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MRSLLSQIDEFIAHTNEQTDDIIAAAENLNALAGQVAAADPVVDKALTSVPKALAVLAQERTKIADTIDR VGKFSAIAADTIHQSKQSLVDNLRNIAPVLRSLADAGPALTRGLDGLATYPWPASTVRNWFRGDYANLTL IVDLTLSRIDQGLFTGSRWEGNLTQLELQWGRTIGMQPSPVTGGNPLTYPYHFGGY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_2068 | - | - | 100% (196) | LprM protein |
| M. avium 104 | MAV_2536 | - | 4e-62 | 54.77% (199) | virulence factor Mce family protein |
| M. avium 104 | MAV_1806 | - | 2e-30 | 65.91% (88) | LprM protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0179 | lprK | 9e-22 | 32.56% (172) | MCE-family lipoprotein LprK |
| M. gilvum PYR-GCK | Mflv_2105 | - | 3e-61 | 55.28% (199) | virulence factor Mce family protein |
| M. tuberculosis H37Rv | Rv1970 | lprM | 8e-58 | 54.77% (199) | MCE-family lipoprotein LprM |
| M. leprae Br4923 | MLBr_02593 | lprK | 3e-20 | 29.07% (172) | putative lipoprotein |
| M. abscessus ATCC 19977 | MAB_4149c | - | 2e-20 | 31.90% (163) | MCE-family protein LprN |
| M. marinum M | MMAR_4055 | lprM_1 | 4e-67 | 61.14% (193) | MCE family lipoprotein LprM |
| M. smegmatis MC2 155 | MSMEG_0350 | - | 1e-62 | 57.51% (193) | virulence factor Mce family protein |
| M. thermoresistible (build 8) | TH_3546 | - | 2e-66 | 61.66% (193) | PUTATIVE MCE-family lipoprotein LprM_1 |
| M. ulcerans Agy99 | MUL_3922 | lprM_1 | 7e-67 | 60.62% (193) | MCE family lipoprotein LprM |
| M. vanbaalenii PYR-1 | Mvan_4600 | - | 4e-63 | 58.29% (199) | virulence factor Mce family protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_2068|M.avium_104 --------------------------------------------------
TH_3546|M.thermoresistible__bu -------------------------------------------MPGTEGG
MMAR_4055|M.marinum_M -------MMWARWTTRIRIAAGIAALAVAVSGCSGWRGLNSLPLPGVQGG
MUL_3922|M.ulcerans_Agy99 --------MRAGWTTRIRIAAGIAALAVAVSGCSGWRGLNSLPLPGVQGG
Mvan_4600|M.vanbaalenii_PYR-1 --------MRARAFRAIVVAA---VLAGLLSGCAGWRGLNSLPLPGVQGT
Mflv_2105|M.gilvum_PYR-GCK --------MTAVRASATMALAVTMAAAVTVSGCG-WRGLNSVPLPGTQGG
MSMEG_0350|M.smegmatis_MC2_155 ---------MTHMRRVVACAATVAALMIGVTGCSNWRGLNSVSLPGTEGG
Rv1970|M.tuberculosis_H37Rv -----------------MRIGLTLVMIAAVVASCGWRGLNSLPLPGTQGN
MAB_4149c|M.abscessus_ATCC_199 ------------MSRNVLRAAVMGVGVAVVVSGCQFNGLNSLNLPGTAGH
Mb0179|M.bovis_AF2122/97 ---MMSVLARMRVMRHRAWQGLVLLVLALLLSSCGWRGISNVAIPGGPGT
MLBr_02593|M.leprae_Br4923 MRRAMSVVHTSRVR-HQTWRGLVMLVAALLLSSCGWRGISNVSIPGGPGS
MAV_2068|M.avium_104 --------------------------------------------------
