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LFRQLEYFVALASERHFARAARACYVSQPALSEAIRKLEQELNVPLVRRGQKFEGLTPEGERLVLWARRI LADHDALKQEVAALQTGLTGELRLGVIPAASSIVALLTDPFCAAHPLVRVQLETSLRSAEIVQRLRRFEL DAGVLYPDRQDVADLLVTPLYTEQQVLIAGAELLPDPSETISWSDALTLPMCLLNQGMRGRRLIDDALAA QELTVTPQLETDSVATLLAHVGTGRWASIIPQTWIHSLRPPAGARILRLENPTVTATVALVTSATEPGSV LTRALVQTARGAGINDVLRKAAPGYSAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4934 | - | - | 100% (309) | transcriptional regulator, LysR family protein |
| M. avium 104 | MAV_5191 | - | 3e-86 | 53.20% (297) | transcriptional regulator, LysR family protein |
| M. avium 104 | MAV_3102 | - | 1e-16 | 26.36% (239) | LysR substrate binding domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0121 | oxyS | 7e-87 | 52.82% (301) | oxidative stress response regulatory protein OXYS |
| M. gilvum PYR-GCK | Mflv_2595 | - | 2e-54 | 39.31% (290) | LysR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0117 | oxyS | 7e-87 | 52.82% (301) | oxidative stress response regulatory protein OXYS |
| M. leprae Br4923 | MLBr_02663 | oxyS | 3e-85 | 50.82% (305) | putative LysR family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_0998 | - | 1e-102 | 65.62% (288) | LysR family transcriptional regulator |
| M. marinum M | MMAR_0317 | oxyS | 7e-89 | 55.18% (299) | oxidative stress response regulatory protein OxyS |
| M. smegmatis MC2 155 | MSMEG_0156 | - | 2e-80 | 52.19% (297) | transcriptional regulator, LysR family protein |
| M. thermoresistible (build 8) | TH_3504 | - | 2e-08 | 32.17% (115) | PUTATIVE putative transcriptional regulator |
| M. ulcerans Agy99 | MUL_4805 | oxyS | 2e-77 | 56.91% (246) | oxidative stress response regulatory protein OxyS |
| M. vanbaalenii PYR-1 | Mvan_4031 | - | 2e-51 | 37.93% (290) | LysR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2595|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4031|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_4934|M.avium_104 --------------------------------------------------
MAB_0998|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_0317|M.marinum_M MKLLGAPKINPELTLAQIPGSDSLVVIPIPRTSGLARRAAPAVQPRCGVT
MUL_4805|M.ulcerans_Agy99 --------------------------------------------------
Mb0121|M.bovis_AF2122/97 --------------------------------------------------
Rv0117|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_02663|M.leprae_Br4923 --------------------------------------------------
MSMEG_0156|M.smegmatis_MC2_155 --------------------------------------------------
TH_3504|M.thermoresistible__bu --------------------------------------------------
Mflv_2595|M.gilvum_PYR-GCK -----------------------------------------MANDVLLQH
Mvan_4031|M.vanbaalenii_PYR-1 ---------------------------------------------MLLQH
MAV_4934|M.avium_104 ---------------------------------------------MLFRQ
MAB_0998|M.abscessus_ATCC_1997 ---------------------------------------------MQFRQ
MMAR_0317|M.marinum_M RTAQWRADLVATVQDLAAQSGTGGRQRSGGGGSLSESVPMTEEVSVLFRQ
MUL_4805|M.ulcerans_Agy99 ---------------------------------------------MLFRQ
Mb0121|M.bovis_AF2122/97 ---------------------------------------------MLFRQ
Rv0117|M.tuberculosis_H37Rv ---------------------------------------------MLFRQ
MLBr_02663|M.leprae_Br4923 ---------------------------------------------MLFRQ
MSMEG_0156|M.smegmatis_MC2_155 ---------------------------------------------MLLRQ
TH_3504|M.thermoresistible__bu ----------------------------------------VPSPKIDLRR
: :::
Mflv_2595|M.gilvum_PYR-GCK LDYLLALAAERHFGRAAARCHVSQPTLSVAIRRLERDLGIVIVQRGHRFE
Mvan_4031|M.vanbaalenii_PYR-1 LDYLLALAAERHFGRAAARCHVSQPTLSVAIRRLERDLGIVIVQRGHRFE
MAV_4934|M.avium_104 LEYFVALASERHFARAARACYVSQPALSEAIRKLEQELNVPLVRRGQKFE
MAB_0998|M.abscessus_ATCC_1997 LEYFVALARERHFARAASACYVSQPALSEAIRKLEHELGVPLVLRGSNFE
MMAR_0317|M.marinum_M LEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELNVTLINRGHSFE
MUL_4805|M.ulcerans_Agy99 LEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELHVTLINRGHSFE
Mb0121|M.bovis_AF2122/97 LEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELNVTLINRGHSFE
Rv0117|M.tuberculosis_H37Rv LEYFVAVAQERHFARAAEKCYVSQPALSSAIAKLERELNVTLINRGHSFE
MLBr_02663|M.leprae_Br4923 LEYFVAVAQERHFARAAERCYVSQPALSSAIAKLERELNVTLINRGHSFE
MSMEG_0156|M.smegmatis_MC2_155 LEYFVAVARERHFARAAEVCYVSQPALSTAIAKLERELDVTLIHRGQNFE
TH_3504|M.thermoresistible__bu LAQFVAVAELGSFTRAAATLHLSQQALSSAVRALENDVGADLFTRDGRRI
* ::*:* * *** ::** :** *: **.:: :. *.
