For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MTVLDYPVWLRVDHWLNVLFVTLIIRSGIEILSTHPKLYWHDDSKPGTEWARFTRKVMPRDRIYDTLDEE EDYHPLISLPGHAQLGMGRHWHFFAVIGWVLVGLSYYVLLFATGQWHRYWPYSWSIFPEAFNDIVTYLTF NLPPVLPGEPLDAMQKLTYAGVVFVLAPFQILTGAAQSPAIEARFPWYVRMWGGRQWARSLHFLGLVAFV VFIVIHLSMIFFWGWGRLTAAMIFGSVRNTYWATAISLLIIAAIVGIHVAATLWSLRHPRSVQRVLGRVV TAARLMLLRPLNSRQNYPASKITPRHRINGKPPTSTEYKVMAVHNFVDWRLRVGGLVENPVVLDLAALRS LAEPETQRVMHNCVQGWTSIGEWTGVHLRRLVDLVRPLPQARYICFLTMQDNSTDEPASHGGGQFYEVLD LEFADKPQTLLAYEMNGAPLPIQHGAPLRLRVETQVGFKMAKWINQIEFVDDFAGIGMGTGGWREDRVYY DKDVEI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1622 | - | - | 100% (496) | oxidoreductase molybdopterin binding subunit |
| M. avium 104 | MAV_2937 | - | 4e-86 | 37.27% (491) | oxidoreductase molybdopterin binding subunit |
| M. avium 104 | MAV_2997 | - | 1e-12 | 36.11% (144) | oxidoreductase, molybdopterin binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0224 | - | 2e-12 | 34.97% (143) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_4320 | - | 7e-07 | 28.77% (146) | oxidoreductase, molybdopterin binding |
| M. tuberculosis H37Rv | Rv0218 | - | 2e-12 | 34.97% (143) | transmembrane protein |
| M. leprae Br4923 | MLBr_00879 | qcrB | 3e-05 | 25.40% (189) | putative cytochrome B |
| M. abscessus ATCC 19977 | MAB_4441 | - | 6e-08 | 31.25% (144) | putative oxidoreductase |
| M. marinum M | MMAR_0461 | - | 2e-12 | 36.62% (142) | hypothetical protein MMAR_0461 |
| M. smegmatis MC2 155 | MSMEG_5334 | - | 3e-11 | 36.17% (94) | hypothetical protein MSMEG_5334 |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_1110 | - | 4e-11 | 35.92% (142) | hypothetical protein MUL_1110 |
| M. vanbaalenii PYR-1 | Mvan_0889 | - | 9e-12 | 30.82% (159) | oxidoreductase, molybdopterin binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0224|M.bovis_AF2122/97 -----------------MSDPARGAEAEDAYGFPAGLWRWLQRHPPPALH
Rv0218|M.tuberculosis_H37Rv -----------------MSDPARGAEAEDAYGFPAGLWRWLQRHPPPALH
MMAR_0461|M.marinum_M ------------MNCPAEDDPERELEPEPAHGFPARLWRTLERHPPPGVR
MUL_1110|M.ulcerans_Agy99 ------------MNCPAEDDPERELEPEPAHGFPARLWRTLERHPPPGVR
Mvan_0889|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_4320|M.gilvum_PYR-GCK ---------MTTPGVRAAGGVAAAAVAVGVASLVGAAFGPEADVRTAVGS