TH_3546|M.thermoresistible__bu GPGAFTVTAQIPDVTTVQQNARVRVGDVNVGTVTRIERQ-----GWHALV
MMAR_4055|M.marinum_M GPGSFTIQAQMPDVDNIEPNSRVRVGDVNVGTVTKIERQ-----GWHALV
MUL_3922|M.ulcerans_Agy99 GPGSFTIQAQMPDVDNIEPNSRVRVGDVNVGTVTKIERQ-----GWHALV
Mvan_4600|M.vanbaalenii_PYR-1 GPGAFQIQAQMPEVDNIEPNSRVRVGDVNVGHVRKIERQ-----GWHALV
Mflv_2105|M.gilvum_PYR-GCK GPGSFTIQAQMPDVDNVEQNSRVRVGDVNVGTVSKIERQ-----GWNALV
MSMEG_0350|M.smegmatis_MC2_155 GPGAFDIQVQMPDITNLQPNSRVRVADVTVGTVTKVERQ-----GWHALL
Rv1970|M.tuberculosis_H37Rv GPGSFAVQAQLPDVNNIQPNSRVRVADVTVGHVTKIERQ-----GWHALV
MAB_4149c|M.abscessus_ATCC_199 GSRSYTVTVELPDVTTLPQNSPVMVDDVTVGSVSGIDAFQKPDGSWYAGV
Mb0179|M.bovis_AF2122/97 GPGSYTIYVQMPDTLAINGNSRVMVADVWVGSIRAIKLKN-----WVATL
MLBr_02593|M.leprae_Br4923 GKGAYTIYVQVPDTLAINGNSKVMVADVTVGSIRAINLKN-----WVATL
MAV_2068|M.avium_104 --------------------------------------------------
TH_3546|M.thermoresistible__bu TMRLNGDVELPANATAKVGQTSLFGSTHIELAPPTDAAPQGRLREGSMVP
MMAR_4055|M.marinum_M TMKLNGNVELPANATATLGQTSLLGSLHIELAPPTDVPPEGNLREGSLIP
MUL_3922|M.ulcerans_Agy99 TMKLNGNVELPANATATLGQTSLLGSLHIELAPPTDVPPEGNLREGSLIP
Mvan_4600|M.vanbaalenii_PYR-1 TIELNGDVELPANATATLGQTSLLGSLHIALAPPTDEAPQGRLKEGSLIP
Mflv_2105|M.gilvum_PYR-GCK TMTLNGDVNLPANATAKVGQTSLLGSQHIELAAPADEAPQGRLEEGTLIP
MSMEG_0350|M.smegmatis_MC2_155 TLRLNGDVNLPANCTATIGQTSLLGSLHVELAPPAAAPPQGRLHQGSLIP
Rv1970|M.tuberculosis_H37Rv TMRLDGDVDLPANATAKIGTTSLLGSYHIELAPPKGEARQGKLRDGSLIA
MAB_4149c|M.abscessus_ATCC_199 KVSLEPEVHLPANAVAKVAQTSLLGSQHIELAAPVGEPAVGKLTGGATIP
Mb0179|M.bovis_AF2122/97 TLSLKKDVTLPKNATAKIGQTSLLGSQHVELAAPPD-PSPVPLKDGDTIP
MLBr_02593|M.leprae_Br4923 TLGLNKDVQLPKNTTAKIGQTSLLGSQHVELAAPAN-PSLELLKNGDTIP
MAV_2068|M.avium_104 ----------------------------------------------MRSL
TH_3546|M.thermoresistible__bu LEQGATYPTTERTLAALSLLLNGGGVGRVQDITTALRTAFAGRERDLRDL
MMAR_4055|M.marinum_M LSSSKAYPSTEQALAATAMLLNGGGIGDIYDITEALSTAFTGRENDLRSL
MUL_3922|M.ulcerans_Agy99 LSSSKAYPSTEQALAATAMLLNGGGIGDIYDITEALSTAFTGRENDLRSL
Mvan_4600|M.vanbaalenii_PYR-1 LSSSRAYPSTEQALAAVALLLNGGGIGDIQDITEALSTAFTGRENDLRSL
Mflv_2105|M.gilvum_PYR-GCK LASAGAYPSTEQALAAVALLLNGGGLGNIQDITDALSTAFSGRENDLRSL
MSMEG_0350|M.smegmatis_MC2_155 LADSTTHPTTEQTLAAVSMLLNGGGLGQMQDITKALSTALRGREADLRNL
Rv1970|M.tuberculosis_H37Rv LSHGSAYPSTEQTLAALSLVLNGGGLGQVQDITEALSTAFAGREHDLRGL
MAB_4149c|M.abscessus_ATCC_199 LSRTGKYPSTEEVLSALSVVVNKGNLGALQDITDETYNLFKGRTGNLTQV
Mb0179|M.bovis_AF2122/97 LKRSSAYPTTEQTLASIATLLRGGGLVNLEGIQQEINAIVTGRADQIRAF
MLBr_02593|M.leprae_Br4923 LKNSSVFPTTEQTLASLSLILRGGGIPNLETLTNEVFNIFHGRADQIHAF
: .
