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THLTTVLRAATAAALMGSFAYLGIGIGTASAEPDNGNPADVDTLAESLSKGYDLTNCAPQPINPGELAEL VCDQSADSAGPAEARYILFANTDAMNGKFKAGLNDETLTSCGESQSPTTWHQGTSGTAGQVACGTHDGAA EIIWTTDAKNVLSDIRGANTDVPSLYRWWQNNG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_0722 | - | - | 100% (174) | hypothetical protein MMAR_0722 |
| M. marinum M | MMAR_1982 | pknH_2 | 8e-18 | 30.46% (151) | transmembrane serine/threonine-protein kinase H PknH_2 |
| M. marinum M | MMAR_4156 | pknH | 6e-16 | 30.86% (162) | transmembrane serine/threonine-protein kinase H PknH |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_2026 | - | 2e-18 | 36.84% (152) | protein kinase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1025 | - | 8e-12 | 29.87% (154) | hypothetical protein MAB_1025 |
| M. avium 104 | MAV_4741 | - | 4e-45 | 50.00% (178) | hypothetical protein MAV_4741 |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | TH_1441 | - | 2e-12 | 30.43% (138) | PROBABLE ATP-DEPENDENT DNA HELICASE |
| M. ulcerans Agy99 | MUL_3375 | pknH_2 | 7e-18 | 32.03% (153) | transmembrane serine/threonine-protein kinase H PknH_2 |
| M. vanbaalenii PYR-1 | Mvan_4693 | - | 3e-19 | 35.53% (152) | protein kinase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_0722|M.marinum_M --------------------------------------------------
MAV_4741|M.avium_104 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
TH_1441|M.thermoresistible__bu LSGAGRAGRIGAAVTARHSPADLAEALGLFPPTEEQAAVIAAPPGPLVVI
Mflv_2026|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4693|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
MAV_4741|M.avium_104 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
TH_1441|M.thermoresistible__bu AGAGAGKTETMAARVVWLVANGYARPDQVLGLTFTRKAAGQLLRRVRSRL
Mflv_2026|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4693|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
MAV_4741|M.avium_104 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
TH_1441|M.thermoresistible__bu ARLAGTGLVPANSAPDWTTESVTVSTYHAFAGTLLREHGLLLPVEPDTRL
Mflv_2026|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4693|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
MAV_4741|M.avium_104 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
TH_1441|M.thermoresistible__bu IGETELWQLAYRVVCEHPGPLDTDKTPAAITAMVLRLAGQLAEHLVDTDQ
Mflv_2026|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4693|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
MAV_4741|M.avium_104 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
TH_1441|M.thermoresistible__bu LRDTHVELERLVHTLPAGPYQRDRGPSQWLLNMLATQTERAALVPLIDAV
Mflv_2026|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4693|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
MAV_4741|M.avium_104 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
TH_1441|M.thermoresistible__bu HRRMRAEKVMDFGMQMAAAARLASEHPQVGAALRQRFRVVLLDEYQDTGH
Mflv_2026|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4693|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
MAV_4741|M.avium_104 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
TH_1441|M.thermoresistible__bu AQRIALSALFGGGVDDDLALTAVGDPIQSIYGWRGASATNLPRFATDFPH
