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M. tuberculosis H37Rv Rv0131c (fadE1)

annotation: PROBABLE ACYL-CoA DEHYDROGENASE FADE1
coordinates: 158315 - 159658
length: 447

PVRRRAGERLPTVWDFETDPQYQSKLDWVEKFMAEELEPLDLVALDPYDKKNADTMAILRPLQRQVKDQG
LWAAHLRPELGGQGFGQVKLALLNEIIGRSRWAPSAFGCQAPDSGNAEILALFGTDEQKARYLRPLLDGE
ITSCYSMTEPQGGSDPGLFVTAATRDAAGNGDWIINGEKWFSTNAKHASFFIVMAVTKPEARTYEKMSLF
IVPADTPGIEIVRNVGVGAESTRHASHGYIRYHDVRVPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIA
LARRAFDMMCERALSRQTRHGRLADLQMTQEKIADSWIQIEQFRLLVLRTAWLIDKHHDYQKVRRDIAAV
KVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMLAAESLGIADGATELHKMTVARRTLREYQPVTTLFP
SQHIPTRRAHAEAWLAQRLEHAIAEF*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. tuberculosis H37RvRv0131cfadE1-100% (447)PROBABLE ACYL-CoA DEHYDROGENASE FADE1
M. tuberculosis H37RvRv0154cfadE29e-7142.70% (356) acyl-CoA dehydrogenase FADE2
M. tuberculosis H37RvRv0752cfadE91e-2829.06% (351) acyl-CoA dehydrogenase FADE9

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0136cfadE10.0100.00% (447) acyl-CoA dehydrogenase FADE1
M. gilvum PYR-GCKMflv_2451-1e-15059.08% (435) acyl-CoA dehydrogenase domain-containing protein
M. leprae Br4923MLBr_00737fadE253e-2325.87% (344) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977MAB_4911c-1e-16162.09% (430) acyl-CoA dehydrogenase FadE
M. marinum MMMAR_0331fadE10.090.55% (434) acyl-CoA dehydrogenase FadE1
M. avium 104MAV_5173-0.090.57% (435) putative acyl-CoA dehydrogenase
M. smegmatis MC2 155MSMEG_4826-1e-15461.72% (431) putative acyl-CoA dehydrogenase
M. thermoresistible (build 8)TH_2939-1e-15360.65% (432) PUTATIVE acyl-CoA dehydrogenase domain protein
M. ulcerans Agy99MUL_4790fadE10.089.63% (434) acyl-CoA dehydrogenase FadE1
M. vanbaalenii PYR-1Mvan_4200-1e-15159.26% (432) acyl-CoA dehydrogenase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_2451|M.gilvum_PYR-GCK          -------------MWSFETDPEYQKV-LDWADEFVREEVEPLDLAFPHQQ
Mvan_4200|M.vanbaalenii_PYR-1       -------------MWSFETDPEYQKV-LDWADEFVREEVEPLDLAFPHQQ
TH_2939|M.thermoresistible__bu      ------------MAWDFETDPEYQKV-LDWADEFVRTEVEPLDLAFPHQQ
MSMEG_4826|M.smegmatis_MC2_155      ------------MAWDFETDPQYQEV-LDWADEFVREKVEPLDLVWPHLQ
Rv0131c|M.tuberculosis_H37Rv        MPVRRRAGERLPTVWDFETDPQYQSK-LDWVEKFMAEELEPLDLVALDP-
Mb0136c|M.bovis_AF2122/97           MPVRRRAGERLPTVWDFETDPQYQSK-LDWVEKFMAEELEPLDLVALDP-
MMAR_0331|M.marinum_M               -------------MWDFETDPEYQAK-LDWVQEFMVNELEPLDLVALDP-
MUL_4790|M.ulcerans_Agy99           -------------MWDFETDPEYQAK-LDWVQEFMVNELEPLDLVALDP-
MAV_5173|M.avium_104                -------------MWDFETDPEYQAK-LDWVEKFMAEELEPLDLVALDP-
MAB_4911c|M.abscessus_ATCC_199      ---------MTAMAWDFETDPEYQEL-LDWADEFVRTEVEPLDYVFPNP-
MLBr_00737|M.leprae_Br4923          -------------MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAP-
                                                   .:. :* ::   *   .: :   :..*        