Mflv_2595|M.gilvum_PYR-GCK GFTVEGQRVVTWAQRIVAERDEMLADLDRMQGRLTASARLGAIPTAVPVC
Mvan_4031|M.vanbaalenii_PYR-1 GFTEEGRRVVTWAQRIIAERDEMLADLERMRGRLTVTARVGAIPTAVPAS
MAV_4934|M.avium_104 GLTPEGERLVLWARRILADHDALKQEVAALQTGLTGELRLGVIPAASSIV
MAB_0998|M.abscessus_ATCC_1997 GLTPEGDRLVLWARRILADRDALEHEVTALRSGLTGELRLGVVPGAATRV
MMAR_0317|M.marinum_M GLTPEGERLVVWAKRIIAEHDAFKAEVDAVRSGITGTLRLGTVPSASTTA
MUL_4805|M.ulcerans_Agy99 GLTPEGERLVVWAKRIIAEHDAFKAEVDAVRSGITGTLRLGTVRSASTTA
Mb0121|M.bovis_AF2122/97 GLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTLRLGTVPTASTTA
Rv0117|M.tuberculosis_H37Rv GLTREGERLVVWAKRILAEHAAFKAEVDAVRSGITGTLRLGTVPTASTTA
MLBr_02663|M.leprae_Br4923 GLTPEGERLVVWAKRILAEHDAFKAEVHAVRSGITGTLRLGTVPTASTTA
MSMEG_0156|M.smegmatis_MC2_155 GLTLEGERLVVWAKRLLAEHDGLKAEAAALRTGISGTLRLGTGPTVSTTT
TH_3504|M.thermoresistible__bu SLTTAGRTLLAEGKPLLAAARTVAEHVRQTEAAAQAHYVIGHTPALSGAE
.:* * :: .: ::* . . . :*
Mflv_2595|M.gilvum_PYR-GCK PFITDEFLRRNPAAAVRIEA-LSSREIARRLADFEIDVGLTY-LDDEAPP
Mvan_4031|M.vanbaalenii_PYR-1 PFITAEFLHRNPAASVRIEA-LSSREIARRLADFEIDAGLTY-LDDEAPP
MAV_4934|M.avium_104 ALLTDPFCAAHPLVRVQLETSLRSAEIVQRLRRFELDAGVLY-PDRQDVA
MAB_0998|M.abscessus_ATCC_1997 ALMADALCAEHPLVRVRIESSLRSVEILDRIRRFELDAGVVY-DDGLQTD
MMAR_0317|M.marinum_M SLVLSDFCSAHPLVKAQICSRLAVTELYRRLRDFELDAAIVY-TSSDDGH
MUL_4805|M.ulcerans_Agy99 SLVLSDFCSAHPLVKAQICSRLAVTELYRRLRDFERDAAIVY-TSSDDGH
Mb0121|M.bovis_AF2122/97 SLVLSAFCSAHPLAKVQVCSRLAATELYRRLREFELDAVIVH-PETQDSD
Rv0117|M.tuberculosis_H37Rv SLVLSAFCSAHPLAKVQVCSRLAATELYRRLREFELDAVIVH-PETQDSD
MLBr_02663|M.leprae_Br4923 SLVLSAFCSEHPLIKVQICSRLPVTELHRRLGDFELDAVIVH-SAPDDTH
MSMEG_0156|M.smegmatis_MC2_155 AIPVAAFCNLHPKANVSISSRLSSAELLRQLRDFELDAAIAH-FGPEDRA
TH_3504|M.thermoresistible__bu AYALIEPAVTAYPSTSFTLRQLYPDALTDAVFDGTVQLGLRRGVVPTPEL
. * : : : :
Mflv_2595|M.gilvum_PYR-GCK GTRAVELYREQYVLVAPADNPLMGLDEVAWSDAAGLQLCVLTTSMRNRRI
Mvan_4031|M.vanbaalenii_PYR-1 GTRSVELYREQYVLVAPHDHRLMEHTEVTWTDAAAMELCVLTTTMRNRRI
MAV_4934|M.avium_104 DLLVTPLYTEQQVLIAGAELLPDPSETISWSDALTLPMCLLNQGMRGRRL
MAB_0998|M.abscessus_ATCC_1997 GLELTRLYEERYVLVAGDGLLRDAHDPIDWSEALSLPMCLLHKGMRDRDR
MMAR_0317|M.marinum_M DVDLVPLYEERYVLLAPPEMLPPGVSTLSWLDAAQLPLALLSSDMRDRQI
MUL_4805|M.ulcerans_Agy99 DVDLVPLYEERYVLLAPPEMLPPGVSTLSWLDAAQLPLALLSSDMRDRQI
Mb0121|M.bovis_AF2122/97 DVDLVPLYEEQYVLLSPADMLPPGTSTLVWRDAAQLPLALLTADMRDRQV
Rv0117|M.tuberculosis_H37Rv DVDLVPLYEEQYVLLSPADMLPPGTSTLVWRDAAQLPLALLTADMRDRQV