Mflv_2026|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4693|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
MAV_4741|M.avium_104 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
TH_1441|M.thermoresistible__bu SDGSPAPTLELRTSWRNPPRTLHLANAISAEARRRSVAVRALRPRPDAEP
Mflv_2026|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4693|M.vanbaalenii_PYR-1 --------------------------------------------------
MUL_3375|M.ulcerans_Agy99 --------------------------------------------------
MMAR_0722|M.marinum_M --------------------------------------------------
MAV_4741|M.avium_104 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
TH_1441|M.thermoresistible__bu GTIRCALLDDVQSEREWVAEQLAALYRHARDAGDTPPTAAVLVRRNADAA
Mflv_2026|M.gilvum_PYR-GCK ------------------------MTDPQHGSRVGSQVGPYRLQRLLGKG
Mvan_4693|M.vanbaalenii_PYR-1 ------------------------MTDPQRGSRVGSQVGPYRLRRLLGKG
MUL_3375|M.ulcerans_Agy99 ------------------------MSASARRSRVGTRFGPYYLKRQLGTG
MMAR_0722|M.marinum_M --------------------------------------------------
MAV_4741|M.avium_104 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 --------------------------------------------------
TH_1441|M.thermoresistible__bu PMAQALTARGVPVEVVGLAGLLAVPEVADVVAMLRLAADPTAGSAAVRIL
Mflv_2026|M.gilvum_PYR-GCK GMGEVYEAYDTVKDRVVALKLLPESASHDPVFRKRLQREAHAAG------
Mvan_4693|M.vanbaalenii_PYR-1 GMGEVYEAEDTVKDRVVALKLLPEAVSHDPVFRKRLQREAHAAG------
MUL_3375|M.ulcerans_Agy99 GMGEVYEAVDTVRQRVVALKLMSESLSHDPVFRMRMQREARNAG------
MMAR_0722|M.marinum_M --------------------------------------------------
MAV_4741|M.avium_104 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 -------------------------------MDTD------TGAGSPASE
TH_1441|M.thermoresistible__bu TGPRWRLGARDLTALWRRAVELGTVEPPGARPDTDGVEQILAGIGPDADE
Mflv_2026|M.gilvum_PYR-GCK -----RLQEPHVVPIHDYGEIDGLLFVDMRMIDGVDLRRILKEQGAMSPA
Mvan_4693|M.vanbaalenii_PYR-1 -----RLQEPHVVPIHDYGEVDGLLFVDMRLIDGTDLRKLLKEQGPMTPA
MUL_3375|M.ulcerans_Agy99 -----RLQEPHVVPIHDYGEIDGQLYLDMRLIERTHLALLLERFGPVTPP
MMAR_0722|M.marinum_M --------------------------------------------------
MAV_4741|M.avium_104 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 ----------GSADAAD-------TAPLPVLNALPGMLSDPGP-------
TH_1441|M.thermoresistible__bu PCLADAICDPGDAAAYSEEGYRRITALAQELTALRAHLHHPLPDLIAEIR
Mflv_2026|M.gilvum_PYR-GCK RATAIVRQIASALDAAHRAGIMHRDVKPENILVTRDDFAYLVDFG-----
Mvan_4693|M.vanbaalenii_PYR-1 RATAIVAQVASALDAAHQNGIMHRDVKPENILINRDDFAYLVDFG-----
MUL_3375|M.ulcerans_Agy99 WAVALVHQVASALDAAHAAGVMHRDVKPENILVTQDDFVYLVDFG-----
MMAR_0722|M.marinum_M --------------------------------------------------
MAV_4741|M.avium_104 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 ---------------------------FAPSEQDFGQPP-----------
TH_1441|M.thermoresistible__bu RILGVDAEARAGQPVAAGWAGTENLDAFADVVAEFAVRPNATVPALLGYL
Mflv_2026|M.gilvum_PYR-GCK ---------------------------IANAATDESLTELGTAVGTYAYM
Mvan_4693|M.vanbaalenii_PYR-1 ---------------------------IANAVTDEALTELGTAVGTYAYM
MUL_3375|M.ulcerans_Agy99 ---------------------------IASAATDEKLTQIGSAVGTWRYM
MMAR_0722|M.marinum_M --------------------------------------------------