Mflv_2451|M.gilvum_PYR-GCK          FVPLDGKRREAIDPLKEEVRRRGLWATHLGADLGGQGYGQLKLALLNEIL
Mvan_4200|M.vanbaalenii_PYR-1       FVPLDGERRRAIDPLKEEVRRRGLWATHLGADLGGQGYGQLKLALLNEIL
TH_2939|M.thermoresistible__bu      FVPLEGTRREAIEPLKQEVRRRGLWATHLGPELGGQGYGQLKLALLNEIL
MSMEG_4826|M.smegmatis_MC2_155      FTPLNEARRQVVDPLKEQVRRKGLWATHLGPELGGQGYGQLKLALLNEIL
Rv0131c|M.tuberculosis_H37Rv        YDKKNADTMAILRPLQRQVKDQGLWAAHLRPELGGQGFGQVKLALLNEII
Mb0136c|M.bovis_AF2122/97           YDKKNADTMAILRPLQRQVKDQGLWAAHLRPELGGQGFGQVKLALLNEII
MMAR_0331|M.marinum_M               YDKKNPEMMAVLRPLQQQVKDQGLWAAHLRPELGGQGFGQVKLALLNEIL
MUL_4790|M.ulcerans_Agy99           YDKKNPEMMAVLRPLQQ-VKNQGLWAAHLRPEVGGQGFGQVKLALLNEIL
MAV_5173|M.avium_104                YDKKNAEMMAILRPLQQQVKDQGLWAAHLRPELGGQGFGQVKLALLNEIL
MAB_4911c|M.abscessus_ATCC_199      YDKSDTVAMDYVRPLKEEVKRRGLWACHLGPELGGPGYGQLKLALLNEIL
MLBr_00737|M.leprae_Br4923          HAADVDQRARFPEEALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEV
                                    .                 :.  *: * *:  : ** * ..:  .:: * :

Mflv_2451|M.gilvum_PYR-GCK          GRSQWAPIIFGCQAPDTGNAEIIAHYGTEEQKQRYLRPLLDGELFSCYSM
Mvan_4200|M.vanbaalenii_PYR-1       GRSQWAPVIFGCQAPDTGNAEIIAHYGTEEQKQKYLRPLLDGELFSCYSM
TH_2939|M.thermoresistible__bu      GRSQWAPVVFGCQAPDTGNAEIIAHYGTEEQQKRYLQPLLDGELFSCYSM
MSMEG_4826|M.smegmatis_MC2_155      GRSQWAPIVFGCQAPDTGNAEIIAHYGTDEQKERYLRPLLEGELFSSYSM
Rv0131c|M.tuberculosis_H37Rv        GRSRWAPSAFGCQAPDSGNAEILALFGTDEQKARYLRPLLDGEITSCYSM
Mb0136c|M.bovis_AF2122/97           GRSRWAPSAFGCQAPDSGNAEILALFGTDEQKARYLRPLLDGEITSCYSM
MMAR_0331|M.marinum_M               GRSRWAPSVFGCQAPDSGNAEILALFGTEDQKARYLQPLLDGEITSCYSM
MUL_4790|M.ulcerans_Agy99           GRSRWAPSVFGCQAPDSGNAEILALFGTEDQKARYLQPLLDGEITSCYSM
MAV_5173|M.avium_104                GRSRWAPSVFGCQAPDSGNAEILALFGTDEQKARYLQPLLDGEITSCYSM
MAB_4911c|M.abscessus_ATCC_199      GRSVWAPSIFGCQAPDTGNAEILAHYGTEAQKAKYLQPLMDGDIGSCYVM
MLBr_00737|M.leprae_Br4923          ARVDASASLIPAVN-KLGTMGLILR-GSEELKKQVLPSLAAEGAMASYAL
                                    .*   :.  : .   . *.  ::   *::  : : * .*      :.* :

Mflv_2451|M.gilvum_PYR-GCK          TEPHAGADPTMFTTSAVRDGD----DWVINGWKFFSSNAATASFLIVMVV
Mvan_4200|M.vanbaalenii_PYR-1       TEPHAGADPTMFTTSAVRDGD----DWVINGWKFFSSNAATASFLIVMVV
TH_2939|M.thermoresistible__bu      TEPHAGADPTLFKTTAVRDGAGPDADWVINGWKFFSSNATTASFLIVMAV
MSMEG_4826|M.smegmatis_MC2_155      TEPHAGADPTLFTTRAVRDGD----DWVINGWKFFSSNAATASFLIVMVV
Rv0131c|M.tuberculosis_H37Rv        TEPQGGSDPGLFVTAATRDAAG-NGDWIINGEKWFSTNAKHASFFIVMAV
Mb0136c|M.bovis_AF2122/97           TEPQGGSDPGLFVTAATRDAAG-NGDWIINGEKWFSTNAKHASFFIVMAV
MMAR_0331|M.marinum_M               TEPQGGSDPGSFVTAATRDGD----SWIINGEKWFSTNAKHASFFIVMAV
MUL_4790|M.ulcerans_Agy99           TEPQGGSDPGSFVTAATRDGD----SWIINGEKWFSTNAKHASFFIVMAV
MAV_5173|M.avium_104                TEPQGGSDPGQFVTAATRDGD----YWVINGEKWFSTNAKHASFFIVMAV
MAB_4911c|M.abscessus_ATCC_199      TEPQGGSDPTLFKTTAVRDGD----EWILNGEKWFNSEARHAAFWIVMAV
MLBr_00737|M.leprae_Br4923          SEREAGSDAASMRTRAKADGD----DWILNGFKCWITNGGKSTWYTVMAV
                                    :* ..*:*.  : * *  *.      *::** * : ::.  :::  **.*

