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MRVLLVEDEPRLAATVARGLKAEGFVVVTVGNGVDGLAEATENPFDVVILDIMLPGRSGYEVLRRMRSNN VWTPVLMLTAKDGEYDETDAFDLGADDYLTKPFSFRVLVARLRALVRRGAPERPVVLTAGSLSLDPARHT VQRGSTPIALTPREYGVLEFLMRNKDVVVTKADILANVWDAHHHGPDNVVEVYVGYLRRKIDVPFGTNTI ETIRGVGYRLLC
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3406 | - | - | 100% (222) | TcrA protein |
| M. avium 104 | MAV_1176 | - | 1e-44 | 43.75% (224) | two component transcriptional regulator trcr |
| M. avium 104 | MAV_0701 | phoP | 3e-44 | 43.50% (223) | DNA-binding response regulator PhoP |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0618c | tcrA | 3e-58 | 50.45% (220) | putative two component DNA binding transcriptional |
| M. gilvum PYR-GCK | Mflv_2266 | - | 5e-45 | 45.74% (223) | two component transcriptional regulator |
| M. tuberculosis H37Rv | Rv0602c | tcrA | 2e-58 | 50.91% (220) | two component DNA binding transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_00174 | - | 5e-41 | 39.46% (223) | putative two-component response regulator |
| M. abscessus ATCC 19977 | MAB_0673 | - | 1e-42 | 43.05% (223) | putative DNA-binding response regulator PhoP |
| M. marinum M | MMAR_5317 | tcrX | 3e-45 | 45.70% (221) | two-component transcriptional regulatory protein TcrX |
| M. smegmatis MC2 155 | MSMEG_4990 | - | 6e-48 | 46.64% (223) | DNA-binding response regulator |
| M. thermoresistible (build 8) | TH_4312 | - | 1e-42 | 42.41% (224) | PUTATIVE two component transcriptional regulator, winged helix |
| M. ulcerans Agy99 | MUL_4624 | trcR | 3e-45 | 43.50% (223) | two component transcriptional regulator TrcR |
| M. vanbaalenii PYR-1 | Mvan_4429 | - | 1e-46 | 45.74% (223) | two component transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0618c|M.bovis_AF2122/97 MADETTMRAGRGPG---------RACGRVSGVRILVIEDEPKMTALLARA
Rv0602c|M.tuberculosis_H37Rv MADETTMRAGRGPG---------RACGRVSGVRILVVEDEPKMTALLARA
MAV_3406|M.avium_104 -------------------------------MRVLLVEDEPRLAATVARG
MLBr_00174|M.leprae_Br4923 -------------------------------MRILAVDDDRAVRESLRRS
MAB_0673|M.abscessus_ATCC_1997 MVSITTETHQG-----------TFSANGTTPAKVLVVDDESNIVELLSVS
Mflv_2266|M.gilvum_PYR-GCK MAHPQSDP-EDPAR-------VVMRRADGSPIRVLVVDDEAVLAELMSMA
Mvan_4429|M.vanbaalenii_PYR-1 MANPQSAHGDDPAR-------VEMRRADGSPIHVLVVDDEPVLAELVSMA
MSMEG_4990|M.smegmatis_MC2_155 MG-TANGTEIETGR-------AVMRRADGNPIRVLVVDDEPVLAELVSMA
MMAR_5317|M.marinum_M ----------------------MMCRADGQPVSVLVVDDEPVLAEMVSMA
MUL_4624|M.ulcerans_Agy99 MKAMTGSTRTQRPRQAILGQLPRIHRADGSPIRVLLVDDEPALTNLVKMA
TH_4312|M.thermoresistible__bu ------------------------------MTSVLIVEDEESLADPLAFL
:* ::*: : :
Mb0618c|M.bovis_AF2122/97 LTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGFEVCARLRRQ
Rv0602c|M.tuberculosis_H37Rv LTEEGHTVDTVADGRHAVAAVDGGDYDAVVLDVMLPGIDGFEVCARLRRQ
MAV_3406|M.avium_104 LKAEGFVVVTVGNGVDGLAEATENPFDVVILDIMLPGRSGYEVLRRMRSN
MLBr_00174|M.leprae_Br4923 LSFNGYSVELANDGVEALEMVARDRPDALVLDVMMPRLDGLEVCRQLRST
MAB_0673|M.abscessus_ATCC_1997 LKFQGFDVYTADSGAAALDLARTVRPDAVILDVMMPGMDGFGVLRRLRAD
Mflv_2266|M.gilvum_PYR-GCK LRYEGWDISTAGDGATAIALARQNPPDVVVLDVMLPDMSGLEVLRTLREQ
Mvan_4429|M.vanbaalenii_PYR-1 LRYEGWEISTAGDGATAIAIARDNPPDVVVLDVMLPDMSGLEVLRKLREQ
MSMEG_4990|M.smegmatis_MC2_155 LRYEGWDITTAGDGASAIAAARETPPDVVVLDVMLPDMSGLDVLRKLREQ
MMAR_5317|M.marinum_M LRYEGWNIATASDGASAIASARAERPDVVVLDVMLPDMSGLEVLHRLRKE
MUL_4624|M.ulcerans_Agy99 LHYEGWDVEIAHNGREAISKFDKISPDVLVLDIMLPDVDGLQILQRVRDS
TH_4312|M.thermoresistible__bu LRKEGFETTIVTDGPSALAEFERSGADIILLDLMLPGMSGTDVCRRLRAK
* :* . .* .: * ::**:*:* .* : :*
Mb0618c|M.bovis_AF2122/97 RVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRG
Rv0602c|M.tuberculosis_H37Rv RVWTPVLMLTARGAVTDRIAGLDGGADDYLTKPFNLDELFARLRALSRRG
MAV_3406|M.avium_104 NVWTPVLMLTAKDGEYDETDAFDLGADDYLTKPFSFRVLVARLRALVRRG
MLBr_00174|M.leprae_Br4923 GDDLPILVLTARDSVSERVAGLDAGADDYLPKPFALEELLARIRALLRRT
MAB_0673|M.abscessus_ATCC_1997 GIDAPTLFLTARDGLQDKIAGLTLGADDYVTKPFSLEEVVARLRVILRRS
Mflv_2266|M.gilvum_PYR-GCK IPGLPLLLLTAKDSVEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLRRT
Mvan_4429|M.vanbaalenii_PYR-1 IPGLPLLLLTAKDSVEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLRRT
MSMEG_4990|M.smegmatis_MC2_155 IPGLPLLLLTAKDSVEDRIAGLTAGGDDYVTKPFSLEEVVLRLRALLRRT
MMAR_5317|M.marinum_M NPALPVLLLTAKDAVEDRIAGLTAGGDDYVTKPFSIEEVVLRLRALLRRT
MUL_4624|M.ulcerans_Agy99 DAYTPTLFLTARDSVMDRVTGLTAGADDYMTKPFSLEELVARLRGLLRRS
TH_4312|M.thermoresistible__bu S-KVPVIMVTARDSEIDKVVGLELGADDYVTKPYSARELIARIRAVLRRG
* :.:**:.. :. .: *.***:.**: :. *:* : **
Mb0618c|M.bovis_AF2122/97 P-IPRPPT----LEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRR
Rv0602c|M.tuberculosis_H37Rv P-IPRPPT----LEAGDLRLDPSEHRVWRADTEIRLSHKEFTLLEALIRR
MAV_3406|M.avium_104 A-PERPVV----LTAGSLSLDPARHTVQRGSTPIALTPREYGVLEFLMRN
MLBr_00174|M.leprae_Br4923 --KPDDAAESVAMSFSDLTLDPVTREVARGQRWISLTRTEFALLEMLIAN
MAB_0673|M.abscessus_ATCC_1997 G-MGSEPARKSRLSFADIELDEDTHEVWKAGEPVALSPTEFTLLRYFMIN
Mflv_2266|M.gilvum_PYR-GCK G-VATATG-GAKLVVGDLVLDEDSHEVTRGGDLITLTATEFELLRFMMRN
Mvan_4429|M.vanbaalenii_PYR-1 G-VSTDTS-GAKIVVGDLVLDEDSHEVTRGGDPITLTATEFELLRFMMRN
MSMEG_4990|M.smegmatis_MC2_155 G-VTSEDG-GAKIVVGDLVLDEDSHEVTRGGDPIALTATEFELLRFMMRN
MMAR_5317|M.marinum_M G-VTTVDS-GAQLVVGDLVLDEDSHEVTRAGEPISLTSTEFELLRFMMRN
MUL_4624|M.ulcerans_Agy99 S-HLAPPA-DESLKVGDLKLDAASREVTRGGTPISLSSTEFELLRFLMRN
TH_4312|M.thermoresistible__bu SDLDGADVDDSVLEAGPVRMDVDRHVVTVRGEPITLPLKEFELLEYLLRN
: . : :* : * : *. *: :*. :: .
