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MAVDYSELPAEEAVRAARAGARRRQVLDAAVKVMGRNGFHRMSMHDLAAEADVSVGLLYKYFGGKQDLLL ATIVRILDVFRDQLAPVIDAAGDDVVDQLSAGIRRYIQIVDENLDGVVLTYRESRTLGAAGRAQIKDLEI ATAAPLRAVIETGIAQGVFRSVDVDLAVFDIMLLAHGWALKHWHFGPIYTLDEYIALQTRHLLNGLISDE RRADYADVLK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4769 | - | - | 100% (220) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_4919 | - | 2e-11 | 34.15% (123) | transcriptional regulator, TetR family protein |
| M. avium 104 | MAV_1977 | - | 6e-08 | 30.43% (92) | TetR-family protein transcriptional regulator |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0244 | - | 2e-11 | 34.15% (123) | TetR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_0414 | - | 7e-11 | 33.01% (103) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0238 | - | 2e-11 | 34.15% (123) | TetR family transcriptional regulator |
| M. leprae Br4923 | MLBr_02568 | - | 1e-11 | 35.04% (117) | putative TetR-family transcriptional regulator |
| M. abscessus ATCC 19977 | MAB_3586c | - | 5e-11 | 29.73% (148) | TetR family transcriptional regulator |
| M. marinum M | MMAR_0500 | - | 5e-12 | 33.83% (133) | TetR family transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_0363 | - | 2e-10 | 31.71% (123) | TetR-family protein regulatory protein |
| M. thermoresistible (build 8) | TH_2855 | - | 5e-11 | 25.39% (193) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_1163 | - | 4e-12 | 33.83% (133) | TetR family transcriptional regulator |
| M. vanbaalenii PYR-1 | Mvan_0257 | - | 6e-11 | 33.01% (103) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0500|M.marinum_M ----------------------------MAGGTKRLPRAIREQQMLDAAV
MUL_1163|M.ulcerans_Agy99 ----------------------------MAGGTKRLPRAIREQQMLDAAV
Mb0244|M.bovis_AF2122/97 ----------------------------MAGGTKRLPRAVREQQMLDAAV
Rv0238|M.tuberculosis_H37Rv ----------------------------MAGGTKRLPRAVREQQMLDAAV
MLBr_02568|M.leprae_Br4923 ----------------------------MAGGAKRIPRAVREQQMLDAAV
Mflv_0414|M.gilvum_PYR-GCK ----------------------------MAGGTKRLPRAVREQQMLDAAV
Mvan_0257|M.vanbaalenii_PYR-1 ----------------------------MAGGTKRLPRAVREQQMLDAAV
MSMEG_0363|M.smegmatis_MC2_155 --------------------------MGMAGGTKRLPRAVREQQMLDAAV
MAV_4769|M.avium_104 -------------------MAVDYSELPAEEAVRAARAGARRRQVLDAAV
TH_2855|M.thermoresistible__bu LSQSPDNATSSSRAGSGAGSGAGSGAEPIGRDTPRRRPRIRPEEIVSAAA
MAB_3586c|M.abscessus_ATCC_199 ----------------------------MPRVVKHP--ELRRTELLDLAM
. * :::. *
MMAR_0500|M.marinum_M QMFSANGYHETSMDTIAAAAQISKPMLYLYYGSKEDLFGACLNREMSRFI
MUL_1163|M.ulcerans_Agy99 QMFSANGYHETSMDTIAAAAQISKPMLYLYYGSKEDLFGACLNREMSRFI
Mb0244|M.bovis_AF2122/97 QMFSVNGYHETSMDAIAAEAQISKPMLYLYYGSKEDLFGACLNREMSRFI
Rv0238|M.tuberculosis_H37Rv QMFSVNGYHETSMDAIAAEAQISKPMLYLYYGSKEDLFGACLNREMSRFI
MLBr_02568|M.leprae_Br4923 QMFSVNGYHKTSMDAIAAEAQISKPMLYLYYGSKEDLFGACLNREMSRFI
Mflv_0414|M.gilvum_PYR-GCK EIFSVNGYHETSMDAIAAEAQISKPMLYLYYGSKEELFGACLHRELTRFV
Mvan_0257|M.vanbaalenii_PYR-1 EIFSVNGYHETSMDAIAAEAQISKPMLYLYYGSKEELFGACLNRELGRFV
MSMEG_0363|M.smegmatis_MC2_155 QMFSVNGYHETSMDAIAAAAEISKPMLYLYYGSKEELFGACLDRELRRFV
MAV_4769|M.avium_104 KVMGRNGFHRMSMHDLAAEADVSVGLLYKYFGGKQDLLLATIVRILDVFR
