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LEVAQFTFVPSAGAVLADWGADVVKIEHPVTGDAQRGLVKVLGAAATVPGSSFAPIMEAPNRGKRSVGLA LDNSEARPLLDELIRRSDVFLTNYLPSTRKKLSIDVDDVRRINPAIIYVVGSGFGLKGPDRDAGAYDATA FWARGGSADGLTSPDATHSPFMPAGAYGDNIGGITIAGAVAAALYGRQATGEPSVLDVSLLAVGAWTTQF NVNMAMLMGGPLPKVERRTQAPGNPLTGAYRTSDGRFVQLSMLQPTRYWPEFCRLMGLHDLAEDPRFTTL DAMAAHSETAQQIVADAIGKLSFAECQALLRKGRGQWGPVQDAWEIANDEALTANGRIAEIVDAEGHPQK LVASPAQFDDDPASLTRAPQFAEHTDAVLRELGIDDDRLIELKIAGVIT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2541 | - | - | 100% (400) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. avium 104 | MAV_1895 | - | e-161 | 68.00% (400) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. avium 104 | MAV_0945 | - | 1e-94 | 47.03% (404) | L-carnitine dehydratase/bile acid-inducible protein F |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 7e-29 | 28.68% (387) | hypothetical protein Mb3300 |
| M. gilvum PYR-GCK | Mflv_2503 | - | 3e-91 | 45.14% (401) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. tuberculosis H37Rv | Rv3272 | - | 7e-29 | 28.68% (387) | hypothetical protein Rv3272 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4651c | - | 3e-23 | 29.44% (360) | putative L-carnitine dehydratase |
| M. marinum M | MMAR_4713 | - | 3e-95 | 47.28% (404) | dehydratase |
| M. smegmatis MC2 155 | MSMEG_4798 | - | 7e-92 | 45.79% (404) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. thermoresistible (build 8) | TH_4667 | - | 2e-97 | 47.75% (400) | PUTATIVE putative L-carnitine dehydratase/bile acid-inducible |
| M. ulcerans Agy99 | MUL_3873 | - | 1e-73 | 42.07% (347) | dehydratase |
| M. vanbaalenii PYR-1 | Mvan_4155 | - | 8e-90 | 44.89% (401) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2503|M.gilvum_PYR-GCK -----MSKPLDGIRVLEVAMYGFVPSAGAVLAEWGADVIKVEHAVTGDPQ
Mvan_4155|M.vanbaalenii_PYR-1 -----MSKPLDGIRVLEVAMYGFVPSAGAVLAEWGADVIKVEHAVTGDPQ
MSMEG_4798|M.smegmatis_MC2_155 -----MSGPLEGIRILEVAMYGFVPSAGAVLGEWGADVIKVEHAVTGDPQ
MMAR_4713|M.marinum_M ------MKPLEGIRVLEVAMYGFVPSAGAVLAEWGADVIKVEHAVTGDPQ
TH_4667|M.thermoresistible__bu --------------VLEVAQWTFVPAAGAVLADWGADVIKVEHPRTGDSQ
MAV_2541|M.avium_104 --------------MLEVAQFTFVPSAGAVLADWGADVVKIEHPVTGDAQ
MUL_3873|M.ulcerans_Agy99 ----------------------------MAFSTWGG--------IALDPE
Mb3300|M.bovis_AF2122/97 MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAPGGEAAR
Rv3272|M.tuberculosis_H37Rv MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAPGGEAAR
MAB_4651c|M.abscessus_ATCC_199 -----MTGALDGIRVLELGTLIAGPFAGRLLGDMGAEVLKIEPPGAPDPL
: *. .
