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GHAPGPKPHRAVRRQIVPPALHIPESAAASVFRAVRLRGPVGRDVIANVTSLSIATVNRQVIALLEAGLL RERADLAVSGAIGRPRVPVEVNHEPFVTLGIHIGARTTSIVATDLFGRTLDTVETPTPRNPAGPALASLA DSARRYLRRWHRRRPLWIGVAIGGTVDSATGQVDHPRLGWRQAPVGQVLADALGLPVSVASHVDAMAGAE LLLGMRRFLPSSPTSLYVYARETVGYALVIGGRVHVPTSGPGTIATLPAHSELLGGTGQLESTVSDEAVV AVARQLRILPFAPANRASGSAAGIADLLRVARAGNEQARELLAERGRVLGEAVALLRDMLNPDELVVGGQ AFTEYPEAMEQVEAAFAARSVLGPRDIRLTAFGNRVQEAGAGTVSLSGLYADPLSAMRRAGALDARLREV ARDESSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_4665 | - | - | 100% (428) | ROK family protein |
| M. avium 104 | MAV_4510 | - | 6e-06 | 23.46% (260) | sugar kinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0495 | - | 0.0 | 83.29% (419) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0087 | - | 1e-168 | 74.46% (415) | ROK family protein |
| M. tuberculosis H37Rv | Rv0485 | - | 0.0 | 83.29% (419) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4059c | - | 1e-169 | 75.25% (400) | hypothetical protein MAB_4059c |
| M. marinum M | MMAR_0811 | - | 0.0 | 82.04% (412) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_0932 | - | 1e-168 | 77.83% (397) | ROK family protein |
| M. thermoresistible (build 8) | TH_0877 | - | 1e-155 | 70.22% (403) | POSSIBLE TRANSCRIPTIONAL REGULATORY PROTEIN |
| M. ulcerans Agy99 | MUL_4555 | - | 0.0 | 81.31% (412) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0826 | - | 1e-160 | 72.25% (418) | ROK family protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0087|M.gilvum_PYR-GCK -MSTTTLAPRTRTTSAENAAAKRPAAGGRYPQALLHQIVAPSLCLPEAAA
Mvan_0826|M.vanbaalenii_PYR-1 -MSTSTLAQRPRAASVTRTG---PATGGRYPHALLHHIVAPALRVPEAAA
MSMEG_0932|M.smegmatis_MC2_155 --------------------------------------MAPSLKVPDAAA
TH_0877|M.thermoresistible__bu VARTANTVSTPRTASSLLRPAGVTASRTRRPLVSRQRVVAPSLRVADAAA
Mb0495|M.bovis_AF2122/97 -----------MYSTNRTSQSLSRKPGRKHQLRSHRYVMPPSLHLSDSAA
Rv0485|M.tuberculosis_H37Rv -----------MYSTNRTSQSLSRKPGRKHQLRSHRYVMPPSLHLSDSAA
MMAR_0811|M.marinum_M -------------------------------------MVAPSLHLADSAA
MUL_4555|M.ulcerans_Agy99 -------------------------------------MVAPSLHLADSAA
MAV_4665|M.avium_104 ---------------------MGHAPGPKPHRAVRRQIVPPALHIPESAA
MAB_4059c|M.abscessus_ATCC_199 ------------------------MTAPVRRPVSRHQIHPPALYIGDSAA
.*:* : ::**