MAV_4741|M.avium_104 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 ----------------------------------------------FVEQ
TH_1441|M.thermoresistible__bu SAAMEVENGLAPADVTVATDRVQILTVHAAKGLEWEVVAVPHLSRRVFPS
Mflv_2026|M.gilvum_PYR-GCK APERFAAGEVTHRADVYALTCVLHECLTGTQPFEGDSVSVVITAHLNQPA
Mvan_4693|M.vanbaalenii_PYR-1 APERFTNGEVTHRADVYALTCVLHECLTGAQPFQGDSVSVVITAHLNDPA
MUL_3375|M.ulcerans_Agy99 APERFSDAEVNQRADIYSLTCVLHECLTGTPPYRADSAGMLITAHLMAPI
MMAR_0722|M.marinum_M --------------------------------------------------
MAV_4741|M.avium_104 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 PASPDPYWSAPAAPTPQFAG--ASTPQP-------------------IGE
TH_1441|M.thermoresistible__bu TASPRTWLTDAGELPPLLRGDRATTSEHGVPVLDTADVNDRKALSDKIAE
Mflv_2026|M.gilvum_PYR-GCK PRPSSLRQGIPAGLDEVIARGMAKRPEDRFASAGELADAATDALTRAEQD
Mvan_4693|M.vanbaalenii_PYR-1 PRPSQSRPGIPAGLDDVISRGMAKRPEDRYASAGEMARAATAALTGAQQD
MUL_3375|M.ulcerans_Agy99 PRPSQLRPDIPATFDAVIARGMAKRPEDRFASAGELAAAAHQALSAPHQA
MMAR_0722|M.marinum_M --------------------------------------------------
MAV_4741|M.avium_104 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 KP--------------------------------WG--------------
TH_1441|M.thermoresistible__bu HKNRLAQRRTDEERRLLYVAVTRAEDTLLVSGHHWGATESKPRGPSEFLL
Mflv_2026|M.gilvum_PYR-GCK QAASILQRSQAA-------------TMMAP--LPPPPPPPPPPPP-----
Mvan_4693|M.vanbaalenii_PYR-1 QADSILQRSQAA-------------TMMAP--LPPPPPPPPPSTPGGPLP
MUL_3375|M.ulcerans_Agy99 QEFRILKRGEEAGGLHTDAAAEAGITFASPSTASPSAPTPVASTSQPDLR
MMAR_0722|M.marinum_M --------------------------------------------------
MAV_4741|M.avium_104 --------------------------------------------------
MAB_1025|M.abscessus_ATCC_1997 -----------SGASAS-----TVDFAS----------WADK--------
TH_1441|M.thermoresistible__bu EIKDVIDRSAEAGDPCG-----TIDLWAPEPPDGTPNPLRDKAFEVLWPA
Mflv_2026|M.gilvum_PYR-GCK ---PQFAATPPPGGA-------ATYQGG--YQPPPPPGWGPP---PVPPG
Mvan_4693|M.vanbaalenii_PYR-1 YGGSPVPPPPPPPGQ-------PTQASG--FHTPPPPGGPPPGWPPQPPQ
MUL_3375|M.ulcerans_Agy99 ISGPLSIPSFPTSEANVPLFDASTSSWGDLTAAPPPQAPPAPLTPPTPPV
MMAR_0722|M.marinum_M -----------------------------MTHLTTVLRAATAAALMGSFA
MAV_4741|M.avium_104 -----------------------------MSEVSNALRAATAAVFTGGFV
MAB_1025|M.abscessus_ATCC_1997 -----------------------GPERSKRPLIIGGAVLAAVVLVGGVIA
TH_1441|M.thermoresistible__bu PPXXXPAGPPPPVSPRITTPSAGGAQPNRRRLIAGVAGVAAVAVLGGLAF
Mflv_2026|M.gilvum_PYR-GCK RPGGSGGSKGPLIAVVAG-AVVLLVLAAVGIWLVTKSDDPGSTTASPTS-
Mvan_4693|M.vanbaalenii_PYR-1 SSGGGGGSKGPMIALLAGAAVIILVLAGLGIWLVVKPDSTSDPVASRTS-
MUL_3375|M.ulcerans_Agy99 PPTPPQPPKQTSDTSPSGPGPHFLAASLRNPWMLLGAAALVALIVFAAQG
:
MMAR_0722|M.marinum_M YLGIGIGTASAEPD-NGNPAD----------VDTLAESLSKGYDLTNCAP
MAV_4741|M.avium_104 FAGS--AAAAADPAGTPNPSD----------INTLAASLSKGYGLNNCTA
MAB_1025|M.abscessus_ATCC_1997 IFASGGGDDAPTEPTAAPPTTTVSS-RDTDAETRLLSMLPAGYAASACKA
TH_1441|M.thermoresistible__bu WLLSPSGTDQADGARADDTAETTSPPRDTAAENRLLTMLPPGYSAGACGP
Mflv_2026|M.gilvum_PYR-GCK --SSAAP-TTSREPTRRTRTTTSAPPATGSYDQQLMAMLSGGHDGSNCEP
Mvan_4693|M.vanbaalenii_PYR-1 --TSAAPTTTSRGSTTRTRTSTSTPPPTESYDQQLMALLSGGHDSSNCEP
MUL_3375|M.ulcerans_Agy99 IWLSFRPKSESASTSPSTASPSAPSPASADALARLLSTLPLGYAPGTCRA
. : * *. *: * .