Mflv_2503|M.gilvum_PYR-GCK RGLRQTG--LLRVEGD-PNPNIEHANRLKRSIGLDMSVPEGKEVLLELAR
Mvan_4155|M.vanbaalenii_PYR-1 RGLRQTG--LLRVEGD-PNPNIEHANRLKRSIGLDMSVAEGREVLLELAR
MSMEG_4798|M.smegmatis_MC2_155 RGLRQTG--PLRVDGD-PNPNIEHANRGKRSIGLDMSVPAGREVLLELAR
MMAR_4713|M.marinum_M RGLRQTG--MLRVEGD-PNPNIEHANRGKRSLGLDMSISEGKEVLHELAR
TH_4667|M.thermoresistible__bu RGLRSLG--HITIEGD-RNPVMEHANRGKRSVAIDMSTPDGHELLMEIAR
MAV_2541|M.avium_104 RGLVKVLGAAATVPGSSFAPIMEAPNRGKRSVGLALDNSEARPLLDELIR
MUL_3873|M.ulcerans_Agy99 R-----------------HPLIEHPNRGKRSVGIDLATSDGQDVLHELAR
Mb3300|M.bovis_AF2122/97 QITSVLP------GRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLAD
Rv3272|M.tuberculosis_H37Rv QITSVLP------GRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLAD
MAB_4651c|M.abscessus_ATCC_199 RTWGQAE-------VDGHHVFWTVHARNKKAITLDLRTEAGRALFLDLVD
: * *::: : : .: : :
Mflv_2503|M.gilvum_PYR-GCK RADVFLTSFLPGHRQKFGIDVDDIRAVNPKIIYARGSALGPRGEESVKGG
Mvan_4155|M.vanbaalenii_PYR-1 RADVFLTSFLPGHRQKFGIDVDDIRAANPKIVYARGSALGPRGEESVKGG
MSMEG_4798|M.smegmatis_MC2_155 RADVFLTSFLPGHREKFGIDVDDIRAVNPKIIYARGSALGPRGEESVKGG
MMAR_4713|M.marinum_M RSDVFLTSFLPGARRKFGIDLEDIRAVNPSIIYARGSALGPRGEEAAKGG
TH_4667|M.thermoresistible__bu TSDVFLTNFLPEARKKLRIDVEDLRAVNPDIVYARGSAYGPLGAEAEIGG
MAV_2541|M.avium_104 RSDVFLTNYLPSTRKKLSIDVDDVRRINPAIIYVVGSGFGLKGPDRDAGA
MUL_3873|M.ulcerans_Agy99 SADVFLTNYLPSARQKNKFDVEHVRGANPDIIYARGTAYGDKGAERDVGG
Mb3300|M.bovis_AF2122/97 TADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRPG
Rv3272|M.tuberculosis_H37Rv TADVVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRPG
MAB_4651c|M.abscessus_ATCC_199 KSDVIVENFRPGTLERWGLGYDVLAQRNKGIILVRVSGYGQTGPDAHKAG
:**.: : * .: :. : : * :: . :. * * . .
Mflv_2503|M.gilvum_PYR-GCK YDMTAFWCRAGTAATITPPGTPGMVGPPGPAYGDTISGTNLAGGIAAALL
Mvan_4155|M.vanbaalenii_PYR-1 YDMTAFWCRAGTAATITPPGTPGMVGPPGPAYGDTISGTNLAGGIAAALL
MSMEG_4798|M.smegmatis_MC2_155 YDMTAFWCRAGAAATITPPGIEGMIGPPGPAYGDTISGTNLAGGIAAALF
MMAR_4713|M.marinum_M YDMTAFWCRAGTAATITPMGYQGMINPPGPAYGDTISGTNLAGGIAAALL
TH_4667|M.thermoresistible__bu YDMTGFWSRAAGAMGSTPSDMEGVVPQPGPAYGDSIGGMTIAGGIAAALF