MAB_4441|M.abscessus_ATCC_1997 ---------MEHAARRIIAGLIAAAAALAVGQLAAAAVAPDSAPFYAVGN
MAV_1622|M.avium_104 --------------MTVLDYPVWLRVDHWLNVLFVTLIIRSGIEILSTHP
MSMEG_5334|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00879|M.leprae_Br4923 MSPKSVPDIGDVLARQAEDIDTRYHPSAALRRQLNKVFPTHWSFLLGEIA
Mb0224|M.bovis_AF2122/97 RLTRFRSPLRGPWLTSVFGLVLLVAL---PFVIITGLLSYIAYAPQL---
Rv0218|M.tuberculosis_H37Rv RLTRFRSPLRGPWLTSVFGLVLLVAL---PFVIITGLLSYIAYAPQL---
MMAR_0461|M.marinum_M RLAAFRSPLRGPWLTSVFGLVLLVAM---PIVILTGLLSYIAYAPQF---
MUL_1110|M.ulcerans_Agy99 RLAAFRSPLRGPWLTSVFGLVLLVAM---PIVILTGLLSYIAYAPQF---
Mvan_0889|M.vanbaalenii_PYR-1 ----MAASMRGTAITARVGVALGVAI---AVCLVTGLISHLIQHPQ----
Mflv_4320|M.gilvum_PYR-GCK SVIDLTPGPVKEWAIATFGTADKLAL---AVMVLLTIAAIAAVAGLAETR
MAB_4441|M.abscessus_ATCC_1997 TVVDHTPAAVREWVIGIFGTSDKAVL---FACLTVIIALLAALAGLVEGE
MAV_1622|M.avium_104 KLYWHDDSKPGTEWARFTRKVMPRDR---IYDTLDEEEDYHPLISLPG--
MSMEG_5334|M.smegmatis_MC2_155 ---------------MTSAPRIHRTT---TVAQLHALLDHHS--------
MLBr_00879|M.leprae_Br4923 LYSFIVLLLTGVYLTLFFDPSMTDVTYNGVYQPLRGVEMSRAYQSTLDIS
Mb0224|M.bovis_AF2122/97 ----GQAIPGDVGWLRLPAFTWPTRPSWLYRLTQGLHVGLG-----LVII
Rv0218|M.tuberculosis_H37Rv ----GQAIPGDVGWLRLPAFTWPTRPSWLYRLTQGLHVGLG-----LVII
MMAR_0461|M.marinum_M ----GQAIPADVGWLRLPGFDWPAHPSWLYRLTQGLHVGLG-----LVLI
MUL_1110|M.ulcerans_Agy99 ----GQAIPADVGWLRLPGFDWPAHPSWLYRLTQGLHVGLG-----LVLI
Mvan_0889|M.vanbaalenii_PYR-1 -----------------PWFDWPTRPVWLYRFTQGLHVASG-----IAAI
Mflv_4320|M.gilvum_PYR-GCK RRPVCSIAIVIAGGIGCAAVLSRAGSTGADIIPTLIGTACG-----VAVL
MAB_4441|M.abscessus_ATCC_1997 RR-YGTVLIGLLGVFGAVAAVTRPAGTFAWIWPSVIAAVAG-----ALVL
MAV_1622|M.avium_104 --HAQLGMGRHWHFFAVIGWVLVGLSYYVLLFATGQWHRYWPY--SWSIF
MSMEG_5334|M.smegmatis_MC2_155 -----------------------PRPTFQQRVDVDEFCG-----------
MLBr_00879|M.leprae_Br4923 FEVRGGLFVRQIHHWAALMFTAAIMVHLARIFFTGAFRRPRETNWVIGSL
Mb0224|M.bovis_AF2122/97 PVVLAK----LWSVIPRLFVWPPARSIAQVLERLSVLMLVGGILFQIVT-
Rv0218|M.tuberculosis_H37Rv PVVLAK----LWSVIPRLFVWPPARSIAQVLERLSVLMLVGGILFQIVT-
MMAR_0461|M.marinum_M PVVLAK----LWSVIPKLFVWPPARSIATLLERLSLLMLVGGVLFEIVT-
MUL_1110|M.ulcerans_Agy99 PVVVAK----LWSVIPKLFVWPPARSIATLLERLSLLMLVGGVLFEIVT-