Mflv_0087|M.gilvum_PYR-GCK ASVFAAARQRGPIARDVIAQVTGLSIATVNRQVTALLDAGLLRERADLAV
Mvan_0826|M.vanbaalenii_PYR-1 AAVLAAARQRGPIARDVIAQVTGLSIATVNRQVTALLEVGLLRERADLAV
MSMEG_0932|M.smegmatis_MC2_155 ASVFNAVRLRGPIARDVIAQHTSLSIATVNRQVTALLEAGVLRERADLAV
TH_0877|M.thermoresistible__bu ASVFEAARLRGPIARDAIAKATGLSIATVNRQVIALLEAGLLRERPDLAV
Mb0495|M.bovis_AF2122/97 ASVFRAVRLRGPVGRDVIAGSTSLSIATVNRQVIALLEAGLLRERADLAV
Rv0485|M.tuberculosis_H37Rv ASVFRAVRLRGPVGRDVIAGSTSLSIATVNRQVIALLEAGLLRERADLAV
MMAR_0811|M.marinum_M ASVFRAVRLRGPVGRDVIATTTSLSIATVNRQVIALLDAGLLRERADLAV
MUL_4555|M.ulcerans_Agy99 ASVFRAVRLRGPVGRDVIATTTSLSIATVNRQVIALLDAGLLWERADLAV
MAV_4665|M.avium_104 ASVFRAVRLRGPVGRDVIANVTSLSIATVNRQVIALLEAGLLRERADLAV
MAB_4059c|M.abscessus_ATCC_199 SSVFRAARVRGPVARDAIAQVTGLSIATVNRQVTALLDAGLLRERADLAV
::*: *.* ***:.**.** *.********** ***:.*:* **.****
Mflv_0087|M.gilvum_PYR-GCK SGAIGRPRVPVEVNHEPFLTLGIHIGARTTSIVAADLFGRTLDVVETPTP
Mvan_0826|M.vanbaalenii_PYR-1 SGAIGRPRVPVEVNHGPFLTLGIHIGARTTSIVATDLLGRTLDVVETATP
MSMEG_0932|M.smegmatis_MC2_155 SGAIGRPRVPVEVNHEPYLTLGVHIGAKTTAIVATDLLGRTLDVVETPTP
TH_0877|M.thermoresistible__bu SGAIGRPRVPVEVDHDPYLTLGIHIGARTTSIAATDLFGRTLDVVETPTP
Mb0495|M.bovis_AF2122/97 SGAIGRPRVPVEVNHEPFVTLGIHIGARTTSIVATDLFGRTLDTVETPTP
Rv0485|M.tuberculosis_H37Rv SGAIGRPRVPVEVNHEPFVTLGIHIGARTTSIVATDLFGRTLDTVETPTP
MMAR_0811|M.marinum_M SGAIGRPRVPVEVNHEPFVTLGLHIGARTTSIVATDLLGRTLDTVETATP
MUL_4555|M.ulcerans_Agy99 SGAIGRPRVPVEVNHEPFVTLGLHIGARTTSIVATDLLGRTLDTVETATP
MAV_4665|M.avium_104 SGAIGRPRVPVEVNHEPFVTLGIHIGARTTSIVATDLFGRTLDTVETPTP
MAB_4059c|M.abscessus_ATCC_199 SGAIGRPRVPVELNHEPFLTLGIHIGARATSIVATDLFGRTLDVVETPTP
************::* *::***:****::*:*.*:**:*****.***.**
Mflv_0087|M.gilvum_PYR-GCK RGPQAVALTAIAGSASRYLSR--------WHRRRPLWVGVATGGVVDSAT
Mvan_0826|M.vanbaalenii_PYR-1 RGPQAAALAAVAGSARRYLSRPPRAGGAPRRRRRPLWVGVATGGVVDSAT
MSMEG_0932|M.smegmatis_MC2_155 TGTQAAALATLASSARRYLSR--------WHRRRPLWVGVAAGGVVDSAT
TH_0877|M.thermoresistible__bu RGAQPGAVASLAESARRYLSR--------WHRRRPLWVGVAAGGVFDVTT
Mb0495|M.bovis_AF2122/97 RNAAGAALTSLADSADRYLQR--------WRRRRALWVGVTLGGAVDSAT
Rv0485|M.tuberculosis_H37Rv RNAAGAALTSLADSADRYLQR--------WRRRRALWVGVTLGGAVDSAT
MMAR_0811|M.marinum_M RSSASSALASLADSAGRYLRR--------WHRRRALWVGVAIGGTVDDAS
MUL_4555|M.ulcerans_Agy99 RSSASSALASLADSAGRYLRR--------WHRRRALWVGVAIGGTVDDAS
MAV_4665|M.avium_104 RNPAGPALASLADSARRYLRR--------WHRRRPLWIGVAIGGTVDSAT