MAV_2541|M.avium_104 YDATAFWARGGSADGLTSPDATHSPFMPAGAYGDNIGGITIAGAVAAALY
MUL_3873|M.ulcerans_Agy99 YDGTAFWTRSGVGHALTPPELGAPLAQGIPAFGDSIGGMNIAGGISAALL
Mb3300|M.bovis_AF2122/97 IDLVVAAEAGMTTGMPTPEGKPQIIP---FQLVDNASGHVLAQAVLAALL
Rv3272|M.tuberculosis_H37Rv IDLVVAAEAGMTTGMPTPEGKPQIIP---FQLVDNASGHVLAQAVLAALL
MAB_4651c|M.abscessus_ATCC_199 YASVAEAASGLRHLNGFPGGPP---PRMALSIGDTLAGMFAAQGALAALY
. . . *. .* * . ***
Mflv_2503|M.gilvum_PYR-GCK KRERSGEPSVVDVSLLGSGLWALGHTVALTTHLGQRMEAFPPGVHGSPIN
Mvan_4155|M.vanbaalenii_PYR-1 KRERTGEPSIVDVSLLGSGLWALGHTVALTNHLHERMEAFPPGAHGSPIN
MSMEG_4798|M.smegmatis_MC2_155 KRERTGEPSVVDVSLLGSGLWAMGHTIALTSHLNELMVQPPPGVHGSPIN
MMAR_4713|M.marinum_M KRERTGEPSVVDVSLLGSGLWSLGHTVALTRHLGQRLEAPPPGIHGSPIN
TH_4667|M.thermoresistible__bu ERERTGVARVVDISLLGVGVWASGVAINAALISGQPWIPNPTGANVAPNN
MAV_2541|M.avium_104 GRQATGEPSVLDVSLLAVGAWTTQFNVNMAMLMGGPLPKVERRTQ-APGN
MUL_3873|M.ulcerans_Agy99 HRERTGEALEVDVSLLSTAWWAAGASMTQGMDTGETMRSRMPQSGGMPMN
Mb3300|M.bovis_AF2122/97 HRERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPKAKRR
Rv3272|M.tuberculosis_H37Rv HRERNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPKAKRR
MAB_4651c|M.abscessus_ATCC_199 RRTVTGRGQVVDAALTESCLAVQESTIPDYDVGRVVRGPSGTRLEGIAPS
* .* :: :: :
Mflv_2503|M.gilvum_PYR-GCK PLVG-------LYATADDRYISFVMMQPTKFWADVCKHMDLDELADDPRF
Mvan_4155|M.vanbaalenii_PYR-1 PLVG-------LYPTADDRYISFVMMQPTKFWADVCSHMDLDELVDDPRF
MSMEG_4798|M.smegmatis_MC2_155 PLVG-------LYGTADGRYISFVMMQPTKFWADVCRHMDLEHYIDDPRF
MMAR_4713|M.marinum_M PLVG-------VYATSDGRYISLVMMQPTKFWADVCRHIDRPDLAEDPRF
TH_4667|M.thermoresistible__bu PLVG-------FYRTADGRFLSLSMLQGFRFFGEFCKRIGVGELAADERF
MAV_2541|M.avium_104 PLTG-------AYRTSDGRFVQLSMLQPTRYWPEFCRLMGLHDLAEDPRF
MUL_3873|M.ulcerans_Agy99 PFMG-------NYQTSDGGTINLCILSPTGYIRDTFEHLGIPEAADDPRF
Mb3300|M.bovis_AF2122/97 KGVGFATQPSDAFRTADG-YIVISAYVP-KHWQKLCYLIGRPDLVEDQRF
Rv3272|M.tuberculosis_H37Rv KGVGFATQPSDAFRTADG-YIVISAYVP-KHWQKLCYLIGRPDLVEDQRF
MAB_4651c|M.abscessus_ATCC_199 ----------NIYQSADGSWVVIAANQDTVFRR-LCEAMGRPELSSDARF
: ::*. : : . :. . * **
Mflv_2503|M.gilvum_PYR-GCK ATAESIAEHTALANEILTEAMAKRPLTEWSERFATLAGPWAPVQDTLQAA
