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MTISILRTADAWWVQTATGAVKVNTDATTTRELLADRAAIDAAASSSDAVPVEGLNLLSPVTAPCRVVAQ MTNFASHVKDAGMDPNTIPLTFFRKASGSITGPFDDIVKPDHVRFLDYEVEIGLVIGRELPVGAAVSEAN LADYTAGAVVTNDVSARDIQLPKTQFYESKSYPTFTPVGPALVLLDADELKRFGDLRLQLRVNGQVRQDM RVDGDMIYPPVQALQALARFQRLDPGDLVLTGTPVGTALSAPPKPVQIIASLLPPAVKWKAFFNAQAKNP KYLRDGDVVETAIATDDGAIDLGTQRNVVRFAK
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1803 | - | - | 100% (313) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. avium 104 | MAV_3844 | - | 3e-22 | 35.11% (225) | 5-carboxymethyl-2-hydroxymuconate delta-isomerase |
| M. avium 104 | MAV_1057 | - | 4e-09 | 25.69% (288) | fumarylacetoacetate hydrolase family protein, putative |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3017c | - | 1e-21 | 35.56% (225) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. gilvum PYR-GCK | Mflv_4230 | - | 7e-21 | 35.03% (197) | 5-carboxymethyl-2-hydroxymuconate Delta-isomerase |
| M. tuberculosis H37Rv | Rv2993c | - | 1e-21 | 35.56% (225) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. leprae Br4923 | MLBr_01689 | - | 1e-18 | 34.34% (198) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_2575c | - | 1e-134 | 73.72% (312) | putative fumarylacetoacetate (FAA) hydrolase |
| M. marinum M | MMAR_2986 | - | 1e-135 | 74.04% (312) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. smegmatis MC2 155 | MSMEG_2007 | - | 5e-23 | 35.35% (198) | putative HpcE protein |
| M. thermoresistible (build 8) | TH_3311 | - | 9e-26 | 36.57% (216) | PUTATIVE putative HpcE protein |
| M. ulcerans Agy99 | MUL_1956 | - | 2e-20 | 35.68% (199) | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase |
| M. vanbaalenii PYR-1 | Mvan_4907 | - | 1e-138 | 76.28% (312) | fumarylacetoacetate (FAA) hydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3017c|M.bovis_AF2122/97 ---------------------------MTAREIAEHP-------------
Rv2993c|M.tuberculosis_H37Rv ---------------------------MTAREIAEHP-------------
MUL_1956|M.ulcerans_Agy99 ---------------------------MTAREIAEDP-------------
MLBr_01689|M.leprae_Br4923 ---------------------------MFARELAEYP-------------
Mflv_4230|M.gilvum_PYR-GCK -MRLGRIASPDGVAFVAVEGPPDDPAAAVAREIAEHP-------------
MSMEG_2007|M.smegmatis_MC2_155 ----MRLINLDGRIHLVTGDGVVDVAKASEQRFGPDPQDLYQHWDAFQEW
TH_3311|M.thermoresistible__bu ----MRLINQGGRLKIDVDGLAADVEKTSDYRFSADPQEIYARWEEFTAW
MMAR_2986|M.marinum_M MTISVLHTADGWWVKTASGAAQVATAAVTTAELLTDR----------AAI
Mvan_4907|M.vanbaalenii_PYR-1 MTLSVLRTADAWWVHTPAGAARIDTKATTTAQLLADR----------AAV
MAV_1803|M.avium_104 MTISILRTADAWWVQTATGAVKVNTDATTTRELLADR----------AAI
