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VAFSTWGGIALDPERHPLIEHPNRGKRSVGIDLATSDGQDVLHELARSADVFLTNYLPSARQKNKFDVEH VRGANPDIIYARGTAYGDKGAERDVGGYDGTAFWTRSGVGHALTPPELGAPLAQGIPAFGDSIGGMNIAG GISAALLHRERTGEALEVDVSLLSTAWWAAGASMTQGMDTGETMRSRMPQSGGMPMNPFMGNYQTSDGGT INLCILSPTGYIRDTFEHLGIPEAADDPRFGEAEQLLRNADAAGALIARAVAARPFEYWRQRLKTMKGQW APFQSLIELADDEQALANDMVAEVDLGAGGPPFRVVRGPVQFNHEPLTTTRAPQPGEHTETVLLELGMDW DRIDQLKRSGAIS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_3873 | - | - | 100% (363) | dehydratase |
| M. ulcerans Agy99 | MUL_1046 | - | 8e-40 | 33.24% (340) | acyl-CoA transferase |
| M. ulcerans Agy99 | MUL_4811 | - | 1e-20 | 28.79% (330) | hypothetical protein MUL_4811 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 1e-20 | 27.01% (348) | hypothetical protein Mb3300 |
| M. gilvum PYR-GCK | Mflv_4341 | - | 1e-164 | 74.79% (361) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. tuberculosis H37Rv | Rv3272 | - | 4e-21 | 27.30% (348) | hypothetical protein Rv3272 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4651c | - | 4e-18 | 27.91% (301) | putative L-carnitine dehydratase |
| M. marinum M | MMAR_4009 | - | 0.0 | 98.61% (361) | dehydratase |
| M. avium 104 | MAV_1597 | - | 1e-171 | 76.73% (361) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. smegmatis MC2 155 | MSMEG_0585 | - | 1e-164 | 75.35% (361) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. thermoresistible (build 8) | TH_2620 | - | 1e-163 | 73.13% (361) | PUTATIVE L-carnitine dehydratase/bile acid-inducible protein F |
| M. vanbaalenii PYR-1 | Mvan_4155 | - | 2e-80 | 42.30% (357) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_3873|M.ulcerans_Agy99 --------------------------------------------------
MMAR_4009|M.marinum_M ---------MAGYRVLEVAQFTFVPAAGAILADWGADVIKVEHPRRGDTQ
Mflv_4341|M.gilvum_PYR-GCK -----MIKVMEGVRVLEVAQFTFVPAAGAILADWGADVIKIEHPVRGDTQ
MSMEG_0585|M.smegmatis_MC2_155 -----MIKVMQGVRVLEVAQFTFVPAAGAILADWGADVIKVEHPVRGDTQ
TH_2620|M.thermoresistible__bu -MTEKTTRVMQGVRVLEVAQFTFVPAAGAILADWGADVIKVEHPVRGDTQ
MAV_1597|M.avium_104 ---------MQGFRVLEVAQFTFVPAAGAILADWGADVIKVEHPVRGDTQ
Mvan_4155|M.vanbaalenii_PYR-1 -----MSKPLDGIRVLEVAMYGFVPSAGAVLAEWGADVIKVEHAVTGDPQ
Mb3300|M.bovis_AF2122/97 MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAP-GGEAA
Rv3272|M.tuberculosis_H37Rv MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAP-GGEAA
MAB_4651c|M.abscessus_ATCC_199 -----MTGALDGIRVLELGTLIAGPFAGRLLGDMGAEVLKIEPPGAPDPL
MUL_3873|M.ulcerans_Agy99 MAFSTWGGIALDPERHPLIEHPNRGKRSVGIDLATSDGQDVLHELARSAD
MMAR_4009|M.marinum_M RGFLNVGGIALDPERHPLIEHPNRGKRSVGIDLATSDGQDVLHELARTAD
Mflv_4341|M.gilvum_PYR-GCK RGFINMGGFQLDPNRHPLIEHPNRGKRSVGIDVSTPEGQEVLYEIAKTAD
MSMEG_0585|M.smegmatis_MC2_155 RGFINMGGFQLDPNRHPLIEHPNRGKRSVGIDVSKPEGQEVLYELAQVSD
TH_2620|M.thermoresistible__bu RGFIHMGGFELNPDRHPLIEHPNRGKRSIGIDISTDGGREVLYEIAKTSD
MAV_1597|M.avium_104 RGFVNMGGIQVDPERHPLMEHPNRGKRSVGVDVSTPGGQEVIYELAKTSD
Mvan_4155|M.vanbaalenii_PYR-1 RGLRQTGLLRVEGDPNPNIEHANRLKRSIGLDMSVAEGREVLLELARRAD
Mb3300|M.bovis_AF2122/97 RQITSV--LPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLADTAD
Rv3272|M.tuberculosis_H37Rv RQITSV--LPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLADTAD
MAB_4651c|M.abscessus_ATCC_199 R---TWGQAEVDG-HHVFWTVHARNKKAITLDLRTEAGRALFLDLVDKSD
* *::: :*: .: : :. :*
MUL_3873|M.ulcerans_Agy99 VFLTNYLPSARQKNKFDVEHVRGANPDIIYARGTAYGDKGAERDVGGYDG
MMAR_4009|M.marinum_M VFLTNYLPSARQKNKFDVEHVRGANPDIIYARGTAYGDKGAERDVGGYDG
Mflv_4341|M.gilvum_PYR-GCK VFLTNYMPQARQKNKFDIEHIRAVNPNIIYARGSAYGDKGPERLVGGFDG
MSMEG_0585|M.smegmatis_MC2_155 VFLTNYMPQAREKNKFDVEHIRAVNPNIIYARGSAYGDKGPERLAGGFDG
TH_2620|M.thermoresistible__bu VFLTNYLPVQRQKHKFDVEHIREVNPGIIYARGSAYGDKGPQRDVGGFDG
MAV_1597|M.avium_104 VFLTNYMPAQRRKHKFDVEHIRAVNPNIVYARGSAYGDKGAERDVGGYDG
Mvan_4155|M.vanbaalenii_PYR-1 VFLTSFLPGHRQKFGIDVDDIRAANPKIVYARGSALGPRGEESVKGGYDM
Mb3300|M.bovis_AF2122/97 VVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRPGIDL
Rv3272|M.tuberculosis_H37Rv VVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRPGIDL
MAB_4651c|M.abscessus_ATCC_199 VIVENFRPGTLERWGLGYDVLAQRNKGIILVRVSGYGQTGPDAHKAGYAS
*.: : * .: :. : : * :: .* :. * * . *
MUL_3873|M.ulcerans_Agy99 TAFWTRSGVGHALTPPELGAPLAQGIPAFGDSIGGMNIAGGISAALLHRE
MMAR_4009|M.marinum_M TAFWTRSGVGHALTPPELGAPLAQGIPAFGDSIGGMNIAGGISAALLHRE
Mflv_4341|M.gilvum_PYR-GCK TAFWTRSGVGHALTPEELGGALPQGIPAFGDSIGGMNIAGGISAALFHRE