Mvan_0889|M.vanbaalenii_PYR-1 PLVVVK----LWSVWPKLFDRPVIGGPVRALERMSILVLVASVLFQLST-
Mflv_4320|M.gilvum_PYR-GCK RILQSDRLDGPSSETGTDPGRRRSLLTIGLLAAGAVSGVAGVVISRLAS-
MAB_4441|M.abscessus_ATCC_1997 GTLVHR------AQSQAVPDRRRFFGTAAVFALGSAGLYWLGTRWSKGT-
MAV_1622|M.avium_104 PEAFNDIVTYLTFNLPPVLPGEPLDAMQKLTYAGVVFVLAPFQILTGAA-
MSMEG_5334|M.smegmatis_MC2_155 -------------GIPQVPAHAPSVRIGRHWVSFAWLAVGALVALAVIV-
MLBr_00879|M.leprae_Br4923 LLILAMFEGYFGYSMPDDLLSGIGLRAALSSITLGIPVIGTWLHWALFGG
Mb0224|M.bovis_AF2122/97 ---GVLNIQYDYIFGFSFYTGHYFGAWVFIAGFLL-------------HI
Rv0218|M.tuberculosis_H37Rv ---GVLNIQYDYIFGFSFYTGHYFGAWVFIAGFLL-------------HI
MMAR_0461|M.marinum_M ---GVLNIQYDYIFGFSFYDGHYFGAWVFIAGFLM-------------HI
MUL_1110|M.ulcerans_Agy99 ---GVLNIQYDYIFGFSFYDGHYFGAWVFIAGFLM-------------HI
Mvan_0889|M.vanbaalenii_PYR-1 ---GLLNIAQWYVFGFFFTTAHYAMAYVAVGAVVV-------------HI
Mflv_4320|M.gilvum_PYR-GCK ---SVAGDRDAFALPRIDTPAAPIPESVQPKGVELPSWVTGNDDFYRIDT
MAB_4441|M.abscessus_ATCC_1997 ---VVAAERREATVPAPVAPAPPLPEGIDVKGAVP--YITSNTDFYRIDT
MAV_1622|M.avium_104 ---QSPAIEARFPWYVRMWGGRQWARSLHFLGLVA----------FVVFI
MSMEG_5334|M.smegmatis_MC2_155 ---AVAMQLRTYGWVQSFIAHYPGTSASYAQPVTT---------------
MLBr_00879|M.leprae_Br4923 DFPGTILIPRLYALHILLIPGVILALIGLHLALVW------------FQK
Mb0224|M.bovis_AF2122/97 VVKIPHMVTGLRSIPMREVLG-------TNVADTRAQPCDPDGLVSVNPG
Rv0218|M.tuberculosis_H37Rv VVKIPHMVTGLRSIPMREVLG-------TNVADTRAQPCDPDGLVSVNPG
MMAR_0461|M.marinum_M AVKMPKMITGLRSFSIREVLR-------TNVTDTRPEPPDASGLVSEDPA
MUL_1110|M.ulcerans_Agy99 AVKMPKMITGLRSFSIREVLR-------TNVTNTRPEPPDASGLVSADPA
Mvan_0889|M.vanbaalenii_PYR-1 GVKLP---------VIRRALG-------EPLDDVARSG-------SLGPS
Mflv_4320|M.gilvum_PYR-GCK ALSVPQLSRSEWRLRIHGMVDREVTFTYEDLDRFEVVEKVITLTCVSNPV
MAB_4441|M.abscessus_ATCC_1997 ALRVPQVSTAEWQLNIHGMVDRPRTLMWADLNAMAATQRAVTLTCVSNEI
MAV_1622|M.avium_104 VIHLSMIFFWGWGRLTAAMIFG------SVRNTYWATAISLLIIAAIVGI
MSMEG_5334|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00879|M.leprae_Br4923 HTQFPGPGRTEYNVVGVRVMPVFAFKSGAFFAAIVGVLGLMGGFLQINPI
Mb0224|M.bovis_AF2122/97 EATLSRRGALGLVGAGVLLIGVLTVGQTLGGFTRKAALLLPRG-------
Rv0218|M.tuberculosis_H37Rv EATLSRRGALGLVGAGVLLIGVLTVGQTLGGFTRKAALLLPRG-------