MAV_2068|M.avium_104 LSQIDEFIAHTNEQTDDIIAAAENLNALAGQVAAADPVVDKALTSVPKAL
TH_3546|M.thermoresistible__bu IGELDRFIAAVDTQTDDIIAATESLDNLVSQVAEQRPVLDRALQTVPDAL
MMAR_4055|M.marinum_M IEQLDEAIGHLDDQKGDIIAAAESLNNLMAQLAAQRPVLDKALRTIPDAL
MUL_3922|M.ulcerans_Agy99 IEQLDEAIGHLDDQKGDIIAAAESLNNLMAQLAAQRPVLDKALRTIPDAL
Mvan_4600|M.vanbaalenii_PYR-1 IEQLDKAIGYLDDQKDDIIAAAESLNNLMGQLAEQKPVVDKALRTIPDAL
Mflv_2105|M.gilvum_PYR-GCK IEQLDIAVGHLDDQTGDIIATSESLNNVVGQIAEQKPVVDKALRTIPDAL
MSMEG_0350|M.smegmatis_MC2_155 IGQLETFVAKTNDQTGDIIEATEKLNRLTGKFAAQQPVVDKAVRTIPDAL
Rv1970|M.tuberculosis_H37Rv IGQLDTFTAYLNNQSGDIIAATDSLNRLVGKFADQQPVFDRALATIPDAL
MAB_4149c|M.abscessus_ATCC_199 LPKLATLISSLNSQRDDIISAIEGIDKFSRVLAEHKESLGRAIDSIEPAL
Mb0179|M.bovis_AF2122/97 LGKLDTFTDELNQQRDDITRAIDSTNRLLAYVGGRSEVLNRVLTDLPPLI
MLBr_02593|M.leprae_Br4923 LTKLDTFASQLNQQRDDITHAIDSTNRLLTYVGGRSDVLDQILTDIPPLI
: :: : * .** : : : . .. ..: : : :
MAV_2068|M.avium_104 AVLAQERTKIADTIDRVGKFSAIAADTIHQSKQSLVDNLRNIAPVLRSLA
TH_3546|M.thermoresistible__bu AVLRDRRETLAEALVRFGEFSSLTADTVEHSKESLATELRNLVAVLKSLA
MMAR_4055|M.marinum_M AVLKNERENLADALTQLGRFSALAADSVNQTKDALVQELKDLGPTLESLA
MUL_3922|M.ulcerans_Agy99 TVLKNERENLADALTQLGRFSALAADSVNQTKDALVQELKDLGPTLESLA
Mvan_4600|M.vanbaalenii_PYR-1 AVLKDQRNNLAEALTQLGRFSALAADSVNQTKEALVAELEDLGPVLEELA
Mflv_2105|M.gilvum_PYR-GCK AVLRDQRDTLSEALVQLGRFSALAADSVTKTREALIQELKDLGPVLQSLA
MSMEG_0350|M.smegmatis_MC2_155 EVLKDQRDNLTAALDQLGRFSALAADSTRQTKDSLVREFRNIGPVLESLA
Rv1970|M.tuberculosis_H37Rv AVLADERDTLVEAAEQLSKFSALTVDSVNKTTANLVTELRQLGPVLESLA
MAB_4149c|M.abscessus_ATCC_199 KVLNENRANIIEAFRSVGNLAKITDRVLRTTKDDIVADLKGLYPVVRALA
Mb0179|M.bovis_AF2122/97 KHFADKQELLINASDAVGRLSQSADQYLSAARGDLHQDLQALQCPLKELR
MLBr_02593|M.leprae_Br4923 KHFADTKNLLINAVGSVGQLSQAVDQYLSEARGPLHTDLQALACPLRELG
: : : : : ...:: . : : ::. : :. *