MSMEG_0585|M.smegmatis_MC2_155 TAFWTRSGVGHALTPEELGGALSQGIPAFGDSIGGMNIAGGIAAALFHRD
TH_2620|M.thermoresistible__bu TAFWTRSGIGHALTPEELGGALSQGIPAFGDSIGGMNIAGGIAAALFHRE
MAV_1597|M.avium_104 TAFWTRSGIGYALTPEELGGALGQGIPAFGDSIGGMFIAGGISAALLHRE
Mvan_4155|M.vanbaalenii_PYR-1 TAFWCRAGTAATITPPGTPGMVGPPGPAYGDTISGTNLAGGIAAALLKRE
Mb3300|M.bovis_AF2122/97 VVAAEAGMTTGMPTPEGKPQIIP---FQLVDNASGHVLAQAVLAALLHRE
Rv3272|M.tuberculosis_H37Rv VVAAEAGMTTGMPTPEGKPQIIP---FQLVDNASGHVLAQAVLAALLHRE
MAB_4651c|M.abscessus_ATCC_199 VAEAASGLRHLNGFPGGPP---PRMALSIGDTLAGMFAAQGALAALYRRT
.. . * *. .* * . *** :*
MUL_3873|M.ulcerans_Agy99 RTGEALEVDVSLLSTAWWAAGASMTQGMDTGETMRSRMPQSGGMPMNPFM
MMAR_4009|M.marinum_M RTGEALEVDVSLLSTAWWAAGASVTQGMDTGETMRSRMPQSGGMPMNPFM
Mflv_4341|M.gilvum_PYR-GCK RTGEAVEIDVSLLSTAWWAAGASVTQGMETGETMRSLMPGTT-TSVNPFM
MSMEG_0585|M.smegmatis_MC2_155 RTGEALEVDVSLLSTAWWAAGASVTQGMETGETMRSQMPDTIGPTVNPFL
TH_2620|M.thermoresistible__bu RTGEAVEIDVSLLSTAWWAAGASVTQGMETGETMRSQMPDTVGPTVNPFL
MAV_1597|M.avium_104 RTGEAVELDVSLLSTAWWAAGASVTQGMETGEVMRTPMPGAGAPSVNPFM
Mvan_4155|M.vanbaalenii_PYR-1 RTGEPSIVDVSLLGSGLWALGHTVALTNHLHERMEAFPPGAHGSPINPLV
Mb3300|M.bovis_AF2122/97 RNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPKAKRRKGV
Rv3272|M.tuberculosis_H37Rv RNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPKAKRRKGV
MAB_4651c|M.abscessus_ATCC_199 VTGRGQVVDAALTESCLAVQESTIPD-YDVGRVVRG--PSGTRLEGIAPS
.* ::.:: : . .
MUL_3873|M.ulcerans_Agy99 GNYQTSD------GGTINLCILSPTGYIRDTFEHLGIPEAADDPRFGEAE
MMAR_4009|M.marinum_M GNYQTSD------GGTINLCILSPTGYIRDTFEHLGIPEAADDPRFGEAE
Mflv_4341|M.gilvum_PYR-GCK ANYQTSD------GGTINLCIVSPTGYIRDTWEHLGLPELADDPRFSDVM
MSMEG_0585|M.smegmatis_MC2_155 GNYQTSD------GGTINLCIVSPTGYIRDTFEHLGLAELADDPRFCDVL
TH_2620|M.thermoresistible__bu GNYLTSD------GGTINLCIVSPTGYIRDAFEHLDLPELADDPRFCDVM
MAV_1597|M.avium_104 GNYETSD------GGTINLCIISPTGLIRDTFEHLGIPEAADDPRFCDVL
Mvan_4155|M.vanbaalenii_PYR-1 GLYPTAD------DRYISFVMMQPTKFWADVCSHMDLDELVDDPRFATAE
Mb3300|M.bovis_AF2122/97 GFATQPSDAFRTADGYIVISAYVPK-HWQKLCYLIGRPDLVEDQRFAEQR
Rv3272|M.tuberculosis_H37Rv GFATQPSDAFRTADGYIVISAYVPK-HWQKLCYLIGRPDLVEDQRFAEQR
MAB_4651c|M.abscessus_ATCC_199 NIYQSAD-------GSWVVIAANQDTVFRRLCEAMGRPELSSDARFANHV
