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NQPLSGRVVLVTGGGRGIGRAHCLALSAQGAAVVVNDPGVRRDGTAGDGAGPAADVVAEIEAAGGKAVAH TGSVSSWDDVADMINTAVETFGTITGVVNNAGIVRDSMVATSTEADWDAVIAVHLKGTFAVTKHACEYWR AQFKAGNQIDARIVNTVSGAGLWGNVGQSAYGAAKAAIANLTIVTAMEAARYGVAVNAISPLAVTRISEG FFSGEKADDPALDPARSSDVVAWLQSPEAGWLTGQILRVNGHTLSRIEGYAEAPGRYHAKDGASLQFSEI GQAVSWLYRTSPRGLAGPLPAD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1833 | - | - | 100% (303) | peroxisomal hydratase-dehydrogenase-epimerase (HDE) (multifunctionalbeta-oxidation protein) (MFP) |
| M. avium 104 | MAV_0612 | - | 1e-72 | 52.10% (286) | short chain dehydrogenase |
| M. avium 104 | MAV_2639 | - | 3e-51 | 43.66% (268) | short chain dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3578c | - | 2e-70 | 50.51% (295) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1492 | - | 1e-69 | 50.88% (285) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv3548c | - | 2e-70 | 50.51% (295) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_02565 | fabG | 5e-19 | 28.41% (264) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_0608 | - | 2e-72 | 50.87% (287) | short chain dehydrogenase |
| M. marinum M | MMAR_5036 | - | 1e-73 | 55.47% (265) | short-chain type dehydrogenase/reductase |
| M. smegmatis MC2 155 | MSMEG_5999 | - | 7e-72 | 51.40% (286) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4393 | - | 1e-144 | 85.86% (290) | PUTATIVE peroxisomal hydratase-dehydrogenase-epimerase (HDE) |
| M. ulcerans Agy99 | MUL_4110 | - | 6e-73 | 54.72% (265) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5264 | - | 4e-70 | 50.53% (285) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_1833|M.avium_104 ---------MNQPLSGRVVLVTGGGRGIGRAHCLALSAQGAAVVVNDPGV
TH_4393|M.thermoresistible__bu --------------------VTGGGRGIGRAHCLALAKHGAAVVVNDPGV
Mflv_1492|M.gilvum_PYR-GCK ----------MGLLDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGV
Mvan_5264|M.vanbaalenii_PYR-1 ----------MGLLDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGV
MSMEG_5999|M.smegmatis_MC2_155 ----------MGLLDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGV
Mb3578c|M.bovis_AF2122/97 ----------MGLVDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGV
Rv3548c|M.tuberculosis_H37Rv ----------MGLVDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGV
MMAR_5036|M.marinum_M ----------MGLLDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGV
MUL_4110|M.ulcerans_Agy99 ----------MGLLDGRVVIVTGAGGGIGRAHALAFAVEGARVVVNDIGV
MAB_0608|M.abscessus_ATCC_1997 ---------MPGLLDGRVVIITGAGRGIGRAHALAFAAEGARVVVNDIGV
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
... *: *.. * . : .. :
MAV_1833|M.avium_104 RRDGTAGDGAGPAADVVAEIEAA----------GGKAVAHT--GSVSSWD
TH_4393|M.thermoresistible__bu GRDGTAGD-AGPAAQVVAEIEAM----------GGKAVAHT--GSVAKWD
Mflv_1492|M.gilvum_PYR-GCK GLDGSPAGGGSAAQTVVDEIIAA----------GGEAVTSG--ANVADWG
Mvan_5264|M.vanbaalenii_PYR-1 GLDGSPAGGGSAAQAVVDEIVGA----------GGEAVTSG--ANVADWA
MSMEG_5999|M.smegmatis_MC2_155 GLDGSPASGGSAAQTVVDEIVAA----------GGEAVANG--SNVADWA
Mb3578c|M.bovis_AF2122/97 GLDGSPASGGSAAQDVVDEILAA----------GGQAVADG--SDISDWD
Rv3548c|M.tuberculosis_H37Rv GLDGSPASGGSAAQDVVDEILAA----------GGQAVADG--SDISDWD
MMAR_5036|M.marinum_M GLDGSPAGGGSAAHGVVDEITAA----------GGEAVANG--SDVSNWQ
MUL_4110|M.ulcerans_Agy99 GLDGSPAGGGSAAHGVVDEITAA----------GGEAVANG--SDVSNWQ
MAB_0608|M.abscessus_ATCC_1997 GLDGS--AGISPAQEVVEEITAA----------GGEAVTNG--DDVADWS
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
** .: :: . ** .. :.
MAV_1833|M.avium_104 DVADMINTAVETFGTITGVVNN-----AGIVRDSMVATSTEADWDAVIAV
TH_4393|M.thermoresistible__bu DVADMIRTAVDTFGMLTGVVNN-----AGIVRDATVANATEEDWDAVIAV
Mflv_1492|M.gilvum_PYR-GCK QAEGLIQTAVDAFGGLDVLVNN-----AGIVRDRMFANTSEEEFDAVTAV
Mvan_5264|M.vanbaalenii_PYR-1 QAEGLIQTAVDSFGTLDVLVNN-----AGIVRDRMFANTSEEEFDAVTAV
MSMEG_5999|M.smegmatis_MC2_155 QAESLVQTAVDTFGGLDVLVNN-----AGIVRDRMFANTSEEEFDAVVAV
Mb3578c|M.bovis_AF2122/97 QAANLIQAAVETYGGVDVLVNN-----AGIVRDRMIANTSEEEFDAVIAV
Rv3548c|M.tuberculosis_H37Rv QAANLIQAAVETYGGVDVLVNN-----AGIVRDRMIANTSEEEFDAVIAV
MMAR_5036|M.marinum_M QAADLISTAVDTFGGLDVLVNN-----AGIVRDRMMANTSEEEFDAVIAV
MUL_4110|M.ulcerans_Agy99 QAADLISTAVDTFGGLDVLVNN-----AGIVRDRMMANTSEEEFDAVIAV
MAB_0608|M.abscessus_ATCC_1997 GAKNLIDTAVNSFGRLDVLVNN-----AGFLRDRMLANMSEEEWDAVIRV
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
.:. . : * :* * * .* : :.
MAV_1833|M.avium_104 HLKG------------------------TFAVTKHACEYWRAQFKAGNQ-
TH_4393|M.thermoresistible__bu HLKG------------------------TFAVTRHACEYWRAQAKAGNQ-
Mflv_1492|M.gilvum_PYR-GCK HLKG------------------------HFATMRHAAAYWRAKSKAGDT-
Mvan_5264|M.vanbaalenii_PYR-1 HLKG------------------------HFATMKHAAAYWRAKSKAGES-
MSMEG_5999|M.smegmatis_MC2_155 HLKG------------------------HFATMKHAAAYWRAKSKAGET-
Mb3578c|M.bovis_AF2122/97 HLKG------------------------HFATMRHAASHWRGLSKAGKAP
Rv3548c|M.tuberculosis_H37Rv HLKG------------------------HFATMRHAASHWRGLSKAGKAP
MMAR_5036|M.marinum_M HLKG------------------------HFATMRHAASYWRGLSKAGKA-
MUL_4110|M.ulcerans_Agy99 HLKG------------------------HFATMRHAASYWRGLSKVGKA-
MAB_0608|M.abscessus_ATCC_1997 HLKG------------------------HFAPLRHAAAYWRDEFKAGNA-
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
.*: * ::. .*
MAV_1833|M.avium_104 ----------IDARIVNTVSGAGLWGNVGQSAYGAAKAAIANLTIVTAME
TH_4393|M.thermoresistible__bu ----------IDARIVNTVSGAGLWGNIGQAAYGAAKAAIANLTVVTAME
Mflv_1492|M.gilvum_PYR-GCK ----------VDARIINTSSGAGLQGSVGQANYSAAKAGIAALTLVAAAE
Mvan_5264|M.vanbaalenii_PYR-1 ----------VDARIINTSSGAGLQGSVGQANYSASKAGIAALTLVAAAE
MSMEG_5999|M.smegmatis_MC2_155 ----------VDARIINTSSGAGLQGSVGQANYSAAKAGIAALTLVAAAE
Mb3578c|M.bovis_AF2122/97 KD--------IDARIINTSSGAGLQGSVGQGNYSAAKAGIAALTLVGAAE
Rv3548c|M.tuberculosis_H37Rv KD--------IDARIINTSSGAGLQGSVGQGNYSAAKAGIAALTLVGAAE
MMAR_5036|M.marinum_M ----------VDARIINTSSGAGLQGSVGQANYSAAKAGIAALTLVGAAE
MUL_4110|M.ulcerans_Agy99 ----------VDARIINTSSGAGLQGSVGQANYSAAKAGIAALTLVGAAE
MAB_0608|M.abscessus_ATCC_1997 ----------VDARIINTSSAAGLQGSVGQGNYAAAKAGIATLTLQAAAE
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
:: :: . ..* * . * :. : : * *
MAV_1833|M.avium_104 -----AARYG---VAVNAISPLAVTRISEGFFSGE---------------
TH_4393|M.thermoresistible__bu -----GRRYG---VVANAISPLAVTRISQDFFKGE---------------
Mflv_1492|M.gilvum_PYR-GCK -----MGRYG---VSVNAIAPSARTRMTETVFADM---------------
Mvan_5264|M.vanbaalenii_PYR-1 -----MGRYG---VSVNAIAPSARTRMTESVFADM---------------
MSMEG_5999|M.smegmatis_MC2_155 -----MGRYG---VTVNAIAPSARTRMTETVFADM---------------
Mb3578c|M.bovis_AF2122/97 -----MRRYG---VTVNAIAPAARTRMTETVFAEV---------------
Rv3548c|M.tuberculosis_H37Rv -----MRRYG---VTVNAIAPAARTRMTETVFAEM---------------
MMAR_5036|M.marinum_M -----MGRYG---VTVNAIAPAARTRMTETVFAEM---------------
MUL_4110|M.ulcerans_Agy99 -----MGRYG---VTVNAIAPAARTRMTETVFAEM---------------
MAB_0608|M.abscessus_ATCC_1997 -----MGRYG---ITVNAIAPAARTRMTEAVFAET---------------
MLBr_02565|M.leprae_Br4923 ALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGITR
* * : :. : * :::: ..
MAV_1833|M.avium_104 ---KADD-----------PALDPARSSD---------------VVAWLQS
TH_4393|M.thermoresistible__bu ---RADD-----------PALDPARSSE---------------VVAWLQS
Mflv_1492|M.gilvum_PYR-GCK ---MATQDK-------DFDAMAPENVSP---------------LVVWLGS
Mvan_5264|M.vanbaalenii_PYR-1 ---MATQDK-------DFDSMAPENISP---------------LVVWLGS
MSMEG_5999|M.smegmatis_MC2_155 ---MATQDQ-------EFDAMAPENISP---------------IVVWLGS
Mb3578c|M.bovis_AF2122/97 ---MAKPQE-------GFDAMAPENVSP---------------LVVWLGS
Rv3548c|M.tuberculosis_H37Rv ---MAKPQE-------GFDAMAPENVSP---------------LVVWLGS
MMAR_5036|M.marinum_M ---MAKPDE-------GFDAMAPENVSP---------------LVVWLAS
MUL_4110|M.ulcerans_Agy99 ---MAKPDE-------GFDAMAPENVSP---------------LVVWLAS
MAB_0608|M.abscessus_ATCC_1997 ---MAKPEDG------AFDAMAPENVSP---------------LVVWLGS
MLBr_02565|M.leprae_Br4923 DKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVIVLSSMAG
* : * . : :: : .
MAV_1833|M.avium_104 PEAGWLTGQILRVNGHTLSRIEGYAEAPGRY--------------HAKDG
TH_4393|M.thermoresistible__bu AESGWLTGQILRVDGHKLSRIEGFTEAPSRY--------------HAKDG
Mflv_1492|M.gilvum_PYR-GCK VESRDVTGKMFEVEGGKIRVAEGWAHGP-----------------EIDKG
Mvan_5264|M.vanbaalenii_PYR-1 VESRDVTGRVFEVEGGKIRVAEGWAHGP-----------------EIDKG
MSMEG_5999|M.smegmatis_MC2_155 AEARDVTGKMFEVEGGKIRIAEGWAHGP-----------------EIDKG
Mb3578c|M.bovis_AF2122/97 AESRDVTGKVFEVEGGIIRVAEGWAHGP-----------------QVDKG
Rv3548c|M.tuberculosis_H37Rv AESRDVTGKVFEVEGGIIRVAEGWAHGP-----------------QVDKG
MMAR_5036|M.marinum_M AEAGAVTGKVFEVEGGVIRVAEGWAHGP-----------------EVDKG
MUL_4110|M.ulcerans_Agy99 AEAGAVTGKVFEVEGGVIRVAEGWAHGP-----------------EVDKG
MAB_0608|M.abscessus_ATCC_1997 PESREVTGKVFEVEAGIIRVAEGWAHGP-----------------QVDKG
MLBr_02565|M.leprae_Br4923 IAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGFIETQMTAA
. . ... : :. : . . .
MAV_1833|M.avium_104 ASLQFSEIGQAVSWLYRTSPRG--------LAGPLPAD------------
TH_4393|M.thermoresistible__bu ASLEFSEIGQAVSWLYGTSPRG--------LAGPLPRT------------
Mflv_1492|M.gilvum_PYR-GCK ARWDPAELGPVVGDLLAKART----------PVPVYGA------------
Mvan_5264|M.vanbaalenii_PYR-1 ARWDPAELGSVVPDLLAKART----------PVPVYGA------------
MSMEG_5999|M.smegmatis_MC2_155 ARWDPAELGPVVADLLAKARP----------AVPVYGA------------
Mb3578c|M.bovis_AF2122/97 VKWDPAELGPVVSDLLAKSRP----------PVPVYGA------------
Rv3548c|M.tuberculosis_H37Rv VKWDPAELGPVVSDLLAKSRP----------PVPVYGA------------
MMAR_5036|M.marinum_M AKWDPAELRLVVADLLAKSRP----------SVPVYGA------------
MUL_4110|M.ulcerans_Agy99 AKWDPAELRLVVADLLAKSRP----------SVPVYGA------------
MAB_0608|M.abscessus_ATCC_1997 ARWDPSELGPVVTDLLDKART----------PVPVYGSQG----------
MLBr_02565|M.leprae_Br4923 IPLATREVGRRLNSLLQGGLPVDVAETIAYFAIPASNAVTGNVIRVCGQA
*: : * . . *
MAV_1833|M.avium_104 ----
TH_4393|M.thermoresistible__bu ----
Mflv_1492|M.gilvum_PYR-GCK ----
Mvan_5264|M.vanbaalenii_PYR-1 ----
MSMEG_5999|M.smegmatis_MC2_155 ----
Mb3578c|M.bovis_AF2122/97 ----
Rv3548c|M.tuberculosis_H37Rv ----
MMAR_5036|M.marinum_M ----
MUL_4110|M.ulcerans_Agy99 ----
MAB_0608|M.abscessus_ATCC_1997 ----
MLBr_02565|M.leprae_Br4923 MLGA