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KPLEGIRVLEVAMYGFVPSAGAVLAEWGADVIKVEHAVTGDPQRGLRQTGMLRVEGDPNPNIEHANRGKR SLGLDMSISEGKEVLHELARRSDVFLTSFLPGARRKFGIDLEDIRAVNPSIIYARGSALGPRGEEAAKGG YDMTAFWCRAGTAATITPMGYQGMINPPGPAYGDTISGTNLAGGIAAALLKRERTGEPSVVDVSLLGSGL WSLGHTVALTRHLGQRLEAPPPGIHGSPINPLVGVYATSDGRYISLVMMQPTKFWADVCRHIDRPDLAED PRFATVEKIAAHTADAVEILTKAISARTLAEWSERFATLAGPWAPVQDTLQAADDAQVRANEYVVRAGEL ELVANPVQFDVAAPQTGPAPGFAEQTDDILLELGFDWDRIIELKTAGAVT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_4713 | - | - | 100% (401) | dehydratase |
| M. marinum M | MMAR_4009 | - | e-102 | 46.29% (404) | dehydratase |
| M. marinum M | MMAR_0396 | - | 1e-53 | 34.36% (390) | acyl-CoA transferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3300 | - | 2e-33 | 31.74% (397) | hypothetical protein Mb3300 |
| M. gilvum PYR-GCK | Mflv_2503 | - | 0.0 | 86.00% (400) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. tuberculosis H37Rv | Rv3272 | - | 2e-33 | 31.74% (397) | hypothetical protein Rv3272 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4651c | - | 7e-28 | 30.20% (351) | putative L-carnitine dehydratase |
| M. avium 104 | MAV_0945 | - | 0.0 | 87.78% (401) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. smegmatis MC2 155 | MSMEG_4798 | - | 0.0 | 83.21% (399) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. thermoresistible (build 8) | TH_4316 | - | 0.0 | 85.04% (401) | PUTATIVE L-carnitine dehydratase/bile acid-inducible protein F |
| M. ulcerans Agy99 | MUL_3873 | - | 5e-84 | 43.70% (357) | dehydratase |
| M. vanbaalenii PYR-1 | Mvan_4155 | - | 0.0 | 85.25% (400) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4713|M.marinum_M ------MKPLEGIRVLEVAMYGFVPSAGAVLAEWGADVIKVEHAVTGDPQ
MAV_0945|M.avium_104 ------MRPLEGIRVLEVAMYGFVPSAGAVLAEWGAEVVKVEHAVTGDPQ
Mflv_2503|M.gilvum_PYR-GCK -----MSKPLDGIRVLEVAMYGFVPSAGAVLAEWGADVIKVEHAVTGDPQ
Mvan_4155|M.vanbaalenii_PYR-1 -----MSKPLDGIRVLEVAMYGFVPSAGAVLAEWGADVIKVEHAVTGDPQ
TH_4316|M.thermoresistible__bu ------MRPLEGIRVLEVAMYGFVPSAGAVLGEWGADVIKVEHAVTGDPQ
MSMEG_4798|M.smegmatis_MC2_155 -----MSGPLEGIRILEVAMYGFVPSAGAVLGEWGADVIKVEHAVTGDPQ
MUL_3873|M.ulcerans_Agy99 ----------------------------MAFSTWGG--------IALDPE
Mb3300|M.bovis_AF2122/97 MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAPGGEAAR
Rv3272|M.tuberculosis_H37Rv MPTSNPAKPLDGFRVLDFTQNVAGPLAGQVLVDLGAEVIKVEAPGGEAAR
MAB_4651c|M.abscessus_ATCC_199 -----MTGALDGIRVLELGTLIAGPFAGRLLGDMGAEVLKIEPPGAPDPL
: *. .