MAV_2068|M.avium_104 DAGPALTRGLDGLATYPWPASTVRNWFRGDYANLTLIVDLTLSRIDQGLF
TH_3546|M.thermoresistible__bu DAGPALTRSLSLLATFPWPKETVENWFRGDYANLTWIIDLTLSRIDTSFF
MMAR_4055|M.marinum_M NAGPALTRALSFLPTYPFPKETLTNWMRGDYANLTLIIDMTLSRIDAGFF
MUL_3922|M.ulcerans_Agy99 NAGPALTRALSFLPTYPFPKETLTNWMRGDYANLTLIIDMTLSRIDAGFF
Mvan_4600|M.vanbaalenii_PYR-1 DAGPALTRALSFLPTFPFPKETLTNWMRGDYANLTLILDLTLSRIDSGFF
Mflv_2105|M.gilvum_PYR-GCK DAGPALTRALSFLPTFPFPKETLTNWMRGDYANLTLVVDLTLSRIDQGFF
MSMEG_0350|M.smegmatis_MC2_155 NAGPNMTRALSILTTYPFPNETLEKWLRGDYGNMTAIVDLTLSRIDAGFF
Rv1970|M.tuberculosis_H37Rv NSGPALTRSLSLLATFPFPNETFQNFQRGEYANLTAIVDLTLSRIDQGLL
MAB_4149c|M.abscessus_ATCC_199 ENRDVLIDSLDLLPTFPFSTKYLRNAVRGDYLNVFVTFDLTARRLGETLF
Mb0179|M.bovis_AF2122/97 RAAPYLVGALKLILTQPFDVDTVPQLVRGDYMNLSLTLDLTYSAIDNAFL
MLBr_02593|M.leprae_Br4923 RGAPYFIGAMKLILTQPYDVDTVPKIMRGDYQNVSLTLDVTYSAMDNAVL
: .:. : * *: . . : **:* *: .*:* :. .:
MAV_2068|M.avium_104 TGSRWEGNLTQLELQWGRTIGMQPSPV------TGGNPLTYPYHFG-GY-
TH_3546|M.thermoresistible__bu TGTRWEGDLTELELQWGRTIGQTPSPY------TATNPLVAPYRFDQGP-
MMAR_4055|M.marinum_M TGTRWEGDLTELELQWGRTIGQMPSPY------TVGNPLIVPYRWDQGP-
MUL_3922|M.ulcerans_Agy99 TGTRWEGDLTELELQWGRTIGQMPSPY------TVGNPLIVPYRWDQGP-
Mvan_4600|M.vanbaalenii_PYR-1 TGSRWECDLTWLELQWGRTIGQFPNPCNAGGPGTAGNPLIAPYRWDQGP-
Mflv_2105|M.gilvum_PYR-GCK TGTRFECNLTWLELQWGRTIGQTPSPCNHNVPPPGSNPLVAPYRWDQGR-
MSMEG_0350|M.smegmatis_MC2_155 TGTRWEGDLTELEMQWGRTIGQLPSPY------TAVNPLVAPYRWDQGR-
Rv1970|M.tuberculosis_H37Rv TGTRWECHLTQLELQWGRTIGQFPSPCTAGYRGTPGNPLTIAYRWDQGP-
MAB_4149c|M.abscessus_ATCC_199 TTSFFDPNMQHFNDVVNPPEWLIGSMANLNGKETSPFDLPAPAAPQGGGR
Mb0179|M.bovis_AF2122/97 TGTGFSGALRALEQSFGRDPETMIPDIRYTPNPNDAPGGPLVERGNRQC-
MLBr_02593|M.leprae_Br4923 TGTGLSGALRALEQSFGRDPETMIPDVRYTTNPNDAPGGPLVERADRRC-
* : . : :: .