Mflv_2451|M.gilvum_PYR-GCK          TNPDVSAYQGMSMFLVPTDTPGVTIERNVGLYGEREGEGSHALIHYDNVR
Mvan_4200|M.vanbaalenii_PYR-1       TNREVSAYQGMSMFLVPTDTPGVKIERNIGLYGEGAEHGSHALIHYDNVR
TH_2939|M.thermoresistible__bu      TNPDVSAYQGMSMFLVPTDTPGVKIERSIGLYGDPPGTGSHALIHYDNVR
MSMEG_4826|M.smegmatis_MC2_155      TNPDVSAYQGMSMFLVPTDTPGVEIVRNVGLYGERDNEGSHALIHYDNVR
Rv0131c|M.tuberculosis_H37Rv        TKPEARTYEKMSLFIVPADTPGIEIVRNVGVGAESTRHASHGYIRYHDVR
Mb0136c|M.bovis_AF2122/97           TKPEARTYEKMSLFIVPADTPGIEIVRNVGVGAESTRHASHGYIRYHDVR
MMAR_0331|M.marinum_M               TNPQARTYEKMSLFIVPAETPGIEIVRNVGVGTESSKHASHGYVRYHDVR
MUL_4790|M.ulcerans_Agy99           TNPQARTYEKMSLFIVPAETPGIEIVRNVGVGTESSKHASHGYVRYHDVR
MAV_5173|M.avium_104                TNPEARTYDKMSLFIVPAETPGIEIVRNVGVGAESSSRASHGYVGYTDVR
MAB_4911c|M.abscessus_ATCC_199      TNTEVSPYQGMSMFIVDPNAPGVEIVRNITVHGFS---EDEAYTRFTNAR
MLBr_00737|M.leprae_Br4923          TDPDK-GANGISAFIVHKDDEGFSIGPKE--KKLGIKGSPTTELYFDKCR
                                    *. :    : :* *:*  :  *. *  .                 : . *

Mflv_2451|M.gilvum_PYR-GCK          VPSEALLGGEGQAFAIAQTRLGGGRIHHAMRTIGLSRKALDMMCERALSR
Mvan_4200|M.vanbaalenii_PYR-1       VPAEALLGGEGQAFVIAQTRLGGGRIHHAMRTIGLSRKALDMMCERALSR
TH_2939|M.thermoresistible__bu      VPADALLGGEGQAFAIAQTRLGGGRIHHAMRTIGLARKALDMMCERALSR
MSMEG_4826|M.smegmatis_MC2_155      VPAEALLGGEGQAFVIAQTRLGGGRIHHAMRTIGLARKALDMMCERALSR
Rv0131c|M.tuberculosis_H37Rv        VPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIALARRAFDMMCERALSR
Mb0136c|M.bovis_AF2122/97           VPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIALARRAFDMMCERALSR
MMAR_0331|M.marinum_M               VPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIALARRAFDMMCERAVSR
MUL_4790|M.ulcerans_Agy99           VPADHVLGGEGQAFMTAQTRLGGGRIHHAMRTIALARRAFDMMCERAVSR
MAV_5173|M.avium_104                VPADHVLGGEGQAFMIAQTRLGGGRIHHAMRTIALARSAFDMMCERAVSR
MAB_4911c|M.abscessus_ATCC_199      IPAENMLGAEGGAFAIAQTRLGGGRVHHAMRTVAQVRKAFDMMCERVVSR
MLBr_00737|M.leprae_Br4923          IPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDR
                                    :*.: ::*  * .*  * : *.  *   . :::.  : *:*     . .*