MMAR_0722|M.marinum_M QPINPG-ELAELVCDQSADSAGPAEARYILFANTDAMNGKFKAGLND--E
MAV_4741|M.avium_104 GNIDRGRQLAVLTCGQSPDPKGPAQAKYVLFTNPENLATAFRATIKE--D
MAB_1025|M.abscessus_ATCC_1997 VEPANE-AVAQVKCGRSDDPDGPIEASYSLVKDKSALAAGLSRLTKR--N
TH_1441|M.thermoresistible__bu VPAPEG-ALAQVVCRENTDPGGPPTATYTLARDEAAMQRAFDEIIAA--S
Mflv_2026|M.gilvum_PYR-GCK VSPPAQTAVATVDCTQNTNPGGPAFTRYSLFADRGALDAAFDEAIRVNSE
Mvan_4693|M.vanbaalenii_PYR-1 VDPPAPTILATVDCTQALTPGGPAFTRYSLFEDRGALDAAFEEAIRVNSE
MUL_3375|M.ulcerans_Agy99 FLP-AKDSLARVTCDKNVDPGGPSRGVYTLFGETATLRQYFDGLLRT-DI
:* : * . . ** * * : : :
MMAR_0722|M.marinum_M TLTSCGESQ-SPTTWHQ-GTSGTAG-QVACGTHDGAAEIIWTTDAKNVLS
MAV_4741|M.avium_104 VLTPCGDAHESPSSWHKDGSSASAG-QAACGTFRNAAEIIWTIDAKNILS
MAB_1025|M.abscessus_ATCC_1997 AVVVCPGRIQSPGPWRRNATPDQVSGTVFCGTNQGHPVVAWTDEERLLLS
TH_1441|M.thermoresistible__bu ATVNCPNFIQSPGPWRRNATPDRISGTLFCGIQQNEPLVAWTDDANLVVS
Mflv_2026|M.gilvum_PYR-GCK LLECPGSGVDSPTTWHYTETPDQVVGQVACGTYNENPDIVWTNDEKLLL-
Mvan_4693|M.vanbaalenii_PYR-1 LVQCPGSGVDSPTTWHYTETPDQVVGQIACGTYDGNPDLVWTKDDDLLL-
MUL_3375|M.ulcerans_Agy99 MVDCPGE-KKSPTAWHHPDSP-QVGGMIFCAIQEGSPSVVWTNEAQLMIS
** .*: :. *. . : ** : ::
MMAR_0722|M.marinum_M DIRGAN--TDVPSLYRWWQNNG
MAV_4741|M.avium_104 YLRASN--TDVAALYQWWRANG
MAB_1025|M.abscessus_ATCC_1997 ETRSGATGPTLDQLYAWWSSHS
TH_1441|M.thermoresistible__bu AVHSGPQGPTLDELYAWWTTHS
Mflv_2026|M.gilvum_PYR-GCK ---ADAQSPNLEDLHDWWLEFG
Mvan_4693|M.vanbaalenii_PYR-1 ---ADAQGPNLEELHNWWLEFG
MUL_3375|M.ulcerans_Agy99 VVPGDPRGPNLEELYSWWKKHS
. . : *: ** .