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VEADLKDPADHAAVRRLIDRADVLIEGFRPGVTERLGLGPEVCCAANPGLVYLRLTGWGQGGPRALQAGH DINYIGLTGLLHPIGPASQPPVPPLNLVGDYGGGSMPAVIGVLAALIERQTSGRGQVIDAAIVNGAAQLA QAIWSMRADGRWSDDRGANIFDGSAPFYRTYECADGRYVAVGALEPEFFAEMLAILDLDPEAVGPQRDKS RWPAMHALLSEKFAQRSRDEWSAVFANTDACVTPVLSMAEAATDAHLTERCVFIEIDGVTQPAPAPRFSR TPQPLPSGPPRRAEMVDDVWQD
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1893 | - | - | 100% (302) | Mcr protein |
| M. avium 104 | MAV_2653 | - | e-118 | 68.86% (289) | fatty acid-CoA racemase |
| M. avium 104 | MAV_1284 | - | e-105 | 59.93% (302) | Mcr protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1175 | mcr | 1e-103 | 61.25% (289) | alpha-methylacyl-CoA racemase |
| M. gilvum PYR-GCK | Mflv_2126 | - | 4e-95 | 57.44% (289) | L-carnitine dehydratase/bile acid-inducible protein F |
| M. tuberculosis H37Rv | Rv1143 | mcr | 1e-103 | 61.25% (289) | alpha-methylacyl-CoA racemase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0845 | - | 9e-91 | 52.82% (301) | fatty-acid-CoA racemase Far |
| M. marinum M | MMAR_4308 | mcr | 4e-99 | 58.36% (305) | alpha-methylacyl-CoA racemase Mcr |
| M. smegmatis MC2 155 | MSMEG_5184 | - | 1e-97 | 56.29% (302) | alpha-methylacyl-CoA racemase, putative |
| M. thermoresistible (build 8) | TH_4477 | - | 6e-99 | 57.95% (302) | PUTATIVE L-carnitine dehydratase/bile acid-inducible protein F |
| M. ulcerans Agy99 | MUL_0986 | mcr | 3e-99 | 58.36% (305) | alpha-methylacyl-CoA racemase Mcr |
| M. vanbaalenii PYR-1 | Mvan_4578 | - | 1e-96 | 58.48% (289) | L-carnitine dehydratase/bile acid-inducible protein F |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2126|M.gilvum_PYR-GCK ------MAGPLQGLRVVELAGIGPGPHAAMIFGDLGADVVRIERPGKGPG
Mvan_4578|M.vanbaalenii_PYR-1 ------MAGPLQGLRVVELAGIGPGPHAAMILGDLGADVVRIERPGKGPG
TH_4477|M.thermoresistible__bu ------MAGPLQGLRVVELAGIGPGPHAAMILGDLGADVVRIERPRNTPG
MSMEG_5184|M.smegmatis_MC2_155 ------MAGPLQGLRVVELAGIGPGPHAAMILGDLGADVVRIERPGKGGG
Mb1175|M.bovis_AF2122/97 ------MAGPLSGLRVVELAGIGPGPHAAMILGDLGADVVRIDRPSSVDG
Rv1143|M.tuberculosis_H37Rv ------MAGPLSGLRVVELAGIGPGPHAAMILGDLGADVVRIDRPSSVDG
MMAR_4308|M.marinum_M ------MSGPLNGLRVVELAGIGPGPHAAMILGDLGADVVRIDRPSSSAG
MUL_0986|M.ulcerans_Agy99 ------MSGPLNGLRVVELAGIGPGPHAAMILGDLGADVVRIDRPSSSAG
MAV_1893|M.avium_104 --------------------------------------------------
MAB_0845|M.abscessus_ATCC_1997 MADTGVKTGPLAGVKVIELGGIGPGPHAAMMLSDLGADVIRVRRPG---G
Mflv_2126|M.gilvum_PYR-GCK PATKPGG-DYLLRNRRSVAANLKSDEDREMVLRLIAKADVLIEGFRPGVT
Mvan_4578|M.vanbaalenii_PYR-1 PATKPGG-DYLLRNRRSVAANLKSEEDRDMVLRLIAKADVLIEGFRPGVT
TH_4477|M.thermoresistible__bu PGIPRGAKDHLLRNRRSVAADLKTEEGKELVRKLIAKADVLIEGYRPGVT
MSMEG_5184|M.smegmatis_MC2_155 --VPAGDRDAMLRNRRSVVADLKAPEGRDLVLQLVAKADVLIEGYRPGVT
Mb1175|M.bovis_AF2122/97 -----ISRDAMLRNRRIVTADLKSDQGLELALKLIAKADVLIEGYRPGVT