MAB_2575c|M.abscessus_ATCC_199 MTIAILRTADAWWVHTATGAVRIDSSATTTGGLLSDR----------AAI
:
Mb3017c|M.bovis_AF2122/97 FGTPTFTGRSWPLADVRLLAPILASKVVCVGKNYADHIAEMGGRP---PA
Rv2993c|M.tuberculosis_H37Rv FGTPTFTGRSWPLADVRLLAPILASKVVCVGKNYADHIAEMGGRP---PA
MUL_1956|M.ulcerans_Agy99 FGTPNFTGRSWPLADVRLLAPILASKVVCVGKNYTGHIAEMGGQTGPTPA
MLBr_01689|M.leprae_Br4923 FGELTFTGRSWPLADVRLLAPMLASKVVCIGKNYADHIVEMGGQTGLASA
Mflv_4230|M.gilvum_PYR-GCK FGTPTFTGRQWPLADVRLLAPILASKVVCMGKNYAAHIEEMGGGT---FE
MSMEG_2007|M.smegmatis_MC2_155 ARTAALPAPSARVG-TIGSPAPLPRQVFAVGLNYDDHATESGLSK---PE
TH_3311|M.thermoresistible__bu ASAADLSGGDPIVEAELGPPVPRPAQVFAIGINYRDHMDEAGLSE---PE
MMAR_2986|M.marinum_M DLAANSGDRTPIDGLQLISPVTRPCRVVAQMTNFESHVKDAGMDP--TAV
Mvan_4907|M.vanbaalenii_PYR-1 EEAASSTPTAAVSELNLLSPVTAPCRVVAQMTNFESHVKDAGMDP--KTV
MAV_1803|M.avium_104 DAAASSSDAVPVEGLNLLSPVTAPCRVVAQMTNFASHVKDAGMDP--NTI
MAB_2575c|M.abscessus_ATCC_199 AAATRGGDAVPIDALELLSPVTAPCRVVAQMTNFASHVKDAGMDP--KTI
. . :*.. *: * : *
Mb3017c|M.bovis_AF2122/97 DPVIFLKPNTAIIGPNTPIRLPANASPVHFEGELAIVIGRACKD---VPA
Rv2993c|M.tuberculosis_H37Rv DPVIFLKPNTAIIGPNTPIRLPANASPVHFEGELAIVIGRACKD---VPA
MUL_1956|M.ulcerans_Agy99 DPVIFLKSNTAIVGPNVPIRLPANASPVHFEGELAIVIGRPCKD---VSA
MLBr_01689|M.leprae_Br4923 DPVIFLKPNTAIIGPNVPIRLPANASPVHFEGELALVVGRSCKD---VPA
Mflv_4230|M.gilvum_PYR-GCK DPIIFLKPNTAIIGPYTPIQLPADADPVHFEGELAAVIGRPCKD---VPA
MSMEG_2007|M.smegmatis_MC2_155 HPVIFTKFVSSITGPVETVQLPA--GSVDWEVELVVVMGRGGRN---IPE
TH_3311|M.thermoresistible__bu APFVFTKFPAAITGPYDVIELPD--GSVDWEVELVAVIGRRAHR---VSE
MMAR_2986|M.marinum_M PLTFFRKASASITGPFDDIVKPAHVQLLDYEVEIGLVIGRAIPLGTNLSD
Mvan_4907|M.vanbaalenii_PYR-1 PLTFFRKSSASISGPFDDIVRPSHVRLLDYEVEIGLVIGRDIPVGTTLTD
MAV_1803|M.avium_104 PLTFFRKASGSITGPFDDIVKPDHVRFLDYEVEIGLVIGRELPVGAAVSE
MAB_2575c|M.abscessus_ATCC_199 PLTFFRKSSSSISGPFDDIVKPAHVQYLDYEVEIGIVIGQTIEVGSVITR
.* * :* ** : * :.:* *: *:*: :.
Mb3017c|M.bovis_AF2122/97 AQAVDNILGYTIGNDVSARDQQQS---DGQWTRAKGHDTFCPVGP--WIV
Rv2993c|M.tuberculosis_H37Rv AQAVDNILGYTIGNDVSARDQQQS---DGQWTRAKGHDTFCPVGP--WIV
MUL_1956|M.ulcerans_Agy99 AQAVDNILGYTIGNDVSARDQQKS---DGQWTRAKGHDTFCPVGP--WIV
MLBr_01689|M.leprae_Br4923 VQAVDCILGYTIGNDMSARDQQRA---DGQWTRAKGHDTFCPVGP--WIV
Mflv_4230|M.gilvum_PYR-GCK SRAAENILGYTIANDVSARDQQKK---DGQWMRAKGHDTFCPVGP--WIV
MSMEG_2007|M.smegmatis_MC2_155 DRAWEFVAGVSVGQDLSERDLQLAGPAP-QFSLAKSHAGFSPIGP--ELV
TH_3311|M.thermoresistible__bu RDGWNYVAGLTVGQDLSERELQLSGPPPQQFNLGKSYTGFAPIGP--AVV
MMAR_2986|M.marinum_M ANLADFIAGLVVANDVSARDIQLP---QTQFYEAKSYPTFTPIGPQLVLL
Mvan_4907|M.vanbaalenii_PYR-1 ANLADYVAALAITNDVSARDIQLP---QTQFYEAKSYPTFTPVGPALVLV
MAV_1803|M.avium_104 ANLADYTAGAVVTNDVSARDIQLP---KTQFYESKSYPTFTPVGPALVLL
MAB_2575c|M.abscessus_ATCC_199 DNLADYITAWVVTNDVSARDVQLT---KTQFYEAKSYPTFTPVGPSLVLI
: . : :*:* *: * *: .*.: * *:** ::
Mb3017c|M.bovis_AF2122/97 TDLAPFDPADLELRTVVNGDVKQHARTS-LMIHDIGAIVEWISAIMTLLP
Rv2993c|M.tuberculosis_H37Rv TDLAPFDPADLELRTVVNGDVKQHARTS-LMIHDIGAIVEWISAIMTLLP
MUL_1956|M.ulcerans_Agy99 TDV---DPAGLELRTEVNGAVKQHARTS-LMIHDVGAIVEWISAVMTLLP
MLBr_01689|M.leprae_Br4923 TDLGPLDPADLELRTAVNGEVKQHSRTS-LMIHGIGAIMEWISAVMTLLP
Mflv_4230|M.gilvum_PYR-GCK TDI---DPSDLEIRTEVNGELKQHSRTS-LMIHDIGAIIEWISSVMTLLP
MSMEG_2007|M.smegmatis_MC2_155 TVDELPDPDDLELGAEINGETVQHSRTS-QLIFPVSNLIAYLSDTVELYP
TH_3311|M.thermoresistible__bu TLDEFADPADVEISTTLSGELMQLARTR-DVFFSVPQLVAYLSQILPLLP
MMAR_2986|M.marinum_M DADELRRFGELRLRLSVNGDERQNSLVEGDMLYRPLQALQSLNQFQELAP
Mvan_4907|M.vanbaalenii_PYR-1 NAEELARFGDLRLRLRVNGDERQNALVEGDMLYRPLQALQSLARFQDLAA
MAV_1803|M.avium_104 DADELKRFGDLRLQLRVNGQVRQDMRVDGDMIYPPVQALQALARFQRLDP
MAB_2575c|M.abscessus_ATCC_199 DPAELQRFNELRLQLKVNGQLRQNMLVGADMIFSPLQALQALTRFQRLDA
:.: :.* * . ::. : : * .
Mb3017c|M.bovis_AF2122/97 GDLILTGTPAGVGP-----------------------IEDGDTVSITIEG
Rv2993c|M.tuberculosis_H37Rv GDLILTGTPAGVGP-----------------------IEDGDTVSITIEG
MUL_1956|M.ulcerans_Agy99 GDLILTGTPAGVGP-----------------------IEDGDTVSITIEG
MLBr_01689|M.leprae_Br4923 GDLILTGTPAGVGP-----------------------VEDGDIVSITVEG
Mflv_4230|M.gilvum_PYR-GCK GDLILTGTPEGVGP-----------------------LEHGDTVSITVEG
MSMEG_2007|M.smegmatis_MC2_155 GDVIFTGTPSGVGMGRNPK----------------RFLAPGDELRTYITG
TH_3311|M.thermoresistible__bu GDLIFTGTPSGIGWARTPK----------------RFIDSDDELVTRAEG
MMAR_2986|M.marinum_M GDLVLTGTPVGTALSAPPKPVEIIGNLLPPALKWKAFFKRQASNPKYLQD
Mvan_4907|M.vanbaalenii_PYR-1 GDLVLTGTPVGTALSAPPKPIEIIGNLLPPAVKWKAFFARQAKNPKYLRH
MAV_1803|M.avium_104 GDLVLTGTPVGTALSAPPKPVQIIASLLPPAVKWKAFFNAQAKNPKYLRD
MAB_2575c|M.abscessus_ATCC_199 GDLLLTGTPVGTALSAPPKPVEKIGALLPPALKWRLFFASQGKNPKYLHD
**:::**** * . .
Mb3017c|M.bovis_AF2122/97 IGTLTNPVVRKGKP--------------
Rv2993c|M.tuberculosis_H37Rv IGTLTNPVVRKGKP--------------
MUL_1956|M.ulcerans_Agy99 IDTLTNPVVRKGKS--------------
MLBr_01689|M.leprae_Br4923 IGTLTNPVVRKGKS--------------
Mflv_4230|M.gilvum_PYR-GCK IGTLSNPVVRKGKS--------------
MSMEG_2007|M.smegmatis_MC2_155 VGEFTQRFVTAD-SASVAPRS-------
TH_3311|M.thermoresistible__bu IGEMRHRFTRADRSVAKGNRING-----
MMAR_2986|M.marinum_M GDIVEASVRTDDGLIDLGTQHTAVRYA-
Mvan_4907|M.vanbaalenii_PYR-1 GDVVEASIATDDGAIDLGTQRLTVRFA-
MAV_1803|M.avium_104 GDVVETAIATDDGAIDLGTQRNVVRFAK
MAB_2575c|M.abscessus_ATCC_199 GDVVEASVATDDGSICLGTQRTTVRFS-
. . . .