDPNQIVACPAPGARCDQRVAPGQVVPAPSINNGQNPLPADELPPPAS
Mvan_0139|M.vanbaalenii_PYR-1 WYGDPNQIVACPAPGARCDQRVAPGQVIPAPSVNNGQNPLPADQLPPPQS
TH_2681|M.thermoresistible__bu WYGDPNQIRNCPAPGARCDQPVDPGKVIPAESVNNGMNPLPADRLPGP--
MSMEG_0139|M.smegmatis_MC2_155 WYGDPDQIRNCPAPGARCDQPVDPGRVIPAPSINNGLNPLPASQLPPPEV
MAB_4148c|M.abscessus_ATCC_199 WRGPPAPYDTPVEDPRNILPPNKFPNIPPGAEPDPGTPTLPPPSPPAP-E
* * * . : . : * . *.
MAV_5010|M.avium_104 TPPPVSDPLSRPG-SGTVQCNGQQPNPCVYKPSGPP---TAVYSPQSGEL
MLBr_02594|M.leprae_Br4923 TPPPVSDPLSQPR-SGSVQCNGQQPNTCVYTPSGPP---SAVYSPQSGEL
MMAR_0417|M.marinum_M TPPPISDPLQRPG-SGTVQCNGQQPNPCVYTP-GPP---TAVYSPQSGEL
MUL_1067|M.ulcerans_Agy99 TPPPISDPLERPG-SGTVQCNGQQPNPCVYTP-GPP---TAVYSPQSGKL
Mb0180|M.bovis_AF2122/97 TPPPVSDPLQRPG-SGTVQCNGQQPNPCVYTPTSGP---SAVYSPASGEL
Rv0174|M.tuberculosis_H37Rv TPPPVSDPLQRPG-SGTVQCNGQQPNPCVYTPTSGP---SAVYSPASGEL
Mflv_0706|M.gilvum_PYR-GCK -LAPVSDPVSPPG-SGTVRCSGQQPNPCTYTPAQGPPGTTAGYSPSSGEV
Mvan_0139|M.vanbaalenii_PYR-1 -LAPVSDPLSPPG-SGTVRCSGQQPNPCAYTPAQGPPGTTAGYSPSSGEV
TH_2681|M.thermoresistible__bu -VPPVSDPLTPPGPSGMVECSGQQPNPCIYTPAPG----TAIYNPASGEA
MSMEG_0139|M.smegmatis_MC2_155 SSGPSSDPLTAPR-GGTVTCSGQQPNPCIYTPAAG---ATATYNPASGEV
MAB_4148c|M.abscessus_ATCC_199 VPPAGGDVMPVSAQSGPMAARAYDPKNGVFLDANNQ---PSVYAP-----
. .* : . .* : . . :*: : .: * *
MAV_5010|M.avium_104 VGPDGVKYSVENSTRTGDDGWKEMLAPAG-
MLBr_02594|M.leprae_Br4923 VGPDGVAYAVENSTKTGDDGWKEMLAPAG-
MMAR_0417|M.marinum_M VGPDGVKYSVENSTKTGDDGWKEMLAPAG-
MUL_1067|M.ulcerans_Agy99 VGPDGVKYSVENSTKTGDDGWKEMLAPAG-
Mb0180|M.bovis_AF2122/97 VGPDGVKYAVANSSTTGDDGWKEMLAPAS-
Rv0174|M.tuberculosis_H37Rv VGPDGVKYAVANSSTTGDDGWKEMLAPAS-
Mflv_0706|M.gilvum_PYR-GCK VGPDGVRYSVTNSTNPGDDGWKEMLAPAG-
Mvan_0139|M.vanbaalenii_PYR-1 VGPDGVRYNVSNSNNPGDDGWKEMLAPAG-
TH_2681|M.thermoresistible__bu VGPDGVKYSVSNSSNPGDDGWKEMLAPAG-
MSMEG_0139|M.smegmatis_MC2_155 VGPGGVKYSVTNSNTPGDDGWKEMLAPAS-
MAB_4148c|M.abscessus_ATCC_199 ---------ALDRGTEAETWADLMLGPKPV
. : .: . **.*