MMAR_4713|M.marinum_M RGLRQTGMLRVEGDPNPNIEHANRGKRSLGLDMSISEGKEVLHELARRSD
MAV_0945|M.avium_104 RGLRQTGMLRVEGDPNPNIEHANRGKRSIGLDISVPEGKEVLYELARRSD
Mflv_2503|M.gilvum_PYR-GCK RGLRQTGLLRVEGDPNPNIEHANRLKRSIGLDMSVPEGKEVLLELARRAD
Mvan_4155|M.vanbaalenii_PYR-1 RGLRQTGLLRVEGDPNPNIEHANRLKRSIGLDMSVAEGREVLLELARRAD
TH_4316|M.thermoresistible__bu RGLRQTGLLRVEGDPNPNIEHANRGKRSIGLDMSVPEGREVLLELARRSD
MSMEG_4798|M.smegmatis_MC2_155 RGLRQTGPLRVDGDPNPNIEHANRGKRSIGLDMSVPAGREVLLELARRAD
MUL_3873|M.ulcerans_Agy99 R--------------HPLIEHPNRGKRSVGIDLATSDGQDVLHELARSAD
Mb3300|M.bovis_AF2122/97 Q---ITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLADTAD
Rv3272|M.tuberculosis_H37Rv Q---ITSVLPGRPPLATYFLPNNRGKKSVTVDLTTEQAKQQMLRLADTAD
MAB_4651c|M.abscessus_ATCC_199 R----TWGQAEVDGHHVFWTVHARNKKAITLDLRTEAGRALFLDLVDKSD
: * *::: :*: .: : *. :*
MMAR_4713|M.marinum_M VFLTSFLPGARRKFGIDLEDIRAVNPSIIYARGSALGPRGEEAAKGGYDM
MAV_0945|M.avium_104 VFLTSFLPAHRKKFGIDVDDIRTVNPKIVYARGSALGPRGAESEKGGYDM
Mflv_2503|M.gilvum_PYR-GCK VFLTSFLPGHRQKFGIDVDDIRAVNPKIIYARGSALGPRGEESVKGGYDM
Mvan_4155|M.vanbaalenii_PYR-1 VFLTSFLPGHRQKFGIDVDDIRAANPKIVYARGSALGPRGEESVKGGYDM
TH_4316|M.thermoresistible__bu VFLTSFLPGHRQKFKIDVDDIRAVNPKIIYARGSALGPRGEEAVKGGYDM
MSMEG_4798|M.smegmatis_MC2_155 VFLTSFLPGHREKFGIDVDDIRAVNPKIIYARGSALGPRGEESVKGGYDM
MUL_3873|M.ulcerans_Agy99 VFLTNYLPSARQKNKFDVEHVRGANPDIIYARGTAYGDKGAERDVGGYDG
Mb3300|M.bovis_AF2122/97 VVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRPGIDL
Rv3272|M.tuberculosis_H37Rv VVLEAFRPGTMEKLGLGPDDLRSRNPNLIYARLTAYGGNGPHGSRPGIDL
MAB_4651c|M.abscessus_ATCC_199 VIVENFRPGTLERWGLGYDVLAQRNKGIILVRVSGYGQTGPDAHKAGYAS
*.: : *. .: :. : : * :: .* :. * * . *
MMAR_4713|M.marinum_M TAFWCRAGTAATITPMGYQGMINPPGPAYGDTISGTNLAGGIAAALLKRE
MAV_0945|M.avium_104 TAFWCRAGTAATITPAGMPGMIAPPGPAYGDTISGTNLAGGIAAALLKRE
Mflv_2503|M.gilvum_PYR-GCK TAFWCRAGTAATITPPGTPGMVGPPGPAYGDTISGTNLAGGIAAALLKRE
Mvan_4155|M.vanbaalenii_PYR-1 TAFWCRAGTAATITPPGTPGMVGPPGPAYGDTISGTNLAGGIAAALLKRE
TH_4316|M.thermoresistible__bu TAFWCRAGTARTITPPDMPGMIGPPGPAYGDTISGTNLAGGIAAALLKRE