MMAR_0461|M.marinum_M EPTVSRRGALALVGSGVLLLGVLTVGQTLGGPLRNIALLLPRG-------
MUL_1110|M.ulcerans_Agy99 EPTVSRRGALALVGSGVLLLGVLTVGQTLGGPLRNIALLLPRG-------
Mvan_0889|M.vanbaalenii_PYR-1 RRTVLR-GTWLAVG----LATLVTAGQTVP-LLRRVSVLAPRT-------
Mflv_4320|M.gilvum_PYR-GCK GGELISNAVWTGYRVKDLLAEAGVRSGADMVLSMSVDGWTAGTPVEALT-
MAB_4441|M.abscessus_ATCC_1997 GGNLIGNAVWTGFPIKPILESVGVHPDADMLLSKSVDGWTAGTPLQVLTD
MAV_1622|M.avium_104 HVAATLWSLRHPRSVQRVLGRVVTAARLMLLRPLNSRQNYPAS-------
MSMEG_5334|M.smegmatis_MC2_155 --------------------------------------------------
MLBr_00879|M.leprae_Br4923 WNLGPYKPSQVSAGSQPDFYMMWTEGLARIWPAWEFYFWHHTIPAP----
Mb0224|M.bovis_AF2122/97 ------RVVSPG-DFPVNK----TAAAAGITAEAIGPDWRLVLR-GGPAE
Rv0218|M.tuberculosis_H37Rv ------RVVSPG-DFPVNK----TAAAAGITAEAIGPDWRLVLC-GGPAE
MMAR_0461|M.marinum_M ------RPAQGNREFPVNK----TAAVAGITPEAVGPAWRLVLR-GGPNE
MUL_1110|M.ulcerans_Agy99 ------RPAQGNREFPVNK----TAAVAGITPEAVGPAWRLVLR-GGPNE
Mvan_0889|M.vanbaalenii_PYR-1 ------GEGPQG--VPVNR----TAVAAGVLGSARSADYRLTVI-NGDRA
Mflv_4320|M.gilvum_PYR-GCK GDDALLAIGMNGEPLPIEHGYPARLVVPGLYGYVSATKWVTALE-LTRFD
MAB_4441|M.abscessus_ATCC_1997 GRDAILAIAMNGTPLPVEHGYPVRQVVPGLYGYVSATKWVVDWE-ITRFD
MAV_1622|M.avium_104 ------KITPRHRINGKPP----TSTEYKVMAVHNFVDWRLRVGGLVENP
MSMEG_5334|M.smegmatis_MC2_155 -------------------------------GFPAWLRWQHFFN------
MLBr_00879|M.leprae_Br4923 ---VWVAVIMALVFVLLITYPFLEKRFTGDYAHHNLLQRPRDVPVRTSIG
Mb0224|M.bovis_AF2122/97 VVLDRATLAGLPQ-RTARLPLACVEGWSAVRTWSGVPLAELALLAGVPAA
Rv0218|M.tuberculosis_H37Rv VVLDRATLAGLPQ-RTARLPLACVEGWSAVRTWSGVPLAELALLAGVPAA
MMAR_0461|M.marinum_M VVLDRAALAGLPQ-HTARLPIACVEGWSTVQTWTGVRLSELARRAGVAAP
MUL_1110|M.ulcerans_Agy99 VVLDRAALAGLPQ-HTARLPIACVEGWSTVQTWTGVRLSELARRAGVAAP
Mvan_0889|M.vanbaalenii_PYR-1 QEFTVDELRAMPQ-ATRRLPIVCVEGWSAEGQWSGVVLAHLVALVGASPD
Mflv_4320|M.gilvum_PYR-GCK RAQAYWTRLGWSA-RGP-IKTASRVDVPRSGQDVALGPVTFGGVAWAQNR
MAB_4441|M.abscessus_ATCC_1997 KADAYWTIRGWSA-RGP-IKTGCRIDTPRTGDRLGTGTQIVAGTAWAQHR
MAV_1622|M.avium_104 VVLDLAALRSLAEPETQRVMHNCVQGWTSIGEWTGVHLRRLVDLVRPLPQ
MSMEG_5334|M.smegmatis_MC2_155 IVFMMFIIRSGLQILADHPRLYLNAGCRPGSEWFRMSHAVPADRTDKSDP
MLBr_00879|M.leprae_Br4923 AMAITFYMVLTLAAMNDIIALKFHISLNATTWIGRIGMVILPLLVYFITY
. .