Rv1143|M.tuberculosis_H37Rv -----ISRDAMLRNRRIVTADLKSDQGLELALKLIAKADVLIEGYRPGVT
MMAR_4308|M.marinum_M G-RGGGVKDAMLRNRRIVTADLKSDQGRELVLKLVAKADVLIEGYRPGVT
MUL_0986|M.ulcerans_Agy99 G-RGGGVKDAMLRNRRIVTADLKSDQGRELVLKLVAKADVLIEGYRPGVT
MAV_1893|M.avium_104 -----------------MEADLKDPADHAAVRRLIDRADVLIEGFRPGVT
MAB_0845|M.abscessus_ATCC_1997 LAIPAEETDLFHRGKRLVNLDVK--KDPEALLALVDKADVLLDPFRPGVC
: ::* . *: :****:: :****
Mflv_2126|M.gilvum_PYR-GCK ERLGLGPEDCAKVNEKLVYARMTGWGQDGPRAQQAGHDINYISLNGVLHA
Mvan_4578|M.vanbaalenii_PYR-1 ERLGLGPHDCAKVNEKLIYARMTGWGQDGPRAQQAGHDINYISLNGALHA
TH_4477|M.thermoresistible__bu ERLGLGPEDCAKINPRLIYGRMTGWGQDGPRAQQAGHDINYISLNGTLHA
MSMEG_5184|M.smegmatis_MC2_155 ERLGLGPEDCAKVNERLIYARMTGWGQDGPRALQAGHDINYISLNGTLHA
Mb1175|M.bovis_AF2122/97 ERLGLGPEECAKVNDRLIYARMTGWGQTGPRSQQAGHDINYISLNGILHA
Rv1143|M.tuberculosis_H37Rv ERLGLGPEECAKVNDRLIYARMTGWGQTGPRSQQAGHDINYISLNGILHA
MMAR_4308|M.marinum_M ERLGLGPQDCAKVNDRLIYARMTGWGQAGPRSQQAGHDINYISLNGILHA
MUL_0986|M.ulcerans_Agy99 ERLGLGPQDCAKVNDRLIYARMTGWGQAGPRSQQAGHDINYISLNGILHA
MAV_1893|M.avium_104 ERLGLGPEVCCAANPGLVYLRLTGWGQGGPRALQAGHDINYIGLTGLLHP
MAB_0845|M.abscessus_ATCC_1997 ERIGIGPEECAKRNPRLIFARMTGWGQHGPMADRAGHDINYLSLTGALGS
**:*:**. *. * *:: *:***** ** : :*******:.*.* * .
Mflv_2126|M.gilvum_PYR-GCK IGRHGERPVPPLNLAGDFGGGSMFLLVGVLAALWERERSGKGQVVDAAMV
Mvan_4578|M.vanbaalenii_PYR-1 IGRAGERPVPPLNLVGDFGGGSMFLLVGVLSALYERERSGKGQVVDAAMV
TH_4477|M.thermoresistible__bu VGRKGERPVPPLNLAGDFGGGSMFLLVGILAALFERQTSGKGQVVDAAMI
MSMEG_5184|M.smegmatis_MC2_155 VGRKGGRPVPPLNLAGDFGGGSMFLLVGILSALYERQASGKGQVIDAAMV
Mb1175|M.bovis_AF2122/97 IGRGDERPVPPLNLVGDFGGGSMFLLVGILAALWERQSSGKGQVVDAAMV
Rv1143|M.tuberculosis_H37Rv IGRGDERPVPPLNLVGDFGGGSMFLLVGILAALWERQSSGKGQVVDAAMV
MMAR_4308|M.marinum_M IGRVGERPVPPLNLVGDFGGGSMFLLVGILAALWERHNSGKGQVIDAAMV
MUL_0986|M.ulcerans_Agy99 IGRVGERPVPPLNLVGDFGGGSMFLLVGILAALWERHNSGKGQVIDAAMV
MAV_1893|M.avium_104 IGPASQPPVPPLNLVGDYGGGSMPAVIGVLAALIERQTSGRGQVIDAAIV
MAB_0845|M.abscessus_ATCC_1997 MGYKDRPPMPPMNLVADFGGGSMLLVQGILAALYEREKSGKGQVIDGAMV
:* . *:**:**..*:***** : *:*:** **. **:***:*.*::
Mflv_2126|M.gilvum_PYR-GCK DGSSVLSMMMWSFRGMGMWSDERGVNMLDTGAPYYDTYECSDGRHIAVGC
Mvan_4578|M.vanbaalenii_PYR-1 DGSSVLSMMMWAFRGMGMWSDERGTNMLDTGAPYYDTYETADGKYVAVGA
TH_4477|M.thermoresistible__bu DGSAVLMQMMWAFRAMGMWSDERGVNMLDTGAPYYDTYETADGKYVAVGA
MSMEG_5184|M.smegmatis_MC2_155 DGSAVLMEMMWSFRANGMWSDERGTNMLDTGAPYYDTYETADGKYIAVGA
Mb1175|M.bovis_AF2122/97 DGSSVLIQMMWAMRATGMWTDTRGANMLDGGAPYYDTYECADGRYVAVGA
Rv1143|M.tuberculosis_H37Rv DGSSVLIQMMWAMRATGMWTDTRGANMLDGGAPYYDTYECADGRYVAVGA
MMAR_4308|M.marinum_M DGSSVLVQMMWAMRGIGIWSDVRGTNMLDGGAPYYDTYECADGGYVAVGA
MUL_0986|M.ulcerans_Agy99 DGSSVLVQMMWAMRGIGIWSDVRGTNMLDGGAPYYDTYECADGGYVAVGA
MAV_1893|M.avium_104 NGAAQLAQAIWSMRADGRWSDDRGANIFDGSAPFYRTYECADGRYVAVGA
MAB_0845|M.abscessus_ATCC_1997 DGVSQLAQMQWTMYNNGLLFDEREAGLLDGGSPFYGTYETSDGKYMAVGS
:* : * *:: * * * ..::* .:*:* *** :** ::***.