MLBr_02663|M.leprae_Br4923 AVDLVPLYHEHYVLVSPADMLPPGASVLAWPEASQLPLALLTPDMRDRQL
MSMEG_0156|M.smegmatis_MC2_155 GLEVVPLYKERYVLLVSGDQLAPGTRAITWSDAAQLPLALLEPHMRFRQF
TH_3504|M.thermoresistible__bu ATAVIGYHRVRVAFVDSHPLAARESVDITELAREQVALWAPPGTSYYSDF
: : .:: : : :
Mflv_2595|M.gilvum_PYR-GCK LDANMAAEGIRYRPVVEADSVDALYAHLTGSHRATIASTAWLPKLGLP--
Mvan_4031|M.vanbaalenii_PYR-1 LDANMAAEGVSYRPAVEADSVDALYAHLTHSRRATIASTAWLPQLGVP--
MAV_4934|M.avium_104 IDDALAAQELTVTPQLETDSVATLLAHVGTGRWASIIPQTWIHSLRPP--
MAB_0998|M.abscessus_ATCC_1997 IDEAAAEHGLAVSPRLEADSVATLLALVGTGRWAAIVARTWFATAAPP--
MMAR_0317|M.marinum_M IDAAFADHAITVSPQVETDSVASLFAQVATGNSASIVPHTWLWTTPAG--
MUL_4805|M.ulcerans_Agy99 IDAAFADHAITVSPQVETDSVASLFAQVATGNSASIVPHTWLWTTPGR--
Mb0121|M.bovis_AF2122/97 IDAAFADHAVSAIPQVETDSVASLFAQVATGNWASIVPHTWLWAMPMSGP
Rv0117|M.tuberculosis_H37Rv IDAAFADHAVSAIPQVETDSVASLFAQVATGNWASIVPHTWLWAMPMSGP
MLBr_02663|M.leprae_Br4923 IDRAFAGHAITATPQVETDSVASLFAQVATGNWACIVPHTWLWTTPIG--
MSMEG_0156|M.smegmatis_MC2_155 IDKAFAENGVTPSPQVETDSVASLYALVATGAWASVVPHTWLRAVPQL--
TH_3504|M.thermoresistible__bu LMGACRRAGFEPDYVVSRVQGAATVAAPLTTGGIAFVTAAAGPTMNGR--
: . :. . : * . . :
Mflv_2595|M.gilvum_PYR-GCK --QGFGARPMVRHGPRPPIGLVVLDRAPASIVAAALVEVAGELDLGVRID
Mvan_4031|M.vanbaalenii_PYR-1 --QGFAARPMVQHGPRPAIGLVVLDRAPASIVAAALVAVAADIDLGSRID
MAV_4934|M.avium_104 --AGARILRLENPTVTATVALVTSATEPGSVLTRALVQTARGAGINDVLR
MAB_0998|M.abscessus_ATCC_1997 --AGTRTVELQAPTLGSPVALVRAAGDPASLLARALAQVV----------
MMAR_0317|M.marinum_M --GEIRPVQLVSPVVKAQVALATSSTGPGSPVARALMTSAQGLALDEFFQ
MUL_4805|M.ulcerans_Agy99 --------------------------------------------------
Mb0121|M.bovis_AF2122/97 TGGEIRAVELVDPVLKAQIALATNALGPGSPVARALITCAQALALNEFFD
Rv0117|M.tuberculosis_H37Rv TGGEIRAVELVDPVLKAQIALATNALGPGSPVARALITCAQALALNEFFD
MLBr_02663|M.leprae_Br4923 --AEIRAVEMVDPVLKADVALATNSAGPGSPVARALVASAKQLALNEFFE
MSMEG_0156|M.smegmatis_MC2_155 --GAARAVRLIEPETTAQISLAIH-AGRGSAAARAFVNVAAGARLDDQFD
TH_3504|M.thermoresistible__bu ----VQVVDLTPP-LLVPVQALWQRHTLSAIRDRILEGLG----------
Mflv_2595|M.gilvum_PYR-GCK RMWSAAAL-------
Mvan_4031|M.vanbaalenii_PYR-1 SMWSEMTAVTRGPRR
MAV_4934|M.avium_104 KAAPGYSAG------
MAB_0998|M.abscessus_ATCC_1997 -APPDQP--------
MMAR_0317|M.marinum_M TRLMEISRRR-----
MUL_4805|M.ulcerans_Agy99 ---------------
Mb0121|M.bovis_AF2122/97 TQLRGITRRR-----
Rv0117|M.tuberculosis_H37Rv TQLRGITRRR-----
MLBr_02663|M.leprae_Br4923 AQLAGITRRR-----
MSMEG_0156|M.smegmatis_MC2_155 LQSEHWLLK------
TH_3504|M.thermoresistible__bu ---------------