Mb0224|M.bovis_AF2122/97 R-----------------SARVTSLQRGGAFGEAKLAANQIADPDALLAL
Rv0218|M.tuberculosis_H37Rv R-----------------SARVTSLQRGGAFGEAKLAANQIADPDALLAL
MMAR_0461|M.marinum_M R-----------------SARVTSLQRGGAFGEATLQGNQVGAPDALLAL
MUL_1110|M.ulcerans_Agy99 R-----------------SARVTSLQRGGAFGEATLQGNQVGASDALLAL
Mvan_0889|M.vanbaalenii_PYR-1 S-----------------DVRMISLEPPGPYSRTVLPARHARDDMTLVAL
Mflv_4320|M.gilvum_PYR-GCK G-----------------VRSVEVQMDDGPWEQATLGDSYSGDTWRMWSY
MAB_4441|M.abscessus_ATCC_1997 G-----------------IATVEVQIDDGPWLPARLAPEYSVDTWRQWWF
MAV_1622|M.avium_104 ARYI-------CFLTMQDNSTDEPASHGGGQFYEVLDLEFADKPQTLLAY
MSMEG_5334|M.smegmatis_MC2_155 P------------------------------------RVWTSKDDAVSLP
MLBr_00879|M.leprae_Br4923 RWCIGLQRSDRAVLEHGIETGIIKRLPHGAYIELHQPLGPVDDHGHPIPL
Mb0224|M.bovis_AF2122/97 RVDG------------ADLSLNHGYPARIIVPALPGVHNTKWVAGIEFHK
Rv0218|M.tuberculosis_H37Rv RVDG------------ADLSLDHGYPARIIVPALPGVHNTKWVAGIEFHK
MMAR_0461|M.marinum_M RVNG------------EDLPLDHGYPARIIVPALPGVHNTKWVASINFEA
MUL_1110|M.ulcerans_Agy99 RGNG------------EDLPLDHGYPARIIVPALPGVHNTKWVASINFEA
Mvan_0889|M.vanbaalenii_PYR-1 DLNG------------EPLDLDHGYPCRLIAPSRPGVLQTKWLSRIEVVP
Mflv_4320|M.gilvum_PYR-GCK AWEARDTGFHT---ITVRATDDSGYTQTPDRADPVPDGATGWHSITFAVK
MAB_4441|M.abscessus_ATCC_1997 AWQA-TAGEHI---ITARATDGTGAVQTDQIASPVPDGATGYPKRLVTVA
MAV_1622|M.avium_104 EMNG------------APLPIQHGAPLRLRVETQVGFKMAKWINQIEFVD
MSMEG_5334|M.smegmatis_MC2_155 KWLG-----------------------------IPGLRHAVGLARL----
MLBr_00879|M.leprae_Br4923 EYQGTAVPKRMNKLGSAGSPSSGSFLFADPVSEDAALREATHVAEQRALT
. :
Mb0224|M.bovis_AF2122/97 R------------------------
Rv0218|M.tuberculosis_H37Rv R------------------------
MMAR_0461|M.marinum_M G------------------------
MUL_1110|M.ulcerans_Agy99 G------------------------
Mvan_0889|M.vanbaalenii_PYR-1 -------------------------
Mflv_4320|M.gilvum_PYR-GCK -------------------------
MAB_4441|M.abscessus_ATCC_1997 A------------------------
MAV_1622|M.avium_104 DFAGIGMGTGGWREDRVYYDKDVEI
MSMEG_5334|M.smegmatis_MC2_155 -------------------------
MLBr_00879|M.leprae_Br4923 ALREHQDSIASSPNGERGKH-----