Mflv_2126|M.gilvum_PYR-GCK IEPQFYAEFLKGVGLEGADLPGQNDMGRWPELREAFSKAIAAHDRDHWAG
Mvan_4578|M.vanbaalenii_PYR-1 IEPQFYAEMLKGIGLDGADLPDQNDMSRWPELREAFTKAFAAHDRDHWAK
TH_4477|M.thermoresistible__bu IEPQFYAEMLKGLGLEGEDLPDQNDMSRWDELRARFAEVFKSKDRDHWAQ
MSMEG_5184|M.smegmatis_MC2_155 IEPQFYAELLKGLGLDGADLPAQNDISRWPELREAFAKAFAAHDRAHWTK
Mb1175|M.bovis_AF2122/97 IEPQFYAAMLAGLGLDAAELPPQNDRARWPELRALLTEAFASHDRDHWGA
Rv1143|M.tuberculosis_H37Rv IEPQFYAAMLAGLGLDAAELPPQNDRARWPELRALLTEAFASHDRDHWGA
MMAR_4308|M.marinum_M IEPQFYAAMLAGLGLDAVNLPPQNDVARWPELRAVLTEAFGRYDRDHWAK
MUL_0986|M.ulcerans_Agy99 IEPQFYAAMLAGLGLDAVNLPPQNDVARWPELRAVLTEAFGRYDRDHWAK
MAV_1893|M.avium_104 LEPEFFAEMLAILDLDPEAVGPQRDKSRWPAMHALLSEKFAQRSRDEWSA
MAB_0845|M.abscessus_ATCC_1997 IEPQFFAILVQGLGLDPESVPFQLDKARYPEMRKMFDDAFKTKTRDEWTE
:**:*:* :: :.*: : * * .*: :: : . : * .*
Mflv_2126|M.gilvum_PYR-GCK VFAGTDACVTPVLSFAEVESEPHNTERDTFYSEN-GSLYPAPAPRFSRSV
Mvan_4578|M.vanbaalenii_PYR-1 VFAGTDACVTPVLSFAEVESEPHNTERDTFYSEN-GSLYPAPAPRFSRSA
TH_4477|M.thermoresistible__bu VFAGTDACVTPVLSFAEVESEAHVVERNTFYREG-DHLLPAPAPRFSRSV
MSMEG_5184|M.smegmatis_MC2_155 VFEGTDACTTPVLSFAEVLDEPHVAERNTFYDDE-GNLQPMPAPRFSRTQ
Mb1175|M.bovis_AF2122/97 VFANSDACVTPVLAFGEVHNEPHIIERNTFYEAN-GGWQPMPAPRFSRTA
Rv1143|M.tuberculosis_H37Rv VFANSDACVTPVLAFGEVHNEPHIIERNTFYEAN-GGWQPMPAPRFSRTA
MMAR_4308|M.marinum_M VFADSDACVTPVLSFGEVHTEPHIAERNTFYEGDDGGPQPMPAPRFSRTV
MUL_0986|M.ulcerans_Agy99 VFADSDACVTPVLSFGEVHTEPHIAERNTFYEGDDGGPQPMPAPRFSRTV
MAV_1893|M.avium_104 VFANTDACVTPVLSMAEAATDAHLTERCVFIEID-GVTQPAPAPRFSRTP
MAB_0845|M.abscessus_ATCC_1997 IFIGTDACVSPVLTWGEAKQNEHLRDRGTIVDVD-GVTQAAPAPRFSRTP
:* .:***.:***: .*. : * :* .: . . *******:
Mflv_2126|M.gilvum_PYR-GCK PSAPKAPGVPGADTEAVLQEWV-
Mvan_4578|M.vanbaalenii_PYR-1 PSAPKPPGVPGADTEAVLREWV-
TH_4477|M.thermoresistible__bu PSAPTPPRDPGADTDAVLQDWQ-
MSMEG_5184|M.smegmatis_MC2_155 PGRPTPPPQRGADTEAVLRDWS-
Mb1175|M.bovis_AF2122/97 SSQPRPPAATI-DIEAVLTDWDG
Rv1143|M.tuberculosis_H37Rv SSQPRPPAATI-DIEAVLTDWDG
MMAR_4308|M.marinum_M PSRPRPPAAPLTDVEAVLSDWV-
MUL_0986|M.ulcerans_Agy99 PSRPRPPAAPLTDVEAVLSDWA-
MAV_1893|M.avium_104 QPLPSGPPRRAEMVDDVWQD---
MAB_0845|M.abscessus_ATCC_1997 SGPLGAPPKDTTELSDIGW----
* . :