MAB_4059c|M.abscessus_ATCC_199 NGPQGAALASLAGSAQRYLAR--------WHRRRPLWVGVATGGVVDGPA
.. *::::* ** *** * :***.**:**: **..* .:
Mflv_0087|M.gilvum_PYR-GCK GYLDHPRLGWADAPVGPVLAETLGLPVSVASHVDAMAGAELLLGVRRRP-
Mvan_0826|M.vanbaalenii_PYR-1 GYVNHPRLGWSDAPVGTVLGEALGLPVSLASHVDAMAGAELLLGVRRQP-
MSMEG_0932|M.smegmatis_MC2_155 GYLDHPRLGWADAPVGPVLAEALGLPVSMASHVDAMAGAELLLSGRRAEN
TH_0877|M.thermoresistible__bu GHLDHPLLGWTDAPVGPVLAETLGLPVSVAPHLDAMAAAELLLGRSRRR-
Mb0495|M.bovis_AF2122/97 GHVDHPRLGWRQAPVGPVLADALGLPVSVASHVDAMAGAELMLGMRRFAP
Rv0485|M.tuberculosis_H37Rv GHVDHPRLGWRQAPVGPVLADALGLPVSVASHVDAMAGAELMLGMRRFAP
MMAR_0811|M.marinum_M GHVDHQRLGWRQAPVGPALADALGLPVSVASHVDAMAGAELLLGTRRLAG
MUL_4555|M.ulcerans_Agy99 GHVDHQRLGWRHAPVGPALADALGLPVSVASHVDAMAGAELLLGTRRLAG
MAV_4665|M.avium_104 GQVDHPRLGWRQAPVGQVLADALGLPVSVASHVDAMAGAELLLGMRRFLP
MAB_4059c|M.abscessus_ATCC_199 GTVDHPRLGWTEAPVGRVFADTLGLPVSVASHVDAMAGAELLLGLRRFAA
* ::* *** .**** .:.::******:*.*:****.***:*. *
Mflv_0087|M.gilvum_PYR-GCK --GKAATGLYVYARETVGYALSIGGRVHSPTSGPGTIASLPVRSELLGGT
Mvan_0826|M.vanbaalenii_PYR-1 --AKSTTSLYVYARETVGYALSIGGQVHSPSSGPGTIAALPAFSELLGGT
MSMEG_0932|M.smegmatis_MC2_155 AGGASRTSLYVYARETVGYALSIDGRVHSPASGPGTIAGLPARSELLGGT
TH_0877|M.thermoresistible__bu ----GTTSLFMYARETVGYALSIAGRVHSPAAGPGTIAALPVNSDLLGGT
Mb0495|M.bovis_AF2122/97 ---SSSTSLYVYARETVGYALMIGGRVHCPASGPGTIAPLPVHSEMLGGT
Rv0485|M.tuberculosis_H37Rv ---SSSTSLYVYARETVGYALMIGGRVHCPASGPGTIAPLPVHSEMLGGT
MMAR_0811|M.marinum_M ---GSSTSLYVYARETVGYALVIDGRVHCPASGPGTIAGLPAHSELLGGT
MUL_4555|M.ulcerans_Agy99 ---GSSTSLYVYARETVGYALVIDGRVHCPASGPGTIAGLPAHSELLGGT
MAV_4665|M.avium_104 ---SSPTSLYVYARETVGYALVIGGRVHVPTSGPGTIATLPAHSELLGGT
MAB_4059c|M.abscessus_ATCC_199 ---RSLTSLYVYARETVGFALAIDGRVHSPSSGPGTIAALPVDSELLGGS
. *.*::*******:** * *:** *::****** **. *::***:
Mflv_0087|M.gilvum_PYR-GCK GQLESTVSDEAVLTAARRAGVVPADG-------PASTVTAVLRAARQGDE
Mvan_0826|M.vanbaalenii_PYR-1 GQLESTVSDEAVLTAARKAGIVAAEG-------PTSTVTAVLRAARQGNA
MSMEG_0932|M.smegmatis_MC2_155 GQLESTVSDEAVLNAARRLRIVPAEG-------PASTLPAVLRAARGGNE
TH_0877|M.thermoresistible__bu GQLETTVSDQAVVTAARRLNVIPPEG-------PASTIAAVLRAAQRGDS
Mb0495|M.bovis_AF2122/97 GQLESTVSDEAVLAAARRLRIIPGIASRTRTGGSATAITDLLRVARAGNQ
Rv0485|M.tuberculosis_H37Rv GQLESTVSDEAVLAAARRLRIIPGIASRTRTGGSATAITDLLRVARAGNQ
MMAR_0811|M.marinum_M GQLESTVSDEAVLAAARRLRIIAATP-QARTNGSVTAMTDLLRVARAGNQ