MSMEG_4798|M.smegmatis_MC2_155 TAFWCRAGAAATITPPGIEGMIGPPGPAYGDTISGTNLAGGIAAALFKRE
MUL_3873|M.ulcerans_Agy99 TAFWTRSGVGHALTPPELGAPLAQGIPAFGDSIGGMNIAGGISAALLHRE
Mb3300|M.bovis_AF2122/97 VVAAEAGMTTGMPTPEGKPQIIP---FQLVDNASGHVLAQAVLAALLHRE
Rv3272|M.tuberculosis_H37Rv VVAAEAGMTTGMPTPEGKPQIIP---FQLVDNASGHVLAQAVLAALLHRE
MAB_4651c|M.abscessus_ATCC_199 VAEAASGLRHLNGFPGGPP---PRMALSIGDTLAGMFAAQGALAALYRRT
.. . * *. .* * . *** :*
MMAR_4713|M.marinum_M RTGEPSVVDVSLLGSGLWSLGHTVALTRHLGQRLEAPPPGIHGSPINPLV
MAV_0945|M.avium_104 RTGEPSVVDVSLLGSGLWSLGHTVALTNHLHQRLESPPPGVHGAPNNPLV
Mflv_2503|M.gilvum_PYR-GCK RSGEPSVVDVSLLGSGLWALGHTVALTTHLGQRMEAFPPGVHGSPINPLV
Mvan_4155|M.vanbaalenii_PYR-1 RTGEPSIVDVSLLGSGLWALGHTVALTNHLHERMEAFPPGAHGSPINPLV
TH_4316|M.thermoresistible__bu RTGEPSIVDVSLLGSGLWSLGHTVALTNHLGERLEAFPPGVHGSPINPLV
MSMEG_4798|M.smegmatis_MC2_155 RTGEPSVVDVSLLGSGLWAMGHTIALTSHLNELMVQPPPGVHGSPINPLV
MUL_3873|M.ulcerans_Agy99 RTGEALEVDVSLLSTAWWAAGASMTQGMDTGETMRSRMPQSGGMPMNPFM
Mb3300|M.bovis_AF2122/97 RNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPKAKRRKGV
Rv3272|M.tuberculosis_H37Rv RNGVADVVQVAMYDVAVGLQANQLMMHLNRAASDQPKPEPAPKAKRRKGV
MAB_4651c|M.abscessus_ATCC_199 VTGRGQVVDAALTESCLAVQESTIPDYDVGRVVRGPSGTRLEGIAPSN--
.* *:.:: :
MMAR_4713|M.marinum_M GVYATSD------GRYISLVMMQPTKFWADVCRHIDRPDLAEDPRFATVE
MAV_0945|M.avium_104 GLYTTSD------GRYISFVMMQPTKFWADVCRHVDLPELADDPRFDTAE
Mflv_2503|M.gilvum_PYR-GCK GLYATAD------DRYISFVMMQPTKFWADVCKHMDLDELADDPRFATAE
Mvan_4155|M.vanbaalenii_PYR-1 GLYPTAD------DRYISFVMMQPTKFWADVCSHMDLDELVDDPRFATAE
TH_4316|M.thermoresistible__bu GLYPTAD------DRYISFVMMQPTKFWADVCRHMDLDELIDDPRFATAE
MSMEG_4798|M.smegmatis_MC2_155 GLYGTAD------GRYISFVMMQPTKFWADVCRHMDLEHYIDDPRFATAE
MUL_3873|M.ulcerans_Agy99 GNYQTSD------GGTINLCILSPTGYIRDTFEHLGIPEAADDPRFGEAE
Mb3300|M.bovis_AF2122/97 GFATQPSDAFRTADGYIVISAYVP-KHWQKLCYLIGRPDLVEDQRFAEQR
Rv3272|M.tuberculosis_H37Rv GFATQPSDAFRTADGYIVISAYVP-KHWQKLCYLIGRPDLVEDQRFAEQR
MAB_4651c|M.abscessus_ATCC_199 -IYQSAD-------GSWVVIAANQDTVFRRLCEAMGRPELSSDARFANHV
.. . :. . .* **
MMAR_4713|M.marinum_M KIAAHTADAVEILTKAISARTLAEWSERFATLAGPWAPVQDTLQAADDAQ
