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VSIPNVLAARYASAEMVAIWSPEAKVVAERRLWLAVLRAQQQLGVAVPAEAIADYERVLEDVDLASIADR ERLLRHDVKARIEEFNALAGHEHVHKGMTSRDLTENVEQLQIRRSLELVFAHGVAVAARLAERAVAYRDL VMAGRSHNVAAQATTLGKRFASAAQETLIALARLRELIDRYPLRGIKGPMGTSQDMLDLLGGDPAKLAEL ERRVAEFLGFSTVLTSVGQVYPRSLDHDVISALVQLGAGPSSMAHTIRLMAGHELVTEGFAPGQVGSSAM PHKMNTRSCERVNGLQVVLRGYASMAAELAGAQWNEGDVFCSVVRRVALPDSFFAIDGQIETFLTVLDEF GAYPAVIGRELDRYLPFLATTKVLIAAVRAGMGREAAHHVIREHAVATALAMREHGAEPDLLERLAADER LPLDRAALDAALADRRAFTGAAADQVDEVAAQVDALVSRYPDAAKYTPGAIL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_0722 | purB | - | 100% (472) | adenylosuccinate lyase |
| M. avium 104 | MAV_3504 | pcaB | 8e-05 | 25.48% (263) | 3-carboxy-cis,cis-muconate cycloisomerase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0800 | purB | 0.0 | 88.77% (472) | adenylosuccinate lyase |
| M. gilvum PYR-GCK | Mflv_1613 | - | 0.0 | 84.96% (472) | adenylosuccinate lyase |
| M. tuberculosis H37Rv | Rv0777 | purB | 0.0 | 88.56% (472) | adenylosuccinate lyase |
| M. leprae Br4923 | MLBr_02230 | purB | 0.0 | 90.47% (472) | adenylosuccinate lyase |
| M. abscessus ATCC 19977 | MAB_0687 | - | 0.0 | 83.26% (472) | adenylosuccinate lyase |
| M. marinum M | MMAR_4916 | purB | 0.0 | 90.95% (475) | adenylosuccinate lyase, PurB |
| M. smegmatis MC2 155 | MSMEG_5847 | purB | 0.0 | 86.23% (472) | adenylosuccinate lyase |
| M. thermoresistible (build 8) | TH_1267 | purB | 0.0 | 85.81% (472) | PROBABLE ADENYLOSUCCINATE LYASE PURB (ADENYLOSUCCINASE) |
| M. ulcerans Agy99 | MUL_0490 | purB | 0.0 | 90.74% (475) | adenylosuccinate lyase |
| M. vanbaalenii PYR-1 | Mvan_5145 | - | 0.0 | 85.17% (472) | adenylosuccinate lyase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1613|M.gilvum_PYR-GCK ------MRGLVSCVFVS----IPNVLANRYASEEMVAIWSPEAKIVAERR
Mvan_5145|M.vanbaalenii_PYR-1 MPHYLPVQGPISCVFVSNPVPVPDVLAHRYASEEMVAIWSPEAKIVAERR
MSMEG_5847|M.smegmatis_MC2_155 -------------MFVT----IPNVLANRYASDEMVAIWSPEAKIIAERR
TH_1267|M.thermoresistible__bu ---------------VT----IPNVLAHRYASDEMTAIWSPKAKVVAERR
Mb0800|M.bovis_AF2122/97 ---------------MS----IPNVLATRYASAEMVAIWSPEAKVVSERR
Rv0777|M.tuberculosis_H37Rv ---------------MS----IPNVLATRYASAEMVAIWSPEAKVVSERR
MMAR_4916|M.marinum_M ---------------MS----VPNVLAARYASAEMVAIWSPQAKVVAERR
MUL_0490|M.ulcerans_Agy99 ---------------MS----VPNVLAARYASAEMVAIWSPQAKVVAERR
MAV_0722|M.avium_104 ---------------MS----IPNVLAARYASAEMVAIWSPEAKVVAERR
MLBr_02230|M.leprae_Br4923 ---------------MS----IPNVLAARYASAELVAIWSPEARVIAERQ
MAB_0687|M.abscessus_ATCC_1997 ---------------MQ----IPNVLASRYASDAMTALWSPQSKVVLERQ
: :*:*** **** :.*:***::::: **:
Mflv_1613|M.gilvum_PYR-GCK LWIAVLKAQAELGVP---VPDGVVDDYERVLENVDLASIAARERVTRHDV
Mvan_5145|M.vanbaalenii_PYR-1 LWLAVLKAQAELGVG---VPDGVVADYERVLEEVDLASIAARERVLRHDV
MSMEG_5847|M.smegmatis_MC2_155 LWLAVLRAQAELGVA---VPDGVVEDYERVLENVDLESIAARERVTRHDV
TH_1267|M.thermoresistible__bu LWIAVMRAQAELGVD---IPDEVIADYERVVEDVDLDAIAARERVLRHDV
Mb0800|M.bovis_AF2122/97 LWLAVLRAQAELGVA---VADSVLADYERVVDDVDLASISARERVLRHDV
Rv0777|M.tuberculosis_H37Rv LWLAVLRAQAELGVA---VADSVLADYERVVDDVDLASISARERVLRHDV
MMAR_4916|M.marinum_M LWLAVLRAQRELGAKGTDVPADAIADYERVIDDVDLDSIASRERVLRHDV
MUL_0490|M.ulcerans_Agy99 LWLAVLRAQRELGAKGTDVPADAIADYERVIDDVDLDSIASRERVLRHDV
MAV_0722|M.avium_104 LWLAVLRAQQQLGVA---VPAEAIADYERVLEDVDLASIADRERLLRHDV
MLBr_02230|M.leprae_Br4923 LWLAVLRAQAELSVP---MPVKAIADYERVLGEVDLASIAARERVLRHDV
MAB_0687|M.abscessus_ATCC_1997 LWIAVLRAQRDLGIE---VPDGVIEDYERVVENVDLDSISARERVTRHDV
**:**::** :*. :. .: *****: :*** :*: ***: ****
Mflv_1613|M.gilvum_PYR-GCK KARIEEFNALAGHEHVHKGMTSRDLTENVEQLQIRRSLELVHAHGVAVVA
Mvan_5145|M.vanbaalenii_PYR-1 KARIEEFNALAGHEHVHKGMTSRDLTENVEQLQIRRSLELVHARGIAVVA
MSMEG_5847|M.smegmatis_MC2_155 KARIEEFNALAGHEHVHKGMTSRDLTENVEQLQIRQSLELVFSHGVAVVA
TH_1267|M.thermoresistible__bu KARIEEFNARAGHEHVHKGMTSRDLTENVEQLQIRRSLELVHAHGVAVVA
Mb0800|M.bovis_AF2122/97 KARIEEFNALAGHEHVHKGMTSRDLTENVEQLQIRRSLEVIFAHGVAAVA
Rv0777|M.tuberculosis_H37Rv KARIEEFNALAGHEHVHKGMTSRDLTENVEQLQIRRSLEVIFAHGVAAVA
MMAR_4916|M.marinum_M KARIEEFNALAGHEHVHKGMTSRDLTENVEQLQIRQSLDLTFAHGVAVAA
MUL_0490|M.ulcerans_Agy99 KARIEEFNALAGHEHVHKGMTSRDLTENVEQLQIRQSLDLTFAHGVAVAA
MAV_0722|M.avium_104 KARIEEFNALAGHEHVHKGMTSRDLTENVEQLQIRRSLELVFAHGVAVAA
MLBr_02230|M.leprae_Br4923 KARIEEFNALAGHEQVHKGMTSRDLTENVEQLQIRRSLELVFCHGVAVVA
MAB_0687|M.abscessus_ATCC_1997 KARIEEFNALAGHEHIHKGMTSRDLTENVEQLQIRRSLEYVHAHGVAVVA
********* ****::*******************:**: ..:*:*..*
Mflv_1613|M.gilvum_PYR-GCK RLAERAALYRDVVMAGRSHNVAAQATTLGKRFASAAEEMLVALKRVGELI
Mvan_5145|M.vanbaalenii_PYR-1 RLAERAALYRDLVMAGRSHNVAAQATTLGKRFASAAEELLVALQRVRELI
MSMEG_5847|M.smegmatis_MC2_155 RLAERAVVYRDLVMAGRSHNVAAQATTLGKRFASAAEETLVALTRLRELI
TH_1267|M.thermoresistible__bu RLAERALSYRDLVMAGRSHNVAAQATTLGKRFASAAEEMLGALTRLEEII
Mb0800|M.bovis_AF2122/97 RLAERAVSYRDLIMAGRSHNVAAQATTLGKRFASAAQEMMIALRRLRELI
Rv0777|M.tuberculosis_H37Rv RLAERAVSYRDLIMAGRSHNVAAQATTLGKRFASAAQEMMIALRRLRELI
MMAR_4916|M.marinum_M RLAERAVAYRDLVMAGRSHNVAAQATTLGKRFASAAQETLIALVRLRELI
MUL_0490|M.ulcerans_Agy99 RLAERAVAYRDLVMAGRSHNVAAQATTLGKRFASAAQETLIALVRLRELI
MAV_0722|M.avium_104 RLAERAVAYRDLVMAGRSHNVAAQATTLGKRFASAAQETLIALARLRELI
MLBr_02230|M.leprae_Br4923 RLAECAVSYRDLVMAGRSHNVAAQATTLGKRFASATQETLIALTRLRELI
MAB_0687|M.abscessus_ATCC_1997 RLARHAVEYRDVVMAGRSHNVAAQATTLGKRFASAADETLLALTRLRELL
***. * ***::**********************::* : ** *: *::
Mflv_1613|M.gilvum_PYR-GCK DRYPLRGIKGPMGTAQDMLDLFDGDTERLADLERRVAGFLGFTDMFTSVG
Mvan_5145|M.vanbaalenii_PYR-1 DRYPLRGIKGPMGTAQDMLDLFDGDTDRLADLERRVAGFLGFTDIFTSVG
MSMEG_5847|M.smegmatis_MC2_155 DRYPLRGVKGPMGTAQDMLDLFGGDVGKLADLERRVAEFLGFTEVFTSVG
TH_1267|M.thermoresistible__bu ARYPLRGIKGPMGTAQDMLDLFGGDSERLAELERRVAEFLGFKEVFTSVG
Mb0800|M.bovis_AF2122/97 DRYPLRGIKGPMGTGQDMLDLLGGDRAALADLERRVADFLGFATVFNSVG
Rv0777|M.tuberculosis_H37Rv DRYPLRGIKGPMGTGQDMLDLLGGDRAALADLERRVADFLGFATVFNSVG
MMAR_4916|M.marinum_M DRYPLRGIKGPMGTAQDMLDLLDGDSAKLTDLEQRVADFLGFSTVLTSVG
MUL_0490|M.ulcerans_Agy99 DRYPLRGIKGPMGTAQDMLDLLDGDSAKLTDLEQRVADFLGFSTVLTSVG
MAV_0722|M.avium_104 DRYPLRGIKGPMGTSQDMLDLLGGDPAKLAELERRVAEFLGFSTVLTSVG
MLBr_02230|M.leprae_Br4923 DRYPLRGIKGPMGTGQDMLDLLGGDAAALAELEQRIAEFLGFTKVLASVG
MAB_0687|M.abscessus_ATCC_1997 DRYPLRGIKGPMGTGQDMLDLFNGDVVKLAELEERVAGFLGFSTTLTSVG
******:******.******:.** *::**.*:* **** : ***
Mflv_1613|M.gilvum_PYR-GCK QVYPRSLDHDVVSALVQLGAGPSSLAHTIRLMAGHELVTEGFAPGQVGSS
Mvan_5145|M.vanbaalenii_PYR-1 QVYPRSLDHDVVSALVQLGAGPSSMAHTIRLMAGHELVTEGFAPGQVGSS
MSMEG_5847|M.smegmatis_MC2_155 QVYPRSLDHDVLSALVQFGAGPSSMAHTIRLMAGHELVTEGFAPGQVGSS
TH_1267|M.thermoresistible__bu QVYPRSLDYEVISALVQLGAAPSSLATTIRLMAGHELVTEGFAPGQVGSS
Mb0800|M.bovis_AF2122/97 QVYPRSLDHDVVSALVQLGAGPSSLAHTIRLMAGHELATEGFAPGQVGSS
Rv0777|M.tuberculosis_H37Rv QVYPRSLDHDVVSALVQLGAGPSSLAHTIRLMAGHELATEGFAPGQVGSS
MMAR_4916|M.marinum_M QVYPRSLDHDVVSALVQLGAGPSSLAHTIRLMAGHELVTEGFAAGQVGSS
MUL_0490|M.ulcerans_Agy99 QVYPRSLDHDVVSALVQLGAGPSSLAHTIRLMAGHELVTEGFAPGQVGSS
MAV_0722|M.avium_104 QVYPRSLDHDVISALVQLGAGPSSMAHTIRLMAGHELVTEGFAPGQVGSS
MLBr_02230|M.leprae_Br4923 QVYPRSLDHDVISALVQLGAGSSSLAHTIRLMAGHELVTEGFAPGQVGSS
MAB_0687|M.abscessus_ATCC_1997 QVYPRSLDHDVVSALVQLGAGPSSLAHTIRLMAGHELVTEGFAPGQVGSS
********::*:*****:**..**:* **********.*****.******
Mflv_1613|M.gilvum_PYR-GCK AMPHKMNSRSCERVNGLQVVLRGYGSMAAELAGAQWNEGDVFCSVVRRVA
Mvan_5145|M.vanbaalenii_PYR-1 AMPHKMNTRSCERVNGLQVVLRGYASMTAELAGAQWNEGDVFCSVVRRVA
MSMEG_5847|M.smegmatis_MC2_155 AMPHKMNTRSCERVNGLQVVLRGYASMAAELAGAQWNEGDVFCSVVRRVA
TH_1267|M.thermoresistible__bu AMPHKMNARSCERVNGLQVVLRGYASMAAELAGAQWNEGDVFCSVVRRVA
Mb0800|M.bovis_AF2122/97 AMPHKMNTRSCERVNGLQVVLRGYASMVAELAGAQWNEGDVFCSVVRRVA
Rv0777|M.tuberculosis_H37Rv AMPHKMNTRSCERVNGLQVVLRGYASMVAELAGAQWNEGDVFCSVVRRVA
MMAR_4916|M.marinum_M AMPHKMNTRSCERVNGLQVVLRGYASMAAELAGAQWNEGDVFCSVVRRVV
MUL_0490|M.ulcerans_Agy99 AMPHKMNTRSCERVNGLQVVLRGYASMAAELAGAQWNEGDVFCSVVRRVV
MAV_0722|M.avium_104 AMPHKMNTRSCERVNGLQVVLRGYASMAAELAGAQWNEGDVFCSVVRRVA
MLBr_02230|M.leprae_Br4923 AMPHKMNSRSCERVNGLQVVLRGYAAMAAELAGAQWNEGDVFCSVVRRVA
MAB_0687|M.abscessus_ATCC_1997 AMPHKMNTRSCERVNGLQVILRGYGSMAAELAGAQWNEGDVFCSVVRRVA
*******:***********:****.:*.*********************.
Mflv_1613|M.gilvum_PYR-GCK LPDAFFALDGQTETFLTVLDEFGAYPAVIQRELDRYLPFLATTRILIAAV
Mvan_5145|M.vanbaalenii_PYR-1 LPDAFFALDGQTETFLTVLDEFGAYPAVIQRELDRYLPFLATTRILIAAV
MSMEG_5847|M.smegmatis_MC2_155 LPDAFFAIDGQTETFLTVLDEFGAYPAVIQRELDRYLPFLATTRILMAAV
TH_1267|M.thermoresistible__bu LPDAFFAIDGQIETFLTVLDEFGAYPAVIQRELDRYLPFLATTRILMAAV
Mb0800|M.bovis_AF2122/97 LPDSFFAVDGQIETFLTVLDEFGAYPAVIGRELDRYLPFLATTKVLMAAV
Rv0777|M.tuberculosis_H37Rv LPDSFFAVDGQIETFLTVLDEFGAYPAVIGRELDRYLPFLATTKVLMAAV
MMAR_4916|M.marinum_M LPDSFFAIDGQTETFLTVLDEFGAYPAVIARELDRYLPFLATTKVLMAAV
MUL_0490|M.ulcerans_Agy99 LPDSFIAIDGQTETFLTVLDEFGAYPAVIARELDRYLPFLATTKVLMAAV
MAV_0722|M.avium_104 LPDSFFAIDGQIETFLTVLDEFGAYPAVIGRELDRYLPFLATTKVLIAAV
MLBr_02230|M.leprae_Br4923 LPDSFFAIDGQIETFLTVLDEFGAYPAVIRRELDRYLPFLATTKVLIAAV
MAB_0687|M.abscessus_ATCC_1997 LPDAFFAIDGMIETFLTVLDEFGAYPAVIDRELRRYLPFLATTKVLMAAV
***:*:*:** ***************** *** *********::*:***
Mflv_1613|M.gilvum_PYR-GCK RAGVGRETAHEVIKEHAVAVALAMRERGAEPDLLDRLAADPRLPLDRPAL
Mvan_5145|M.vanbaalenii_PYR-1 RAGVGRETAHEVIKEHAVAVALAMREKGAEPDLLDRLAADPRLPLDRQAL
MSMEG_5847|M.smegmatis_MC2_155 RAGVGREAAHEVIKEHAVAVALAMREQGREPDLIDRLAGDPRLPLDKVAL
TH_1267|M.thermoresistible__bu RAGMGREAAHEVIKEHAVAVALDMREKGSEPDLLDRLAADPRLPLDRPAL
Mb0800|M.bovis_AF2122/97 RAGMGRESAHRLISEHAVATALAMREHGAEPDLLDRLAADPRLPLGRDAL
Rv0777|M.tuberculosis_H37Rv RAGMGRESAHRLISEHAVATALAMREHGAEPDLLDRLAADPRLTLGRDAL
MMAR_4916|M.marinum_M RAGMGRESAHHVIREHAVATALAMREHGSEPDLLDRLAADPRLPLDRAAL
MUL_0490|M.ulcerans_Agy99 RAGMGRESAHHVIREHAVATALAMREHGSEPDLLDRLAADPRLPLDRAAL
MAV_0722|M.avium_104 RAGMGREAAHHVIREHAVATALAMREHGAEPDLLERLAADERLPLDRAAL
MLBr_02230|M.leprae_Br4923 RAGMGREAAHHVIREHAVATALAMRECGAEPDLLDRLAADGRLPLDRAAL
MAB_0687|M.abscessus_ATCC_1997 RAGVGREEAHEVIKEHAVATALAMREKGAEPNLLGLLAEDARLPLDADAL
***:*** **.:* *****.** *** * **:*: ** * **.*. **
Mflv_1613|M.gilvum_PYR-GCK DAALADRQAFSGAAGDQVDRVVAEVEDLVARYPGAAEYTSGAIL
Mvan_5145|M.vanbaalenii_PYR-1 DAALADKQVFTGAAGDQVDRVVAAVDDLIARYPEAAEYTSGAIL
MSMEG_5847|M.smegmatis_MC2_155 EAALEDKQAFTGAAGDQVDGVVAAVGELVSRYPEAAKYTSGAIL
TH_1267|M.thermoresistible__bu DAALADRQAFTGAAASQVDTVVGAVDELVSRYPEAAKYTSGAIL
Mb0800|M.bovis_AF2122/97 EAALADKKAFAGAAGDQVDDVVAMVDALVSRYPDAAKYTPGAIL
Rv0777|M.tuberculosis_H37Rv EAALADKKAFAGAAGDQVDDVVAMVDALVSRYPDAAKYTPGAIL
MMAR_4916|M.marinum_M DAALADKAAFTGAAADQVDQVAAQVDALVGRYPEAAKYAPGAIL
MUL_0490|M.ulcerans_Agy99 DAALADKAAFTGAAADQVEQVAAQVDALVGRYPEAAKYAPGAIL
MAV_0722|M.avium_104 DAALADRRAFTGAAADQVDEVAAQVDALVSRYPDAAKYTPGAIL
MLBr_02230|M.leprae_Br4923 DAALADKKAFTGAAADQVDEVVAMVDKLVGRYPEAAKYTPGAIL
MAB_0687|M.abscessus_ATCC_1997 EAALADRASFTGAAADQVDRVVAEVEALAAEYPDAAVYSPGAIL
:*** *: *:***..**: *.. * * ..** ** *:.****