Mb0618c|M.bovis_AF2122/97 PGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRP-FGVTSLETI
Rv0602c|M.tuberculosis_H37Rv PGIVHTRAQLLERCWDAAYEARSNIVDVYIRYLRDKIDRP-FGVTSLETI
MAV_3406|M.avium_104 KDVVVTKADILANVWDAHHHGPDNVVEVYVGYLRRKIDVP-FGTNTIETI
MLBr_00174|M.leprae_Br4923 PRRVLTRSRILEEVWGFDFPTSGNALEVYVGYLRRKTEAD-GESRLIHTV
MAB_0673|M.abscessus_ATCC_1997 AGTVLSKPKILDHVWRYDFGGDVNVVESYVSYLRRKIDN--GEKRLLHTL
Mflv_2266|M.gilvum_PYR-GCK ARCVLSKAQILDRVWSYDFGGRSNIVELYVSYLRKKIDS--GREPMIHTL
Mvan_4429|M.vanbaalenii_PYR-1 AKRVLSKTQILDRVWSYDFGGRSNIVELYVSYLRKKIDS--GREPMIHTL
MSMEG_4990|M.smegmatis_MC2_155 AKRVLSKAQILDRVWSYDFGGRSNIVELYVSYLRKKIDS--GREPMIHTL
MMAR_5317|M.marinum_M SKRVLSKAQILDRVWSYDFGGRSNIVELYISYLRKKIDN--GREPMIHTL
MUL_4624|M.ulcerans_Agy99 PRRALSRTEILDRVWNYDFAGRTSIVDLYISYLRKKIDA--DREPMIHTV
TH_4312|M.thermoresistible__bu SGRVLTRGQLIDRVWGADYVGDTKTLDVHVKRLRSKIEEDPANPVHLVTV
. :: :: . * . . :: :: ** * : : *:
Mb0618c|M.bovis_AF2122/97 RGAGYRLRKDGGRHALPR
Rv0602c|M.tuberculosis_H37Rv RGAGYRLRKDGGRHALPR
MAV_3406|M.avium_104 RGVGYRLLC---------
MLBr_00174|M.leprae_Br4923 RGVGYVLRETPP------
MAB_0673|M.abscessus_ATCC_1997 RGVGYVLREPR-------
Mflv_2266|M.gilvum_PYR-GCK RGAGYVLKPAR-------
Mvan_4429|M.vanbaalenii_PYR-1 RGAGYVLKPAR-------
MSMEG_4990|M.smegmatis_MC2_155 RGAGYVLRPPR-------
MMAR_5317|M.marinum_M RGAGYVLKPAR-------
MUL_4624|M.ulcerans_Agy99 RGIGYMLRPAE-------
TH_4312|M.thermoresistible__bu RGLGYKLEG---------
** ** *