TH_2855|M.thermoresistible__bu EFFAREGYANVGMRDVAEAVGIRGASLYHHFGSKEEILYAICLTVTKEPN
MAB_3586c|M.abscessus_ATCC_199 TLFLERGYERVSLNDLIATSGMSKGAFYHYFSSKEALVSALAARSADQAF
.: .*: . .: : : :* ::..*: :. *
MMAR_0500|M.marinum_M DAVRADIDLS-QSPKDLLRNAIVSFLRYIDQNQASWIVMYTQAVSS-QAF
MUL_1163|M.ulcerans_Agy99 DAVRADIDLS-QSPKDLLRNAIVSFLRYIDQNQASWIVMYTQAVSS-QAF
Mb0244|M.bovis_AF2122/97 DALRSSINFD-QSPKDLLRNTIVSFLRYIDANRASWIVMYTQATSS-QAF
Rv0238|M.tuberculosis_H37Rv DALRSSINFD-QSPKDLLRNTIVSFLRYIDANRASWIVMYTQATSS-QAF
MLBr_02568|M.leprae_Br4923 AMVRADIDFT-QSPKDLLRNTIVSFLRYIDANRASWIVMYIQAMSL-PAF
Mflv_0414|M.gilvum_PYR-GCK DEVNSNIDFT-APPKELLRTAVLAFLNYIDANRASWMVLYTQATSS-QAF
Mvan_0257|M.vanbaalenii_PYR-1 DEVNSNIDFS-AAPKELLRTAVLAFLKYIDANRASWMVLYTQATSS-QAF
MSMEG_0363|M.smegmatis_MC2_155 DTVRGQIDFS-QSPKELLRTAVLAFLTYIDRNRASWMVLYTQATSS-QAF
MAV_4769|M.avium_104 DQLAPVIDAAGDDVVDQLSAGIRRYIQIVDENLDGVVLTYRESRTLGAAG
TH_2855|M.thermoresistible__bu ELNLPLLDAA-GTPAERLSALIRAHLEHLIRRRVEHLVALHDINSLTPEH
MAB_3586c|M.abscessus_ATCC_199 EALRPVFEAQGRGALERLNSGLRAGYEVKMALGAPESIGAMASMMR-PEN
:: : * : :
MMAR_0500|M.marinum_M AQTVREG----REQIVELVAGMLRAGTRS---PRSDA--EIDMMAAALVG
MUL_1163|M.ulcerans_Agy99 AQTVREG----REQIVELVAGMLRAGTRS---PRSDA--EIDMMAAALVG
Mb0244|M.bovis_AF2122/97 AHTVREG----REQIVQLVAELVRAGTRG---PLTDA--EIEMMAVALVG
Rv0238|M.tuberculosis_H37Rv AHTVREG----REQIVQLVAELVRAGTRG---PLTDA--EIEMMAVALVG
MLBr_02568|M.leprae_Br4923 AQTVREA----RDQITELVAGLMRVGTRS---SRPDH--EYEIMAGALVG
Mflv_0414|M.gilvum_PYR-GCK AHTVREG----RERIIEIVGRLLRSGTRF---PEPDT--DFDMMAVALVG
Mvan_0257|M.vanbaalenii_PYR-1 AHTVREG----RERIIELVGRLLRSGTKF---PEPDT--DFELMAVALVG
MSMEG_0363|M.smegmatis_MC2_155 AHTVREG----RERIIDLVARLLSTGTRN---PQPDS--DFEMMAVALVG
MAV_4769|M.avium_104 RAQIKDL----EIATAAPLRAVIETGIAQGVFRSVDV--DLAVFDIMLLA
TH_2855|M.thermoresistible__bu RAIIDDL----RRYYQRRVRDVIVAGVRS---GEFDVP-DPKLAALLILD
MAB_3586c|M.abscessus_ATCC_199 QSLLRRISAIWEDRFRPVLTEVIAQGVAEGVFDTFDPEGVGDMIQGLAAT
: . : :: * * :
MMAR_0500|M.marinum_M AGEAVANRLSAG-DTDVDEAAEMMIDLFWRGLKGAPSDRE------IGSN
MUL_1163|M.ulcerans_Agy99 AGEAVANRLSAG-DTDVDEAAEMMIDLLWRGLKGAPSDRE------IGSN
Mb0244|M.bovis_AF2122/97 AGEAVATRLGIG-DTDVDEAAEMMINLFWLGLKGAPVDR-------LETG
Rv0238|M.tuberculosis_H37Rv AGEAVATRLGIG-DTDVDEAAEMMINLFWLGLKGAPVDR-------LETG
MLBr_02568|M.leprae_Br4923 AGEAMATRLTTG-DIAVDEAAELMINLFWHGLKGAPADRD------FGPS
Mflv_0414|M.gilvum_PYR-GCK AGEAIASRVSTG-DADVHEASELMINLFWRGLKGSPSAASDRDADATDAT
Mvan_0257|M.vanbaalenii_PYR-1 AGEAIASRVSTG-DADVDEAAELMINLFWLGLKGAPSAAD------VDAT
MSMEG_0363|M.smegmatis_MC2_155 AGEAIATRVSTG-DADVDEAAELMINLFWRGLKGTPSDAG------TPPV
MAV_4769|M.avium_104 HGWALKHWHFGP-IYTLDEYIALQTRHLLNGLISDERRAD------YADV
TH_2855|M.thermoresistible__bu ALNGVSGWFHPDRGHSLPDVIAAYTEMIVERVLRARIS------------
MAB_3586c|M.abscessus_ATCC_199 MGTAVQRIIAAP--DAPARAQAIDAAVLRQRLYGIATDRILGLPDGTVEV
.: : :
MMAR_0500|M.marinum_M FAAG---------
MUL_1163|M.ulcerans_Agy99 FAAG---------
Mb0244|M.bovis_AF2122/97 H------------
Rv0238|M.tuberculosis_H37Rv H------------
MLBr_02568|M.leprae_Br4923 IVAG---------
Mflv_0414|M.gilvum_PYR-GCK AVITS--------
Mvan_0257|M.vanbaalenii_PYR-1 AVISS--------
MSMEG_0363|M.smegmatis_MC2_155 SAGSSG-------
MAV_4769|M.avium_104 LK-----------
TH_2855|M.thermoresistible__bu -------------
MAB_3586c|M.abscessus_ATCC_199 LDRDQIEALVAML