Mflv_2451|M.gilvum_PYR-GCK          ETQGSRLSDKQFVQGYIADSYAQLLQFRLMVLYTAWEIDKYNDYKKVRKD
Mvan_4200|M.vanbaalenii_PYR-1       ETQGSRLSDKQFVQGYIADSYAQLLQFRLMVLYTAWEIDKYNDYKKVRKD
TH_2939|M.thermoresistible__bu      QTQGSRLSDKQFVQGYIADSYAQLLQFRLMVLYTAWEIDKYNDYKKVRKD
MSMEG_4826|M.smegmatis_MC2_155      KTQGSRLSDKQFVQGYIADSYAQLLQFRLMVLYTAWEIDKYNDYKLVRKD
Rv0131c|M.tuberculosis_H37Rv        QTRHGRLADLQMTQEKIADSWIQIEQFRLLVLRTAWLIDKHHDYQKVRRD
Mb0136c|M.bovis_AF2122/97           QTRHGRLADLQMTQEKIADSWIQIEQFRLLVLRTAWLIDKHHDYQKVRRD
MMAR_0331|M.marinum_M               QTRHGRLSDLQMTQEKVADSWIQIEQFRLLVLRTAWLIDKHHDYQKVRRD
MUL_4790|M.ulcerans_Agy99           QTRHGRLSDLQMTQEKVADSWIQIEQFRLLVLRTAWLIDKHHDYQKVRRD
MAV_5173|M.avium_104                KTRHGRLADFQMTQEKIADSWIQIEQFRLLVLRTAWLIDKHHDYQKVRRD
MAB_4911c|M.abscessus_ATCC_199      EARGGTIAKLQMTQERIADSWIEMESFRLLVLRTAWLIDKHQDYLKVRKD
MLBr_00737|M.leprae_Br4923          KQFGESISTFQSIQFMLADMAMKVEAARLIVYAAAARAERGEPDLGFIS-
                                    :     ::  *  *  :**   ::   **:*  :*   :: .    .   

Mflv_2451|M.gilvum_PYR-GCK          IAAVKVVMPTVLHDIAWRAMQVHGALGVTNEVPFLGMVTGAAVMGLADGP
Mvan_4200|M.vanbaalenii_PYR-1       IAAVKVVMPTVLHDIAWRAMQVHGALGVTNEVPFLGMVTGAAVMGLADGP
TH_2939|M.thermoresistible__bu      IAAVKATMPTVLHDIAWRAMQVHGALGVTDEMPFMGMITGAAVMGLADGP
MSMEG_4826|M.smegmatis_MC2_155      IAAVKVVMPTVLHDIAWRAMQVHGALGVTNEMPFLGMVTGAAVMGLADGP
Rv0131c|M.tuberculosis_H37Rv        IAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMLAAESLGIADGA
Mb0136c|M.bovis_AF2122/97           IAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMLAAESLGIADGA
MMAR_0331|M.marinum_M               IAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMVAAESLGIADGA
MUL_4790|M.ulcerans_Agy99           IAAVKVAMPQVLHDVVQRAMHLHGALGVSDEMPFVKMMVAAESLGIADGA
MAV_5173|M.avium_104                IAAVKVAMPQVLHDVAQRALHLHGALGVSDEMPFVKMLVAAESLGIADGA
MAB_4911c|M.abscessus_ATCC_199      ISAIKAAMPKVMHDVAQRALHLHGSLGVSEEMPLAKMFLYSEVMGLVDGP
MLBr_00737|M.leprae_Br4923          -AASKCFASDIAMEVTTDAVQLFGGAGYTSDFPVERFMRDAKITQIYEGT
                                     :* *   . :  ::.  *:::.*. * :.:.*.  :.  :    : :*.

Mflv_2451|M.gilvum_PYR-GCK          TEVHKTTVAKQVLRDHRPAEGMWPSEWIPAKREAAQAKYADFIEHEVGNL
Mvan_4200|M.vanbaalenii_PYR-1       TEVHKTTVAKQVLRDYRPAEGLWPSEWIPAKREAARAKYAEYLENEVGNL
TH_2939|M.thermoresistible__bu      TEVHKATVAKQVLRDYRPSDDVWPSEWIPRKREAALAKYAEYLEHEVGNL
MSMEG_4826|M.smegmatis_MC2_155      TEVHKTTVAKQVLRDYQPTEDTWPTEWIPRKREAARAKLADYLENEVGNL
Rv0131c|M.tuberculosis_H37Rv        TELHKMTVARRTLREYQPVTTLFPSQHIPTRRAHAEAWLAQRLEHAIAEF
Mb0136c|M.bovis_AF2122/97           TELHKMTVARRTLREYQPVTTLFPSQHIPTRRAHAEAWLAQRLEHAIAEF
MMAR_0331|M.marinum_M               TELHKMTVARRTLRQYEPVTTPFPSQHIPTRRAAAEARLAERLEHSIAEF
MUL_4790|M.ulcerans_Agy99           TELHKMTVARRTLRQYEPVATPFPSQHIPTRRAAAEARLAERLEHSIAEF
MAV_5173|M.avium_104                TELHKMTVARRTLREYEPVSTPFPSAHIPTRRAEAQARLAERLEHAVAEF
MAB_4911c|M.abscessus_ATCC_199      TEVHKVTIAKEVLKDYTPYEGLFPPSHIPALTEKARAHVAARLEHRVGNL
MLBr_00737|M.leprae_Br4923          NQIQRVVMSRALLR------------------------------------
                                    .:::: .:::  *: