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M. thermoresistible (build 8) TH_4393 (-)

annotation: peroxisomal hydratase-dehydrogenase-epimerase (HDE)
coordinates: 237121 - 237996
length: 292

aa seq not available

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. thermoresistible (build 8) TH_4393 - - 100% (292) peroxisomal hydratase-dehydrogenase-epimerase (HDE)
M. thermoresistible (build 8) TH_3887 - 4e-70 51.44% (278) PUTATIVE short chain dehydrogenase
M. thermoresistible (build 8) TH_4061 - 1e-47 40.85% (284) PUTATIVE peroxisomal hydratase-dehydrogenase-epimerase

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3578c - 4e-67 50.35% (288) short chain dehydrogenase
M. gilvum PYR-GCK Mflv_1492 - 3e-68 52.52% (278) short chain dehydrogenase
M. tuberculosis H37Rv Rv3548c - 4e-67 50.35% (288) short chain dehydrogenase
M. leprae Br4923 MLBr_02565 fabG 2e-15 29.30% (256) 3-ketoacyl-(acyl-carrier-protein) reductase
M. abscessus ATCC 19977 MAB_0608 - 7e-67 49.82% (279) short chain dehydrogenase
M. marinum M MMAR_5036 - 1e-69 51.93% (285) short-chain type dehydrogenase/reductase
M. avium 104 MAV_1833 - 1e-144 85.86% (290) peroxisomal hydratase-dehydrogenase-epimerase (HDE)
M. smegmatis MC2 155 MSMEG_5999 - 8e-70 51.97% (279) short chain dehydrogenase
M. ulcerans Agy99 MUL_4110 - 3e-69 51.58% (285) short chain dehydrogenase
M. vanbaalenii PYR-1 Mvan_5264 - 2e-67 51.08% (278) short chain dehydrogenase

CLUSTAL 2.0.9 multiple sequence alignment


TH_4393|M.thermoresistible__bu      --------------------VTGGGRGIGRAHCLALAKHGAAVVVNDPGV
MAV_1833|M.avium_104                ---------MNQPLSGRVVLVTGGGRGIGRAHCLALSAQGAAVVVNDPGV
Mflv_1492|M.gilvum_PYR-GCK          ----------MGLLDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGV
Mvan_5264|M.vanbaalenii_PYR-1       ----------MGLLDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGV
MSMEG_5999|M.smegmatis_MC2_155      ----------MGLLDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGV
Mb3578c|M.bovis_AF2122/97           ----------MGLVDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGV
Rv3548c|M.tuberculosis_H37Rv        ----------MGLVDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGV
MMAR_5036|M.marinum_M               ----------MGLLDGRVVIVTGAGGGIGRAHALAFAAEGARVVVNDIGV
MUL_4110|M.ulcerans_Agy99           ----------MGLLDGRVVIVTGAGGGIGRAHALAFAVEGARVVVNDIGV
MAB_0608|M.abscessus_ATCC_1997      ---------MPGLLDGRVVIITGAGRGIGRAHALAFAAEGARVVVNDIGV
MLBr_02565|M.leprae_Br4923          MAPKCSSDLFSQIVSSGPGSFVAKQLGVPRPETLRRYRPSDAPLCGSLLI
                                                        ...   *: *.. *     .   : ..  :

TH_4393|M.thermoresistible__bu      GRDGTAGD-AGPAAQVVAEIEAM----------GGKAVAHT--GSVAKWD
MAV_1833|M.avium_104                RRDGTAGDGAGPAADVVAEIEAA----------GGKAVAHT--GSVSSWD
Mflv_1492|M.gilvum_PYR-GCK          GLDGSPAGGGSAAQTVVDEIIAA----------GGEAVTSG--ANVADWG
Mvan_5264|M.vanbaalenii_PYR-1       GLDGSPAGGGSAAQAVVDEIVGA----------GGEAVTSG--ANVADWA
MSMEG_5999|M.smegmatis_MC2_155      GLDGSPASGGSAAQTVVDEIVAA----------GGEAVANG--SNVADWA
Mb3578c|M.bovis_AF2122/97           GLDGSPASGGSAAQDVVDEILAA----------GGQAVADG--SDISDWD
Rv3548c|M.tuberculosis_H37Rv        GLDGSPASGGSAAQDVVDEILAA----------GGQAVADG--SDISDWD
MMAR_5036|M.marinum_M               GLDGSPAGGGSAAHGVVDEITAA----------GGEAVANG--SDVSNWQ
MUL_4110|M.ulcerans_Agy99           GLDGSPAGGGSAAHGVVDEITAA----------GGEAVANG--SDVSNWQ
MAB_0608|M.abscessus_ATCC_1997      GLDGS--AGISPAQEVVEEITAA----------GGEAVTNG--DDVADWS
MLBr_02565|M.leprae_Br4923          GGDGRLVEPLRATLEKDYDLVSNNLGGRWTDSFGGLVFDATGITAPAELK
                                      **       .:     :: .           ** ..        :.  

TH_4393|M.thermoresistible__bu      DVADMIRTAVDTFGMLTGVVNN-----AGIVRDATVANATEEDWDAVIAV
MAV_1833|M.avium_104                DVADMINTAVETFGTITGVVNN-----AGIVRDSMVATSTEADWDAVIAV
Mflv_1492|M.gilvum_PYR-GCK          QAEGLIQTAVDAFGGLDVLVNN-----AGIVRDRMFANTSEEEFDAVTAV
Mvan_5264|M.vanbaalenii_PYR-1       QAEGLIQTAVDSFGTLDVLVNN-----AGIVRDRMFANTSEEEFDAVTAV
MSMEG_5999|M.smegmatis_MC2_155      QAESLVQTAVDTFGGLDVLVNN-----AGIVRDRMFANTSEEEFDAVVAV
Mb3578c|M.bovis_AF2122/97           QAANLIQAAVETYGGVDVLVNN-----AGIVRDRMIANTSEEEFDAVIAV
Rv3548c|M.tuberculosis_H37Rv        QAANLIQAAVETYGGVDVLVNN-----AGIVRDRMIANTSEEEFDAVIAV
MMAR_5036|M.marinum_M               QAADLISTAVDTFGGLDVLVNN-----AGIVRDRMMANTSEEEFDAVIAV
MUL_4110|M.ulcerans_Agy99           QAADLISTAVDTFGGLDVLVNN-----AGIVRDRMMANTSEEEFDAVIAV
MAB_0608|M.abscessus_ATCC_1997      GAKNLIDTAVNSFGRLDVLVNN-----AGFLRDRMLANMSEEEWDAVIRV
MLBr_02565|M.leprae_Br4923          GLHNFFTPLLRNLGRCARVVVIGTTPDATTSTDERIAQRALEGFSRSLGK
                                       .:. . :   *    :*       *    *  .*  :   :.     

TH_4393|M.thermoresistible__bu      HLKG------------------------TFAVTRHACEYWRAQAKAGNQ-
MAV_1833|M.avium_104                HLKG------------------------TFAVTKHACEYWRAQFKAGNQ-
Mflv_1492|M.gilvum_PYR-GCK          HLKG------------------------HFATMRHAAAYWRAKSKAGDT-
Mvan_5264|M.vanbaalenii_PYR-1       HLKG------------------------HFATMKHAAAYWRAKSKAGES-
MSMEG_5999|M.smegmatis_MC2_155      HLKG------------------------HFATMKHAAAYWRAKSKAGET-
Mb3578c|M.bovis_AF2122/97           HLKG------------------------HFATMRHAASHWRGLSKAGKAP
Rv3548c|M.tuberculosis_H37Rv        HLKG------------------------HFATMRHAASHWRGLSKAGKAP
MMAR_5036|M.marinum_M               HLKG------------------------HFATMRHAASYWRGLSKAGKA-
MUL_4110|M.ulcerans_Agy99           HLKG------------------------HFATMRHAASYWRGLSKVGKA-
MAB_0608|M.abscessus_ATCC_1997      HLKG------------------------HFAPLRHAAAYWRDEFKAGNA-
MLBr_02565|M.leprae_Br4923          ELRRGATVALVYLSPDAKPAATGLESTMRFILSAKSAYVNGQVFYVGAAD
                                    .*:                          *    ::.        .*   

TH_4393|M.thermoresistible__bu      ----------IDARIVNTVSGAGLWGNIGQAAYGAAKAAIANLTVVTAME
MAV_1833|M.avium_104                ----------IDARIVNTVSGAGLWGNVGQSAYGAAKAAIANLTIVTAME
Mflv_1492|M.gilvum_PYR-GCK          ----------VDARIINTSSGAGLQGSVGQANYSAAKAGIAALTLVAAAE
Mvan_5264|M.vanbaalenii_PYR-1       ----------VDARIINTSSGAGLQGSVGQANYSASKAGIAALTLVAAAE
MSMEG_5999|M.smegmatis_MC2_155      ----------VDARIINTSSGAGLQGSVGQANYSAAKAGIAALTLVAAAE
Mb3578c|M.bovis_AF2122/97           KD--------IDARIINTSSGAGLQGSVGQGNYSAAKAGIAALTLVGAAE
Rv3548c|M.tuberculosis_H37Rv        KD--------IDARIINTSSGAGLQGSVGQGNYSAAKAGIAALTLVGAAE
MMAR_5036|M.marinum_M               ----------VDARIINTSSGAGLQGSVGQANYSAAKAGIAALTLVGAAE
MUL_4110|M.ulcerans_Agy99           ----------VDARIINTSSGAGLQGSVGQANYSAAKAGIAALTLVGAAE
MAB_0608|M.abscessus_ATCC_1997      ----------VDARIINTSSAAGLQGSVGQGNYAAAKAGIATLTLQAAAE
MLBr_02565|M.leprae_Br4923          STPPTNWDRPLENKVAIVTGAARGIGAAIAEVVARDGARVVAIDVESAAE
                                              :: ::  . ..*   *       .   * :. : :  * *

TH_4393|M.thermoresistible__bu      -----GRRYG---VVANAISPLAVTRISQDFFKGE---------------
MAV_1833|M.avium_104                -----AARYG---VAVNAISPLAVTRISEGFFSGE---------------
Mflv_1492|M.gilvum_PYR-GCK          -----MGRYG---VSVNAIAPSARTRMTETVFADM---------------
Mvan_5264|M.vanbaalenii_PYR-1       -----MGRYG---VSVNAIAPSARTRMTESVFADM---------------
MSMEG_5999|M.smegmatis_MC2_155      -----MGRYG---VTVNAIAPSARTRMTETVFADM---------------
Mb3578c|M.bovis_AF2122/97           -----MRRYG---VTVNAIAPAARTRMTETVFAEV---------------
Rv3548c|M.tuberculosis_H37Rv        -----MRRYG---VTVNAIAPAARTRMTETVFAEM---------------
MMAR_5036|M.marinum_M               -----MGRYG---VTVNAIAPAARTRMTETVFAEM---------------
MUL_4110|M.ulcerans_Agy99           -----MGRYG---VTVNAIAPAARTRMTETVFAEM---------------
MAB_0608|M.abscessus_ATCC_1997      -----MGRYG---ITVNAIAPAARTRMTEAVFAET---------------
MLBr_02565|M.leprae_Br4923          ALDETANRVGGTTLSLDVTADDAVDKITEHLHDYQGGHADILVNNAGITR
                                           * *   :  :. :  *  :::: ..                  

TH_4393|M.thermoresistible__bu      ---RADD-----------PALDPARSSE---------------VVAWLQS
MAV_1833|M.avium_104                ---KADD-----------PALDPARSSD---------------VVAWLQS
Mflv_1492|M.gilvum_PYR-GCK          ---MATQDK-------DFDAMAPENVSP---------------LVVWLGS
Mvan_5264|M.vanbaalenii_PYR-1       ---MATQDK-------DFDSMAPENISP---------------LVVWLGS
MSMEG_5999|M.smegmatis_MC2_155      ---MATQDQ-------EFDAMAPENISP---------------IVVWLGS
Mb3578c|M.bovis_AF2122/97           ---MAKPQE-------GFDAMAPENVSP---------------LVVWLGS
Rv3548c|M.tuberculosis_H37Rv        ---MAKPQE-------GFDAMAPENVSP---------------LVVWLGS
MMAR_5036|M.marinum_M               ---MAKPDE-------GFDAMAPENVSP---------------LVVWLAS
MUL_4110|M.ulcerans_Agy99           ---MAKPDE-------GFDAMAPENVSP---------------LVVWLAS
MAB_0608|M.abscessus_ATCC_1997      ---MAKPEDG------AFDAMAPENVSP---------------LVVWLGS
MLBr_02565|M.leprae_Br4923          DKLLANMDDCRWDAVLEVNLLAPQRLTEGLVGNGSISKGGRVIVLSSMAG
                                        *               : * . :                ::  : .

TH_4393|M.thermoresistible__bu      AESGWLTGQILRVDGHKLSRIEGFTEAPSRY--------------HAKDG
MAV_1833|M.avium_104                PEAGWLTGQILRVNGHTLSRIEGYAEAPGRY--------------HAKDG
Mflv_1492|M.gilvum_PYR-GCK          VESRDVTGKMFEVEGGKIRVAEGWAHGP-----------------EIDKG
Mvan_5264|M.vanbaalenii_PYR-1       VESRDVTGRVFEVEGGKIRVAEGWAHGP-----------------EIDKG
MSMEG_5999|M.smegmatis_MC2_155      AEARDVTGKMFEVEGGKIRIAEGWAHGP-----------------EIDKG
Mb3578c|M.bovis_AF2122/97           AESRDVTGKVFEVEGGIIRVAEGWAHGP-----------------QVDKG
Rv3548c|M.tuberculosis_H37Rv        AESRDVTGKVFEVEGGIIRVAEGWAHGP-----------------QVDKG
MMAR_5036|M.marinum_M               AEAGAVTGKVFEVEGGVIRVAEGWAHGP-----------------EVDKG
MUL_4110|M.ulcerans_Agy99           AEAGAVTGKVFEVEGGVIRVAEGWAHGP-----------------EVDKG
MAB_0608|M.abscessus_ATCC_1997      PESREVTGKVFEVEAGIIRVAEGWAHGP-----------------QVDKG
MLBr_02565|M.leprae_Br4923          IAGNRGQTNYATAKAGVIGLTQALAPGLAEKGITINAVAPGFIETQMTAA
                                      .     .   ...  :   :. : .                  .   .

TH_4393|M.thermoresistible__bu      ASLEFSEIGQAVSWLYGTSPRG--------LAGPLPRT------------
MAV_1833|M.avium_104                ASLQFSEIGQAVSWLYRTSPRG--------LAGPLPAD------------
Mflv_1492|M.gilvum_PYR-GCK          ARWDPAELGPVVGDLLAKART----------PVPVYGA------------
Mvan_5264|M.vanbaalenii_PYR-1       ARWDPAELGSVVPDLLAKART----------PVPVYGA------------
MSMEG_5999|M.smegmatis_MC2_155      ARWDPAELGPVVADLLAKARP----------AVPVYGA------------
Mb3578c|M.bovis_AF2122/97           VKWDPAELGPVVSDLLAKSRP----------PVPVYGA------------
Rv3548c|M.tuberculosis_H37Rv        VKWDPAELGPVVSDLLAKSRP----------PVPVYGA------------
MMAR_5036|M.marinum_M               AKWDPAELRLVVADLLAKSRP----------SVPVYGA------------
MUL_4110|M.ulcerans_Agy99           AKWDPAELRLVVADLLAKSRP----------SVPVYGA------------
MAB_0608|M.abscessus_ATCC_1997      ARWDPSELGPVVTDLLDKART----------PVPVYGSQG----------
MLBr_02565|M.leprae_Br4923          IPLATREVGRRLNSLLQGGLPVDVAETIAYFAIPASNAVTGNVIRVCGQA
                                          *:   :  *   .            . *                

TH_4393|M.thermoresistible__bu      ----
MAV_1833|M.avium_104                ----
Mflv_1492|M.gilvum_PYR-GCK          ----
Mvan_5264|M.vanbaalenii_PYR-1       ----
MSMEG_5999|M.smegmatis_MC2_155      ----
Mb3578c|M.bovis_AF2122/97           ----
Rv3548c|M.tuberculosis_H37Rv        ----
MMAR_5036|M.marinum_M               ----
MUL_4110|M.ulcerans_Agy99           ----
MAB_0608|M.abscessus_ATCC_1997      ----
MLBr_02565|M.leprae_Br4923          MLGA

species	id	gene	e-value	identity (len)	annotation
M. thermoresistible (build 8)	TH_4393	-	-	100% (292)	peroxisomal hydratase-dehydrogenase-epimerase (HDE)
M. thermoresistible (build 8)	TH_3887	-	4e-70	51.44% (278)	PUTATIVE short chain dehydrogenase
M. thermoresistible (build 8)	TH_4061	-	1e-47	40.85% (284)	PUTATIVE peroxisomal hydratase-dehydrogenase-epimerase