MAV_0945|M.avium_104 NIAANTADAVELLTKAIATRTLAEWTERFATLAGPWAPVQDTLQAADDAQ
Mflv_2503|M.gilvum_PYR-GCK SIAEHTALANEILTEAMAKRPLTEWSERFATLAGPWAPVQDTLQAAEDAQ
Mvan_4155|M.vanbaalenii_PYR-1 SIAENTADAAEILKEAMSKRTLAEWSERFATLAGPWAPVQDTLQAAEDAQ
TH_4316|M.thermoresistible__bu AIAENTEVATKILTEAMSKRTLAEWSERFATLAGPWAPVQDTLQAAQDSQ
MSMEG_4798|M.smegmatis_MC2_155 SIAENTAAAVDILTEAMKKRTLPEWSERFATLAGPWAPVQDTLQAAQDAQ
MUL_3873|M.ulcerans_Agy99 QLLRNADAAGALIARAVAARPFEYWRQRLKTMKGQWAPFQSLIELADDEQ
Mb3300|M.bovis_AF2122/97 SRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVVDTPL
Rv3272|M.tuberculosis_H37Rv SRSINYAELTAELELALASKTATEWVQLLQANGLMACLAHTWKQVVDTPL
MAB_4651c|M.abscessus_ATCC_199 ARGRNQDDLDAIIAQWAAQRLPTDIIDVLSAAGVIAGPINTVADVVQDPQ
: : : : : : : : .:
MMAR_4713|M.marinum_M VRANEYVVRAG-------ELELVANPVQFDVAAPQTGPAPG-FAEQTDDI
MAV_0945|M.avium_104 IRANEYIVRAG-------ELELVANPVQFDVAAPQTGPAPG-FAEQTDEI
Mflv_2503|M.gilvum_PYR-GCK IRANEYLVQAG-------ELELVSNPVQFDVAAPVSGPAPG-FAEQTDDI
Mvan_4155|M.vanbaalenii_PYR-1 VRANEYLVQAG-------ELELVANPVQFDVAAPASGPAPG-FAEQTDDI
TH_4316|M.thermoresistible__bu IRANEYLIRAG-------EMELVANPVQFDVTAPSTGPAPG-FAEQTDEI
MSMEG_4798|M.smegmatis_MC2_155 IRANEYLVQAG-------ELELVTNPVQFDVSAPSPGPAPG-FAEQTDDI
MUL_3873|M.ulcerans_Agy99 ALANDMVAEVDLG-AGGPPFRVVRGPVQFNHEPLTTTRAPQ-PGEHTETV
Mb3300|M.bovis_AF2122/97 FAESDLTLEVG---RGADTITVIRTPARYASFRAVVTDPPP-TAGEHNAV
Rv3272|M.tuberculosis_H37Rv FAENDLTLEVG---RGADTITVIRTPARYASFRAVVTDPPP-TAGEHNAV
MAB_4651c|M.abscessus_ATCC_199 LKAREMLVEHFDERLGRSVLGPGVVPVLSESPGGVRNAGPARPGQDNDDV
: . : *. * . . : :
MMAR_4713|M.marinum_M LLELGFDWDRIIELKTAGAVT
MAV_0945|M.avium_104 LMELGLDWDRIIELKTAGAVT
Mflv_2503|M.gilvum_PYR-GCK LVELGLDWDRIIELKTAGAVT
Mvan_4155|M.vanbaalenii_PYR-1 LVELGLDWDRIIELKTAGAVT
TH_4316|M.thermoresistible__bu LTELGLDWDRIIELKTVGAVT
MSMEG_4798|M.smegmatis_MC2_155 LAELGLDWDRIIELKTAGAVT
MUL_3873|M.ulcerans_Agy99 LLELGMDWDRIDQLKRSGAIS
Mb3300|M.bovis_AF2122/97 FLARP----------------
Rv3272|M.tuberculosis_H37Rv FLARP----------------
MAB_4651c|M.abscessus_ATCC_199 YVGLLGKSAQDIERLRAEGVL