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RTALVTGGSGGIGKGCARKLVERGYDVLLCARREAPLRAAAEEIGARYMVADASDPIGFPAALSTLETVD LVVHAAGALGGTYARKQTFEQWRAIISANLDSCFVVTSAVLPKMKAGSRLVFISSSAAHEPMPARTAYSA SKAGMNAFARALALEVDRDGISVHLVTPGPVATEMLQDVPFEMYAIAVSDVAEAVVFLDTVDPSVDLPEI RLSAVQRGPFARPPVVPTEARRRAQRG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_1633 | - | - | 100% (238) | NAD dependent epimerase/dehydratase family protein |
| M. avium 104 | MAV_0942 | - | 7e-22 | 38.04% (184) | 3-oxoacyl-(acyl-carrier-protein) reductase, putative |
| M. avium 104 | MAV_4667 | - | 4e-21 | 32.58% (221) | oxidoreductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0494c | - | 3e-21 | 32.14% (224) | putative short-chain type oxidoreductase |
| M. gilvum PYR-GCK | Mflv_0088 | - | 5e-22 | 33.48% (221) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0484c | - | 3e-21 | 32.14% (224) | short-chain type oxidoreductase |
| M. leprae Br4923 | MLBr_00429 | - | 4e-16 | 32.07% (184) | putative oxidoreductase |
| M. abscessus ATCC 19977 | MAB_4060 | - | 1e-20 | 31.70% (224) | putative short chain dehydrogenase/reductase |
| M. marinum M | MMAR_4715 | - | 3e-22 | 38.38% (185) | 3-oxoacyl- |
| M. smegmatis MC2 155 | MSMEG_2013 | - | 2e-22 | 32.00% (225) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. thermoresistible (build 8) | TH_3102 | - | 9e-20 | 34.85% (198) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_0315 | fabG2 | 1e-21 | 37.70% (183) | 3-oxoacyl- |
| M. vanbaalenii PYR-1 | Mvan_6051 | - | 1e-23 | 34.64% (179) | short chain dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0494c|M.bovis_AF2122/97 MTTIGTRKR---VAVVTGASSGIGEATARTLAAQGFHVVAVARRADRITA
Rv0484c|M.tuberculosis_H37Rv MTTIGTRKR---VAVVTGASSGIGEATARTLAAQGFHVVAVARRADRITA
MAB_4060|M.abscessus_ATCC_1997 MTNPTFDGR---VAVVTGASSGIGAATAKSLAALGFHVVVAARREDRVKS
Mflv_0088|M.gilvum_PYR-GCK MTTPSDARR---VAVVTGASAGIGEAIARTLAAQGFHVICVARREGPIKA
MMAR_4715|M.marinum_M MK----------TAVVTGGASGIGLAIARRLRADGIDVATLDLK----TP
MUL_0315|M.ulcerans_Agy99 MRPDSSPSWCTITSVVTGGASGIGLAIARRLSADGTDVATLDLK----TP
TH_3102|M.thermoresistible__bu LK----------NAVVTGGGSGIGQAVAARLRADGYHVATIDLK----PG
Mvan_6051|M.vanbaalenii_PYR-1 ----------MPTAMITGASGGVGSALADALAPT-HTLFLAGRPSPRLDA
MAV_1633|M.avium_104 ----------MRTALVTGGSGGIGKGCARKLVERGYDVLLCARREAPLRA
MSMEG_2013|M.smegmatis_MC2_155 -------MITGRTALVTGAGNGLGRAIALALAHNGARVVLVGRRREPLAA
MLBr_00429|M.leprae_Br4923 --MPIPAPSPEARAVVTGASQNIGEALATELAAHGHSLIVIARREDVLVD
:::**.. .:* . * * :
Mb0494c|M.bovis_AF2122/97 LANQIGGTA------IVADVTDDAAVEALARALSR--VDVLVNNAGGAKG
Rv0484c|M.tuberculosis_H37Rv LANQIGGTA------IVADVTDDAAVEALARALSR--VDVLVNNAGGAKG
MAB_4060|M.abscessus_ATCC_1997 LAGEIGGTA------FVLDVTDADSVAALTQSLDR--VDVLVNNAGGAWG
Mflv_0088|M.gilvum_PYR-GCK LAAEIDGTA------IVADVTDPTAVAALAGRLDR--VDVLVNNAGGARG
MMAR_4715|M.marinum_M DGELAFSAD------VTNRSQVDAALTAIRQRLGP--VTILVN-AAGLDG
MUL_0315|M.ulcerans_Agy99 DGGLAFSAD------VTNRSQVDAALAAIRQRLGP--VTILVN-AAGLDG
TH_3102|M.thermoresistible__bu DDEFSHAAD------VTDRAQVDAAFDAIRTQLGP--VTILVN-AAGLDL
Mvan_6051|M.vanbaalenii_PYR-1 VAERLGATT------WPVDLADPDAIPAVVEPIVE--LDVLIHNAGVAY-
MAV_1633|M.avium_104 AAEEIGARY------MVADASDPIGFPAALSTLET--VDLVVH-AAGALG
MSMEG_2013|M.smegmatis_MC2_155 VAQEIGEAARW----VDCDTSDPAAVAALGAALSDEDISILVNNAGVAGP
MLBr_00429|M.leprae_Br4923 LAARLADKYRVAVEVRPADLTDPSERVKLADELTVRPISILCANAGTAT-
: : :: *.
Mb0494c|M.bovis_AF2122/97 LQFVADADLEHWRWMWDTNVLGTLRVTRALLPKLIDSGDGLIVTVTSIAA
Rv0484c|M.tuberculosis_H37Rv LQFVADADLEHWRWMWDTNVLGTLRVTRALLPKLIDSGDGLIVTVTSIAA
MAB_4060|M.abscessus_ATCC_1997 LEPVLEADLEHWRWMWETNVVGTLQVTRALLPKLIDSGDGLIVTVTSIAA
Mflv_0088|M.gilvum_PYR-GCK LESISDADVENWRWMWEANVMGTLHVTRALLPKLIDSGDGLIVTITSIAA
MMAR_4715|M.marinum_M FKRFSNITFEDWQRVIDVNLNGVFHTIQAVLPDMVAAGWGRIVNISSSST
MUL_0315|M.ulcerans_Agy99 FKRFSNITFEDWQRVIDVNLNGVFHTIQAVLPDMVAAGWGRIVNISSSST
TH_3102|M.thermoresistible__bu FRRFTDISFEDWERVINVNLHGVFHCIQAVLPDMIEAGWGRIVNISSSST
Mvan_6051|M.vanbaalenii_PYR-1 PGRVAESDVDQWRATMAVNVVGAVALTLELLPALRSAG-GHVVFINSGAG
MAV_1633|M.avium_104 GTYARKQTFEQWRAIISANLDSCFVVTSAVLPKMKAGS--RLVFISSSAA
MSMEG_2013|M.smegmatis_MC2_155 VAALTDIEPHEWDEVFAVNVRGVYLMCRQFLPAMTTRGRGDIINVASVSG
MLBr_00429|M.leprae_Br4923 FGPVSALDPAGEKAQVQLNAVAVHDLTLAVLPGMIERKAGGILISGSAAG
* . .** : :: * :
Mb0494c|M.bovis_AF2122/97 LEVYDGGAGYTAAKHAQGALHRTLRGELLGKPVRLTEIAPGAVET-EFS-
Rv0484c|M.tuberculosis_H37Rv IEVYDGGAGYTAAKHAQGALHRTLRGELLGKPVRLTEIAPGAVET-EFS-
MAB_4060|M.abscessus_ATCC_1997 LDVYDGGSGYTSAKHAQAALHRTLRGELLGKPVRLTEVAPGAVET-EFS-
Mflv_0088|M.gilvum_PYR-GCK VEIYDNGGGYTSAKHAQGVLHRTLRSELLGKPVRLTEVAPGMVKT-DFS-
MMAR_4715|M.marinum_M HSGTPYMTHYVAAKSAVNGLTKALALEYGPSGITVNAVPPGFIDT-PMLR
MUL_0315|M.ulcerans_Agy99 HSGTPYMTHYVAAKSAVNGLTKALALEYGPSGITVNAVPPGFIDT-PMLR
TH_3102|M.thermoresistible__bu HSGAPYMAPYVAAKSGVNGLTKTLALEYGPAGITVNAVPPGFIDT-PMLR
Mvan_6051|M.vanbaalenii_PYR-1 INASPGLASYSASKFALRAFADSLRADE--PGLRVTSVHPGRIAT-AMQE
MAV_1633|M.avium_104 HEPMPARTAYSASKAGMNAFARALALEVDRDGISVHLVTPGPVAT-EMLQ
MSMEG_2013|M.smegmatis_MC2_155 KRPLPRRTPYTASKMAVIGLTSTLAFEVGPLGVNVNTLSPGPVDGPRMDR
MLBr_00429|M.leprae_Br4923 NSPIPYNATYAATKAFANTFSESLRGELHGSGVHVTLLAPGPVRT-ELPD
* ::* : :* : : : : ** : :
Mb0494c|M.bovis_AF2122/97 ---LVRFDGDQQRADAVYAGMTPLVAADVAEVIGFVATRPSHVNLDQIVI
Rv0484c|M.tuberculosis_H37Rv ---LVRFDGDQQRADAVYAGMTPLVAADVAEVIGFVATRPSHVNLDQIVI
MAB_4060|M.abscessus_ATCC_1997 ---VVRFDGDQDRADAVYRGITPLVAEDVAEIIAFVASRPPHVNLDQIVV
Mflv_0088|M.gilvum_PYR-GCK ---LNRFDGDAERAEKVYEGVTPLVAEDIAEVVGFVASRPSHVDLDLIVV
MMAR_4715|M.marinum_M NAAAQGHLGDIEQNIARTPVRRIGKPEDIAAACAFLVSEEAGYITGQILG
MUL_0315|M.ulcerans_Agy99 NAAAQGHLGDIEQNIARTPVRRIGKPEDIAAACAFLVSEEAGYITGQILG
TH_3102|M.thermoresistible__bu AAAAKGYLGDIDKTIEATPVRRMGKPEDIAAACAFLISEEAGYITGQILG
Mvan_6051|M.vanbaalenii_PYR-1 D--LVAYEG------RPYDPAQFLSPQTVAQVTADAINAPADAHIHEVIV
MAV_1633|M.avium_104 DVPFEMYAIAVSDVAEAVVFLDTVDPSVDLPEIRLSAVQRGPFARPPVVP
MSMEG_2013|M.smegmatis_MC2_155 NFALEAKTLGISEDQAREAFVGRAALRRMVTEEEVAAAAVAMLNMPGLCG
MLBr_00429|M.leprae_Br4923 HDEASLVEKLVPDFLWISTEHTARLSLDALERNKMRVVPGLTSKAMSVAS
:
Mb0494c|M.bovis_AF2122/97 RPRDQAS--ASRRATHPVR---
Rv0484c|M.tuberculosis_H37Rv RPRDQAS--ASRRATHPVR---
MAB_4060|M.abscessus_ATCC_1997 KPRDQAS--STRRATRQ-----
Mflv_0088|M.gilvum_PYR-GCK RPRDQVSGASGSRFHRQS----
MMAR_4715|M.marinum_M VNGGRNT---------------
MUL_0315|M.ulcerans_Agy99 VNGGRNT---------------
TH_3102|M.thermoresistible__bu VNGGRNT---------------
Mvan_6051|M.vanbaalenii_PYR-1 RPR-------------------
MAV_1633|M.avium_104 TEARRRAQRG------------
MSMEG_2013|M.smegmatis_MC2_155 ADIDLSAGMIAR----------
MLBr_00429|M.leprae_Br4923 RYAPRAIVASIVGNFYKKLGGG