MUL_4555|M.ulcerans_Agy99 GQLESTVSDEAVLAAARRLRIIAATP-QARTNGSITAMTDLLRVARAGNQ
MAV_4665|M.avium_104 GQLESTVSDEAVVAVARQLRILPFAP-ANRASGSAAGIADLLRVARAGNE
MAB_4059c|M.abscessus_ATCC_199 GKLETTVSDEAVLAAARKLRIVPAGD--------GVSVSAVYKAARGGNE
*:**:****:**: .**: ::. :. : :.*: *:
Mflv_0087|M.gilvum_PYR-GCK HAVALIAERARVLGEAVALLRDMLNPDDLVVGGQAFTEYPEGMSIVEEAF
Mvan_0826|M.vanbaalenii_PYR-1 AAAALVAERARVLGEAVALLRDMLNPDDLVVGGQAFTEYPEGMPLVESAF
MSMEG_0932|M.smegmatis_MC2_155 KAVELLADRARVLGEAVALLRDMLNPDELVVGGQAFTEYPEGMEAVEAAF
TH_0877|M.thermoresistible__bu TARELLDERARVLGESLALLRDMLNPDEVVVGGQAFTDYPAGMETLTAAF
Mb0495|M.bovis_AF2122/97 QAKELLAERARVLGGAVALLRDLLNPDEVVVGGQAFTEYPEAMEQVEAAF
Rv0485|M.tuberculosis_H37Rv QAKELLAERARVLGGAVALLRDLLNPDEVVVGGQAFTEYPEAMEQVEAAF
MMAR_0811|M.marinum_M QARELLAERARVLGETVALLRDVLNPDELVVGGQAFTEYPEGMRQVEEAF
MUL_4555|M.ulcerans_Agy99 QARELLAERARVLGETVALLRDVLNPDELVVGGQAFTEYPEGMRQVKEAF
MAV_4665|M.avium_104 QARELLAERGRVLGEAVALLRDMLNPDELVVGGQAFTEYPEAMEQVEAAF
MAB_4059c|M.abscessus_ATCC_199 SARELLSERGRVLGQSVALLRDILNPDEVIVGGQAFTEYPEVMNDVETAF
* *: :*.**** ::*****:****:::*******:** * : **
Mflv_0087|M.gilvum_PYR-GCK NERSALGHRDIRLTAFGNRVQEAGAGIVSLGGLYADPIAAMRRALARNER
Mvan_0826|M.vanbaalenii_PYR-1 AARSVLPHRDIRVTAFGNRIQEAGAGIVSLGGLYADPIGAMRR--ARRPQ
MSMEG_0932|M.smegmatis_MC2_155 AERSMLGPRDIRLTAFGNRVQEAGAGVVSLGGLYADPIGAMRR--AQTRR
TH_0877|M.thermoresistible__bu TTRSVLPPLEIRTTAFGNRVQEAGAGVVSLGSLYADPIGAMRRALDAPRT
Mb0495|M.bovis_AF2122/97 TAGSVLAPRDIRVTVFGNRVQEAGAGIVSLSGLYADPLGALRRSGALDAR
Rv0485|M.tuberculosis_H37Rv TAGSVLAPRDIRVTVFGNRVQEAGAGIVSLSGLYADPLGALRRSGALDAR
MMAR_0811|M.marinum_M TARSVLAPRDIRVTSFGNRVQEAGAGIVSLGGLYADPRGAMRRSGALNTR
MUL_4555|M.ulcerans_Agy99 TARSVLAPRDIRVTSFGNRVQEAGAGIVSLGGLYADPRGAMRRSGALNTR
MAV_4665|M.avium_104 AARSVLGPRDIRLTAFGNRVQEAGAGTVSLSGLYADPLSAMRRAGALDAR
MAB_4059c|M.abscessus_ATCC_199 LDRSTLSKRDIRVTAFGNRVQEAGAGVVSLGGLFADPLGAMRRASARRGE
* * :** * ****:****** ***..*:*** .*:**
Mflv_0087|M.gilvum_PYR-GCK LGSASPAAV---
Mvan_0826|M.vanbaalenii_PYR-1 VSA---------
MSMEG_0932|M.smegmatis_MC2_155 AAAV--------
TH_0877|M.thermoresistible__bu SARVLTGQHATG
Mb0495|M.bovis_AF2122/97 LQDTAPEALA--
Rv0485|M.tuberculosis_H37Rv LQDTAPEALA--
MMAR_0811|M.marinum_M LRQAEPEASA--
MUL_4555|M.ulcerans_Agy99 LRQAEPEASA--
MAV_4665|M.avium_104 LREVARDESSA-
MAB_4059c|M.abscessus_ATCC_199 ASALA-------