.. . :. : .* **
MUL_3873|M.ulcerans_Agy99 QLLRNADAAGALIARAVAARPFEYWRQRLKTMKGQWAPFQSLIELADDEQ
MMAR_4009|M.marinum_M QLLRNADAAGALIARAVAARPFEYWRQRLKTMKGQWAPFQSLIELADDEQ
Mflv_4341|M.gilvum_PYR-GCK PLIQNAEEGVRLITEAIAAKPFEYWRRHLKTMKGQWAPFQSLVDLGTDEQ
MSMEG_0585|M.smegmatis_MC2_155 PLIEHAAEAAERIAEAIRSRPFEYWRRHLKTMKGQWAPFQSLVDLATDEQ
TH_2620|M.thermoresistible__bu PLFENAAEAARLIADSIRSKPFDYWRERLKTMKGQWAPFQSLVDLAGDEQ
MAV_1597|M.avium_104 PLIQNADAAAELIAKAFAAKPFDYWRQHLKTMKGQWAPFQSLLDLIDDEQ
Mvan_4155|M.vanbaalenii_PYR-1 SIAENTADAAEILKEAMSKRTLAEWSERFATLAGPWAPVQDTLQAAEDAQ
Mb3300|M.bovis_AF2122/97 SRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVVDTPL
Rv3272|M.tuberculosis_H37Rv SRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVVDTPL
MAB_4651c|M.abscessus_ATCC_199 ARGRNQDDLDAIIAQWAAQRLPTDIIDVLSAAGVIAGPINTVADVVQDPQ
: : : : : : :
MUL_3873|M.ulcerans_Agy99 ALANDMVAEVDLGAGGPPFRVVRGPVQFN-HEPLTTTRAPQ--PGEHTET
MMAR_4009|M.marinum_M ALANDMVAEVDLGAGGPPFRVVRGPVQFN-HEPLTTTRAPQ--PGEHTET
Mflv_4341|M.gilvum_PYR-GCK AIANDMIVEVEASDGGKPFKVVRGPVQFN-HEPLETTRAPQ--ASEHTEI
MSMEG_0585|M.smegmatis_MC2_155 AIANDMVVEVEAADGGEPFRVVRGPVQFN-HEPLETTRAPQ--ASEHTEV
TH_2620|M.thermoresistible__bu AIANDMIVEVDAADGGPPFKVVRGPVQFN-HEPLRTTRAPL--ASEHTEL
MAV_1597|M.avium_104 AIANDMIAEVELAGGGKPFRVVRGPVQFN-HEPLATTRAPQ--ASEHTEL
Mvan_4155|M.vanbaalenii_PYR-1 VRANEYLVQAG------ELELVANPVQFD-VAAPASGPAPG--FAEQTDD
Mb3300|M.bovis_AF2122/97 FAESDLTLEVG--RGADTITVIRTPARYASFRAVVTDPPPT--AGEHNAV
Rv3272|M.tuberculosis_H37Rv FAENDLTLEVG--RGADTITVIRTPARYASFRAVVTDPPPT--AGEHNAV
MAB_4651c|M.abscessus_ATCC_199 LKAREMLVEHFDERLGRSVLGPGVVPVLSESPGGVRNAGPARPGQDNDDV
: : . * ::
MUL_3873|M.ulcerans_Agy99 VLLELGMDWDRIDQLKRSGAIS
MMAR_4009|M.marinum_M VLLELGMDWDRIDQLKRSGAIS
Mflv_4341|M.gilvum_PYR-GCK VLMELGLEWDRIEELKDKGAIA
MSMEG_0585|M.smegmatis_MC2_155 VLMELGLDWDRIGKLKDVGAIA
TH_2620|M.thermoresistible__bu ILMDIGMDWDRISELKDSGAIA
MAV_1597|M.avium_104 VLMELGMDWDRIEELKNAGAIA
Mvan_4155|M.vanbaalenii_PYR-1 ILVELGLDWDRIIELKTAGAVT
Mb3300|M.bovis_AF2122/97 FLARP-----------------
Rv3272|M.tuberculosis_H37Rv FLARP-----------------
MAB_4651c|M.abscessus_ATCC_199 YVGLLGKSAQDIERLRAEGVL-
: