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GLLDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGVGLDGSPAGGGSAAQAVVDEIVGAGGEAVTSG ANVADWAQAEGLIQTAVDSFGTLDVLVNNAGIVRDRMFANTSEEEFDAVTAVHLKGHFATMKHAAAYWRA KSKAGESVDARIINTSSGAGLQGSVGQANYSASKAGIAALTLVAAAEMGRYGVSVNAIAPSARTRMTESV FADMMATQDKDFDSMAPENISPLVVWLGSVESRDVTGRVFEVEGGKIRVAEGWAHGPEIDKGARWDPAEL GSVVPDLLAKARTPVPVYGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5264 | - | - | 100% (301) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2341 | - | 4e-77 | 53.45% (290) | short chain dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5205 | fabG | 9e-61 | 45.24% (294) | 3-ketoacyl-(acyl-carrier-protein) reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3578c | - | 1e-139 | 79.93% (304) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1492 | - | 1e-162 | 94.35% (301) | short chain dehydrogenase |
| M. tuberculosis H37Rv | Rv3548c | - | 1e-139 | 80.26% (304) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_02565 | fabG | 3e-23 | 32.57% (261) | 3-ketoacyl-(acyl-carrier-protein) reductase |
| M. abscessus ATCC 19977 | MAB_0608 | - | 1e-130 | 77.74% (301) | short chain dehydrogenase |
| M. marinum M | MMAR_5036 | - | 1e-141 | 83.06% (301) | short-chain type dehydrogenase/reductase |
| M. avium 104 | MAV_0612 | - | 1e-150 | 86.71% (301) | short chain dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5999 | - | 1e-156 | 90.70% (301) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_3887 | - | 1e-149 | 86.05% (301) | PUTATIVE short chain dehydrogenase |
| M. ulcerans Agy99 | MUL_4110 | - | 1e-140 | 82.39% (301) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3578c|M.bovis_AF2122/97 ----------------------------------------------MGLV
Rv3548c|M.tuberculosis_H37Rv ----------------------------------------------MGLV
MMAR_5036|M.marinum_M ----------------------------------------------MGLL
MUL_4110|M.ulcerans_Agy99 ----------------------------------------------MGLL
Mvan_5264|M.vanbaalenii_PYR-1 ----------------------------------------------MGLL
Mflv_1492|M.gilvum_PYR-GCK ----------------------------------------------MGLL
MSMEG_5999|M.smegmatis_MC2_155 ----------------------------------------------MGLL
TH_3887|M.thermoresistible__bu ----------------------------------------------MGIV
MAV_0612|M.avium_104 ----------------------------------------------MGVV
MAB_0608|M.abscessus_ATCC_1997 ---------------------------------------------MPGLL
MLBr_02565|M.leprae_Br4923 MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
::
Mb3578c|M.bovis_AF2122/97 DGRVVIVTGAGGGIGRAHALAFAAEG-------ARVVVNDIGVGLDGSPA
Rv3548c|M.tuberculosis_H37Rv DGRVVIVTGAGGGIGRAHALAFAAEG-------ARVVVNDIGVGLDGSPA
MMAR_5036|M.marinum_M DGRVVIVTGAGGGIGRAHALAFAAEG-------ARVVVNDIGVGLDGSPA
MUL_4110|M.ulcerans_Agy99 DGRVVIVTGAGGGIGRAHALAFAVEG-------ARVVVNDIGVGLDGSPA
Mvan_5264|M.vanbaalenii_PYR-1 DGRVVIVTGAGGGIGRAHALAFAAEG-------ARVVVNDIGVGLDGSPA
Mflv_1492|M.gilvum_PYR-GCK DGRVVIVTGAGGGIGRAHALAFAAEG-------ARVVVNDIGVGLDGSPA
MSMEG_5999|M.smegmatis_MC2_155 DGRVVIVTGAGGGIGRAHALAFAAEG-------ARVVVNDIGVGLDGSPA
TH_3887|M.thermoresistible__bu DGRVVIVTGAGNGIGRAHALAFAAEG-------ARVVVNDIGVGLDGSPA
MAV_0612|M.avium_104 DGRVVIVTGAGGGIGRAHALAFAAEG-------ARVVVNDIGVGLDGSPA
MAB_0608|M.abscessus_ATCC_1997 DGRVVIITGAGRGIGRAHALAFAAEG-------ARVVVNDIGVGLDGS--
MLBr_02565|M.leprae_Br4923 GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
.* :: : : : *. * . :*.: *: ..
Mb3578c|M.bovis_AF2122/97 SGGSAAQDVVDEILAAGGQAVADGSDISDWDQAANLIQAAVETYG-GVDV
Rv3548c|M.tuberculosis_H37Rv SGGSAAQDVVDEILAAGGQAVADGSDISDWDQAANLIQAAVETYG-GVDV
MMAR_5036|M.marinum_M GGGSAAHGVVDEITAAGGEAVANGSDVSNWQQAADLISTAVDTFG-GLDV
MUL_4110|M.ulcerans_Agy99 GGGSAAHGVVDEITAAGGEAVANGSDVSNWQQAADLISTAVDTFG-GLDV
Mvan_5264|M.vanbaalenii_PYR-1 GGGSAAQAVVDEIVGAGGEAVTSGANVADWAQAEGLIQTAVDSFG-TLDV
Mflv_1492|M.gilvum_PYR-GCK GGGSAAQTVVDEIIAAGGEAVTSGANVADWGQAEGLIQTAVDAFG-GLDV
MSMEG_5999|M.smegmatis_MC2_155 SGGSAAQTVVDEIVAAGGEAVANGSNVADWAQAESLVQTAVDTFG-GLDV
TH_3887|M.thermoresistible__bu SGGSAAQAVVDEIKAAGGEAVANGSNVADWAQAEELVKTAIDTYG-GLDV
MAV_0612|M.avium_104 SGGSAAQSVVDEITAAGGEAVADGSNVADWDQAAGLIQTAVETFG-GLDV
MAB_0608|M.abscessus_ATCC_1997 AGISPAQEVVEEITAAGGEAVTNGDDVADWSGAKNLIDTAVNSFG-RLDV
MLBr_02565|M.leprae_Br4923 GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
. . :: :: .. .* . : : . *:: :. :.
Mb3578c|M.bovis_AF2122/97 LVNN---AGIVRDRMIANTSEEEFDAVIAVHLKGHFATMRHAASHWRGLS
Rv3548c|M.tuberculosis_H37Rv LVNN---AGIVRDRMIANTSEEEFDAVIAVHLKGHFATMRHAASHWRGLS
MMAR_5036|M.marinum_M LVNN---AGIVRDRMMANTSEEEFDAVIAVHLKGHFATMRHAASYWRGLS
MUL_4110|M.ulcerans_Agy99 LVNN---AGIVRDRMMANTSEEEFDAVIAVHLKGHFATMRHAASYWRGLS
Mvan_5264|M.vanbaalenii_PYR-1 LVNN---AGIVRDRMFANTSEEEFDAVTAVHLKGHFATMKHAAAYWRAKS
Mflv_1492|M.gilvum_PYR-GCK LVNN---AGIVRDRMFANTSEEEFDAVTAVHLKGHFATMRHAAAYWRAKS
MSMEG_5999|M.smegmatis_MC2_155 LVNN---AGIVRDRMFANTSEEEFDAVVAVHLKGHFATMKHAAAYWRAKS
TH_3887|M.thermoresistible__bu LVNN---AGIVRDRMIANTSEEEFDAVVAVHLKGHFATTRHAAAYWRGLA
MAV_0612|M.avium_104 LVNN---AGIVRDRMIANTSEEEFDAVIAVHLKGHFATMRHAAAYWRGLS
MAB_0608|M.abscessus_ATCC_1997 LVNN---AGFLRDRMLANMSEEEWDAVIRVHLKGHFAPLRHAAAYWRDEF
MLBr_02565|M.leprae_Br4923 ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
:.. ..:: *: : ::. . *..: * . . :
Mb3578c|M.bovis_AF2122/97 KAGKAPKD--IDARIINTSSGAGLQGSVGQGNYSAAKAGIAALTLVGAAE
Rv3548c|M.tuberculosis_H37Rv KAGKAPKD--IDARIINTSSGAGLQGSVGQGNYSAAKAGIAALTLVGAAE
MMAR_5036|M.marinum_M KAGKA-----VDARIINTSSGAGLQGSVGQANYSAAKAGIAALTLVGAAE
MUL_4110|M.ulcerans_Agy99 KVGKA-----VDARIINTSSGAGLQGSVGQANYSAAKAGIAALTLVGAAE
Mvan_5264|M.vanbaalenii_PYR-1 KAGES-----VDARIINTSSGAGLQGSVGQANYSASKAGIAALTLVAAAE
Mflv_1492|M.gilvum_PYR-GCK KAGDT-----VDARIINTSSGAGLQGSVGQANYSAAKAGIAALTLVAAAE
MSMEG_5999|M.smegmatis_MC2_155 KAGET-----VDARIINTSSGAGLQGSVGQANYSAAKAGIAALTLVAAAE
TH_3887|M.thermoresistible__bu KEGKA-----VDARIINTSSGAGLQGSVGQGNYSAAKAGIAALTLVAAAE
MAV_0612|M.avium_104 KAGKA-----VDGRIINTSSGAGLQGSVGQGNYSAAKAGIATLTLVGAAE
MAB_0608|M.abscessus_ATCC_1997 KAGNA-----VDARIINTSSAAGLQGSVGQGNYAAAKAGIATLTLQAAAE
MLBr_02565|M.leprae_Br4923 STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
. : :: :: .:..* *:. : * :.:: : .***
Mb3578c|M.bovis_AF2122/97 MR-----RYG---VTVNAIAPAARTRMTETVFA-----------------
Rv3548c|M.tuberculosis_H37Rv MR-----RYG---VTVNAIAPAARTRMTETVFA-----------------
MMAR_5036|M.marinum_M MG-----RYG---VTVNAIAPAARTRMTETVFA-----------------
MUL_4110|M.ulcerans_Agy99 MG-----RYG---VTVNAIAPAARTRMTETVFA-----------------
Mvan_5264|M.vanbaalenii_PYR-1 MG-----RYG---VSVNAIAPSARTRMTESVFA-----------------
Mflv_1492|M.gilvum_PYR-GCK MG-----RYG---VSVNAIAPSARTRMTETVFA-----------------
MSMEG_5999|M.smegmatis_MC2_155 MG-----RYG---VTVNAIAPSARTRMTETVFA-----------------
TH_3887|M.thermoresistible__bu LG-----RYG---VTVNAIAPSARTRMTETVFA-----------------
MAV_0612|M.avium_104 MG-----RYG---VTVNAIAPSARTRMTETVFA-----------------
MAB_0608|M.abscessus_ATCC_1997 MG-----RYG---ITVNAIAPAARTRMTEAVFA-----------------
MLBr_02565|M.leprae_Br4923 ALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGITR
* * ::::. * * ::** :.
Mb3578c|M.bovis_AF2122/97 -EVMAKPQE-------GFDAMAPENVSPLVVWLGSAESRD----------
Rv3548c|M.tuberculosis_H37Rv -EMMAKPQE-------GFDAMAPENVSPLVVWLGSAESRD----------
MMAR_5036|M.marinum_M -EMMAKPDE-------GFDAMAPENVSPLVVWLASAEAGA----------
MUL_4110|M.ulcerans_Agy99 -EMMAKPDE-------GFDAMAPENVSPLVVWLASAEAGA----------
Mvan_5264|M.vanbaalenii_PYR-1 -DMMATQDK-------DFDSMAPENISPLVVWLGSVESRD----------
Mflv_1492|M.gilvum_PYR-GCK -DMMATQDK-------DFDAMAPENVSPLVVWLGSVESRD----------
MSMEG_5999|M.smegmatis_MC2_155 -DMMATQDQ-------EFDAMAPENISPIVVWLGSAEARD----------
TH_3887|M.thermoresistible__bu -EMMATQDQ-------EFDSMAPENISPLVVWLGSAESKD----------
MAV_0612|M.avium_104 -EMMATQDQ-------DFDAMAPENVSPLVVWLGSAEARD----------
MAB_0608|M.abscessus_ATCC_1997 -ETMAKPEDG------AFDAMAPENVSPLVVWLGSPESRE----------
MLBr_02565|M.leprae_Br4923 DKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVIVLSSMAG
. :*. :. .: :**:.:: :* .* .
Mb3578c|M.bovis_AF2122/97 VTG-----KVFEVEGGIIRVAEGWAHGPQVDKGVKWDPAELGPVVSDLLA
Rv3548c|M.tuberculosis_H37Rv VTG-----KVFEVEGGIIRVAEGWAHGPQVDKGVKWDPAELGPVVSDLLA
MMAR_5036|M.marinum_M VTG-----KVFEVEGGVIRVAEGWAHGPEVDKGAKWDPAELRLVVADLLA
MUL_4110|M.ulcerans_Agy99 VTG-----KVFEVEGGVIRVAEGWAHGPEVDKGAKWDPAELRLVVADLLA
Mvan_5264|M.vanbaalenii_PYR-1 VTG-----RVFEVEGGKIRVAEGWAHGPEIDKGARWDPAELGSVVPDLLA
Mflv_1492|M.gilvum_PYR-GCK VTG-----KMFEVEGGKIRVAEGWAHGPEIDKGARWDPAELGPVVGDLLA
MSMEG_5999|M.smegmatis_MC2_155 VTG-----KMFEVEGGKIRIAEGWAHGPEIDKGARWDPAELGPVVADLLA
TH_3887|M.thermoresistible__bu VSG-----RVFEVEGGKVRVAEGWAHGPEADKGARWDPAELGPVVRDLLA
MAV_0612|M.avium_104 VTG-----KVFEVEGGKIRVAEGWAHGPQIDKGARWDPAELGPVVADLLG
MAB_0608|M.abscessus_ATCC_1997 VTG-----KVFEVEAGIIRVAEGWAHGPQVDKGARWDPSELGPVVTDLLD
MLBr_02565|M.leprae_Br4923 IAGNRGQTNYATAKAGVIGLTQALAPG-LAEKGITINAVAPGFIETQMTA
::* . .:.* : :::. * * :** :. : ::
Mb3578c|M.bovis_AF2122/97 KSRPPVPVYGA---------------------------------------
Rv3548c|M.tuberculosis_H37Rv KSRPPVPVYGA---------------------------------------
MMAR_5036|M.marinum_M KSRPSVPVYGA---------------------------------------
MUL_4110|M.ulcerans_Agy99 KSRPSVPVYGA---------------------------------------
Mvan_5264|M.vanbaalenii_PYR-1 KARTPVPVYGA---------------------------------------
Mflv_1492|M.gilvum_PYR-GCK KARTPVPVYGA---------------------------------------
MSMEG_5999|M.smegmatis_MC2_155 KARPAVPVYGA---------------------------------------
TH_3887|M.thermoresistible__bu KARQPVPVYGAXXAPPSTACSRSTSALSLRQLVANV--------------
MAV_0612|M.avium_104 KARPPVPVYGA---------------------------------------
MAB_0608|M.abscessus_ATCC_1997 KARTPVPVYGSQG-------------------------------------
MLBr_02565|M.leprae_Br4923 AIPLATREVGRRLNSLLQGGLPVDVAETIAYFAIPASNAVTGNVIRVCGQ
.. *
Mb3578c|M.bovis_AF2122/97 -----
Rv3548c|M.tuberculosis_H37Rv -----
MMAR_5036|M.marinum_M -----
MUL_4110|M.ulcerans_Agy99 -----
Mvan_5264|M.vanbaalenii_PYR-1 -----
Mflv_1492|M.gilvum_PYR-GCK -----
MSMEG_5999|M.smegmatis_MC2_155 -----
TH_3887|M.thermoresistible__bu -----
MAV_0612|M.avium_104 -----
MAB_0608|M.abscessus_ATCC_1997 -----
MLBr_02565|M.leprae_Br4923 AMLGA