Mvan_4155|M.vanbaalenii_PYR-1 ATAESIAENTADAAEILKEAMSKRTLAEWSERFATLAGPWAPVQDTLQAA
MSMEG_4798|M.smegmatis_MC2_155 ATAESIAENTAAAVDILTEAMKKRTLPEWSERFATLAGPWAPVQDTLQAA
MMAR_4713|M.marinum_M ATVEKIAAHTADAVEILTKAISARTLAEWSERFATLAGPWAPVQDTLQAA
TH_4667|M.thermoresistible__bu ASHAALTANAAAATEILRATIAAQPLEHWRRVLDGFEGQWAVVQNTAEVA
MAV_2541|M.avium_104 TTLDAMAAHSETAQQIVADAIGKLSFAECQALLRKGRGQWGPVQDAWEIA
MUL_3873|M.ulcerans_Agy99 GEAEQLLRNADAAGALIARAVAARPFEYWRQRLKTMKGQWAPFQSLIELA
Mb3300|M.bovis_AF2122/97 AEQRSRSINYAELTAELELALASKTATEWVQLLQAN-GLMACLAHTWKQV
Rv3272|M.tuberculosis_H37Rv AEQRSRSINYAELTAELELALASKTATEWVQLLQAN-GLMACLAHTWKQV
MAB_4651c|M.abscessus_ATCC_199 ANHVARGRNQDDLDAIIAQWAAQRLPTDIIDVLSAAGVIAGPINTVADVV
: : : . . . .
Mflv_2503|M.gilvum_PYR-GCK EDAQIRAN----EYLVQ---AGE--LELVSNPVQFDVAAPVSGPAPGFAE
Mvan_4155|M.vanbaalenii_PYR-1 EDAQVRAN----EYLVQ---AGE--LELVANPVQFDVAAPASGPAPGFAE
MSMEG_4798|M.smegmatis_MC2_155 QDAQIRAN----EYLVQ---AGE--LELVTNPVQFDVSAPSPGPAPGFAE
MMAR_4713|M.marinum_M DDAQVRAN----EYVVR---AGE--LELVANPVQFDVAAPQTGPAPGFAE
TH_4667|M.thermoresistible__bu ADPQVRANGGIVEVETG---SGK--TELVASPVLFDETPLNLRPMPEFAA
MAV_2541|M.avium_104 NDEALTANGRIAEIVDA---EGHP-QKLVASPAQFDDDPASLTRAPQFAE
MUL_3873|M.ulcerans_Agy99 DDEQALANDMVAEVDLG---AGGPPFRVVRGPVQFNHEPLTTTRAPQPGE
Mb3300|M.bovis_AF2122/97 VDTPLFAES-DLTLEVG---RGADTITVIRTPARYASFRAVVTDPPPTAG
Rv3272|M.tuberculosis_H37Rv VDTPLFAEN-DLTLEVG---RGADTITVIRTPARYASFRAVVTDPPPTAG
MAB_4651c|M.abscessus_ATCC_199 QDPQLKAREMLVEHFDERLGRSVLGPGVVPVLSESPGGVRNAGPARPGQD
* *. . ::
Mflv_2503|M.gilvum_PYR-GCK QTDDILVELGLDWDRIIELKTAGAVT
Mvan_4155|M.vanbaalenii_PYR-1 QTDDILVELGLDWDRIIELKTAGAVT
MSMEG_4798|M.smegmatis_MC2_155 QTDDILAELGLDWDRIIELKTAGAVT
MMAR_4713|M.marinum_M QTDDILLELGFDWDRIIELKTAGAVT
TH_4667|M.thermoresistible__bu DTEQLILELGGDWDRITALKDSGAIA
MAV_2541|M.avium_104 HTDAVLRELGIDDDRLIELKIAGVIT
MUL_3873|M.ulcerans_Agy99 HTETVLLELGMDWDRIDQLKRSGAIS
Mb3300|M.bovis_AF2122/97 EHNAVFLARP----------------
Rv3272|M.tuberculosis_H37Rv EHNAVFLARP----------------
MAB_4651c|M.abscessus_ATCC_199 NDDVYVGLLGKSAQDIERLRAEGVL-
. : .